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9040111 Method of making a stent  
A method of making a stent, including preparing a solution containing a composition, the composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind,...
9034363 Drug-eluting insertable medical device for treating acute myocardial infarction, thrombus containing lesions and saphenous-vein graft lesions  
A method for delivering at least one drug at a target site in a blood vessel for treating at least one of an acute myocardial infarction, a thrombus containing lesion and a saphenous-vein graft...
9017711 Soft tissue wrap  
Compositions and methods for treating and healing injured soft tissues such as tendons and ligaments are provided. The composition may be a wrap comprising human collagen in the form of a sheet....
9011899 Methods and devices for cellular transplantation  
Devices and methods for transplanting cells in a host body are described. The cell comprises a porous scaffold that allows ingrowth of vascular and connective tissues, a plug or plug system...
9005960 Functionalized membrane for a chamber for encapsulating cells producing at least one substance of therapeutic interest and bioartificial organ comprising such a membrane  
The present invention relates to a functionalized semi-permeable membrane composed of a porous biocompatible support pretreated so as to increase the surface energy thereof and characterized in...
8992961 Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles  
This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended...
8980302 Therapeutic implant  
Surgical implants of the present disclosed include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct...
8980298 Implantable tizanidine compositions and methods of treatment thereof  
A method of treating the symptoms of spasticity comprises implanting a reservoir-based drug delivery composition into a subject to systemically deliver a therapeutically effective amount of...
8968392 Method of inhibiting vascular intimal hyperplasia using stent  
A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces...
8968417 Bioactive implant for myocardial regeneration and ventricular chamber restoration  
Bioactive implant for myocardial regeneration and ventricular chamber support including an elastomeric microporous membrane. The elastomeric microporous membrane being at least one non-degradable...
8968762 Implant for tissue repair including chitosan  
The present disclosure provides mono- and multi-layered implants which include at least one porous layer made from a freeze-dried aqueous solution containing chitosan, the solution having a pH of...
8945600 Methods of delivering pharmaceutical agents  
Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include...
8905032 Occlusion of fallopian tubes in a vertebrate subject  
According to one claim of the invention, a method for occluding a fallopian tube in a vertebrate subject is described, which comprises comprising transcervically delivering a solid blocking...
8906403 Biomaterials carrying cyclodextrins having improved absorption properties and used for the progressive and delayed release of therapeutic molecules  
A method for preparing a biomaterial containing at least one bioactive molecule from a base biomaterial, comprising the following successive operations carried out on the base biomaterial: a)...
8900865 Blood brain barrier device  
Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to...
8883186 Coatings for drug delivery devices  
A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The...
8877225 Controlled release copolymer formulation with improved release kinetics  
The present invention provides a constant release copolymer composition adapted for use in a controlled release formulation for a bioactive agent, such as a formulation adapted for implantation...
8871241 Injectable sustained release delivery devices  
An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as...
8864844 Tissue scaffold  
A tissue engineered construct made totally or in part from biocompatible materials and mammalian cells and/or cell products is provided. These constructs are useful in regenerating complex tissues...
8858982 Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts  
This invention is a prosthetic device generally placed on the outside surface of the vessel or graft which then elutes antiproliferative drugs or agents from a drug-eluting matrix material....
8846069 Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same  
Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
8834979 Bag for forming an implantable artificial organ  
A pouch for forming an implantable artificial organ, including a closed shell provided in a semi-pervious membrane. The pouch further includes a sheet contained within the shell, the sheet...
8828418 Methods of forming coating layers for medical devices utilizing flash vaporization  
Methods are disclosed for controlling the morphology and the release-rate of active agent from coating layers for medical devices comprising a polymer matrix and one or more active agents. The...
8815278 Drug delivery device and method  
Many people need vascular access for procedures such as hemodialysis. It is desirable that this access remain open or patent for the entire duration of the course of treatments. A drug delivery...
8815276 Three-dimensional nanostructured hybrid scaffold and manufacture thereof  
A method of making a three-dimensional biocompatible scaffold capable of supporting cell activities such as growth and differentiation, the method includes providing a supporting grid that forms...
8815274 Poly(ester amides) for the control of agent-release from polymeric compositions  
The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a...
8808727 Posterior segment drug delivery  
A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic...
8802184 Medical devices containing biobeneficial particles  
A method of modifying a medical device such as a stent with nano-constructs is disclosed. The method comprises applying a first fluid to the stent; immersing the stent being wet from the first...
8795712 Posterior segment drug delivery  
A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic...
8784859 Biobeneficial coating compositions and methods of making and using thereof  
A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the...
8784866 Water-soluble carbon nanotube compositions for drug delivery and medicinal applications  
Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some...
8758799 Therapeutic implant  
Surgical implants are provided which include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct contact...
8758800 Therapeutic implant  
Surgical implants are provided which include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct contact...
8758798 Therapeutic implant  
Surgical implants are provided which include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct contact...
8758796 Functionalizing implantable devices with a poly (diol citrate) polymer  
The present invention is directed to a novel poly(diol citrates)-based coating for implantable devices. More specifically, the specification describes methods and compositions for making and using...
8734834 Acrylic hydrogels with deprotonated amine groups that undergo volumetric expansion in response to changes in environmental pH  
Hydrogels are described that expand volumetrically in response to a change in their environment and as well as their methods of manufacture and use.
8734818 Methods for treating cognitive/attention deficit disorders using tetrahydroindolone analogues and derivatives  
The present specification discloses tetrahydroindolone derivatives or analogues and methods for treating cognitive/attention deficit disorders using such tetrahydroindolone derivatives and analogues.
8728509 Implant depots to deliver growth factors to treat osteoporotic bone  
The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat osteoporotic bone, in that such depot implant is constructed to be in...
8715436 Microfabricated biopolymer scaffolds and method of making same  
The invention is a series of soft lithographic methods for the microfabrication of biopolymer scaffolds for use in tissue engineering and the development of artificial organs. The methods present...
8707958 Methods and devices for deployment into a lumen  
The invention described is directed to an intracorporeal occluding device having elements with non-traumatic ends and devices, systems and methods for occluding the lumens of anatomical...
8703168 Medical devices for releasing therapeutic agent and methods of making the same  
An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be...
8702810 Bio-artificial pancreas and a procedure for preparation of same  
The present invention generally relates to implantable devices for producing insulin in diabetic animals and to methods of making same. Some embodiments include amphiphilic biomembranes for use in...
8702645 Implantable-glucose responsive insulin delivery device  
A biocompatible insulin delivery device is provided comprising an insulin reservoir sealed with a glucose-responsive plug or membrane. The plug functions to release insulin from the reservoir in...
8703110 Coating system  
Embodiments of the invention include a system comprising: an Acetoxy curable silicone Binder; and an active agent blended with the silicone binder, effective for one or more of radiopacification,...
8696740 Implantable pressure-actuated drug delivery systems and methods of manufacture and use  
Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication...
8691263 Extracellular matrix comprising platelet concentrate and cryoprecipitate polymerized in situ  
The present invention describes an extracellular matrix comprising human platelet derived growth factors, that permits the maximizing of therapeutic efficacy, combining the benefits of both...
8685429 Shaped bodies and methods for their production and use  
Shaped, composite bodies are provided. One portion of the shaped bodies comprises an RPR-derived porous inorganic material, preferably a calcium phosphate. Another portion of the composite bodies...
8679519 Coating designs for the tailored release of dual drugs from polymeric coatings  
Provided herein are coating designs for the tailored release of two therapeutic agents from polymer coatings and methods of making and using the same.
8673338 Methods of delivering pharmaceutical agents  
Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include...
8668919 Polymer for creating hemocompatible surface  
A polymer comprising a phosphoryl choline moiety(ies), a composition comprising the polymer and optionally a bioactive agent, an implantable device such as a DES or a non-implantable device such...