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8962324 Method and system for treatment of biological tissue  
A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ECM) composition that includes an ECM scaffold component and a...
8962011 Process and intra-cervical device for the local release of drugs in the local-regional treatment of cervical cancer  
An intrauterine device and more specifically an intracervical device (ICD) for the local release of drugs in the loco-regional treatment of tumours of the uterine cervix comprises an elongated stem...
8962008 Hybrid polymeric materials for medical applications and preparation thereof  
The present invention relates to a novel polymeric material with enhanced hydrophilicity for medical use comprising a biocompatible polyester material selected from the group consisting of...
8962023 UV cured gel and method of making  
A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide...
8956603 Amphiphilic compounds and self-assembling compositions made therefrom  
The present disclosure relates to amphiphilic compounds, self assembling compositions formed from the amphiphilic compounds and methods of making such compositions.
8956682 Hydrophilic polymeric coatings for medical articles with visualization moiety  
The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The...
8956640 Block copolymers including a methoxyethyl methacrylate midblock  
A block copolymer comprising a methoxyethyl methacrylate (MOEMA) midblock is provided for forming a coating a medical device for controlled release of a bioactive agent.
8956638 Biocompatible poly (amic acid) and method of preparation thereof  
A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine...
8956637 Medical device applications of nanostructured surfaces  
This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such...
8945604 Ophthalmic device, and method of use thereof, for increasing ocular boundary lubrication  
The present invention provides an ophthalmic device, and method of use thereof, for an individual wearing an ophthalmic lens to increase ocular surface boundary lubrication. The invention device...
8945535 Implant for the repair of a cartilage defect and method for manufacturing the implant  
For the repair of a cartilage defect in a human or animal patient use is made of an implant comprising an implant body including a natural cartilage matrix and being coated with cells having a...
8945599 Immobilized biologically active entities having a high degree of biological activity  
The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity.
8945598 Low temperature drying methods for forming drug-containing polymeric compositions  
The present invention relates to a process for reducing solvent contents in drug-containing polymeric compositions. Specifically, the solvent contents in the drug-containing polymeric compositions...
8945600 Methods of delivering pharmaceutical agents  
Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include...
8946192 Heat stable hyaluronic acid compositions for dermatological use  
The disclosure provides hyaluronic acid (HA) gel formulations and methods for treating the appearance of the skin. The formulations hyaluronic acid and at least one additional ingredient. Methods...
8940292 Enhancement of angiogenesis to grafts using cells engineered to produce growth factors  
The present invention provides methods and compositions of engineered cells for use in the continuous or transient delivery of growth factors and angiogenesis modulating agents, such as vascular...
8940316 Osmotic delivery comprising an insulinotropic peptide and uses thereof  
A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non-aqueous, single-phase...
8940357 Marked precoated medical device and method of manufacturing same  
A medical device, such as a medical wire, which includes a coating applied to the surface of the medical wire. The coating includes a base layer bonded to the surface of the medical wire and an at...
8936780 Stimuli responsive polyester amide particles  
A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including...
8936805 Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same  
A structure of, and a method of producing, a biocompatible structure for bone and tissue regeneration are disclosed. The method includes dissolving a polyurethane polymer in methanol, adding...
8936806 Periostin induces proliferation of cardiomyocytes and promotes cardiac regeneration  
The present invention provides compositions and methods for increasing proliferation, increasing cell cycle activity, and/or proliferation of postmitotic mammalian differentiated cardiomyocytes....
8932620 Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices  
Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by...
8932619 Dural repair material  
Multilayer structures including a porous layer and a non-porous layer having a reinforcement member are useful as dural repair materials.
8932621 Implantable film/mesh composite  
The present disclosure relates to implantable medical devices which include at least one mesh and at least one film attached to the mesh along different portions of the mesh creating at least one...
8932560 Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells  
A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the...
8932618 Biodegradable osmotic pump implant for drug delivery  
The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a...
8932615 Implantable devices formed on non-fouling methacrylate or acrylate polymers  
Implantable devices formed of or coated with a material that includes a polymer having a non-fouling acrylate or methacrylate polymer are provided. The implantable device can be used for treating...
8932637 Injectable and swellable microspheres for tissue bulking  
The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The...
8932347 Implantable materials having engineered surfaces and method of making same  
Implantable materials having engineered surfaces and method of making same comprising geometric features on at least one surface of the material having at least one of chemical, physiochemical and...
8932617 Methods for treating or preventing restenosis and other vascular proliferative disorders  
Described herein is the use of ribonucleotide reductase inhibitors in the prevention or treatment of restenosis and other vascular proliferative disorders.
8927003 Extracellular matrix based gastroesophageal junction reinforcement device  
Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part...
8927002 Stent with a coating or a basic body containing a lithium salt and use of lithium salts for prevention of restenosis  
The invention relates to a stent with in particular a coated basic body made of an implant material the use of lithium salts as a coating material or a component of an implant material for stents...
8927004 Bioabsorbable substrates and systems that controllably release antimicrobial metal ions  
Bioabsorbable substrates having antimicrobial metal ion coatings that are well suited for implantation in to a subject's body to treat and/or prevent infection. In particular, described herein are...
8927876 Electrode array and method of fabrication  
An electrode array, having application as a cochlear implant, includes a tube formed of Parylene defining a hollow channel. A substrate formed primarily of Parylene is supported by the tube. In...
8927001 Bioswellable, crystalline, amphiphilic, block/graft polymers and applications thereof  
Absorbable, essentially non-absorbable, and non-absorbable crystalline, amphiphilic, block/graft copolymeric compositions exhibit an inherent viscosity of at least 0.5 dL/g, a heat of fusion of at...
8920828 Implants for treatment of symptomatic or degenerated intervertebral discs  
Devices for the treatment of intervertebral discs are described. The devices, when implanted into the nucleus pulposus of an intervertebral disc, provide for the controlled release of one or more...
8920827 Keratin bioceramic compositions  
A malleable bone graft composition is described. The composition comprises: (a) keratose; (b) particulate filler; (c) antibiotic; and (f) water. The invention may be provided in sterile form in an...
8921109 Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof  
A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of...
8916185 Immobilizing particles onto surfaces  
A method for immobilizing micro-particles, nano-particles or combinations thereof onto a surface is disclosed. The method includes distributing the micro-particles, nano-particles or combinations...
8916187 Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same  
The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
8916184 Artificial tissue systems and uses thereof  
An implant system and a method for controlling the natural and artificial microenvironments surrounding an implanted device using an artificial tissue system (ATS) and includes methods of...
8916186 Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws  
A method of correcting spinal deformity, which includes locating pharmaceutical-loaded implants adjacent to targeted spinal growth plates, and then eluting the pharmaceutical onto the growth...
8916339 Spinal cord tissue dehydrated and micronized  
A composition of neural tissue is made of spinal cord tissue harvested from a spinal cord of a mammal. The spinal cord tissue is harvested from vertebral column of the mammal. The spinal cord...
8916143 Polymer compositions of dihydroxyacetone and uses thereof  
The present disclosure provides injectable synthetic and biodegradable polymeric biomaterials that effectively prevent seroma, a common postoperative complication following ablative and...
8911492 Coating for a medical device having an anti-thrombotic conjugate  
An implantable device having a coating comprising a comb-type anti-thrombotic conjugate to prevent or reduce the formation of thrombosis on the surface of the device. The device includes a frame...
8911761 Composite materials  
This application discloses a composite material comprising one or more silk elements in an acrylic or cross-linked protein matrix. The silk elements are made from the group of silk elements...
8911789 Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom  
Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be...
8911762 Polylactic acid/calcium sulfate scaffold  
The invention relates to a method of preparing a composite or porous composite used as a biodegradable scaffold, the composite prepared therefrom and the use of the composite. In particular, the...
8906362 Tissue engineered meniscus scaffolds and methods of use  
Provided herein are methods of producing a meniscus scaffold to remove material and increase the pore size and porosity therein. In some embodiments, methods include seeding the tissue with...
8906394 Hyaluronic acid based copolymers  
Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis,...