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9005648 Inorganically surface-modified polymers and methods for making and using them  
In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned)...
9005650 Microfabricated nanopore device for sustained release of therapeutic agent  
A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for...
9006182 Light activated composite tissue adhesives  
A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adheives that are...
9005606 Silk fibroin hydrogels and uses thereof  
The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such...
9005649 Methods for making controlled delivery devices having zero order kinetics  
A method of making an injectable or implantable active agent delivery device capable of delivering a diagnostic, therapeutic, and/or prophylactic agent to a desired targeted site having orifice(s)...
8999364 Implantable article, method of forming same and method for reducing thrombogenicity  
Endothelialization of a bodily fluid or tissue-contacting, particularly blood-contacting, surface may be accomplished to render that surface substantially non-thrombogenic. Thrombosis may also be...
8999365 Prevention of bacterial contamination  
A compound of formula I: wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl...
8999366 Porous biomaterial on hydroxyapatite  
The present invention provides a synthetic non-resorbable silicon-containing calcium phosphate biomaterial having a microporosity of 23% by volume or greater, wherein the surface free energy of the...
8999945 Methods, compositions and systems for local delivery of drugs  
Implantable medical device eluting drug locally and in a prolonged fashion are provided.
8999367 Bioabsorbable substrates and systems that controllably release antimicrobial metal ions  
Bioabsorbable substrates having antimicrobial metal ion coatings that are well suited for implantation in to a subject's body to treat and/or prevent infection. In particular, described herein are...
8992963 Immobilised biological entities  
There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting...
8992961 Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles  
This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended...
8992964 Process for demineralization of bone matrix with preservation of natural growth factors  
A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically...
8992978 Material compositions which comprise adult stem cells obtained from exocrine glandular tissue, in particular for use in regenerative medicine  
The invention relates to material compositions comprising adult stem cells obtained from exocrine gland tissue and a supporting matrix having the shape of a thread structure and/or of a net. The...
8992967 Poly (diol-co-citrate) hydroxyapatite composite for tissue engineering and orthopaedic fixation devices  
The present invention is directed to a novel poly(diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in...
8986737 Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth  
A method of treating or preventing infection at a surgical site comprising a bony defect and an implanted metal device is disclosed. Biodegradable microspheres are placed at the site and are...
8986726 Biocompatible polyacrylate compositions for medical applications  
A composition comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and...
8986728 Soluble implantable device comprising polyelectrolyte with hydrophobic counterions  
The present invention provides an implantable device having a biosoluble coating or a biosoluble body structure comprising a polyelectrolyte and a counterion and the methods of making and using the...
8986725 Silicone-peroxide compositions for long-term, controlled oxygen release  
A composite for delivering extended-release of oxygen is disclosed. The composite can include a biocompatible polymeric support having a plurality of solid peroxide particles suspended therein. The...
8986713 Medical device capable of being compacted and expanded having anti-thrombin III binding activity  
The present invention relates to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities...
8980302 Therapeutic implant  
Surgical implants of the present disclosed include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct...
8980300 Plasticizers for coating compositions  
A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive...
8980278 Bio-functionalized stimulus-responsive dissolvable PEG-hydrogels  
The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of...
8980296 Compositions and methods for preventing cardiac arrhythmia  
Disclosed herein are compositions and methods for treating or preventing cardiac arrhythmia in a subject.
8980299 Method of making a vascular closure device  
A method of making a biocompatible, implantable medical device, including a vascular closure device is disclosed. The method includes forming a biocompatible polymer into at least one fiber and...
8980297 Thermo-mechanically controlled implants and methods of use  
An implant comprises a structure that may be implanted into tissue and that has a first material property at normal body temperature. The first material property is variable at elevated...
8979534 Tooth scaffolds  
Provided is an acellular mammalian tooth-shaped scaffold including a compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. Also provided is a method of replacing a...
8974809 Medical devices having a filter insert for controlled diffusion  
An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic...
8974811 Stabilized pharmaceutical formulations comprising antineoplastic compounds  
The present invention relates to stabilized pharmaceutical formulations prepared from solutions comprising an antineoplastic compound having a cyclic or non-cyclic hydrazine, triazine, or tetrazine...
8975073 Microfluidic device comprising silk films coupled to form a microchannel  
A microfluidic device includes, in one embodiment, a first silk film coupled to a second silk film with at least one microchannel therebetween.
8975275 Use of chemotherapeutic agents  
The invention relates to the use of chemotherapeutic agents for the production of a medicament for the topical and/or local treatment of diseases caused by bacteria and/or for prophylaxis in humans...
8974810 Tissue graft compositions and methods for producing same  
A tissue graft composition is described herein that includes a segment of small intestinal submucosa having at least one nanoparticle incorporated therein such that the permeability of the segment...
8974520 Method for producing a bioactive surface on the balloon of a balloon catheter  
The invention relates to a method for producing a bioactive surface on the balloon (3) of a balloon catheter (1). According to said method, the surface of the balloon (3) is at least partially...
8975075 Hemostatic device  
A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce hemostasis at an anatomical site.
8968392 Method of inhibiting vascular intimal hyperplasia using stent  
A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces...
8968760 Attachment of a biomaterial to tissue  
A method for attaching an implant to tissue is disclosed. In embodiments, a method includes applying a sprayable material to tissue, the sprayable material possessing functional groups capable of...
8968417 Bioactive implant for myocardial regeneration and ventricular chamber restoration  
Bioactive implant for myocardial regeneration and ventricular chamber support including an elastomeric microporous membrane. The elastomeric microporous membrane being at least one non-degradable...
8968782 Combination degradable and non-degradable matrices for active agent delivery  
The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix...
8968353 Method and apparatus for impeding migration of an implanted occlusive structure  
A method of treating a hollow anatomical structure of a patient comprises implanting a bioabsorbable fibrous body in a hollow anatomical structure. The body is secured in the hollow anatomical...
8968797 Bioactive load-bearing composites  
Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.
8962324 Method and system for treatment of biological tissue  
A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ECM) composition that includes an ECM scaffold component and a...
8962011 Process and intra-cervical device for the local release of drugs in the local-regional treatment of cervical cancer  
An intrauterine device and more specifically an intracervical device (ICD) for the local release of drugs in the loco-regional treatment of tumours of the uterine cervix comprises an elongated stem...
8962008 Hybrid polymeric materials for medical applications and preparation thereof  
The present invention relates to a novel polymeric material with enhanced hydrophilicity for medical use comprising a biocompatible polyester material selected from the group consisting of...
8962023 UV cured gel and method of making  
A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide...
8956603 Amphiphilic compounds and self-assembling compositions made therefrom  
The present disclosure relates to amphiphilic compounds, self assembling compositions formed from the amphiphilic compounds and methods of making such compositions.
8956682 Hydrophilic polymeric coatings for medical articles with visualization moiety  
The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The...
8956640 Block copolymers including a methoxyethyl methacrylate midblock  
A block copolymer comprising a methoxyethyl methacrylate (MOEMA) midblock is provided for forming a coating a medical device for controlled release of a bioactive agent.
8956638 Biocompatible poly (amic acid) and method of preparation thereof  
A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine...
8956637 Medical device applications of nanostructured surfaces  
This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such...
8945604 Ophthalmic device, and method of use thereof, for increasing ocular boundary lubrication  
The present invention provides an ophthalmic device, and method of use thereof, for an individual wearing an ophthalmic lens to increase ocular surface boundary lubrication. The invention device...