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8815275 Coatings for medical devices comprising a therapeutic agent and a metallic material  
The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular,...
8815276 Three-dimensional nanostructured hybrid scaffold and manufacture thereof  
A method of making a three-dimensional biocompatible scaffold capable of supporting cell activities such as growth and differentiation, the method includes providing a supporting grid that forms an...
8815973 Cement products and methods of making and using the same  
Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement...
8813753 Implantable obstructive sleep apnea sensor  
Systems and methods for detecting an obstructive sleep apnea event are disclosed herein. The systems and methods may use an electrical output generating ionic polymer metal composite sensor...
8815274 Poly(ester amides) for the control of agent-release from polymeric compositions  
The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a...
8815277 In situ forming hydrogel and biomedical use thereof  
Disclosed are in situ-forming injectable hydrogel and medical uses thereof. In the in situ-forming injectable hydrogel two or more homogeneous or heterogeneous polymers are bonded to each other by...
8808723 Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same  
Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate...
8808727 Posterior segment drug delivery  
A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts...
8808725 Solid forms for tissue repair  
This invention provides coral-based scaffolds for cartilage repair, and instruments for insertion and utilization of same within a site of cartilage repair.
8808357 Radiopaque iodinated and iodide-containing crystalline absorbable aliphatic polymeric materials and applications thereof  
Radiopaque, iodinated, absorbable polyesters, polyester urethanes, and polyether-ester-urethanes with and without inorganic iodide micro-/nanoparticles dispersed or solubilized therein, and...
8808724 Antimicrobial coatings with preferred microstructure for medical devices  
A medical device having an antimicrobial coating. The device has a first coating layer having an antimicrobial agent over at least part of the outer surfaces of the device. The first coating has an...
8802184 Medical devices containing biobeneficial particles  
A method of modifying a medical device such as a stent with nano-constructs is disclosed. The method comprises applying a first fluid to the stent; immersing the stent being wet from the first...
8802122 Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue of bone  
Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The...
8801694 Intravesical drug delivery device  
Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube...
8802123 Endosseous implant  
Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture,...
8802113 Extracellular matrix cancer vaccine adjuvant  
Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an...
8795705 Dermatologic compositions comprising pyrrolidone-5-carboxylic acid and at least one entity chosen from citrulline, arginine and asparagine, and uses thereof in the treatment of atopic dermatitis  
Combination comprising pyrrolidone-5-carboxylic acid and at least one compound from citrulline, arginine and asparagine, and use thereof in the treatment of atopic dermatitis The present invention...
8795712 Posterior segment drug delivery  
A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts...
8795706 Methods of treating ocular diseases using derivatives of lipoic acid  
Methods of treating ocular diseases using dithiol compounds, their derivatives, and pharmaceutically acceptable salts thereof are disclosed. In particular, methods using dithiol compounds that...
8795703 Stand-alone film and methods for making the same  
A stand-alone film is derived at least in part from fatty acids. The stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally...
8795707 Compliant composites for application of drug-eluting coatings to tissue surfaces  
A compliant composite for delivering a bioactive agent including a scaffolding material and a polymer coating that together can be attached to compliant tissue surfaces is disclosed, along with...
8795728 Compositions for regenerating defective or absent myocardium  
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an...
8795708 Treating defective dura with synthetic artificial dura substitute  
Disclosed are an artificial dura mater and manufacturing method thereof. The artificial dura mater includes electrospun layers prepared by electrostatic spinning, at least one of which is a...
8795704 Medical devices having fluorine-containing polymer coatings with improved adhesion  
According to an aspect of the present invention, medical devices are provided which include a metallic substrate and a polymeric region disposed over and in contact with the metallic substrate. The...
8791171 Biodegradable coatings for implantable medical devices  
Biodegradable coatings for implantable medical devices are disclosed.
8790681 Solid forms for tissue repair  
This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at...
8791172 Three-component bone cement  
A paste is provided from which bone cement can be formed, which is to the largest extent possible bubble-free and has a high impact strength. The paste includes (i) 15-50 weight percent of at least...
8790680 Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair  
A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the...
8790678 Biomaterials having nanoscale layers and coatings  
The invention generally relates to substrates and surfaces having substrates. Generally speaking, the substrates may be thinly layered substrates, and the surfaces may comprise thinly layered...
8790682 Devices and methods for tissue engineering  
A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is...
8790679 Intracutaneous paste composition  
The delivery of biopharmaceutical and other therapeutic agents parenterally to an animal via a minimally invasive, low pain administration is provided. The agents are delivered to the patient via,...
8784860 Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease  
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to...
8785197 Compositions for regenerating defective or absent myocardium  
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an...
8784864 Bone repair material and method for producing the same  
Bone repair materials are disclosed, from which ions are hardly eluted in living body and which are superior in apatite-forming ability and resistance to apatite peeling and have a scratch...
8784863 Particulate cadaveric allogenic cartilage system  
The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include...
8784862 Compounds and method for coating surfaces in a hemocompatible manner  
The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or...
8784865 Long term drug delivery devices with polyurethane-based polymers and their manufacture  
This invention is related to the use of polyurethane-based polymer as a drug delivery device to deliver biologically active compounds at a constant rate for an extended period of time and methods...
8785198 Compositions for regenerating defective or absent myocardium  
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an...
8784891 Compositions for regenerating defective or absent myocardium  
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an...
8784861 Swellable fiber- and microfiber-forming polyether-esters and applications thereof  
Biomedical and tissue engineering devices, such as surgical sutures and microporous scaffolds, respectively, which undergo swelling and increase in dimensions when placed in aqueous environments...
8784859 Biobeneficial coating compositions and methods of making and using thereof  
A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, an implantable device coated with the...
8784890 Methods for producing ECM-based biomaterials  
A method for forming an extracellular matrix material (ECM) material includes providing at least an ECM composition containing ECM particles varying in their capacity for migration through a fluid...
8778378 Bioactive antibacterial bone graft materials  
The present invention generally relates to bioactive antibacterial materials and composites that enhance bone growth while preventing surgical site infection. The present invention also relates to...
8778822 Artificial bone and joint compositions and methods of use and manufacture  
The present invention provides a ceramic porous body for in-vitro and in-vivo use comprising a composition comprising a calcium aluminate (CA) containing phase and optionally at least one of an...
8778374 Bone formation agent and method of production  
The invention relates to a bone formation agent of porous calcium phosphate having an isotropic sintered structure and, between the particles of the calcium phosphate, statistically distributed...
8778377 Drug implant carrier for drug delivery  
The present invention relates to ceramic precursor material exhibiting injectability and properties that make the material suitable as a carrier material used in drug delivery. According to the...
8778869 Tissue regeneration system  
A system for growing tissue based upon layers of an inorganic extracellular matrix, wherein each layer of the inorganic matrix is designed to dissolve at a separate rate and result in sequential...
8778380 Apparatus for fabricating 3D scaffold for inserting in a body to regenerate tissue  
An apparatus for fabricating a 3D scaffold includes: a plotter generating a microfiber structure; an electrospinning unit installed to be adjacent to the plotter along a first direction and...
8779089 Methods and compositions for soft tissue repair  
Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts,...
8778376 Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating  
A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided.