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6413537 |
Nystatin formulation having reduced toxicity
The present invention provides a novel formulation of nystatin for parenteral administration to treat systemic fungal infections. The formulation avoids the toxicity and solubility problems of...
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6406711 |
Bone regeneration material
A bone regeneration material uses polyphosphoric acid and/or a polyphosphate together with a biocompatible material, a filler for cosmetic surgery, or a bone morphogenetic protein, to expedite new...
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6406710 |
Protein occlusion for delivery of small molecules
The present invention relates to complexes between (1) a target-binding moiety; (2) a cavity-forming moiety; and (3) a pharmacological compound to be delivered to a target, wherein the...
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6403758 |
Bioresorbable compositions for implantable prostheses
Crosslinked compositions formed from a water-insoluble copolymer are disclosed. These compositions are copolymers having a bioresorbable region, a hydrophilic region and at least two crosslinkable...
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6399103 |
Method of producing a sustained-release preparation
A method of producing sustained-release microcapsules which comprises dispersing a physiologically active polypeptide into a solution of a biodegradable polymer and zinc oxide in an organic...
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6398816 |
Genetic engineering of cells to enhance healing and tissue regeneration
A method for enhancing and/or increasing the efficiency of repair of tissues, primarily bone or cartilage, using genetically engineered cells has been developed. In the preferred embodiment,...
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RE37718 |
Ion beam modification of bioactive ceramics to accelerate biointegration of said ceramics
The present invention provides for faster and stronger tissue-implant bonding by treating a ceramic implant with an ion beam to modify the surface of the ceramic. The surface modification can give...
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6395293 |
Biodegradable implant precursor
The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable,...
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6395294 |
Method of visualization of the vitreous during vitrectomy
A composition for rendering a vitreous cavity visible during a surgical procedure to alleviate a structural disorder caused by the vitreous in an eye, and a method of using the composition. The...
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6391339 |
Use of oligosaccharide for preventing blood clotting in extracorporeal blood circuits
The invention relates to the use of a certain oligosaccharide for preventing clotting in an extracorporeal blood circuit of a patient undergoing extracorporeal blood treatment.
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6391861 |
Method for the prevention of tissue elastic fiber injury
The subject invention is directed to the prevention of elastic fiber injury by administering HA or any other polysaccharide or carbohydrate moiety that binds to and coats elastic fibers, thereby...
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6387391 |
Bioresorbable polymeric clayey and sticky substance
This invention provides a claycy and sticky substance as a new biomaterial that cannot be found in the current medical field, which is bioresorbable, shows tackiness, plasticity and shape holding...
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6387363 |
Biocompatible medical devices
Biocompatible medical devices, including sutures, are disclosed which are produced from polyesters formed from lactide and glycolide copolymers. In a preferred mode of the invention, the...
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6383509 |
Biodegradable neurotoxin implant
A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer,...
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6385491 |
Temporary medical electrical lead having biodegradable electrode mounting pad loaded with therapeutic drug
A temporary cardiac electrical stimulating lead comprises a stimulating electrode mounted in or on a biodegradable electrode mounting pad disposed at a distal end of the lead. The electrode...
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6379690 |
Keratin-based hydrogel for biomedical applications and method of production
A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide...
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6375971 |
Medicament dosing ballistic implant of improved accuracy
Solid dose ballistic projectile for medicating animals which comprises a biologically compatible projectile casing which defines an interior cavity having a wall with a frictionally engagement...
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6375972 |
Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained...
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6372244 |
RETRIEVABLE BIOARTIFICIAL IMPLANTS HAVING DIMENSIONS ALLOWING RAPID DIFFUSION OF OXYGEN AND RAPID BIOLOGICAL RESPONSE TO PHYSIOLOGICAL CHANGE, PROCESSES FOR THEIR MANUFACTURE, AND METHODS FOR THEIR USE
Bioartificial implants and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be...
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6371992 |
Acellular matrix grafts: preparation and use
Acellular matrix grafts are provided with are isolated from natural sources and consist essentially of a collagen and elastin matrix which is devoid of cellular components. The grafts are useful...
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6372243 |
Low-oxygen fluorocarbon as an agent for ophthalmology
The present invention concerns fluorocarbons for use in ophthalmology. Fluorocarbons disclosed in the prior art can only be left in the eye for a limited period of time because they cause damage to...
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6372228 |
Method of producing elastin, elastin-based biomaterials and tropoelastin materials
A method is provided for producing elastin or elastin-based materials or tropoelastin materials which have a substantially reduced level of calcification. These materials are typically capable of...
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6368592 |
Method of delivering oxygen to cells by electrolyzing water
Oxygen is supplied to cells in vitro or in vivo by generating oxygen with an oxygen generator that electrolyzes water to oxygen and hydrogen. Oxygen can be generated substantially without...
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6368858 |
Modulation of multicellular aggregates by pressure from growth in a matrix
Cells in a matrix or in the matrix in a vessel are grown to form a multicellular aggregate. Pressure is exerted on the growing cells by the matrix or the matrix together with the vessel due to...
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6368612 |
Devices for cloaking transplanted cells
Implantable devices that include a source of a therapeutic substance and a capture agent are disclosed.
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6368611 |
Anti-infective covering for percutaneous and vascular access device and coating method
A part that can be introduced and/or implanted in the body, in body parts, or in body cavities, made of nonmetallic material or having a nonmetallic surface is designed such that infections...
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6368613 |
Use of fluorocarbons for diagnosis and treatment of articular disorders
Methods for the diagnosis and treatment of articular disorders comprising the use of fluorocarbons are disclosed. The methods provide for the introduction of a fluorocarbon into an articular region...
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6365153 |
Mechanically elongated neuronal cells and methods for producing and using these cells
Mechanically elongated neuronal cells and methods of mechanically producing elongated cells are provided. Also provided are methods for transplanting elongated neuronal cells into an animal for...
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6365385 |
Methods of culturing and encapsulating pancreatic islet cells
Cells, preferably isolated pancreatic islet cells, are treated with a compound or a combination of compounds selected from an antioxidant, an anti-cytokine, an anti-endotoxin and an antibiotic. The...
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6365172 |
Device of bioabsorbable triglycolic acid poly(ester-amide)s, and methods of making the same
This invention relates to fiber-forming bioabsorbable poly(ester-amide)s made by the polymerization of diamidediols with 3,6-dioxaoctanedioic acid, also known as “triglycolic acid”. More...
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6361797 |
Hydrogel compositions useful for the sustained release of macromolecules and methods of making same
A method of producing a homogenous porous hydrogel useful for drug delivery is described. The pores of the hydrogel are created by diffusion enhancers to facilitate sustained delivery of...
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6361780 |
Microporous drug delivery system
A drug delivery device is described comprising a porous biocompatible solid having at least one therapeutic drug within its pores, the therapeutic drug being removable from the pores by immersion...
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6358532 |
Calcium phosphate microcarriers and microspheres
The present invention provides calcium phosphate-based (CaP) microcarriers and their use, for example, in cell culturing systems, chromatography, and implantable biomedical materials.
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6355275 |
Embolization using carbon coated microparticles
Described are methods of embolization using an embolizing agent composition that includes microparticles with carbon surfaces, and comprising a contrast agent. Preferred microparticles include a...
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6352707 |
Transplant encapsulation in a hydrogel matrix to obscure immune recognition
Immune recognition of a transplant such as tissue implanted in a host mammal is obscured by encapsulating the transplant in a hydrogel matrix containing gelatin, dextran, at least one nitric oxide...
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6352708 |
Solution and method for treating autologous tissue for implant operation
An aqueous solution containing a water miscible organic solvent, polyethylene glycol and heparine, is used to modify the tissue reactivity of an autologous tissue freshly obtained from a host...
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6350462 |
Hollow porous ceramic carrier for embedding in patient for sustained medicament release and method of preparation thereof
An improved porous ceramic body to be embedded in a patient for sustained release of a medicament, and a method of making the ceramic body is provided. To control the release of the medicament, the...
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6344061 |
Device for incorporation and release of biologically active agents
The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides,...
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6344488 |
Temperature-controlled pH-dependent formation of ionic polysaccharide gels
The present invention relates a temperature-controlled pH-dependant formation of ionic polysaccharide gels, such as chitosan/organo-phosphate aqueous systems, and methods of preparation thereof....
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6340477 |
Bone matrix composition and methods for making and using same
The invention is directed to a bone matrix composition for use in the repair and healing of osseous tissue. The composition can be used in load-bearing and non-load bearing applications, including...
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6335384 |
Methods for embolizing blood vessels
Disclosed are methods useful for treating vascular lesions wherein a non-particulate agent such as a metal coil is introduced into a vascular site (e.g., an aneurysm cavity) in conjunction with an...
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6335028 |
Implantable particles for urinary incontinence
The invention encompasses the treatment of urinary incontinence, gastroesophageal reflux disease and the amelioration of skin wrinkles using biocompatible hydrophilic cationic microparticles and a...
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6331311 |
Injectable depot gel composition and method of preparing the composition
An injectable depot gel composition containing a polymer, a solvent that can dissolve the polymer and thereby form a viscous gel, a beneficial agent; and an emulsifying agent in the form of a...
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6331309 |
Hydrogel compositions for the controlled release administration of growth factors
Compositions and methods are disclosed for the controlled release delivery of polypeptide growth factors. The compositions of the invention are hydrogels which comprise: a polypeptide growth factor...
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6331313 |
Controlled-release biocompatible ocular drug delivery implant devices and methods
Controlled release devices are disclosed which are biocompatible and can be implanted into the eye. The devices have a core comprising a drug and a polymeric outer layer which is substantially...
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6331312 |
Bioresorbable ceramic composites
A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The poorly crystalline apatitic calcium...
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6328990 |
Bioactive, degradable composite for tissue engineering
Bioactive, degradable composite material and composite material microspheres were produced using a new solid-in-oil-in-water method. Compositions and methods for tissue engineering and drug...
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6328979 |
Sustained release medicinal compositions
The present invention relates to sustained-release pharmaceutical compositions for ionic pharmaceutically active substances (excluding ionic prostanoic acid derivatives) containing ionic compounds...
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6326018 |
Flexible sheet of demineralized bone
The invention is directed toward a malleable bone putty and a flowable gel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth...
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6326019 |
Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries
A method for making, storing and using a surgical graft from human amniotic membrane; the resulting graft; and the storage solution. The amniotic membrane is obtained from human placenta, from...
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