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8791171 Biodegradable coatings for implantable medical devices  
Biodegradable coatings for implantable medical devices are disclosed.
8790681 Solid forms for tissue repair  
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at...
8791172 Three-component bone cement  
A paste is provided from which bone cement can be formed, which is to the largest extent possible bubble-free and has a high impact strength. The paste includes (i) 15-50 weight percent of at least...
8790680 Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair  
A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the...
8790678 Biomaterials having nanoscale layers and coatings  
The invention generally relates to substrates and surfaces having substrates. Generally speaking, the substrates may be thinly layered substrates, and the surfaces may comprise thinly layered...
8790682 Devices and methods for tissue engineering  
A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is...
8790679 Intracutaneous paste composition  
The delivery of biopharmaceutical and other therapeutic agents parenterally to an animal via a minimally invasive, low pain administration is provided. The agents are delivered to the patient via,...
8784860 Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease  
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to...
8785197 Compositions for regenerating defective or absent myocardium  
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an...
8784864 Bone repair material and method for producing the same  
Bone repair materials are disclosed, from which ions are hardly eluted in living body and which are superior in apatite-forming ability and resistance to apatite peeling and have a scratch...
8784863 Particulate cadaveric allogenic cartilage system  
The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include...
8784862 Compounds and method for coating surfaces in a hemocompatible manner  
The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or...
8784865 Long term drug delivery devices with polyurethane-based polymers and their manufacture  
This invention is related to the use of polyurethane-based polymer as a drug delivery device to deliver biologically active compounds at a constant rate for an extended period of time and methods...
8785198 Compositions for regenerating defective or absent myocardium  
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an...
8784891 Compositions for regenerating defective or absent myocardium  
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an...
8784861 Swellable fiber- and microfiber-forming polyether-esters and applications thereof  
Biomedical and tissue engineering devices, such as surgical sutures and microporous scaffolds, respectively, which undergo swelling and increase in dimensions when placed in aqueous environments...
8784859 Biobeneficial coating compositions and methods of making and using thereof  
A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the...
8784890 Methods for producing ECM-based biomaterials  
A method for forming an extracellular matrix material (ECM) material includes providing at least an ECM composition containing ECM particles varying in their capacity for migration through a fluid...
8778378 Bioactive antibacterial bone graft materials  
The present invention generally relates to bioactive antibacterial materials and composites that enhance bone growth while preventing surgical site infection. The present invention also relates to...
8778822 Artificial bone and joint compositions and methods of use and manufacture  
The present invention provides a ceramic porous body for in-vitro and in-vivo use comprising a composition comprising a calcium aluminate (CA) containing phase and optionally at least one of an...
8778374 Bone formation agent and method of production  
The invention relates to a bone formation agent of porous calcium phosphate having an isotropic sintered structure and, between the particles of the calcium phosphate, statistically distributed...
8778377 Drug implant carrier for drug delivery  
The present invention relates to ceramic precursor material exhibiting injectability and properties that make the material suitable as a carrier material used in drug delivery. According to the...
8778869 Tissue regeneration system  
A system for growing tissue based upon layers of an inorganic extracellular matrix, wherein each layer of the inorganic matrix is designed to dissolve at a separate rate and result in sequential...
8778380 Apparatus for fabricating 3D scaffold for inserting in a body to regenerate tissue  
An apparatus for fabricating a 3D scaffold includes: a plotter generating a microfiber structure; an electrospinning unit installed to be adjacent to the plotter along a first direction and...
8779089 Methods and compositions for soft tissue repair  
Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts,...
8778376 Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating  
A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided.
8778375 Amorphous poly(D,L-lactide) coating  
Implantable devices formed of or coated with a material that includes an amorphous poly(D,L-lactide) formed of a starting material such as meso-D,L-lactide are provided. The implantable device can...
8778360 Extracellular matrix cancer vaccine adjuvant  
Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an...
8778333 Injectable microspheres for tissue construction  
The present invention relates to injectable compositions comprising biocompatible, hydrophilic, non-toxic and substantially spherical microspheres associated with stem cells useful for tissue...
8778379 Insertable medical devices with a porous bed for delivering nano-carriers to a target site and methods of preparing the same  
The invention discloses a method of coating a medical device. The method includes applying a coating composition on the medical device to form a layer on the medical device. The coating composition...
8778362 Anti-tumor/cancer heterologous acellular collagenous preparations and uses thereof  
Disclosed are mammalian tumor and/or cancer cell conditioned substrate preparations having tumor inhibiting activity. In some embodiments, the mammalian tumor and/or cancer cell conditioned...
8771748 Rapid setting calcium phosphate cements  
Methods are provided for producing compositions, e.g. pastes or clays, which rapidly set into high-strength calcium phosphate products. In the subject methods, dry reactants that include calcium...
8771737 Compositions for regenerating defective or absent myocardium  
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an...
8771720 Medical device comprising polyhydroxyalkanoate having pyrogen removed using oxidizing agent  
Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify...
8772368 Bioabsorbable blend for temporary scaffolding of the blood vessel wall  
A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable...
8771719 Synthesis of a bone-polymer composite material  
A method of producing a bone-polymer composite. The method comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing...
8765163 Biocompatible material and uses thereof  
The present invention relates to a biocompatible ceramic material comprising Sr, Mg or Ba doped Hardystonite (Ca2ZnSi2O7), and a method for its synthetic preparation. The present invention also...
8765162 Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same  
The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
8765211 Method for coating metal implants with therapeutic mixtures  
Disclosed herein are methods of treating an article surface. The method comprises delivering a polymer and drug to a medical implant having a porous surface and using at least one particle stream...
8765112 Thermal responsive polymer siloxanes, compositions, and method and applications related thereto  
The invention relates to materials comprising siloxanes, preferably the materials have thermal-responsive properties. In some embodiments, the invention relates to silsesquioxane groups...
8765238 Polymeric/inorganic composite materials for use in medical devices  
In one aspect, the present invention provides composite coatings for implantable or insertable medical devices. These composite coatings comprise (a) an inorganic portion and (b) a polymeric...
8758796 Functionalizing implantable devices with a poly (diol citrate) polymer  
The present invention is directed to a novel poly(diol citrates)-based coating for implantable devices. More specifically, the specification describes methods and compositions for making and using...
8758798 Therapeutic implant  
Surgical implants are provided which include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct contact...
8758799 Therapeutic implant  
Surgical implants are provided which include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct contact...
8758793 Therapeutic agent carrier and method of treating bone fractures  
A therapeutic agent carrier for treating a defect in a bone is disclosed and can include a body that can be configured to approximate a portion of the bone. Further, the therapeutic agent carrier...
8758800 Therapeutic implant  
Surgical implants are provided which include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct contact...
8758794 Cell-free tissue replacement for tissue engineering  
The present invention is a natural, cell-free tissue replacement that does not require difficult or extensive preparation made by washing tissue replacement in a solution including one or more...
8758795 Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use  
Surgically implantable drug delivery systems for long-term delivery of haloperidol containing a biodegradable polymer and haloperidol fabricated into the surgically implantable drug delivery...
8753886 Compositions for regenerating defective or absent myocardium  
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an...
8753661 Biological surfaces  
A base body contains a substrate that is at least partially coated with a carbon-containing layer. The carbon-containing layer is at least partially functionalized with a molecule that is bound...