Sign up


Match Document Document Title
8703157 Phase transitioning hydrogels  
A method of forming and the resulting hydrogel composition comprising poly(vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final...
8703167 Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug  
Provided herein is a coating that includes cRGD for endothelial cells and methods of making and using the same.
8703293 Coating compositions and coatings for medical devices containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer  
Provided herein re a composition and a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the...
8703168 Medical devices for releasing therapeutic agent and methods of making the same  
An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be...
8703180 Multiple growth factor compositions, methods of fabrication, and methods of treatment  
Disclosed are compositions with sustained-release carriers associated with at least two different types of growth factors and methods of fabrication and treatments thereof. In some embodiments,...
8703110 Coating system  
Embodiments of the invention include a system comprising: an Acetoxy curable silicone Binder; and an active agent blended with the silicone binder, effective for one or more of radiopacification,...
8697108 Method for making a porous polymeric material  
Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase...
8697111 Osteochondral implant comprising osseous phase and chondral phase  
An osteochondral plug includes a first scaffold and a second scaffold. The first scaffold may be a solid scaffold containing one or more pendant reactive functional groups. The second scaffold...
8697771 Biocompatible coatings, and methods of making and using the same  
Disclosed herein are biocompatible coatings for a substrate, the biocompatible coating including at least one polyanionic/polycationic bilayer including at least one nitric oxide generating moiety,...
8697109 Caged mercaptan and seleno-mercaptan compounds and methods of using them  
Novel mercaptan compounds, particularly those including a photolabile protecting group, are described as well as methods of using the compounds for the prevention and treatment of ocular damage and...
8697044 Crossed-linked hyaluronic acid and collagen and uses thereof  
The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone....
8697106 Coating composition  
A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or...
8697104 Apparatus, system, and method for creating immunologically enhanced spaces in-vivo  
The present invention creates an immunologically protected/enhanced space in viva in a mammal by removing the impact of soluble inhibitors of the mammal's immune system in a defined space within...
8697110 Polymers comprising amorphous terpolymers and semicrystalline blocks  
The present invention provides an implantable article comprising an amorphous terpolymer and a semi-crystalline polymer. The amorphous terpolymer can be admixed with the semi-crystalline polymer or...
8691265 Drug delivery methods, structures, and compositions for nasolacrimal system  
A drug insert is configured for use with an implant. The implant is configured for insertion into a lacrimal canaliculus. The drug insert includes a drug core comprising a therapeutic agent and a...
8691899 Antimicrobial polymer compositions and the use thereof  
An antimicrobial composition and a medical device having that antimicrobial composition that includes a complex of an anionic polyester with a monomeric amidoamine having at least one amide group...
8691260 Immobilized biologically active entities having a high degree of biological activity  
The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity.
8691245 Composition for forming a temporary obstruction and method of forming the same  
The present invention relates to a method for forming a temporary obstruction of the intestine of a mammal, using a solidifiable composition, said composition being flowable and solidifiable to...
8691263 Extracellular matrix comprising platelet concentrate and cryoprecipitate polymerized in situ  
The present invention describes an extracellular matrix comprising human platelet derived growth factors, that permits the maximizing of therapeutic efficacy, combining the benefits of both...
8691262 Method for aligning cells and applying homogenous strain throughout deformable engineered tissue constructs  
A process creates a homogenous sheet of engineered tissue comprised of encapsulated cells and a deformable engineered tissue construct. In the embodiment consisting of a collagen construct with...
8691203 Method comprising contacting tissue with a cross-linkable polyester prepolymer  
The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a...
8691543 Nanofibrous scaffold comprising immobilized cells  
The invention is directed to a device and method to prevent migration of Human Mesenchymal Stem Cells (hMSCs) from a delivery site while allowing communication between the stem cells and native...
8690874 Composition and process for bone growth and repair  
A composition for the induction of bone growth is disclosed. The composition includes a substrate, bone growth protein, and sources of calcium and phosphate. The composition is acidic which...
8691261 Drug, drug guidance system, magnetic detection system, and drug design method  
It is intended to provide a drug delivery system which makes it possible to solve the existing technical problems and is easily usable in practice. A drug, which comprises an organic compound or an...
8686064 Coupling agents for orthopedic biomaterials  
The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a...
8685429 Shaped bodies and methods for their production and use  
Shaped, composite bodies are provided. One portion of the shaped bodies comprises an RPR-derived porous inorganic material, preferably a calcium phosphate. Another portion of the composite bodies...
8685426 Methods for making biocompatible, implantable, substantially sericin free silk fabric  
Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can...
RE44820 Nanocrystalline apatites and composites, prostheses incorporating them, and methods of their production  
Methods for synthesis of nanocrystalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered...
8685427 Controlled drug delivery  
A medical device for placement in a body of a mammal is provided. The medical device comprises (1) a polymeric matrix forming the device and defining a lumen through the device, the matrix...
8685428 Therapeutic composition and a method of coating implantable medical devices  
A method of making a therapeutic composition, as well as the therapeutic composition so made, is disclosed. The method comprises mixing a hydrophobic drug with an aqueous buffer solution and adding...
8685634 Neural scaffolds  
Disclosed herein are compositions and methods useful for preparing neural scaffolds. The scaffolds comprise tissue taken from the spinal cord and/or dura mater of vertebrate and can be processed to...
8685486 Method of and system for applying blocking material to assay substrates  
Methods of and systems for applying blocking material to assay substrates are disclosed. A method includes supplying an assay substrate having at least one surface. A first portion of the surface...
8679517 Implantable materials having engineered surfaces made by vacuum deposition and method of making same  
An implantable biocompatible material includes one or more vacuum deposited layers of biocompatible materials deposited upon a biocompatible base material. At least a top most vacuum deposited...
8680182 Methods for promoting the revascularization and reenervation of CNS lesions  
The present invention provides methods of promoting the revascularization and/or reenervation of central nervous system lesions using an in-situ crosslinkable hydrogel. The present invention also...
8679520 Coating of stents for preventing restenosis  
The invention relates to stents with at least one hemocompatible coating which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of...
8679518 Antimicrobial compounds having protective or therapeutic leaving groups  
Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing...
8673337 Method of tissue repair using a composite material  
A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium...
8673334 Stent coatings comprising hydrophilic additives  
A coating for implantable medical devices and a method for fabricating thereof are disclosed. The coating includes a mixture of a hydrophobic polymer and a polymeric hydrophilic additive, wherein...
8673335 Methods and compositions for sealing and adhering biological tissues and medical uses thereof  
Compositions and methods for sealing, coating and adhering tissues are provided that utilize a polymeric system comprising at least a Polymer and a crosslinking agent; and, optionally, (i) a...
8673336 Composition, system, and method for modulating release kinetics in implantable drug delivery devices by modifying drug solubility  
An implantable drug delivery device loaded with a beneficial agent is provided, wherein the beneficial agent is in two different forms, a first form having a higher solubility and a second form...
8673339 Demand-release bioactive composition for implantable medical devices  
A biostable polymeric substrate of an implantable medical device unit includes a demand-release bioactive composition including one or more bioactive agents covalently bound to surface-modifying...
8673338 Methods of delivering pharmaceutical agents  
Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include...
8673333 Cross-linked polymer matrices, and methods of making and using same  
Functionalized chondroitin sulfate, cross-linked polymer matrices comprising functionalized chondroitin sulfate, and methods of making and using the same are provided. Such polymer matrices may be...
8669107 Method of preparing a tissue engineering scaffold comprising a plurality of microspheres linked together  
Methods can prepare tissue engineering scaffolds that include a plurality of biocompatible microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of...
8668919 Polymer for creating hemocompatible surface  
A polymer comprising a phosphoryl choline moiety(ies), a composition comprising the polymer and optionally a bioactive agent, an implantable device such as a DES or a non-implantable device such as...
8663673 Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility  
The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention...
8658195 Long term drug delivery devices with polyurethane based polymers and their manufacture  
This invention is related to the use of polyurethane based polymer as a drug delivery device to deliver biologically active compounds at a constant rate for an extended period of time and methods...
8658197 Disruptable medical implants with reservoir (s), and materials preparable from same  
Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body defines one or more reservoirs for receiving amounts of a...
8658196 Graft materials and methods for staged delivery of bioactive components  
Described, in certain aspects of the invention, are multilaminate medical graft products, as well as methods for preparing and using the same. An illustrative multilaminate medical graft product of...
8658215 Injectable microspheres for dermal augmentation and tissue bulking  
The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions...