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6326017 |
Methods for the localized delivery of agents to blood vessels
Methods for the localized delivery of agents to blood vessels are disclosed. The methods of the present invention provide advantages over existing methods for treating, diagnosing, or preventing,...
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6322815 |
Multipart drug delivery system
Polymeric drug conjugates in controlled release matrices are provided which allow sustained concentrations of therapeutic agents within a treated area for a prolonged period. The polymeric drug...
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6319512 |
Implants for controlled release of pharmaceutically active principles and method for making same
The present intention relates to an implant for the controlled release of at least one pharmaceutically active principle comprising a core containing at least one active principle and a sheath...
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6319492 |
Copolymers of tyrosine-based polyarylates and poly(alkylene oxides)
Implantable medical devices and drug delivery implants containing polyarylate random block copolymers are disclosed, along with methods for drug delivery and for preventing the formation of...
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6316018 |
Drug-releasing coatings for medical devices
The invention is directed to medical devices having a drug-releasing coating and methods for making such coated devices. The coating permits timed or prolonged pharmacological activity on the...
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6312708 |
Botulinum toxin implant
A controlled release system for multiphasic, in vivo release of therapeutic amounts of botulinum toxin in a human patient over a prolonged period of time. The controlled release system can comprise...
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6312707 |
Treatment of sickle cell anemia crises with fructose-1,6-diphosphate as an analgesic drug
Fructose-1,6-diphosphate (FDP) has been shown, in double-blinded controlled clinical trials on patients with sickle cell anemia, to substantially reduce the pain suffered by such patients during...
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6309635 |
Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
A method is provided whereby cells having a desired function are seeded on and into biocompatible, biodegradable or non-degradable porous polymer scaffolding matrix, previously implanted in a...
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6306422 |
Compositions and devices for controlled release of active ingredients
A method for the controlled release of a biologically active agent wherein the agent is released from a hydrophobic, pH-sensitive polymer matrix is disclosed and claimed. In one embodiment, the...
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6306419 |
Medical uses of styrene sulfonate polymers
Wound dressings and coated implantable medical devices include a styrene sulfonate polymer. Organic and inorganic therapeutic agents may be incorporated in the copolymer. Inorganic therapeutic...
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6306491 |
Respiratory aids
The present invention is directed to materials that assist respiration of living cells contained in cell-containing systems. The materials form air-filled conduits or channels through which gases,...
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6306845 |
Method for treating demyelinating disease
The present invention provides a method for treating a demyelinating disease in a subject which includes administering to the subject a therapeutically effective amount of a high affinity...
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6306423 |
Neurotoxin implant
A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer,...
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6306420 |
Methods and apparatus for the delivery of solid drug compositions
The invention features an implantable device for the automatic delivery of an active ingredient according to an adjustable delivery profile. The device includes a housing; a reservoir operatively...
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6303355 |
Method of culturing, cryopreserving and encapsulating pancreatic islet cells
Cells, preferably isolated pancreatic islet cells, are treated with a compound or a combination of compounds selected from an antioxidant, an anti-cytokine, an anti-endotoxin and an antibiotic. The...
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6303135 |
Use of quinolines and quinolones to treat male erectile dysfunction
Methods for treating male erectile dysfunction are provided. The methods of the present invention comprise the utilization of pharmaceutical compositions to induce erections in males with male...
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6303138 |
Endothelin-based compositions for enhancing connective tissue repair
The present invention is directed to bioactive composition that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in...
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6299893 |
Method to reduce hair loss and stimulate hair regrowth
This invention is a method for reduction of hair loss and stimulation of hair growth on the scalp of a human patient. The method comprises the step of administering a presynaptic neurotoxin into...
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6294187 |
Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
A load-bearing osteoimplant, method of making the osteoimplant and method for repairing bone using the osteoimplant are provided. The osteoimplant comprises a shaped, compressed composition of bone...
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6290971 |
Adjuvant compositions comprising a mineral salt and another immunostimulating compound
Adjuvant compositions for modulating an immune response to an antigen administered to a host comprise a mineral salt adjuvant and at least one other adjuvant. The compositions provide an...
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6290981 |
Use of nitric oxide-releasing agents to treat impotency
A method of treatment for impotency is provided. The method involves the administration of nitric oxide by a nitric oxide-releasing agent capable of providing a penile erection-inducing amount of...
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6287816 |
BMP-9 compositions
Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing...
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6288043 |
Injectable hyaluronate-sulfated polysaccharide conjugates
An injectable composition is provided for promoting bone and/or cartilage growth comprising hyaluronic acid cross-linked to sulfated polysaccharide through linking groups. The linking groups are...
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6287586 |
Pharmaceutical compositions of vanadium biguanide complexes and their use
Pharmaceutical compositions of vanadium biguanide complexes, and methods of use, are provided for the treatment of hyperglycemia and related disorders, e.g. hypertension, obesity, and lipid...
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6287558 |
Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
A device that includes a living cell or tissue and an agent that inhibits the ability of a host molecule to damage the cell or tissue. The device can be constructed in various forms including an...
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6284260 |
Treatment with erythropoietin of bleeding from benign and malignant lesions with normal and abnormal coagulation parameters
A method for the treatment of bleeding from organs involved with benign and malignant lesions by the subcutaneous administration of Erythropoietin. The method makes unnecessary the need for surgery...
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6283953 |
Osmotic drug delivery monitoring system and method
Performance of delivery systems for delivering beneficial agents to an animal are monitored to determine the delivery rate of the beneficial agent and the proper operation of the beneficial agent...
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6284268 |
Pharmaceutical compositions containing an omega-3 fatty acid oil
Self-emulsifying microemulsion or emulsion preconcentrate pharmaceutical compositions containing an omega-3 fatty acid oil such as a fish oil and a poorly water soluble therapeutic agent such as...
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6281341 |
Hetero-polysaccharide conjugate and methods of making and using the same
Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, and at least one alginate, e.g., sodium alginate, wherein: the at least one glycosaminoglycan and/or...
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6280760 |
Peptide-coated implants and methods for producing same
The invention describes the possibility of the biofunctionalization of biomaterials, in particular implants, by their made-to-measure coating with synthesized cell- or tissue-selective RGD peptides...
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6280745 |
Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
The present invention provides a composition comprising one or more constitutive polymers and modifier polymers and/or hydrophilic co-surfactants useful for reducing adhesions or delivering...
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6277394 |
Collagen-polymer matrices with differential biodegradability
The current invention is a biomedical implant comprising a biomedical matrix material and a biodegradable porosifying agent. As the porosifying agent degrades in situ, an implant with an...
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6274158 |
Treatment with recombinant human erythropoietin of bleeding in patients with normal and abnormal hemostasis
Recombinant human Erythropoietin is used in a method as a hemostatic agent for the treatment or prevention of bleeding from any organ or body part involved with benign or malignant lesions,...
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6274175 |
Prolonged release of GM-CSF
Formulations for controlled, prolonged release of GM-CSF have been developed. These are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as...
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6270788 |
Implantable medical device
A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using...
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6261585 |
Generating blood vessels with angiogenic material containing a biocompatible polymer and polymerizable compound
An angiogenic material is provided which promotes extensive vascularization when implanted in animal tissue. The angiogenic material contains a biocompatible polymer and a vascularizing...
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6262127 |
Polymeric matrices and their uses in pharmaceutical compositions
This invention provides pharmaceutical compositions comprising polymeric matrices, especially those comprising IL-6 as an active ingredient. Specific novel poly(ethylene carbomate) polymers are...
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6261586 |
Bone graft composites and spacers
A bone graft substitute including a composition of natural selectively deactivated bone material which has been processed to remove associated non-collagenous bone proteins, said bone material...
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6261582 |
Surgical method and composition therefor
Administration of a morphine-based analgesic paste directly to the epidural space during lumbar decompressive surgery significantly improves post-operative pain control, reduces prescribed...
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6258371 |
Method for making biocompatible medical article
A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using...
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6254853 |
Water soluble pro-drugs of propofol
This invention provides esters of propofol (2,6,-diisoprophenol). The propofol esters are soluble in water and metabolize rapidly to propofol in the body. The propofol esters are useful as...
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6253443 |
Method of forming a stent
Expandable intraluminal stents are provided as well their method of manufacture. These stents are made of metal, the metal characterized by a desired porosity, with a drug compressed into the pores...
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6251418 |
Systems and methods for local delivery of an agent
A system and method for implanting pellets into myocardial tissue for treatment of coronary artery restenosis, ischemic heart disease, or cardiac conduction of disturbances. The mechanism of...
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6251137 |
Synthetic triglyceride filler material for surgically implanted prostheses
A filler material for a surgically implantable prosthesis comprised of a synthetic triglyceride having a viscosity substantially greater than that of naturally occurring triglycerides is provided....
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6251579 |
Oxidative stabilization of collagen containing materials
This invention relates, in general, to a process for cross-linking and stabilizing proteinaceous material, and in particular, to a process for oxidizing collagenous material, by oxidizing the...
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6248344 |
Composite and its use
A porous composite suitable for filling a recess or a through-passing hole in an implant. The composite includes particles A prepared from a bioactive material and particles B prepared from a...
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6245358 |
Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation
A lyophilized composition comprising (a) a conjugate comprising a N-alkyl methacrylamide-based copolymer and an anthracycline glycoside linked through a peptide spacer to the copolymer and (b) a...
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6245346 |
Pharmaceutical compositions for the sustained release of insoluble active principles
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6238872 |
Targeted therapy to a biomedical device
A biomedical device assembly, such as a stent, for the targeted treatment of a tissue, such as the inhibition of restentosis. The stent is coated with an antigen, which is an example of a lock. The...
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6238688 |
Method for repairing blood vessel system
The present invention generally relates to thermally responsive polymer gel compositions that have enhanced temperature-dependent shrinking rates, increased strength, and improved pliability over...
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