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6667056 |
Pharmaceutical compositions containing an effervescent acid-base couple
A pharmaceutical formulation in the form of a fast dissolving tablet comprising an active ingredient, sodium glycine carbonate and an acid capable of reacting rapidly with sodium glycine carbonate...
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6663879 |
Injectable compositions
A stable injectable composition includes a non-aqueous parasitic agent in a therapeutically effect amount, chosen from the group of avermectin, ivermectin, doramectin, abamectin, milbemycin and...
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6652883 |
Tissue bulking and coating compositions
Compositions comprising macromers having a backbone comprising units having a 1,2-diol and/or 1,3-diol structure for tissue bulking and coating. Such polymers include poly(vinyl alcohol) (PVA) and...
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6649151 |
Cosmetic formulation
The present invention includes a cosmetic formulation. The cosmetic formulation comprises a plurality of spheres having a first desiccated volume and having a second hydrated volume. The hydrated...
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6641831 |
Medical products with sustained pharmacological activity and process for producing them
A non-degradable medical product comprising at least two substances or groups of substances, of which a first substance is referred to as substance A and a second is referred to as substance B,...
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6635268 |
Sustained delivery of an active agent using an implantable system
The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber...
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6630155 |
Controlled release liquid delivery compositions with low initial drug burst
The invention provides a controlled release polymeric composition which includes a base polymer or copolymer, an organic solvent, a polymeric controlled release additive, and a biologically active...
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6627422 |
Device containing cell-supporting yarn matrix encapsulated in a semi-permeable membrane
A device is provided containing cells or tissue distributed on a filamentous cell-supporting matrix which is encapsulated by a semi-permeable membrane which can be immunoisolatory. The matrix may...
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6627600 |
Compressed microparticles for dry injection
The invention relates to a pharmaceutical implant for controllably releasing a drug in a subject and methods for manufacturing and administering the implant. The implant is made of associated...
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6616912 |
Bi-component microporous hollow fiber membrane structure for in vivo propagation of cells
A bi-component microporous hollow fiber membrane structure is provided for in vivo propagation of cells and use in testing of the effect of medical treatments on cells within the structure. The...
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6617151 |
Method of closing a cell containment device with a wet seal
A method is provided for closing a containment device that involves wetting at least a portion of a permeable polymeric membrane such as tubular membrane with a liquid such as a cell suspension or...
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6613355 |
Semi-solid delivery vehicle and pharmaceutical compositions
A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical...
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6602963 |
Polyesters containing (meth)acrylate end groups
The invention describes polyesters containing (meth)acrylate end groups, of the general formula (I) CH 2 ═CRCOO—PE—OCOCR═CH 2 where R=CH 3 or H, where PE=[—A—OCO—B—COO—] m...
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6599515 |
Fibrin porous structure
The present invention provides a porous structure of fibrin or fibrinogen material. The structure in its substantially dry form, having a compression strain of less than 8%, and a creep modulus...
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6596293 |
Polyurethane-biopolymer composite
A method is provided for preparing a drug delivery material and device comprising cross-linking a biological polymer with a cross-linking agent and loading the cross-linked biopolymer with a...
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6565878 |
Method for preparing a non-fibrous porous material
A method for preparing a non-fibrous porous material essentially consisting of one or more hydrophilic polymeric components(s) or one or more hydrophilic polymeric component(s) and one or more...
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6562362 |
Liquefied embolic materials capable of sol-gel phase transition and their use
Disclosed are liquefied embolic materials capable of sol-gel phase transition in response to in vivo conditions, including temperature, ionic strength, and pH, and their uses. The liquefied embolic...
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6544541 |
Devices and compounds for treating arterial restenosis
Described herein is the use of ADPRT decoy substrates to treat or prevent proliferative disorders. In one example, MIBG is shown to prevent restenosis in damaged vessels. In one embodiment, MIBG is...
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6541023 |
Use of collagen of aquatic origin for the production of supports for tissue engineering, and supports and biomaterials obtained
Use of collagen of aquatic origin for the production of supports for tissue engineering is disclosed. The collagen may be obtained from fish skin, preferably in its native form. Novel tissue...
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6541021 |
Devices and methods for pain management
The invention features devices and methods for the systemic delivery of fentanyl or a fentanyl congener (e.g., sufentanil) to treat pain. In the present invention, a drug formulation comprising...
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6541022 |
Mineral and cellular patterning on biomaterial surfaces
Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant...
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6541036 |
Treatment of tumors with oligonucleotides directed to insulin-like growth factor-I receptors (IGF-IR)
A method of inducing resistance to or regression of tumor growth comprising placing tumor cells in culture in vitro or ex vivo supplemented with a pro-apoptotic agent for a period of time,...
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6537565 |
Filamentous porous films and methods for producing the same
The invention is directed to a filamentous porous film that can act as a support for cellular attachment, growth and organization. The film is formed from filaments which define a matrix structure...
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6534084 |
Porous tissue scaffoldings for the repair or regeneration of tissue
The present patent describes a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be...
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6517857 |
Bioactive product and its use
A porous textile product made from bioactive glass fibers. The fibers in the product are of at least two types, fiber A and fiber B, with fiber A being made from a bioactive glass, and fiber B...
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6517858 |
Bioactive prostheses with immunosuppressive, antistenotic and antithrombotic properties
The invention relates to a bioactive implant comprising a substrate coated with a polymer layer with reactive functions, and a bioactive substance fixed on the implant by means of said reactive...
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6514514 |
Device and method for regeneration and repair of cartilage lesions
Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating...
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6506415 |
Method of inducing resistance to tumor growth
A method of inducing resistance to tumor growth comprising placing tumor cells in culture in vitro supplemented with a pro-apoptotic agent for a period of time, transferring the tumor cells into a...
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6503954 |
Biocompatible carrier containing actinomycin D and a method of forming the same
A biocompatible carrier and a composition for forming the carrier are disclosed. The carrier is made from an ethylene vinyl alcohol copolymer which can serve as a reservoir, allowing for the local...
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6495127 |
Compositions and systems for forming high strength medical sealants, and associated methods of preparation and use
The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally...
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6491655 |
Methods for treating hemophilia A and B and AIDS and devices used therein
The present invention provides a method for treating Hemophilia A or B which comprises implanting in fluid communication with the bloodstream of a mammal in need of such treatment a permeable...
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6485721 |
Biologically active substance-secreting hybrid gel
The present invention provides a biologically active substance secreting hybrid gel, which consists essentially of a biopolymeric gel and cells containing an expression vector with a gene encoding...
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6485736 |
Variable release microcapsules
A novel microcapsule comprising a liquid core material which is substantially insoluble in water and enclosed within a solid permeable shell of a polymer resin containing disulfide linkages is...
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6479066 |
Device having a microporous membrane lined deformable wall for implanting cell cultures
A device and method of using the device are provided for implanting cell cultures in a host. The device is formed of a deformable body, a microporous membrane and a sealable port. The shape of the...
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6476079 |
Devices for the delivery of drugs having antiprogestinic properties
A device for the controlled release over a prolonged period of time of a drug having antiprogestinic properties, the device including a core containing the drug, optionally a membrane encasing the...
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6471688 |
Osmotic pump drug delivery systems and methods
Implantable osmotic pump devices and systems include multiple osmotic pumps and/or semipermeable membranes to extend the useful life cycle and functionality of the drug delivery system. Use of an...
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6471993 |
Three-dimensional polymer matrices
Matrices that include a macrostructure having a semi-solid network and voids, and a microstructure having voids, in which the microstructure is located within the semi-solid network are disclosed....
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6471689 |
Implantable drug delivery catheter system with capillary interface
The present invention relates to a drug delivery device which is implantable within a mammal and adapted for long-term efficient drug delivery to surrounding tissue. The drug delivery device is...
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6471987 |
Drug releasing elastic band and method
A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a...
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6444222 |
Reinforced matrices
A reinforced matrix membrane containing one or more scaffold-forming proteins suitable for cell growth and for use in chondrocyte cell transplantation, and method of making same. The scaffold is...
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6440427 |
Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer
A tissue treatment composition, especially an adhesive composition comprises (i) fibrin or fibrinogen and (ii) a biodegradable and biocompatible polymer capable of forming a viscous aqueous...
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6436937 |
Use of desoxypeganine in the treatment of Alzheimer's dementia
The invention relates to a device and method for the treatment of Alzheimer's dementia with desoxypeganine and/or a pharmaceutically acceptable acid addition salt of desoxypeganine.
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6409764 |
Methods and articles for regenerating bone or peridontal tissue
There are numerous medical situations involving deficiencies of living bone or periodontal tissue and where increase of living bone or periodontal tissue mass is desired. Methods are described...
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6406711 |
Bone regeneration material
A bone regeneration material uses polyphosphoric acid and/or a polyphosphate together with a biocompatible material, a filler for cosmetic surgery, or a bone morphogenetic protein, to expedite new...
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6403758 |
Bioresorbable compositions for implantable prostheses
Crosslinked compositions formed from a water-insoluble copolymer are disclosed. These compositions are copolymers having a bioresorbable region, a hydrophilic region and at least two crosslinkable...
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6399341 |
Artificial pancreas
An artificial pancreas is described herein which comprises one or more viable and physiologically active pancreatic islet cells capable of producing insulin, encapsulated within a semipermeable...
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6395293 |
Biodegradable implant precursor
The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable,...
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6391861 |
Method for the prevention of tissue elastic fiber injury
The subject invention is directed to the prevention of elastic fiber injury by administering HA or any other polysaccharide or carbohydrate moiety that binds to and coats elastic fibers, thereby...
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6375978 |
Rate controlling membranes for controlled drug delivery devices
This invention provides rate controlling membranes for controlled drug delivery devices that are stable over time and exhibit more predictable and consistent membrane functionality. According to...
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6372244 |
RETRIEVABLE BIOARTIFICIAL IMPLANTS HAVING DIMENSIONS ALLOWING RAPID DIFFUSION OF OXYGEN AND RAPID BIOLOGICAL RESPONSE TO PHYSIOLOGICAL CHANGE, PROCESSES FOR THEIR MANUFACTURE, AND METHODS FOR THEIR USE
Bioartificial implants and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be...
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