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7147845 |
Antimicrobial silver ion complex resinates
The present invention relates to novel antimicrobial silver ion complex resinates. More particularly, the present invention contemplates silver ion complex resinate compositions comprising a...
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7144573 |
Latent reactive blood compatible agents
A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a...
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7141246 |
Lubricious coating
A lubricant coating vehicle for medical devices used to reduce the coefficient of friction of such devices upon exposure thereof to moisture. The lubricant coating vehicle allows the introduction...
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7138131 |
Method for hand rejuvenation
The present invention provides a method of rejuvenating human skin by implanting a sheet formed of a pliable biocompatible material beneath the skin surface so as to generate a substantially smooth...
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7138106 |
Compositions for use in embolizing blood vessels
Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise a polymer, a biocompatible solvent and a contrast agent. The polymer is selected from the group...
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7135190 |
Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
A water soluble, biodegradable reverse thermal gelation system comprising a mixture of at least two types of tri-block copolymer components is disclosed. The tri-block copolymer components are made...
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7135189 |
Compositions and techniques for localized therapy
A therapeutic medical article is provided which comprises a medical article, a precursor compound and an activator compound. The medical article is adapted, upon administration to a patient, to...
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7132110 |
Tissue repair compositions and methods for their manufacture and use
An osteogenic composition is prepared by a process including the steps of subjecting demineralized bone to an extraction medium to produce an insoluble extraction product and a soluble extraction...
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7131994 |
Muscle-based grafts/implants
The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with...
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7128927 |
Emulsions for in-situ delivery systems
The invention is provides a composition for sustained delivery of a biologically active agent comprising a biologically active mixture and a controlled release formulation. The composition protects...
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7128904 |
Material containing metal ion ligand complex producing nitric oxide in contact with blood
Biocompatible materials that have the ability to release nitric oxide (NO) in situ at the surface-blood interface when in contact with blood. The materials which may be polymers (e.g.,...
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7121999 |
Method of preparing layered graft prostheses
The invention is directed to bioengineered graft prostheses made from two or more superimposed, chemically bonded layers of processed tissue material prepared from cleaned tissue material derived...
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7122200 |
Vitro engineered, regenerated urinary tract tissue compositions and methods for producing same
A method for providing a urinary tract tissue graft composition includes providing a tissue culture frame and a segment of small intestinal submucosa and positioning the segment of small intestinal...
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7122201 |
Composition and method for reducing adverse interactions between phenothiazine derivatives and plasma using surfactants and amino acids
Compositions and methods are provided for reducing adverse reactions as a result of parenteral administration of certain phenothiazine derivatives such as promethazine, including promethazine...
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7118746 |
Conditioned cell culture medium compositions and methods of use
Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known...
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7119038 |
Method for making a porous calcium phosphate article
The present invention discloses a method for making a porous calcium phosphate article including i) preparing a shaped article from a paste containing a calcium phosphate cement, a pore-forming...
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7115274 |
Method of using autologous fibroblasts to promote healing of wounds and fistulas
The present invention provides a method of using autologous fibroblasts to promote wound or fistula healing in an animal.
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7108862 |
Bone growth compositions and methods
The present invention provides an improved technique for spinal fusion involving the administration of an HMG-CoA reductase inhibitor to a fusion. The HMG-CoA reductase inhibitor is preferably...
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7109255 |
Bioresorbable hydrogel compositions for implantable prostheses
Crosslinked compositions formed from water-insoluble copolymers are disclosed. These compositions are copolymers having a bioresorbable region, a hydrophilic region and at least two cross-linkable...
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7105175 |
Implantable or insertable medical devices for controlled delivery of a therapeutic agent
The present invention is directed to novel implantable or insertable medical devices that provide controlled release of a therapeutic agent. According to an embodiment of the present invention, a...
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7101857 |
Crosslinkable biological material and medical uses
A method for promoting angiogenesis in a patient comprising providing crosslinkable biological solution to the target tissue, wherein the crosslinkable biological solution is loaded with at least...
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7101565 |
Probiotic/prebiotic composition and delivery method
A prebiotic, composition comprising a probiotic and prebiotic, and method of delivering a probiotic, prebiotic or composition directly into the intestinal tract of a mammal are disclosed. The...
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7101564 |
Plastically deformable implant
The invention relates to a plastically deformable implant for inserting into bodily orifices of the human or animal body. Implants of this type are used, for example, in ophthalmology, in...
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7101566 |
Polymer coated microparticles for sustained release
The present invention is directed to sustained release microparticle formulation for parenteral administration of biologically active substances, especially drugs. More specifically it relates to...
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7101567 |
Controlled release preparations having multi-layer structure
Preparations whereby two or more drugs can be released separately at appropriate speeds depending on the disease or the release behaviors of one or more drugs can be precisely controlled, which...
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7097850 |
Bioactive agent release coating and controlled humidity method
A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control...
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7097849 |
Injectable aqueous dispersions of propofol
Irritation upon injection of a formulation containing propofol is reduced or substantially eliminated by administering a stable, sterile, and antimicrobial aqueous dispersion comprising a...
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7097855 |
Transdermal thermal polymerization
An invention for polymerizing or crosslinking a prepolymer using a water soluble, thermal polymerization initiator is disclosed. The prepolymer mixed with the initiator is injected or placed into...
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7094428 |
Hemostatic compositions, devices and methods
A hemostatic composition which comprises at least one procoagulant metal ion, such as silver (I) or mercury (II), and at least one procoagulant biopolymer, such as collagen, thrombin, prothrombin,...
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7094419 |
Method of obtaining immune cells from an animal
The present invention is directed to an implantable immune modulation device that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell....
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7094230 |
Systems and methods for delivering drugs to selected locations within the body
An implantable reservoir device ( 400 ) including an enclosed membrane ( 408 ) on an expandable frame ( 402 ) that defines a reservoir ( 410 ) and includes a porous region ( 418 ). The reservoir...
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7094418 |
Crosslinkable macromers
A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue...
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7087237 |
Ocular solutions
Containing at least one macrolide antibiotic and/or mycophenolic acid provide anti-inflammatory, anti-cell proliferation, anti-cell migration, anti-angiogenesis, antimicrobial, and antifungal...
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7078476 |
Copolyester resin for solventborne coating and coating composition comprising the same
Disclosed is a copolyester resin having number average molecular weight over 5,000 for solventborne metal coating binder, which has superior gloss retention and color stability after long term...
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RE39196 |
Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
Methods for synthesis of nanocyrstalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered...
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7078163 |
Process for reducing mineralization of tissue used in transplantation
A method of making a tissue-derived implantable medical device that includes contacting the tissue with a composition comprising at least one oxidizing agent prior to implantation of the medical...
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7074425 |
Hemostatic compositions and methods
The present invention provides methods and compositions involving resorbable hemostatic agents that have the essential absence of microfibrillar collagen. Resorbable hemostatic agents of the...
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7074423 |
Osmotic delivery system with early zero order push power engine
The present invention is directed to an osmotic engine useful in an osmotic delivery system for delivery of a beneficial agent in a controlled manner over a preselected administration period. By...
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7070796 |
Pharmaceutically stable oxaliplatinum preparation for parenteral administration
The invention concerns a pharmaceutically stable oxaliplatinum preparation for parenteral administration, the oxaliplatinum being in a precipitate-free, colorless and clear solution after being...
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7070798 |
Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine
A coating for an implantable medical device is disclosed. The coating comprises a polymer and an amino acid chemically bonded, attached or conjugated to the polymer. In one embodiment, the coating...
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7067121 |
Transplants for myocardial scars
A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal...
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7067143 |
Premixed amiodarone parenteral solution and method for making the same
A premix parenteral solution for intravenous administration having amiodarone, as an active ingredient, solubilized in a solution of water for injection and about 0.4-12 mg/ml of a non-ionic...
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7067144 |
Compositions and methods for systemic inhibition of cartilage degradation
Methods and compositions for inhibiting articular cartilage degradation. The compositions preferably include multiple chondroprotective agents, including at least one agent that promotes cartilage...
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7063857 |
Use of macrolide compounds for the treatment of dry eye
The present invention provides an agent for treating a dry eye, which contains a macrolide compound such as FK506.
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7060287 |
Tissue augmentation material and method
A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a...
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7060684 |
Device for treating diabetes and methods thereof
A composite supported vascular graft comprising Vascular Endothelial Growth Factor (VEGF) and/or Platelet Derived Growth Factor (PDGF) for enhanced site-specific angiogenesis and methods thereof...
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7056495 |
Solid dose delivery vehicle and methods of making same
The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and...
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7056968 |
Calcium phosphate-synthetic resin composite body containing calcium phosphate block and method for production thereof
A calcium phosphate-synthetic resin composite body produced by pressing a calcium phosphate block (or a calcium phosphate block and calcium phosphate particles), and synthetic resin particles I,...
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7052710 |
Polymer re-inforced anatomically accurate bioactive protheses
Customized implants for use in reconstructive bone surgeries where anatomical accuracy and bone adaptation are important, such as plastic and craniomaxillofacial reconstructions. This implant...
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7049293 |
Peptide and osteogenetic accelerator
A peptide has any one of the sequences SEQ ID NO.1 to SEQ ID NO.8, or has a sequence derived from any one of the sequences SEQ ID NO.1 to SEQ ID NO.8 by substitution, deletion or addition of one or...
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