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7501018 |
Chemically bonded biomaterial with tailored properties
A chemically bonded biomaterial element composed of an inorganic cement, exhibiting minimal dimensional changes upon hardening and long-time use, improved mechanical properties and improved...
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7498042 |
Stent for blood vessel and material for stent for blood vessel
A luminal stent, implanted and implanted and left in the blood vessel, is disclosed. By permitting a stent ( 1 ), formed of a biodegradable polymer material ( 2 ), to be swollen, and by...
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7494482 |
Methods and apparatus for application of micro-mechanical forces to tissues
Methods and devices for transmitting micromechanical forces locally to induce surface convolutions into tissues on the millimeter to micron scale for promoting wound healing are presented. These...
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7494664 |
Composite biomaterials
This invention provides novel composite biomaterials having excellent bioadaptability and bone inductivity and a process for producing the same. The composite biomaterials comprise hydroxyapatite,...
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7494665 |
Polymers containing siloxane monomers
A polymer of siloxanes as flexibility monomers and strength monomers is provided. It is also provided a polymer blend that contains a polymer formed of siloxane monomers and strength monomers and...
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RE40640 |
Injectable microfoam containing a sclerosing agent
Injectable microfoam for scleroteraphy. The sclerotherapy of varices is based on the injection of liquid substances capable of suppressing them. The present invention relates to the preparation of...
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7491234 |
Medical devices for delivery of therapeutic agents
The present invention is generally directed to medical devices, and more specifically to medical devices that are at least partially insertable or implantable into the body of a patient. The...
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7491408 |
Polymer, bioabsorbable material and film for preventing tissue fusion
A novel A 1 -B-A 2 polymer having a number average molecular weight of 10000 to 100000 is provided that has excellent bioabsorbability so as to disappear in a predetermined period of time even...
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7485617 |
Osteoinductive materials
The present invention concerns improved osteoinductive materials comprising matrix materials and morphogenetic roteins, wherein depending on the subject matter the proteins may be dimeric or...
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7485317 |
Thermo-reversible polymer for intralumenal implant
An intralumenal implant material, which comprises, a polymer having a sol-gel transition temperature in an aqueous solution thereof, shows a substantial water-insolubility at a temperature higher...
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7476398 |
Corneal implant and uses thereof
A membrane for corneal implant or keratoprosthesis comprising a biological polymer and a polyacrylamide is described. The mixture of both polymers produces a hydrogel that becomes a transparent...
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7473678 |
Platelet-derived growth factor compositions and methods of use thereof
A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived...
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7470469 |
Medical device having surface modification with superoxide dismutase mimic
A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional...
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7470425 |
Population of undifferentiated neural, endocrine or neuroendocrine cells in a hydrogel support
The invention features a method for generating new tissue by obtaining a liquid hydrogel-cell composition including a hydrogel and tissue precursor cells; delivering the liquid hydrogel-cell...
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7468192 |
Method for repair of cartilage lesions
A method for treatment of injured, damaged, diseased or aged articular cartilage using neo-cartilage constructs implanted into a joint cartilage lesion in situ. The implantation of the construct...
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7468210 |
Cross-linked heparin coatings and methods
A thromboresistant coating for a medical device, method of coating and coated medical device, the coating including an in situ cross-linked co-polymer of a cross-linkable biomolecule, preferably an...
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7465458 |
Methods for treating eye disorders
The present invention provides methods of treating an eye disorder. The methods comprise a step of locally administering a Clostridial toxin to the eye of a patient to treat the disorder. The eye...
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7459142 |
High viscosity embolizing compositions comprising prepolymers
Disclosed are novel high viscosity compositions for embolizing blood vessels which comprise a biocompatible prepolymer and a contrast agent, and optionally a thickening agent and/or a biocompatible...
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7455853 |
Medical devices containing rapamycin analogs
A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more...
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7455854 |
Method for producing a mineral fiber
The present invention pertains to mineral fibers useful as biomimetics of tissue, such as dental enamel and bone, and as filler in paper, paint, coatings, and plastic production. The present...
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7445793 |
Support for tissue regeneration and process for producing the same
The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be...
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7445792 |
Medical device having a hydration inhibitor
A medical device having a hydration inhibitor for controlled delivery of a beneficial agent and methods of manufacturing of the same. The medical device includes an interventional component loaded...
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7442402 |
Bioactive agent release coating
A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with...
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7442205 |
Stents and methods for preparing stents from wires having hydrogel coating layers thereon
Radially expandable stents having hydrogel coating layers thereon, and methods of preparing such stents are disclosed. The methods include coating a wire with a solution that includes a solvent and...
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7442389 |
Methods of administering microparticles combined with autologous body components
Microspheres to be implanted into a patient are metered and mixed with fluids, cells, or tissues withdrawn from the patient's own body, and reinserted into the patient's body to achieve...
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7442384 |
Bioresorbable hydrogel compositions for implantable prostheses
Crosslinked compositions formed from water-insoluble copolymers are disclosed. These compositions are copolymers having a bioresorbable region, a hydrophilic region and at least two cross-linkable...
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7442383 |
Use of xenon for the control of neurological deficits associated with cardiopulmonary bypass
The present invention relates to methods of controlling neurological deficits in patients who have undergone cardiopulmonary bypass (CPB) by administering xenon to said patients.
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7439057 |
Convective flow tissue assembly
The present invention provides for an improved in vitro tissue assembly system and related methods that includes and uses a bioreactor, a porous mandrel disposed in the bioreactor, and components...
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7438925 |
Drug eluting coatings for medical implants
Drug eluting coating compositions are composed of at least one therapeutic agent dispersed in modified, biologically active binders. The therapeutic agents included in the coating composition are...
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7435380 |
Pseudo-plastic or thixotropic liquid deodorant product for ostomy pouches
A pseudo-plastic or thixotropic carrier having anti-malodorous components dissolved or suspended therein is sprayed on the internal surfaces of an ostomy bag or pouch. The viscoelastic properties...
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7435788 |
Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents
This disclosure covers polymers, some of which are useful in medical device applications. The polymers comprise at least two different blocks, at least one L1 block with the formula
and at...
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7432241 |
Device for treating diabetes and methods thereof
A composite supported vascular graft comprising Vascular Endothelial Growth Factor (VEGF) and/or Platelet Derived Growth Factor (PDGF) for enhanced site-specific angiogenesis and methods thereof...
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7427410 |
Coating hydrophobic surfaces with amphiphilic thioethers to reduce protein adsorption and cell adhesion
The present invention provides methods and apparatus for coating surfaces with specially designed thioethers and amphiphilic thioethers that reduce protein adsorption and/or cell adhesion. This...
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7419679 |
Medical implant having a layer of titanium or titanium alloy fibers
It is intended to provide a scaffold whereby a bone and a metallic material can three dimensionally form together a stereoscopic binding layer. Thus, a geometric space sufficient for cell actions...
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7419680 |
Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
Compositions useful in the prevention and treatment of osteoporosis and for bone and fracture repair. Slow-releasing calcium phosphate-based materials are disclosed, incorporating Mg, Zn, F and...
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7419678 |
Coated medical devices for the prevention and treatment of vascular disease
A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered...
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7419681 |
Method to enhance drug release from a drug-releasing material
A method of enhancing the drug release rate from a composite material. The composite material includes a synthetic, bioabsorbable polymer matrix and a drug particle phase dispersed therein. The...
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7413746 |
Stent coatings containing self-assembled monolayers
A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a self-assembled monolayer.
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7414038 |
Embolic materials
The object of the present invention is to provide an embolizing material which is easily handleable and stable in quality and is solved by providing an embolizing material comprising an ester...
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7410502 |
Medical prosthetic devices having improved biocompatibility
The invention relates to a medical prosthetic device having a metal material, such as titanium or an alloy thereof, where the surface parts of the metal material are coated with a layer of a...
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7407668 |
Medical articles having enzymatic surfaces for localized therapy
An enzymatically active medical article is provided, which comprises a medical article and an enzyme disposed at or near a surface of the medical article such that the medical article is provided...
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7402172 |
Intraluminal therapeutic patch
The present invention includes systems, methods and apparatus. A system in accord with the present invention may include an intraluminal patch sized to fit within a lumen and an expandable...
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7399739 |
Vertebral augmentation composition and method
A flowable vertebral augmentation composition for the treatment and repair of a vertebral body defect, e.g., an osteoporotic condition, contains biocompatible, optionally osteoconductive, support...
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7399480 |
Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices
A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more...
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7399466 |
Method and compositions for promoting osteogenesis
The object of the present invention is to increase PHEX activity to improve the osteogenic process in a mammal where this process has been diminished due to pathology or a condition that require...
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7396539 |
Stent coatings with engineered drug release rate
Coatings and methods of forming coatings for implantable medical devices, such as stents, are described. The coatings are used for the sustained release of a therapeutic agent or drug.
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7396540 |
In situ blood vessel and aneurysm treatment
Treatment of aneurysmal blood vessels with local delivery of therapeutic agents thereby reduces or lessens the severity of an aneurysm, and, where used in conjunction with the placement of an...
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7396541 |
Heparin prodrugs and drug delivery stents formed therefrom
A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a...
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7393493 |
Crosslinkable polymeric materials and their applications
The present invention relates to a novel composition for dental, orthopedic and drug delivery purpose. Specifically, it relates to composition comprising an admixture of a resorbable bone...
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7390497 |
Poly(ester amide) filler blends for modulation of coating properties
Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the...
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