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5858390 |
Use of autologous undifferentiated mesenchymal cells for the repair of skin and soft tissue defects
The application concerns a method of repairing subcutaneous or dermal tissue in a subject. The method involves the preparation of cultured undifferentiated mesenchymal cells from a specimen...
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5855904 |
Biodegradable sustained release preparation for treating periodontitis
The present invention relates to a biodegradable sustained release preparation for treating periodontitis, especially containing polysaccharide. The core of the preparation according to the present...
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5855915 |
Tablets or biologically acceptable implants for long-term antiinflammatory drug release
The present invention involves an aspirin/polyglycolide complex, its preparation and use. The complex provides a stable aspirin source, slowly releasing aspirin by dissociation or during...
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5856367 |
Biocompatible porous matrix of bioabsorbable material
A process for forming biocompatible porous matrices of bioabsorbable materials comprising: a) providing a bioabsorbable polymer; b) dissolving the bioabsorbable polymer in a volumetric...
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5855905 |
Compound preparation for the treatment of hypogonadal men and men with hypophyseal diseases
A compound preparation for the treatment of hypogonadal men and men with hypophyseal diseases. This invention relates to compound preparations containing biogenous or synthetic androgens and...
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5853746 |
Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
Methods and compositions are provided for the treatment and repair of defects in the cartilage or bone of humans and other animals as in full-thickness defects in joints. To induce cartilage...
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5851546 |
Polymer composition for controlled release of active ingredients in response to pH, and a process of preparing the same
The present invention provides a polymer for the controlled release of a pendent chain linked active ingredient, and a process for the preparation of such a polymer for the controlled release of an...
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5851547 |
Controlled release drug formulation of open end cylindrical rod form
A drug formulation for producing sustained therapeutic efficacy, which releases at least one water-soluble drug over a prolonged period of time at a substantially constant rate wherein said drug...
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5851833 |
Neomorphogenesis of urological structures in vivo from cell culture
Methods and artificial matrices for the growth and implantation of urological structures and surfaces are disclosed in which urothelial cells are grown in culture on biodegradable, biocompatible,...
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5847046 |
Biodegradable bone cement
A surgical bonding material includes a continuous phase and a discontinuous phase. The continuous phase is formed from a polymerizable liquid. The discontinuous phase includes particles of...
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5844017 |
Prepolymers of absorbable polyoxaesters containing amines and/or amido groups
The present invention describes a prepolymer of aliphatic polyoxaesters containing amines and/or amido groups having polymerizable end groups that may be used to produce surgical devices such as...
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5837228 |
Bioerodible implants
A bioerodible controlled release dosage form is disclosed comprising a polymer formed by condensing beneficial agents having a hydroxyl functionality of two or more with diketene acetals or divinyl...
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5837752 |
Semi-interpenetrating polymer networks
Compositions for bone repair have been developed based on linear hydrophobic degradable polymers and monomers or macromers, at least one of which includes an anhydride linkage. The monomers and/or...
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5834001 |
Methods for making immunoisolatory implantable vehicles with a biocompatiable jacket and a biocompatible matrix core
A method of forming an implantable and retrievable immunoisolatory vehicle is disclosed, the method comprising the steps of first forming a jacket of biocompatible thermoplastic or hydrogel, and...
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5830493 |
Bone-forming graft
A bone-forming graft that includes a bone morphogenetic protein (BMP) carried on a composite porous body. The composite porous body has a porous frame of a bioabsorbable hydrophilic material and a...
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5820608 |
Method for in vivo chemically triggered disintegration of medical device
The present invention provides medical devices comprised of ionically crosslinked polymer, especially, stents, catheter or cannula components, plugs, and constrictors. The medical devices of the...
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5817326 |
Processing of hydroxylapatite coatings on titanium alloy bone prostheses
Processing of hydroxylapatite sol-gel films on titanium alloy bone prostheses. A method utilizing non-line-of-sight ion beam implantation and/or rapid thermal processing to provide improved bonding...
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5817328 |
Material for buffered resorbable internal fixation devices and method for making same
A bioerodible implantable material, comprising a bioerodible polymer that produces acidic products upon hydrolytic degradation, and a buffering compound that buffers the acidic products and...
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5814328 |
Preparation of collagen using papain and a reducing agent
Purified collagen is produced by contacting a collagen sample with a first proteolytic enzyme, a reducing agent and a second proteolytic enzyme. Preferably, the first and second proteolytic enzymes...
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5807581 |
Collagen-based injectable drug delivery system and its use
Drugs are delivered in a sustained manner from an in vivo depot which is formed from a collagen-based injectable composition. The injectable composition is fluid when injected but undergoes...
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5804178 |
Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
A matrix structure containing attached cells such as endocrine cells, fibroblasts, endothelial cells or genitourinary cells is implanted in a patient adjacent tissue having a high surface area and...
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5800829 |
Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
A method of making an immunoisolatory vehicle comprised of a core comprising living cells dispersed in a biocompatible matrix is disclosed, the cells being capable of secreting a biologically...
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5800373 |
Initiator priming for improved adherence of gels to substrates
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making for making the barrier. In the preferred...
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5795584 |
Post-surgical anti-adhesion device
Surgical adhesion barriers and methods of using such surgical adhesion barriers are provided. Surgical adhesion barriers according to the present invention have at least one layer of a...
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5792469 |
Biodegradable in situ forming film dressing
The invention is directed to a biodegradable film dressing with or without additional therapeutic agents, an apparatus for spray delivery and a method for formation of the film dressing-on a human...
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5792478 |
Tissue injectable composition and method of use
An improved biocompatible composition consisting of physiologically stable beads or particles carried in a lubricative suspension, solution, other fluid or gel. The composition is intended to be...
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5788976 |
Method for effecting bone repair
A method is provided for the repair of a bone defect in a patient which employs a bone growth-stimulating composition derived from healthy cancellous bone.
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5788979 |
Biodegradable coating with inhibitory properties for application to biocompatible materials
A method is disclosed for coating a biomaterial to be placed in contact with a patient's blood flow to inhibit blood coagulation from adhering to the biomaterial that would otherwise result from...
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5788978 |
Injectable pulsatile ivermectin composition
An injectable ivermectin composition having a programmable release rate and providing multiple concentration peaks of active ivermectin to produce a sequence of ivermectin release pulses into the...
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5783214 |
Bio-erodible matrix for the controlled release of medicinals
A bioerodible matrix for the controlled release of medicinals including protein therapeutics is disclosed. A method for controlled drug release is also disclosed.
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5783205 |
Injectable drug delivery system and method
The present invention is directed to a material which can be used to deliver a drug, such as an antibiotic, into a diseased tissue pocket, such as a periodontal pocket. The material is preferably a...
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5780051 |
Methods and articles of manufacture for nicotine cessation and monitoring nicotine use
The present invention features methods and articles of manufacture for treating nicotine withdrawal symptoms and promoting smoking cessation. The methods and articles feature the administration of...
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5780044 |
Liquid delivery compositions
Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid...
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5770193 |
Preparation of three-dimensional fibrous scaffold for attaching cells to produce vascularized tissue in vivo
Fibers of a biocompatible, biodegradable or non-biodegradable, synthetic polymer are provided, and are formed into a three-dimensional scaffold. The fibers of the scaffold may have a branched...
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5770417 |
Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
A cell-scaffold composition is prepared in vitro for implanting to produce functional organ tissue in vivo. The scaffold is three-dimensional and is composed of hollow or solid fibers of a...
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5770234 |
Particle induced amplification of immune response
A non-specific host defense cell augmentation technique for enhanced microorganism killing utilizes any phagocytosable particle to prime macrophages for enhanced oxidative response and bacterial...
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5766631 |
Wound implant materials
Wound implant materials are described comprising a plurality of bioabsorbable microspheres bound together by a bioabsorbable matrix, such as in a freeze-dried collagen matrix. The microspheres...
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5766584 |
Inhibition of vascular smooth muscle cell proliferation with implanted matrix containing vascular endothelial cells
A composition and method are provided for inhibition of vascular smooth muscle cell proliferation following injury to the endothelial cell lining of a blood vessel such as resulting from...
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5766618 |
Polymeric-hydroxyapatite bone composite
A method for the fabrication of three-dimensional macroporous polymer matrices for use as bone graft or implant material was developed. The composites are formed from a mixture of biodegradable,...
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5762918 |
Methods of using steroid-polyanionic polymer-based conjugated targeted to vascular endothelial cells
This invention discloses new targeted conjugates for the delivery of a compound, and particularly, a steroid, to vascular endothelial cells. The conjugates comprise two components, preferably...
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5762950 |
Bioceramic system for delivery of bioactive compounds
A bioceramic system for delivery of a bioactive compound, which comprises a combination of bioactive glass, bioactive glass ceramic or bioactive ceramic, hydroxyapatite, optionally one or more...
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5759564 |
Iontophoretic material
An iontophoretic material is provided that uses controlled electrical current derived from two dissimilar galvanic materials to drive oligodynamic metal ions into solution to kill microorganisms on...
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5756127 |
Implantable bioresorbable string of calcium sulfate beads
A bioresorbable string of implantable beads in which the beads consist essentially of calcium sulfate and a quantity of a drug suitable for treating tissue disorders, and in which both the beads...
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5756652 |
Poly (ester-anhydrides) and intermediates therefor
Biodegradable poly(ester-anhydrides) designed to display two-stage degradation profiles are described. The presence of the anhydride linkages allows a relatively rapid decrease in molecular weight,...
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5753251 |
Anti-microbial coating for medical device
Anti-microbial coatings and method of forming same on medical devices are provided. The coatings are formed by depositing a biocompatible metal by vapor deposition techniques to produce atomic...
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5750146 |
Translucent collagen formulations with a cytotoxic drug
Disclosed are translucent proteinaceous compositions comprising collagen and an effective amount of a compatible cytotoxic drug which compositions are characterized by having a single collagen...
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5750585 |
Super absorbent hydrogel foams
A water swellable foam matrix formed as a macroporous solid comprising a foam stabilizing agent and a polymer or copolymer of a free radical polymerizable hydrophilic olefin monomer crosslinked...
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5747060 |
Prolonged local anesthesia with colchicine
A formulation for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable,...
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5744166 |
Drug delivery compositions
Compositions for delivery of pharmacologically active agents and methods for their administration are provided. In one embodiment, the compositions include a complex of a polycationic polymer and a...
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5741479 |
Desensitizing teeth with degradable particles
A method for desensitizing a hypersensitive tooth in a patient includes contacting exposed tubules with particles including a degradable material.
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