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8889823 Method to make poly(L-lactide) stent with tunable degradation rate  
Methods of making a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a...
8889169 Drug delivery system and method of manufacturing thereof  
Irradiation of a surface of a material with a gas cluster ion beam modifies the wettability of the surface. The wettability may be increased or decreased dependent on the characteristics of the gas...
8889211 Coating process for drug delivery balloons using heat-induced rewrap memory  
A method of producing a drug coated balloon that comprises the steps of: subjecting a balloon catheter with a folded and wrapped balloon thereon to a pre-annealing step to induce a fold/wrap memory...
8889178 Bioactive porous bone graft compositions in synthetic containment  
Bioactive porous bone graft implants in various forms suitable for use in bone tissue regeneration and/or repair, as well as methods of use are provided. The implants are formed of bioactive glass...
8889168 Stem cell capture and immobilization coatings for medical devices and implants  
Constructs and methods for immobilizing stem and other precursor cells, as well as other bioactive materials of therapeutic value on the surfaces of medical devices, such as bone, cartilage, spinal...
8888840 Drug eluting medical implant  
Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are...
8889170 Implantable device having a coating with a triblock copolymer  
The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.
8883182 Method and material for enhanced tissue-biomaterial integration  
The present invention provides a composition and method for the covalent binding of a hydrogel to an extracellular matrix (ECM). Therapeutic applications include tissue repair and delivery of drugs...
8883175 Block copolymers of acrylates and methacrylates with fluoroalkenes  
A block copolymer comprising a fluorinated block and a non-fluorinated block and method of making the block copolymer are provided. Also provided herein are a coating on an implantable device...
8883184 Methods and compositions for regenerating connective tissue  
Connective tissue regenerative compositions and methods of repairing and regenerating connective tissue using such compositions are provided. The compositions generally comprise a bioactive...
8883186 Coatings for drug delivery devices  
A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The...
8883183 Medical devices incorporating collagen inhibitors  
Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some...
8883195 Bioactive porous bone graft implants  
Bioactive porous bone graft implants in various forms suitable for bone tissue regeneration and/or repair, as well as methods of use, are provided. The implants are formed of bioactive glass and...
8883185 Hydrogel implants with varying degrees of crosslinking  
The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors...
8877508 Devices and systems that deliver nitric oxide  
The present disclosure relates to dressings, such as patches and bandages, and other devices and systems that deliver nitric oxide.
8877233 Porous sponge matrix medical devices and methods  
Described are hemostasis devices useful for implantation in biopsy tracts, which device comprise highly compact, dried hemostatic sponge elements. Preferred devices also include compacted sponge...
8877225 Controlled release copolymer formulation with improved release kinetics  
The present invention provides a constant release copolymer composition adapted for use in a controlled release formulation for a bioactive agent, such as a formulation adapted for implantation...
8876860 Vascular closure device  
The present invention provides a porous structure that works very effectively to seal a puncture site with optimum porosity, absorbent capacity and perfect anatomical fit. The plug density and...
8877224 Compositions for preventing cardiac arrhythmia  
Disclosed herein are compositions and methods for treating or preventing a cardiac arrhythmia in a subject.
8877170 Medical device with inflammatory response-reducing coating  
The present disclosure relates to implantable medical devices having a non-bioabsorbable substrate and an amphiphilic coating covalently bonded to the substrate for reducing the inflammatory...
8877223 Degradable hydrophilic block copolymers with improved biocompatibility for soft tissue regeneration  
The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for...
8871239 Polymeric materials for medical devices  
The present invention includes biocompatible polymeric coatings, membranes, matrices, and films to be used with implantable medical devices. Medical devices containing such materials applied to a...
8871238 Medical devices and coatings therefore comprising biodegradable polymers with enhanced functionality  
Biodegradable polymers useful for fabricating implantable medical devices and as coatings for medical devices are provided. The biodegradable polymers are biocompatible and can be tuned to provide...
8871267 Protein matrix materials, devices and methods of making and using thereof  
The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to...
8870945 Bioabsorbable device having composite structure for accelerating degradation  
A medical device has a structure made of a first biodegradable and/or bioabsorbable material and a second biodegradable and/or bioabsorbable material encapsulating a degradation additive...
8871240 Rapamycin coated expandable devices  
Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the...
8871511 Method for treatment of cardiovascular disorders  
Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular...
8874204 Implantable medical devices comprising isolated extracellular matrix  
Implantable devices containing extracellular matrix and methods of using the devices are provided.
8871237 Medical scaffold, methods of fabrication and using thereof  
Articles of manufacturing comprising electrospun elements having continuous or stepwise gradients of porosity, average pore size, weight per volume and/or of agents for promoting cell colonization,...
8871235 Compositions and their use in bone healing  
The present invention is directed to implantable compositions comprising substantially spherical bioactive glass particles.
8865199 Biomatrix composition and methods of biomatrix seeding  
Apparatus and methods are described for generating autologous tissue grafts, the apparatus including a point of care SVF isolation unit that includes a tissue digestion chamber in fluid...
8858978 Heat cured gel and method of making  
A method of curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide...
8858983 Antioxidants and antimicrobial accessories including antioxidants  
An antimicrobial accessory may include a polymer an antimicrobial mixed in the polymer, and an antioxidant. The antioxidant may include, for example, at least one of citric acid, maltol, kojic...
8858982 Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts  
This invention is a prosthetic device generally placed on the outside surface of the vessel or graft which then elutes antiproliferative drugs or agents from a drug-eluting matrix material. Methods...
8858979 Service induced byproducts for localized drug delivery in orthopaedic implants  
A composite material including ultra-high molecular weight polyethylene in conjunction with a biologically active agent is described. The biologically active agent can be, for example, an...
8858929 Optically sensitive cell network  
A neural network is disclosed. The neural network comprises a plurality of optogenetically modified neural cells being three-dimensionally distributed in a hydrogel medium and being disconnected...
8858980 Synthetic mechanical hemostatic composition, method of making and use thereof  
A biocompatible, polymeric composition is disclosed. The composition comprises a base polymer comprising (i) a prepolymer comprising para-dioxanone (PDO) and trimethylene carbonate (TMC); and (ii)...
8859007 Oxygenated demineralized bone matrix for bone growth  
An improved composition for inducing bone growth is provided that is a mixture of DBM and a perfluorocarbon oxygen carrier. Injection/implantation of a composition of DBM and a perfluorocarbon...
8852623 Implantable polymeric device for sustained release of dopamine agonist  
The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial....
8852620 Medical devices comprising polymeric drug delivery systems with drug solubility gradients  
Disclosed are drug delivery systems comprising drugs admixed with polymers having drug solubility gradients and methods of making the polymers. Also disclosed are medical devices having coatings...
8852622 Coated implant composed of a biocorrodible magnesium alloy  
One embodiment of the invention relates to a coated implant having a base body composed of a biocorrodible magnesium alloy. The coating of the implant comprises: (i) a base layer, which is applied...
8852624 Biomedical implants comprising surface-modified ceramic particles and biodegradable stereo complex polymers, its use for suppressing inflammation and improvement of mechanical property, and preparation method thereof  
A biomedical implant according to this invention comprises ceramic complex, which includes a surface-modified basic ceramic particles, which are basic ceramic particles modified their surface with...
8852936 Autologous lymph node transfer in combination with VEGF-C or VEGF-D growth factor therapy to treat lymphedema and to improve reconstructive surgery  
Materials and methods are provided to improve survival of lymph nodes and integration of lymph nodes into a lymphatic network, following lymph node transplantation. The treatment or prevention of...
8852580 Method and device for synovial cell-charged collagen membrane or gel  
An implant for repair of a cartilaginous defect in a subject includes a collagen matrix charged with synovial cells. A method preparing an implant for repair of a cartilaginous defect in a subject...
8852621 Multilayer fibrous polymer scaffolds, methods of production and methods of use  
Fibrous polymer scaffolds and methods of manufacture are provided. The scaffolds can be formed of multiple layers and the extent and direction of alignment of each layer can be controlled....
8852558 In situ formation of an artificial blockage to control bleeding by polymer expansion with hydrogen peroxide and platinum catalyst  
A composition for in situ formation and/or expansion of a polymer-based hemostatic agent to control bleeding includes a suitable amount of a polymer or polymer-forming component, hydrogen peroxide...
8846069 Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same  
Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
8846845 Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices  
Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the corresponding diamines or diisocyanates thereof, wherein each X independently...
8846070 Biologically degradable compositions for medical applications  
A medical article is disclosed, comprising a biologically degradable AB block copolymer and a biologically degradable polymer that is capable, at equilibrium and at room temperature, of absorbing...
8846059 Extracellular matrix adjuvant and methods for prevention and/or inhibition of ovarian tumors and ovarian cancer  
Compositions suitable for use as ovarian cancer and/or tumor adjuvants in the preparation of ovarian cancer vaccines, particularly those vaccines useful in the treatment of human ovarian cancer,...