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5962005 |
Transparent cellulose hydrogel and production process thereof
A transparent cellulose hydrogel having a transmittance of visible light of not less than 70%/mm and a tensile strength of not less than 10 kg/cm 2 , wherein the hydroxyl groups of cellulose...
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5958427 |
Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
The invention is directed to nitric oxide (NO) donor compounds and to pharmaceutical compositions containing such nitric oxide (NO) donor compounds, for delivering NO to the apical surface of a...
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5958444 |
Method for treating urinary reflux
Disclosed are methods for treating vesicoureteral reflux in a mammal wherein a composition comprising a water insoluble biocompatible polymer and a biocompatible solvent is delivered to the...
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5958430 |
Thin film composition with biological substance and method of making
The invention provides a thin-film composition comprising an underlying substrate of a first material including a plurality of attachment sites; a plurality of functional groups chemically attached...
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5958441 |
Devices comprising chondrogenic protein and methods of inducing endochondral bone formation therewith
Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains...
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5955108 |
Cross-linked microparticles and their use as therapeutic vehicles
A sterile powder comprising microparticles, 0.1 to 50 μm in diameter, obtainable by spray-drying and cross-linking a water-soluble material having free functional groups, is characterized in that...
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5955068 |
Biodegradable polanhydrides derived from dimers of bile acids, and use thereof as controlled drug release systems
New biodegradable polyanhydrides are disclosed, which are prepared by homopolymerization of dimer of bile acid, especially lithocholic acid, or bycopolymerization with linear dicarboxylic acid,...
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5951997 |
Aliphatic polyesters of ε-caprolactone, p-dioxanone and gycolide
Absorbable, segmented polymers of aliphatic polyesters based on lactone monomers glycolide, p-dioxanone and ε-caprolactone are described. The segmented polymers exhibit a broad range of...
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5948427 |
Microparticulate surgical adhesive
Flowable polymeric microparticulate surgical adhesive formulations are provided which can be activated at the site of the repair to produce a cohesive material with tissue bonding properties to...
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5948426 |
Method and article to induce hematopoietic expansion
An article and method to create retrievable sites of implantable and transplantable bone marrow, in a human or animal recipient, by implanting bone-marrow inducing conjugates of collagen and...
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5948429 |
Methods for preparing biopolymer foams
A biopolymer solution is polymerized to form a gel which is freeze-dried and crosslinked with ultraviolet radiation to form a biopolymer foam. The foam is filled with a collagen solution and the...
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5945457 |
Process for preparing biologically compatible polymers and their use in medical devices
A hemocompatible composition comprising a polymer containing at least one pharmacologic material chemically bonded to a polymer backbone. Such compositions may be obtained by reacting a...
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5945115 |
Polymeric compositions useful as controlled release implants
The invention is directed to an improved system for controlled release of biologically active materials and to a liquid composition for its formation. The liquid composition is composed of a...
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5942252 |
Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their release
A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to...
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5942242 |
Medicaments for nasal administration
A medicament for nasal administration to be used for disease prevention or treatment comprising a vaccine or a pharmacologically active peptide compounded with an ion exchange resin or adsorbent...
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5939380 |
Implant preparations containing bioactive macromolecule for sustained delivery
Implant preparations capable of sustained action when inserted are comprised of powder of a natural lipoidal substance in thorough admixture with bioactive macromolecule, followed by compression...
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5939323 |
Hyaluronan based biodegradable scaffolds for tissue repair
A hyaluronic acid derivitized scaffold and method of forming are disclosed. The scaffolds are useful for various medical purposes such as tissue repair, tissue reconstruction and wound healing. In...
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5935594 |
Process and device for treating and healing a tissue deficiency
An improved method or process and device for treating and healing a bone void is disclosed, and in particular a method employing a surfactant for efficiently incorporating a biologically active...
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5925619 |
Formulation for peptide release
A pharmaceutical or veterinary formulation comprising deslorelin and an excipient is provided which releases in vitro deslorelin into phosphate buffered saline at 370° C. at a rate of about 2-80...
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5919473 |
Methods and devices for delivering opioid analgesics to wounds via a subdermal implant
An analgesic agent delivery system and method of treating postoperative pain comprising an analgesic agent such as morphine and an extended-release drug delivery device. The device may be placed in...
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5919835 |
Biodegradable polymer blends for drug delivery
Blends of polymers having properties distinct from the individual polymer components and that are suitable for use as carriers of pharmaceutically active agents, are prepared from two or more...
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5916584 |
Controlled release container with core and outer shell
A controlled release container includes an outer shell and a separately produced core that comprises at least one bioactive molecule. At least a portion of the outer shell comprises a biodegradable...
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5916583 |
Precipitation of one or more active compounds in situ
The present invention relates to an injectable solution for administration of one or more active compounds. According to the invention the active compound, which is in its neutral form, is...
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5916585 |
Materials and method for the immobilization of bioactive species onto biodegradable polymers
The present invention is directed to hydrophobic biodegradable polymeric materials having at least one surface thereof rendered more hydrophilic by attachment of at least one layer of a hydrophilic...
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5914121 |
Formation of human bone in vivo using ceramic powder and human marrow stromal fibroblasts
An in vivo model for human bone metabolism. Human marrow stromal fibroblasts are isolated, expanded in culture, combined with ceramic powder (hydroxyapatite) delivery vehicles with or without...
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5912014 |
Oral salmon calcitonin pharmaceutical products
Bioavailability of salmon calcitonin to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine, together with an absorption...
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5910315 |
Allograft tissue material for filling spinal fusion cages or related surgical spaces
An extrudable allograft bone tissue material for filling surgical sites can be made from mineralized or demineralized cortical, cancellous, or cortical/cancellous bone powder. A method is disclosed...
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5906826 |
Method of inducing an immune response in a young animal
The invention provides a method of priming an immune response in the presence of maternal antibody in a young animal by administering to a 1-90 day old animal, a biocompatible and non-toxic solid...
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5902832 |
Method of synthesizing swollen hydrogel for sphincter augmentation
A synthesis method is set forth for forming a physiologically acceptable composition comprising a plurality of physiologically acceptable hydrogel particles which have been swollen in a water...
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5902599 |
Biodegradable polymer networks for use in orthopedic and dental applications
Biodegradable polymer networks are provided which are useful in a variety of dental and orthopedic applications. The biodegradable polymer networks can be formed in one embodiment by polymerizing...
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5891477 |
Non-steroidal anti-inflammatory agents inhibition of fibrotic response to an implanted device
Methods for inhibition of fibrotic rejection of implanted devices which contain cells by administering to the recipient of the devices an amount of a non-steroidal anti-inflammatory agent (NSAID)...
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5891455 |
Process for producing an implant from cell cultures
In a process for producing an implant from cell cultures in vitro, tissue cells, particularly cartilage cells, are introduced into a three-dimensional self-supporting structure preformed preferably...
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5891456 |
Glyceryl monosterate based biodegradable implants for site-specific delivery of drugs
A method to administer a drug locally to a subject in which biodegradable dosage forms that contain the drug are implanted at a localized site beneath the skin of the subject whereupon the dosage...
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5888988 |
Covalently linked N,O-carboxymethylchitosan and uses thereof
Covalent compositions of N,O-carboxymethyl chitosan (NOCC) are disclosed. NOCC can be intra- or intermolecularly linked, either through a direct bond or through a bridging moiety. Also disclosed...
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5876756 |
Microcapsule containing amorphous water-soluble 2-piperazinone-1-acetic acid compound
A microcapsule contains a pharmaceutically effective amorphous water-soluble 2-piperazinone-1-acetic acid compound or salt thereof and a polymer binder and a method of preparing said microcapsule....
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5876743 |
Biocompatible adhesion in tissue repair
A process for enhancing the (a) normal healing processes involving a live mammalian body of (i) injured non-dental-related soft tissue, and (ii) non-dental-related osseous material, and ...
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5876761 |
Sustained release formulations of water soluble peptides
The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably...
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5874509 |
Surface modified glasses and composites thereof
An inorganic glass having an aliphatic polymer covalently bonded to the surface thereof is disclosed for providing improved adhesion to a matrix polymer when the glass is employed as a composite...
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5874101 |
Bioactive-gel compositions and methods
A process for making bioactive glasses is described including preparing a reaction mixture of reactants capable of forming a sol-gel, aging the reaction mixture, near equilibrium drying a gel...
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5874100 |
Alginate fibres, manufacture and use
A non-immunogenic, bioerodible implantation composition which comprises alginate fibres.
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5874099 |
Methods for making immunoisolatary implantable vehicles with a biocompatible jacket and a biocompatible matrix core
A method of forming an implantable and retrievable immunoisolatory vehicles is disclosed, the method comprising the steps of first forming a core comprising a volume of at least 1 μl and at least...
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5871767 |
Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
A method for treatment of a neurodegenerative condition in a patient comprising implanting in the patient at least one immunoisolatory vehicle comprising a corc comprising a volume of at least 1...
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5871771 |
Micronized biodegradable particles, process for preparing them and use thereof
The invention relates to micronized biodegradable particles, processes for preparing them and use thereof.
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5871778 |
Sustained release microsphere preparation containing antipsychotic drug
A sustained release microsphere preparation which is produced by including a hydrophobic antipsychotic drug such as bromperidol, haloperidol or the like into a base composed of a high molecular...
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5869079 |
Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other's rate of release. Formulations of a therapeutically active agent...
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5869080 |
Absorbable implant materials having controlled porosity
Absorbable implant materials having controlled porosity are formed by a method comprising the steps of: providing a dispersion of a bioabsorbable polymer, such as collagen, in a first solvent, such...
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5869170 |
Preparation of medical devices by solid free-form fabrication methods
Solid free-form techniques for making medical devices for controlled release of bioactive agent and implantation and growth of cells are described using computer aided design. Examples of SFF...
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5869077 |
Methods for treating diabetes by delivering insulin from biocompatible cell-containing devices
A method for treating diabetes in a patient comprising subcutaneously implanting in the patient at least one immunoisolatory vehicle comprising a core comprising a volume of at least 1 μl and at...
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5865814 |
Blood contacting medical device and method
A a blood-contacting medical device with improved biocompatibility. The device is coated with a layer of water-soluble heparin, overlaid by a porous polymeric coating through which the heparin can...
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5866619 |
Colonic drug delivery system
A colonic delivery system for delivering a drug to the colon is provided. The system comprises a drug in combination with a matrix, wherein the matrix comprises a saccharide-containing polymer....
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