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8986737 Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth  
A method of treating or preventing infection at a surgical site comprising a bony defect and an implanted metal device is disclosed. Biodegradable microspheres are placed at the site and are...
8986726 Biocompatible polyacrylate compositions for medical applications  
A composition comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and...
8986728 Soluble implantable device comprising polyelectrolyte with hydrophobic counterions  
The present invention provides an implantable device having a biosoluble coating or a biosoluble body structure comprising a polyelectrolyte and a counterion and the methods of making and using the...
8986725 Silicone-peroxide compositions for long-term, controlled oxygen release  
A composite for delivering extended-release of oxygen is disclosed. The composite can include a biocompatible polymeric support having a plurality of solid peroxide particles suspended therein. The...
8986713 Medical device capable of being compacted and expanded having anti-thrombin III binding activity  
The present invention relates to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities...
8980302 Therapeutic implant  
Surgical implants of the present disclosed include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct...
8980300 Plasticizers for coating compositions  
A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive...
8980278 Bio-functionalized stimulus-responsive dissolvable PEG-hydrogels  
The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of...
8980296 Compositions and methods for preventing cardiac arrhythmia  
Disclosed herein are compositions and methods for treating or preventing cardiac arrhythmia in a subject.
8980299 Method of making a vascular closure device  
A method of making a biocompatible, implantable medical device, including a vascular closure device is disclosed. The method includes forming a biocompatible polymer into at least one fiber and...
8980297 Thermo-mechanically controlled implants and methods of use  
An implant comprises a structure that may be implanted into tissue and that has a first material property at normal body temperature. The first material property is variable at elevated...
8979534 Tooth scaffolds  
Provided is an acellular mammalian tooth-shaped scaffold including a compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. Also provided is a method of replacing a...
8974809 Medical devices having a filter insert for controlled diffusion  
An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic...
8974811 Stabilized pharmaceutical formulations comprising antineoplastic compounds  
The present invention relates to stabilized pharmaceutical formulations prepared from solutions comprising an antineoplastic compound having a cyclic or non-cyclic hydrazine, triazine, or tetrazine...
8975073 Microfluidic device comprising silk films coupled to form a microchannel  
A microfluidic device includes, in one embodiment, a first silk film coupled to a second silk film with at least one microchannel therebetween.
8975275 Use of chemotherapeutic agents  
The invention relates to the use of chemotherapeutic agents for the production of a medicament for the topical and/or local treatment of diseases caused by bacteria and/or for prophylaxis in humans...
8974810 Tissue graft compositions and methods for producing same  
A tissue graft composition is described herein that includes a segment of small intestinal submucosa having at least one nanoparticle incorporated therein such that the permeability of the segment...
8974520 Method for producing a bioactive surface on the balloon of a balloon catheter  
The invention relates to a method for producing a bioactive surface on the balloon (3) of a balloon catheter (1). According to said method, the surface of the balloon (3) is at least partially...
8975075 Hemostatic device  
A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce hemostasis at an anatomical site.
8968392 Method of inhibiting vascular intimal hyperplasia using stent  
A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces...
8968760 Attachment of a biomaterial to tissue  
A method for attaching an implant to tissue is disclosed. In embodiments, a method includes applying a sprayable material to tissue, the sprayable material possessing functional groups capable of...
8968417 Bioactive implant for myocardial regeneration and ventricular chamber restoration  
Bioactive implant for myocardial regeneration and ventricular chamber support including an elastomeric microporous membrane. The elastomeric microporous membrane being at least one non-degradable...
8968782 Combination degradable and non-degradable matrices for active agent delivery  
The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix...
8968353 Method and apparatus for impeding migration of an implanted occlusive structure  
A method of treating a hollow anatomical structure of a patient comprises implanting a bioabsorbable fibrous body in a hollow anatomical structure. The body is secured in the hollow anatomical...
8968797 Bioactive load-bearing composites  
Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.
8962324 Method and system for treatment of biological tissue  
A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ECM) composition that includes an ECM scaffold component and a...
8962011 Process and intra-cervical device for the local release of drugs in the local-regional treatment of cervical cancer  
An intrauterine device and more specifically an intracervical device (ICD) for the local release of drugs in the loco-regional treatment of tumours of the uterine cervix comprises an elongated stem...
8962008 Hybrid polymeric materials for medical applications and preparation thereof  
The present invention relates to a novel polymeric material with enhanced hydrophilicity for medical use comprising a biocompatible polyester material selected from the group consisting of...
8962023 UV cured gel and method of making  
A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide...
8956603 Amphiphilic compounds and self-assembling compositions made therefrom  
The present disclosure relates to amphiphilic compounds, self assembling compositions formed from the amphiphilic compounds and methods of making such compositions.
8956682 Hydrophilic polymeric coatings for medical articles with visualization moiety  
The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The...
8956640 Block copolymers including a methoxyethyl methacrylate midblock  
A block copolymer comprising a methoxyethyl methacrylate (MOEMA) midblock is provided for forming a coating a medical device for controlled release of a bioactive agent.
8956638 Biocompatible poly (amic acid) and method of preparation thereof  
A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine...
8956637 Medical device applications of nanostructured surfaces  
This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such...
8945604 Ophthalmic device, and method of use thereof, for increasing ocular boundary lubrication  
The present invention provides an ophthalmic device, and method of use thereof, for an individual wearing an ophthalmic lens to increase ocular surface boundary lubrication. The invention device...
8945535 Implant for the repair of a cartilage defect and method for manufacturing the implant  
For the repair of a cartilage defect in a human or animal patient use is made of an implant comprising an implant body including a natural cartilage matrix and being coated with cells having a...
8945599 Immobilized biologically active entities having a high degree of biological activity  
The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity.
8945598 Low temperature drying methods for forming drug-containing polymeric compositions  
The present invention relates to a process for reducing solvent contents in drug-containing polymeric compositions. Specifically, the solvent contents in the drug-containing polymeric compositions...
8945600 Methods of delivering pharmaceutical agents  
Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include...
8946192 Heat stable hyaluronic acid compositions for dermatological use  
The disclosure provides hyaluronic acid (HA) gel formulations and methods for treating the appearance of the skin. The formulations hyaluronic acid and at least one additional ingredient. Methods...
8940292 Enhancement of angiogenesis to grafts using cells engineered to produce growth factors  
The present invention provides methods and compositions of engineered cells for use in the continuous or transient delivery of growth factors and angiogenesis modulating agents, such as vascular...
8940316 Osmotic delivery comprising an insulinotropic peptide and uses thereof  
A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non-aqueous, single-phase...
8940357 Marked precoated medical device and method of manufacturing same  
A medical device, such as a medical wire, which includes a coating applied to the surface of the medical wire. The coating includes a base layer bonded to the surface of the medical wire and an at...
8936780 Stimuli responsive polyester amide particles  
A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including...
8936805 Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same  
A structure of, and a method of producing, a biocompatible structure for bone and tissue regeneration are disclosed. The method includes dissolving a polyurethane polymer in methanol, adding...
8936806 Periostin induces proliferation of cardiomyocytes and promotes cardiac regeneration  
The present invention provides compositions and methods for increasing proliferation, increasing cell cycle activity, and/or proliferation of postmitotic mammalian differentiated cardiomyocytes....
8932620 Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices  
Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by...
8932619 Dural repair material  
Multilayer structures including a porous layer and a non-porous layer having a reinforcement member are useful as dural repair materials.
8932621 Implantable film/mesh composite  
The present disclosure relates to implantable medical devices which include at least one mesh and at least one film attached to the mesh along different portions of the mesh creating at least one...
8932560 Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells  
A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the...