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9040070 Material for induction of hard tissue regeneration  
The present invention relates to a material for induction of hard tissue regeneration, comprising platelet-rich plasma and gelatin β-TCP sponge, which promotes angiogenesis, osteogenesis, ...
9040111 Method of making a stent  
A method of making a stent, including preparing a solution containing a composition, the composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind,...
9040071 Pary-xylene based microfilm elution devices  
This invention is in the field of controlled elution devices for therapeutic delivery. There exists a need for a stand-alone capable device for the localized and extended delivery of a therapeutic....
9034357 Anti-adhesion barrier  
The present disclosure relates to medical devices comprising at least a first film layer and at least a second gel layer and to methods for preparing such devices.
9034358 Bone matrix compositions and methods  
The present invention provides methods of improving the osteogenic and/or chondrogenic activity of a bone matrix, e.g., a dermineralized bone matrix (DBM), by exposing the bone matrix to one or...
9034647 Compositions for regenerating defective or absent myocardium  
Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an...
9034355 Materials for modulating biological responses and methods of making  
A polymeric composition capable of releasing nitric oxide and modulating biological responses comprises a biocompatible polymer and S-nitrosated thiol bonded to the biocompatible polymer. The...
9034360 Biogenerator constructed using live cell cultures  
An apparatus (or a biogenerator) is disclosed which utilizes the electrochemical polarization of epithelial cells to generate electricity. The apparatus employs living cells to convert chemical...
9034356 Porous osteoimplant  
The invention is directed toward porous composites for application to a bone defect site to promote new bone growth. The inventive porous composites comprise a biocompatible polymer and a plurality...
9034362 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens  
A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical...
9034378 Biodegradable polyurethane and polyurethane ureas  
This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender...
9034361 Hydroswellable, segmented, aliphatic polyurethanes and polyurethane ureas  
Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at...
9034359 Composition comprising biodegradable hydrating ceramics for controlled drug delivery  
The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in...
9028859 Phase-separated block copolymer coatings for implantable medical devices  
Medical devices and coatings for medical devices are disclosed, including methods for forming the devices and coatings. The devices and coatings comprise a phase-separated block copolymer matrix...
9028871 Resorbable ceramics with controlled strength loss rates  
Particular aspects provide bioresorbable and biocompatible compositions for bioengineering, restoring or regenerating tissue or bone, comprising a three-dimensional porous or non-porous scaffold...
9029418 Capping bioprosthetic tissue to reduce calcification  
A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a...
9028858 Assembly for the preparation of a medical device having a coating comprising hydrogen peroxide  
The present invention provides an assembly for the preparation of a medical device having a porous coating comprising hydrogen peroxide. Particularly interesting medical devices are catheters (such...
9023377 Methods and compositions for enhancing vascular access  
Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable...
9023376 Nanofiber-reinforced composition for application to surgical wounds  
A nanofiber-reinforced composition suited to applying to a wound site in a human body includes a carrier liquid and nanofibers dispersed therein in the carrier liquid. The viscosity of the...
9023378 Implant with surface with calcium, and methods for modifying the surface of an implant to provide said surface with calcium  
The invention relates to an implant for the human or animal body, which on its outer surface comprises at least one calcium salt that is soluble in a polar liquid. The invention also refers to...
9017711 Soft tissue wrap  
Compositions and methods for treating and healing injured soft tissues such as tendons and ligaments are provided. The composition may be a wrap comprising human collagen in the form of a sheet....
9017350 Expandable occlusive structure  
An apparatus for treating a hollow anatomical structure comprises an implant comprising a plurality of bioabsorbable fibers. The implant has a compressed state in which the implant can fit within a...
9017710 Injectable and swellable microspheres for tissue bulking  
The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The...
9017712 Filler composition for tissue reinforcement  
The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive...
9015922 Bone implants and method of manufacture  
An implant device for humans or mammals has a body structure having an exposed surface and one or more selected portions of the exposed surface having a bone formation enhancing 3-dimensional...
9017709 Composition comprising polymeric, water-insoluble, anionic particles, processes and uses  
The present invention relates to an injectable composition which comprises polymeric, water-insoluble, non-biodegradable, anionic particles, these particles having an irregular shape and a...
9011884 Embolic devices  
Described herein are apparatus, compositions, systems and methods for occluding vascular structures and vascular malformations with radiopaque hydrogel filaments. The filaments can contain no...
9011665 Metal implants  
A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer is grown by...
9011894 Sterile hyaluronic acid polymer compositions and related methods  
The present application provides sterile hyaluronic polymer compositions than are useful, e.g., as medical devices, biomedical adhesives, and sealants. Generally, provided are sterile dry...
9011897 Catheter lock solution comprising citrate and a paraben  
This invention relates to compositions, methods, devices and kits relating to the infusion of a catheter lock solution into an indwelling catheter. Inventive compositions, methods, devices and kits...
9011896 Coating formulations for scoring or cutting balloon catheters  
The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive...
9011898 Composition for active principles delivery containing a fatty acid excipient  
Composition for delivery of at least one active principle at the implantation site of an implant device, including: at least one active principle, andat least a first excipient combined with the at...
9011895 EB matrix production from animal tissue and its use for tissue repair  
A method of forming and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue to chemical and mechanical processing. In addition to skin tissue, another source of...
9011899 Methods and devices for cellular transplantation  
Devices and methods for transplanting cells in a host body are described. The cell comprises a porous scaffold that allows ingrowth of vascular and connective tissues, a plug or plug system...
9011831 Methacrylate copolymers for medical devices  
A polymer of hydrophobic monomers and hydrophilic monomers is provided. It is also provided a polymer blend that contains the polymer and another biocompatible polymer. The polymer or polymer blend...
9005648 Inorganically surface-modified polymers and methods for making and using them  
In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned)...
9005650 Microfabricated nanopore device for sustained release of therapeutic agent  
A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for...
9006182 Light activated composite tissue adhesives  
A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adheives that are...
9005606 Silk fibroin hydrogels and uses thereof  
The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such...
9005649 Methods for making controlled delivery devices having zero order kinetics  
A method of making an injectable or implantable active agent delivery device capable of delivering a diagnostic, therapeutic, and/or prophylactic agent to a desired targeted site having orifice(s)...
8999364 Implantable article, method of forming same and method for reducing thrombogenicity  
Endothelialization of a bodily fluid or tissue-contacting, particularly blood-contacting, surface may be accomplished to render that surface substantially non-thrombogenic. Thrombosis may also be...
8999365 Prevention of bacterial contamination  
A compound of formula I: wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl...
8999366 Porous biomaterial on hydroxyapatite  
The present invention provides a synthetic non-resorbable silicon-containing calcium phosphate biomaterial having a microporosity of 23% by volume or greater, wherein the surface free energy of the...
8999945 Methods, compositions and systems for local delivery of drugs  
Implantable medical device eluting drug locally and in a prolonged fashion are provided.
8999367 Bioabsorbable substrates and systems that controllably release antimicrobial metal ions  
Bioabsorbable substrates having antimicrobial metal ion coatings that are well suited for implantation in to a subject's body to treat and/or prevent infection. In particular, described herein are...
8992963 Immobilised biological entities  
There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting...
8992961 Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles  
This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended...
8992964 Process for demineralization of bone matrix with preservation of natural growth factors  
A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically...
8992978 Material compositions which comprise adult stem cells obtained from exocrine glandular tissue, in particular for use in regenerative medicine  
The invention relates to material compositions comprising adult stem cells obtained from exocrine gland tissue and a supporting matrix having the shape of a thread structure and/or of a net. The...
8992967 Poly (diol-co-citrate) hydroxyapatite composite for tissue engineering and orthopaedic fixation devices  
The present invention is directed to a novel poly(diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in...