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7045142 |
Sustained release of superoxide dismutase mimics from implantable of insertable medical devices
An implantable or insertable medical device is provided which comprises (a) a superoxide dismutase mimic and (b) a polymeric release region. Upon administration to a patient, the polymeric release...
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7041309 |
Spinal fusion using an HMG-CoA reductase inhibitor
An improved technique for spinal fusion including administration of an HMG-CoA reductase inhibitor to the fusion site. The HMG-CoA reductase inhibitor is preferably delivered to the site by a...
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7022334 |
Therapeutic composition and a method of coating implantable medical devices
A therapeutic composition is provided including a polysaccharide or a cationic peptide dissolved in an organic substance. The polysaccharide can be heparin or a derivative of heparin. The cationic...
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7001430 |
Matrix composition for human grafts/implants
The present invention is directed to an intermediate composition for producing a muscle tissue matrix suitable for implantation in humans, comprising shredded, allogeneic human muscle tissue that...
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6991652 |
Tissue engineering composite
The invention provides a biocompatible composite for use in a living subject for purposes of repairing damaged tissues and reconstructing a new tissue. The composite includes a biodegradable or...
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6976981 |
Osmotic delivery system with membrane plug retention mechanism
An osmotic delivery system has a membrane plug retention mechanism which can also be used to control the delivery rate of a beneficial agent from the osmotic delivery system. The osmotic delivery...
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6960351 |
Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region...
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6958158 |
Immune modulation device for use in animals
The present invention is directed to an implantable immune modulation device that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell....
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6942873 |
Microfabrication of membranes containing projections and grooves for growing cells
The present invention provides a novel substrate for use in growing cells and for the study of mechanobiology. The membrane of the present invention comprises appropriate microtopography and...
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6942877 |
Method for producing antibiotic composites
A method for producing antibiotic composites is described, which is characterized in that a salt, which can be subjected to plastic deformation and which consists of at least one cationic component...
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6939556 |
Minimally compliant, volume efficient piston for osmotic drug delivery systems
An osmotic pump having a minimally compliant, volume-efficient piston positioned within a capsule is provided. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The...
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6939557 |
Slow release protein polymers
The invention features articles for delivery of a biologically active substance, methods for making such articles, and methods for treating an animal using the articles.
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6936278 |
Microparticles
A process for producing microparticles, in which an aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active...
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6926888 |
Alginate capsules for use in the treatment of brain tumor
Encapsulated producer cells which are capable of expressing a molecule which is an inhibitor of CNS tumour growth provide a novel approach to the treatment of tumours, such as brain tumors which...
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6923990 |
Stabilized silver-ion amine complex compositions and methods
The present invention relates to new silver-ion super-complex compositions. More particularly, the present invention describes silver-ion super-complex compositions comprising a silver-thiosulfate...
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6908624 |
Coating for implantable devices and a method of forming the same
Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active...
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6896894 |
Proteins stabilized with polysaccharide gums
Described are heat stable aqueous solutions or gels comprising a biologically effective amount of a protein and an effective stabilizing amount of a polysaccharide gum as well as heat stable...
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6890897 |
Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair
A melanoma inhibiting activity factor (MIA), preferably in combination with an osteoinductive protein, is a useful pharmaceutical agent for promoting bone healing and/or cartilage repair.
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6878383 |
Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
The invention provides a composition for promoting regeneration of tissue which has degenerated in a subject as a result of a disease or disorder and a method of using the composition is provided....
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6866860 |
Cationic alkyd polyesters for medical applications
The present invention is directed to medical devices or pharmaceutical composition, each containing a synthetic, biodegradable, biocompatible polymer that is the reaction product of a polybasic...
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6861068 |
Pharmaceutical compositions using semi-solid delivery vehicle
A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical...
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6858221 |
Intravascular delivery of mycophenolic acid
The present invention provides improved devices and methods for minimizing and/or inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention...
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6855770 |
Drug delivery compositions and medical devices containing block copolymer
A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic...
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6833408 |
Methods for tissue repair using adhesive materials
A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having...
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6793938 |
Biodegradable compositions for the controlled release of encapsulated substances
Pharmaceutical compositions that enable the release of a physiologically active substance over a prolonged period of time following administration to a patient are described. The pharmaceutical...
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6790454 |
Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained
A composite product is disclosed as a collagen support comprising at least one porous collagen layer covered on at least one side with an essentially compact collagen membrane consisting either of...
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6773713 |
Injection molding of living tissues
The invention features methods of making living tissue constructs having a predetermined shape by providing a negative mold having a defined shape; suspending isolated tissue precursor cells in a...
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6773714 |
Polymeric delivery formulations of leuprolide with improved efficacy
The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that...
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6770729 |
Polymer compositions containing bioactive agents and methods for their use
Embodiments of the invention provide polymer coated implantable medical devices having a bioactive material posited in or on at least a portion of the coating layer, wherein the coating layer...
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6767550 |
Hydroxyapatite based drug delivery implant for cancer treatment
A hydroxyapatite based bioresorbable material is incorporated with anti-cancer agents to form an implant used for treatment against cancer. Sustained release of the anti-cancer agents may be...
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6764517 |
Tissue repair matrix
A porous three-dimensional tissue repair matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium...
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6756048 |
Long time drug-sustained release preparation
The present invention relates to a sustained release preparation of a lipophilic drug, comprising a drug dispersion wherein the lipophilic drug and a water-soluble substance are dispersed, in a...
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6756362 |
Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the...
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6746686 |
Coated implants
An implant, usually a stent, has a coating of a cross-linked water swellable polymer matrix preferably having a dry thickness of at least 0.1 μm, and a pharmaceutically active compound, the...
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6746685 |
Bioabsorbable, biocompatible polymers for tissue engineering
Bioabsorbable biocompatible polymers which provide a good match between their properties and those of certain tissue structures are provided. The bioabsorbable biocompatible polymers can be...
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6733767 |
Liquid polymeric compositions for controlled release of bioactive substances
Controlled release of hydrophobic bioactive substances in vivo over an extended time period and without “bursts” of drug release is achieved using a liquid polymeric composition including a...
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6726922 |
Process and composition for temporarily suppressing pain
A composition and method for suppressing pain and irritation of tissue uses an anti-irritant in an effective amount to suppress pain and irritation temporarily when applied topically to the skin,...
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6726920 |
Implantable drug delivery patch
The present invention features devices and methods for delivery of drug to an internal organ surface by delivery of drug directly to the surface of the organ such that the drug traverses the organ...
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6727322 |
Amphiphilic networks, implantable immunoisolatory devices, and methods of preparation
The present invention provides high mechanical strength amphiphilic polymeric networks and implantable biological devices made therefrom that are capable of encasing and, thus, immunoisolating...
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6713081 |
Ocular therapeutic agent delivery devices and methods for making and using such devices
Ocular implant devices for the delivery of a therapeutic agent to an eye in a controlled and sustained manner. Dual mode and single mode drug delivery devices are illustrated and described....
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6706274 |
Differential delivery of nitric oxide
This invention relates to devices and methods for the local, differential delivery of nitric oxide within the body. The devices include devices having at least two differing nitric oxide donor...
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6702857 |
Membrane for use with implantable devices
The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the...
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6699484 |
Fibrin sealants or adhesives comprising a hyaluronic acid derivative material
An especially useful fibrin glue composition comprises a biocompatible, bioabsorbable hyaluronic acid derivative material, upon which are applied or chemically bonded fibrinogen and thrombin, along...
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6692759 |
Methods for preparing and using implantable substance delivery devices
Method for preparing an implantable device for a sustained delivery of a substance within a body of a human or an animal subject, the method including; dissolving a biocompatible polymer in a...
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6689375 |
Resorbable bone implant material and method for producing the same
The powdery component of the implant material consists essentially of a mixture of hydroxyl apatite powder and calcium sulfate powder, wherein the hydroxyl apatite powder consists of synthetically...
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6689373 |
Devices and methods for pain management
The invention features devices and methods for the systemic delivery of fentanyl or a fentanyl congener (e.g., sufentanil) to treat pain. In the present invention, a drug formulation comprising...
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6682760 |
Cross-linked collagen matrices and methods for their preparation
A method for preparing cross-linked collagen and cross-linked collagen products. The method includes incubating collagen in a solution including water, at least one polar solvent and at least one...
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6680063 |
Biocompatible albumin lamina and method
The present invention provides a denatured albumin lamina, useful for repairing lesions on solid visceral organs. The lamina comprises human serum albumin, formed into a thin, pliant sheet and...
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6676971 |
Embolic compositions
Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains...
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6669959 |
Modulated release particles for lung delivery
A polymeric construct is disclosed. The construct comprises a biodegradable ABA block copolymer having a selected medicament associated therewith. The medicament thus present is provided in a slow...
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