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6368612 |
Devices for cloaking transplanted cells
Implantable devices that include a source of a therapeutic substance and a capture agent are disclosed.
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6350463 |
Method of treatment for premature rupture of membranes in pregnancy (PROM)
Premature Rupture of the Membranes (PROM) is a serious complication of pregnancy. PROM is treated by creation of a seal or barrier at the site of the rupture or in or near the cervix, thereby...
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6331313 |
Controlled-release biocompatible ocular drug delivery implant devices and methods
Controlled release devices are disclosed which are biocompatible and can be implanted into the eye. The devices have a core comprising a drug and a polymeric outer layer which is substantially...
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6326018 |
Flexible sheet of demineralized bone
The invention is directed toward a malleable bone putty and a flowable gel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth...
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6326019 |
Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries
A method for making, storing and using a surgical graft from human amniotic membrane; the resulting graft; and the storage solution. The amniotic membrane is obtained from human placenta, from...
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6319512 |
Implants for controlled release of pharmaceutically active principles and method for making same
The present intention relates to an implant for the controlled release of at least one pharmaceutically active principle comprising a core containing at least one active principle and a sheath...
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6316018 |
Drug-releasing coatings for medical devices
The invention is directed to medical devices having a drug-releasing coating and methods for making such coated devices. The coating permits timed or prolonged pharmacological activity on the...
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6306491 |
Respiratory aids
The present invention is directed to materials that assist respiration of living cells contained in cell-containing systems. The materials form air-filled conduits or channels through which gases,...
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6306845 |
Method for treating demyelinating disease
The present invention provides a method for treating a demyelinating disease in a subject which includes administering to the subject a therapeutically effective amount of a high affinity...
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6303136 |
Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
A device is prepared having cells or tissue attached to a non-degradable filamentous matrix surrounded by a semi-permeable membrane. The matrix is preferably formed of a plurality of monofilaments...
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6303117 |
Ice granules containing endotoxins of Bacillus thuringiensis israelensis (BTI) or Bacillus sphaericus (BS)
Endotoxins, in a preparation of ice granules, from Bacillus thuringiensis and/or Bacillus sphaericus are used to combat mosquito larva.
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6303138 |
Endothelin-based compositions for enhancing connective tissue repair
The present invention is directed to bioactive composition that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in...
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6287601 |
Topical nitric oxide donor compositions
Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID...
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6267980 |
Dosage forms and uses
A pharmaceutical dosage form comprises, in a portion thereof, substantially single enantiomer (R)-verapamil and, in another, separate, portion thereof, substantially single enantiomer...
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6258856 |
Method for preventing or controlling cataract
A method for preventing or treating pathological changes which occur in association with cataract formation in the mammalian eye by protecting lens cells against the cataractogenic effects of...
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6251419 |
Membrane system for controlled tissue regeneration in cases of diseases of the periodontium
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6248344 |
Composite and its use
A porous composite suitable for filling a recess or a through-passing hole in an implant. The composite includes particles A prepared from a bioactive material and particles B prepared from a...
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6238687 |
Biodegradable polymers, compositions, articles and methods for making and using the same
Biodegradable polymer compositions that degrade in vivo into non-toxic residues are described. In part, the present invention is directed to such polymers containing phosphorus and desaminotyrosyl...
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6235726 |
Water insoluble derivatives of polyanionic polysaccharides
A water insoluble, biocompatible composition that includes the reaction product of a polyanionic polysaccharide and an activating agent.
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6214370 |
Method and device for administering analgesics
A device and method is disclosed for continuously administering an analgesic to the neuraxis of an organism. The device comprises a polymeric matrix body loaded with the analgesic. The body is...
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6200589 |
Biological implants of semipermeable amphiphilic membranes
An implantable biological device including a semipermeable membrane formed into a geometric shape capable of encapsulating biological cells and capable of immunoisolating the biological cells upon...
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6190685 |
Antioxidizing composition for scavenging free radicals, pharmaceutical composition comprising the same, and process for preparing the same
An anti-oxidizing composition for scavenging free radicals, comprising at least one essential oil component containing a number of fat-soluble, low-molecular-weight compounds, a pharmaceutical...
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6187329 |
Variable permeability bone implants, methods for their preparation and use
The present invention involves filler for treating injured tissue sites made from compositions having variable permeability to bodily fluid to reduce the flow to these fluids (bleeding) from the...
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6180606 |
Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
Osteogenic compositions, and methods for preparing same, which compositions comprise a porous or semi-porous matrix, an osteogenic factor and an agent such as growth factors, nutrient factors,...
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6180129 |
Polyurethane-containing delivery systems
A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the...
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6180605 |
Composition with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
The present invention provides improved osteogenic compositions having enhanced by the sorption of growth factors, of nutrient factors, or drugs onto or into the compositions. Compositions may...
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6180007 |
Membrane formed by an acrylonitrile-based polymer
A permselective graft polymer is disclosed that is formed by converting into intermediate reactive sites a portion of the cyano groups of a backbone polymer containing --CH 2 --CH(--C.tbd.N)--...
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6174299 |
Method for treating hemophilia A and B and AIDS and devices used therein
The present invention provides a method for treating Hemophilia A or B which comprises implanting in fluid communication with the bloodstream of a mammal in need of such treatment a permeable...
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6168801 |
Controlled release drug delivery
Biologically active materials are provided in a cylindrical carrier medium with better control over the rate of delivery and length of time of delivery by providing a carrier having dissolved or...
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6165486 |
Biocompatible compositions and methods of using same
Blends of biodegradable polymers, preferably poly(caprolactone) and poly(D,L-lactic-co-glycolic) acid are discussed as well as their applications in the medical field, particularly with regard to...
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6159488 |
Intracoronary stents containing quinazolinone derivatives
The invention provides an intracoronary stent coated with a quinazolinone derivative of formula (I), wherein n is 1 or 2, R 1 is a member of the group consisting of hydrogen, halogen, nitro,...
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6153210 |
Use of locally delivered metal ions for treatment of periodontal disease
Periodontal disease can be treated by the administration of metal ions, preferably silver ions, to the site where the microorganisms that cause this disease reside. Administration can be to...
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6146771 |
Process for modifying surfaces using the reaction product of a water-insoluble polymer and a polyalkylene imine
A process for modifying a surface of an article that includes treating a surface with a solution that includes an organic solvent, and the reaction product of a substantially water insoluble...
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6136296 |
Personal care compositions
The present invention relates to personal care compositions. These compositions comprise an adhesive copolymer and a solvent for the copolymer selected from the group consisting of water, ethanol,...
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6123700 |
Method and apparatus for sealing implantable membrane encapsulation devices
A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner...
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6120536 |
Medical devices with long term non-thrombogenic coatings
A coating and method for implantable open lattice metallic stent prostheses are disclosed. The coating includes a relatively thin layer of biostable elastomeric material containing an amount of...
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6118043 |
Bone replacement material with FGF
The invention relates to a bone replacement material which comprises one or more polypeptides having the biological action of fibroblast growth factors in a porous matrix. The healing-in properties...
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6110481 |
Controlled release device based on aqueous-organic partitioning in porous membranes
A novel controlled release device employing microporous membranes with or without a nonporous coating and aqueous-organic partitioning of the bioreactive substances to be delivered is provided....
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6086908 |
Implants with phased release of medicaments
The invention relates to implants with phasewise release of pharmaceutical substance, which consist of a core and layers arranged concentrically around it. The core and at least one of the layers...
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6083523 |
Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products
An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region...
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6074663 |
Method of using cross-linked fibrin material
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6071530 |
Method and composition for treating a bone tissue defect
The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable,...
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6068851 |
Formulation for use in the prevention of pathogen induced diseases including HIV and HSV
This invention relates to formulations comprising film-forming components capable of forming per se a physical barrier to pathogens. Thermoreversible gels such as poloxamers are particularly...
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6063116 |
Modulation of cell proliferation and wound healing
Intraocular devices which are capable of sustained release of a cell proliferation modulating agent, together with methods for their preparation and use, are provided. The proliferation modulating...
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6044981 |
Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
Microfabricated filters utilizing a bulk substrate structure and a thin film structure and a method for constructing such filters. The pores of the filters are defined by spaces between the bulk...
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6042909 |
Encapsulation device
The invention features an empty device for receiving a bioactive agent. The device includes a biocompatible and semi-permeable membrane that defines an enclosed space; the membrane also has at...
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6039760 |
Composite living skin equivalent
Skin equivalents and processes for preparing them are described. The living skin equivalent comprises a layer of cultured keratinocyte cells, a layer of high purity, non-porous collagen and a...
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6022554 |
Polymeric microporous film coated subcutaneous implant
This invention relates to coating formulations for coating sustained-release drug implants. The coating formulations are capable of formulations are capable of forming a porous film coat over a...
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6020326 |
Method for inhibition of bone growth by anionic polymers
The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the...
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6015572 |
Implantable device containing GDNF secreting cells for treating nerve damage and methods of use
A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth medium of B49 glioblastoma cells. Rat and human...
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