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8936780 Stimuli responsive polyester amide particles  
A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including...
8936805 Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same  
A structure of, and a method of producing, a biocompatible structure for bone and tissue regeneration are disclosed. The method includes dissolving a polyurethane polymer in methanol, adding...
8936806 Periostin induces proliferation of cardiomyocytes and promotes cardiac regeneration  
The present invention provides compositions and methods for increasing proliferation, increasing cell cycle activity, and/or proliferation of postmitotic mammalian differentiated cardiomyocytes....
8932620 Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices  
Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by...
8932619 Dural repair material  
Multilayer structures including a porous layer and a non-porous layer having a reinforcement member are useful as dural repair materials.
8932621 Implantable film/mesh composite  
The present disclosure relates to implantable medical devices which include at least one mesh and at least one film attached to the mesh along different portions of the mesh creating at least one...
8932560 Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells  
A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the...
8932618 Biodegradable osmotic pump implant for drug delivery  
The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a...
8932615 Implantable devices formed on non-fouling methacrylate or acrylate polymers  
Implantable devices formed of or coated with a material that includes a polymer having a non-fouling acrylate or methacrylate polymer are provided. The implantable device can be used for treating...
8932637 Injectable and swellable microspheres for tissue bulking  
The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The...
8932347 Implantable materials having engineered surfaces and method of making same  
Implantable materials having engineered surfaces and method of making same comprising geometric features on at least one surface of the material having at least one of chemical, physiochemical and...
8932617 Methods for treating or preventing restenosis and other vascular proliferative disorders  
Described herein is the use of ribonucleotide reductase inhibitors in the prevention or treatment of restenosis and other vascular proliferative disorders.
8927003 Extracellular matrix based gastroesophageal junction reinforcement device  
Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part...
8927002 Stent with a coating or a basic body containing a lithium salt and use of lithium salts for prevention of restenosis  
The invention relates to a stent with in particular a coated basic body made of an implant material the use of lithium salts as a coating material or a component of an implant material for stents...
8927004 Bioabsorbable substrates and systems that controllably release antimicrobial metal ions  
Bioabsorbable substrates having antimicrobial metal ion coatings that are well suited for implantation in to a subject's body to treat and/or prevent infection. In particular, described herein are...
8927876 Electrode array and method of fabrication  
An electrode array, having application as a cochlear implant, includes a tube formed of Parylene defining a hollow channel. A substrate formed primarily of Parylene is supported by the tube. In...
8927001 Bioswellable, crystalline, amphiphilic, block/graft polymers and applications thereof  
Absorbable, essentially non-absorbable, and non-absorbable crystalline, amphiphilic, block/graft copolymeric compositions exhibit an inherent viscosity of at least 0.5 dL/g, a heat of fusion of at...
8920828 Implants for treatment of symptomatic or degenerated intervertebral discs  
Devices for the treatment of intervertebral discs are described. The devices, when implanted into the nucleus pulposus of an intervertebral disc, provide for the controlled release of one or more...
8920827 Keratin bioceramic compositions  
A malleable bone graft composition is described. The composition comprises: (a) keratose; (b) particulate filler; (c) antibiotic; and (f) water. The invention may be provided in sterile form in an...
8921109 Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof  
A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of...
8916185 Immobilizing particles onto surfaces  
A method for immobilizing micro-particles, nano-particles or combinations thereof onto a surface is disclosed. The method includes distributing the micro-particles, nano-particles or combinations...
8916187 Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same  
The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
8916184 Artificial tissue systems and uses thereof  
An implant system and a method for controlling the natural and artificial microenvironments surrounding an implanted device using an artificial tissue system (ATS) and includes methods of...
8916186 Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws  
A method of correcting spinal deformity, which includes locating pharmaceutical-loaded implants adjacent to targeted spinal growth plates, and then eluting the pharmaceutical onto the growth...
8916339 Spinal cord tissue dehydrated and micronized  
A composition of neural tissue is made of spinal cord tissue harvested from a spinal cord of a mammal. The spinal cord tissue is harvested from vertebral column of the mammal. The spinal cord...
8916143 Polymer compositions of dihydroxyacetone and uses thereof  
The present disclosure provides injectable synthetic and biodegradable polymeric biomaterials that effectively prevent seroma, a common postoperative complication following ablative and...
8911492 Coating for a medical device having an anti-thrombotic conjugate  
An implantable device having a coating comprising a comb-type anti-thrombotic conjugate to prevent or reduce the formation of thrombosis on the surface of the device. The device includes a frame...
8911761 Composite materials  
This application discloses a composite material comprising one or more silk elements in an acrylic or cross-linked protein matrix. The silk elements are made from the group of silk elements...
8911789 Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom  
Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be...
8911762 Polylactic acid/calcium sulfate scaffold  
The invention relates to a method of preparing a composite or porous composite used as a biodegradable scaffold, the composite prepared therefrom and the use of the composite. In particular, the...
8906362 Tissue engineered meniscus scaffolds and methods of use  
Provided herein are methods of producing a meniscus scaffold to remove material and increase the pore size and porosity therein. In some embodiments, methods include seeding the tissue with...
8906394 Hyaluronic acid based copolymers  
Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis,...
8906402 System and method for attaching soft tissue to an implant  
One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided...
8906111 Artificial bone material having controlled calcium ion elution  
Disclosed is an artificial bone material having controlled calcium ion elution, which does not induce cytotoxicity or any inflammatory response. It is found that the elution of a calcium ion from...
8906686 Method for preparation of implantable constructs  
Neo-cartilage constructs suitable for implantation into a joint cartilage lesion in situ and a method for repair and restoration of function of injured, traumatized, aged or diseased cartilage. The...
8905032 Occlusion of fallopian tubes in a vertebrate subject  
According to one claim of the invention, a method for occluding a fallopian tube in a vertebrate subject is described, which comprises comprising transcervically delivering a solid blocking...
8906401 Antimicrobial medical devices containing chlorhexidine free base and salt  
The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine...
8900617 Bio-Remodable Bone Augmentation device and method  
A bio-remodable augmentation device including an implantable member configured for maintaining space in a bone defect. The implantable member is formed from a bio-remodable composite having...
8900640 Expandable, porous apatite/collagen composite, and its production method  
A expandable porous body constituted by a compressed apatite/collagen composite, which expands by water absorption, and a method for producing an expandable, porous apatite/collagen composite,...
8900556 Hardenable thermally responsive compositions  
Thermally responsive compositions that include a thermally responsive viscosity modifier, a polymerizable component, and water are provided. The compositions, which optionally may be hardened, are...
8900620 Drug-impregnated encasement  
A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity...
8900616 System and method for satellite drug delivery  
The present disclosure is directed to an implantable repository including a housing comprising at least one bioactive agent and at least one attachment member coupled to the housing, the at least...
8895048 Templated islet cells and small islet cell clusters for diabetes treatment  
Substrates and devices for culturing cells are disclosed, along with methods of using the same. The substrates and devices include top surfaces with one or more divots disposed therein. Each divot...
8895506 Protein stabilization formulations  
The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including...
8895046 Orthopaedic implant for supporting tissue growth and methods of forming the implant and tissue  
Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or...
8895304 Hemostatic device  
A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce hemostasis at an anatomical site.
8895047 Combined fibrinolytic and antimicrobial catheter and uses thereof  
Implantable catheters are provided which comprise an antimicrobial agent incorporated in a coating or bulk distributed, in combination with a fibrinolytic agent incorporated in a top coating.
8895049 Extended release biodegradable ocular implants  
Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a...
8889823 Method to make poly(L-lactide) stent with tunable degradation rate  
Methods of making a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a...
8889169 Drug delivery system and method of manufacturing thereof  
Irradiation of a surface of a material with a gas cluster ion beam modifies the wettability of the surface. The wettability may be increased or decreased dependent on the characteristics of the gas...