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6479065 |
Process for the preparation of polymer-based sustained release compositions
The invention relates to a sustained release composition and methods of forming and using said composition for the sustained release of biologically active agent. The sustained release compositions...
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6479232 |
Human xenografts for microbicide testing and anatomical modeling
A method for screening candidate antimicrobial compounds is described that utilizes a human vaginal xenograft engrafted in a non-human host. The method may be performed by using pathogen inoculated...
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6479064 |
Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
artificial organs are reconstructed using a three-dimensional scaffold produced by decellularizing biostructures from a donor organ. The three-dimensional scaffold is perfused with isolated...
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6475506 |
Infusion preparation
Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation,...
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6475466 |
Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms
Disclosed are methods for treating endoleaks arising from endovascular repair of abdominal aortic aneurysms. The disclosed methods involve the in situ sealing of endoleaks after placement of an...
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6476079 |
Devices for the delivery of drugs having antiprogestinic properties
A device for the controlled release over a prolonged period of time of a drug having antiprogestinic properties, the device including a core containing the drug, optionally a membrane encasing the...
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6471993 |
Three-dimensional polymer matrices
Matrices that include a macrostructure having a semi-solid network and voids, and a microstructure having voids, in which the microstructure is located within the semi-solid network are disclosed....
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6471978 |
Localized use of nitric oxide-adducts to prevent internal tissue damage
A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or...
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6472210 |
Polymer scaffold having microporous polymer struts defining interconnected macropores
A polymer scaffold is provided having an extensively interconnected macroporous network with macropores having microporous struts as walls. Macropore diameter ranges from about 0.5 to about 3.5 mm....
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6471979 |
Apparatus and method for delivering compounds to a living organism
A method of treating or preventing vascular disease in a living organism. The method includes delivering an effective amount of a composition including a sex hormone, anti-hormone, sex-hormone...
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6471987 |
Drug releasing elastic band and method
A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a...
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6468521 |
Stabilized compositions having antibacterial activity
A stabilised composition having antibacterial, antiviral and/or antifungal activity characterised in that it comprises a silver compound and that the compound is in the form of a complex with a...
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6464992 |
Topical micronutrient delivery system and uses thereof
The invention involves methods and compositions useful in delivering micronutrients to cells. By formulating the micronutrient in the form of an ester that is convertible to the active form of the...
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6465226 |
Preparing small microcapsules containing high concentration of cells or tissue
Biologically active substances such as cells or tissue are microencapsulated by methods that provide a high proportion of microcapsules containing a core of the biologically active substance as...
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6465001 |
Treating medical conditions by polymerizing macromers to form polymeric materials
Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions...
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6464999 |
Bioadhesive medical devices
Disclosed herein are bioadhesive medical devices formed in whole or in part of a cohesive bioadhesive copolymer of a carboxyl functional monomer and a hydrophobic functional monomer.
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6462079 |
Pharmaceutical composition and method of using the same
A pharmaceutical composition is provided for systemically treating a living mammal or avian. The composition preferably comprises an alkyl-dimethyl-benzyl-ammonium chloride, an...
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6461629 |
Method of nerve regeneration using biopolymer rods with oriented fibrils
Tissue-equivalent and biopolymer tubes and rods include fibrils which are oriented (aligned) by a magnetic field. These oriented fibrils provide enhanced mechanical and cell guidance properties to...
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6461632 |
Hardenable ceramic hydraulic cement
A method for delivering a therapeutically effective drug via a hardenable ceramic hydraulic cement composition including a first component of at least one sodium or calcium salts of inorganic and...
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6458374 |
Methods and compositions for treating chronic disorders using optically pure (&plus )-bupropion
Methods and compositions are disclosed utilizing the optically pure (+)-isomer of bupropion to assist in smoking cessation, for treating smoking and nicotine addiction, and for treating pain,...
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6458375 |
Malleable paste with allograft bone reinforcement for filling bone defects
The invention is directed toward a sterile malleable bone composition for application to a bone defect site to promote new bone growth at the site comprising a mixture of demineralized osteogenic...
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6458380 |
Dressing and preparation delivery system
A dressing and method of treating wounds is provided. The dressing can comprise water-soluble or swellable polymers which are capable of forming a viscous aqueous or non-aqueous solution and form a...
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6454787 |
Collagen hemostatic foam
A hemostatic device formed of collagen particles and methods for producing and using the hemostatic device to control bleeding are provided. The collagen particles of the hemostatic device have a...
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6454738 |
Methods for delivering in vivo uniform dispersed embolic compositions of high viscosity
Disclosed are novel techniques for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery of an embolic composition.
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6454759 |
Microfabricated injectable drug delivery system
A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow...
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6451334 |
Compositions and administration of compositions for the treatment of blood disorders
The invention relates to novel compositions and to methods for the pulsed administration of compositions to a patient or to cells in vitro for the treatment of human blood disorders. Compositions...
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6444224 |
Intra-vaginal device for pigs
Disclosed herein is a porcine intra-vaginal device of a shape and size adapted to be positionable in the vaginal tract across the hymenal ring of a target animal (e.g., a gilt) to extend to both...
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6444872 |
Large animal model of invasive pulmonary aspergillosis in an immunocompromised host
A model of systemic mold/Aspergillus infection in a profoundly immunocompromised host has been established in the beagle dog. The beagle was rendered immunosuppressed using a combination of total...
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6444217 |
Drug delivery devices, and methods of use
The present invention provides biomedical devices, such as implantable drug delivery devices that possess a surface layer adapted to retain, and controllably release, drug molecules for...
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6440445 |
Methods and compounds for treatment of abnormal uterine bleeding
The invention provides methods for treating abnormal uterine bleeding via application of compounds that block uterine stromal cell response to angiogenic growth factors by interfering with the...
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6440427 |
Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer
A tissue treatment composition, especially an adhesive composition comprises (i) fibrin or fibrinogen and (ii) a biodegradable and biocompatible polymer capable of forming a viscous aqueous...
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6440167 |
Collagen material and its production process
The present invention relates to a collagen material comprising a laminate in which a collagen ultra-fine fibrous non-woven fabric-like multi-layer structure is sandwiched between non-fibrous...
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6440446 |
Agent for anti-osteoporosis
An orally or parenterally administrable agent for anti-osteoporosis, comprising trehalose as an effective ingredient and optionally another ingredients, that exerts a satisfactory...
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6436425 |
Method and non-gelling composition for inhibiting post-surgical adhesions
Non-gelling polyoxyalkylene compositions, and methods of their use for inhibiting surgical adhesion formation/reformation in mammals are disclosed. The useful non-gelling compositions preferably...
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6436633 |
Human xenografts for microbicide testing and anatomical modeling
A method for screening candidate antimicrobial compounds is described that utilizes a human vaginal xenograft engrafted in a non-human host. The method may be performed by using pathogen inoculated...
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6436435 |
Liposome formulation of 5 β steroids
Liposome preparations which comprise a lipid, or lipid like compound and a 5β steroid, DHEA or an organic acid derivative of the 5β steroid or DHEA are described. The lipsome may also include an...
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6432436 |
Partially demineralized cortical bone constructs
The invention is directed toward a sterile bone structure for application to a bone defect site to promote new bone growth at the site comprising a partially demineralized cortical bone structure,...
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6432438 |
Biodegradable vehicle and filler
A biodegradable vehicle and filler (referred to in this invention as biodegradable vehicle), which can be mixed with one or more biologically active substances (BAS), or can be used as a...
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6428561 |
Biocompatible glue
Use of one or more saccharides, for example one or more non-toxic mono-, di-, tri-, oligo- or polysaccharides, in the manufacture of a biocompatible glue for adhering a first structure to a surface...
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6428804 |
Intra-articular preparation for the treatment of arthropathy
This invention relates to an intra-articular preparation for the treatment of arthropathy, which comprises microcapsules of (a) a high-molecular substance, which has biodegradability and...
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6429296 |
Complex of human growth hormone and zinc and use
The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release...
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6428802 |
Preparing artificial organs by forming polylayers of different cell populations on a substrate
Compositions and methods are provided for producing multilayered artificial organs comprising heterogenous polylayers. Polylayers comprising homogenous cell populations are created on one side of a...
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6426332 |
Matrix-free osteogenic devices, implants and methods of use thereof
Provided herein are methods for inducing bone formation in a mammal sufficient to fill a defect defining a void, wherein osteogenic protein is provided alone or dispersed in a biocompatible...
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6426214 |
Cell encapsulating device containing a cell displacing core for maintaining cell viability
Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone...
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6423333 |
Sealing or filling tissue defects using polyfunctional crosslinking agents and protein polymers
Proteinaceous polymers having repetitive units from naturally occurring structural proteins are employed as backbones for functionalities for crosslinking to provide strongly adherent tissue...
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6420421 |
Pharmaceutical composition and of using the same
A pharmaceutical composition is provided for systemically treating a living mammal or avian. The composition preferably comprises an alkyl-dimethyl-benzyl-ammonium chloride, an...
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6416774 |
Hollow bone mineral-like calcium phosphate particles
Hollow particles having a shell substantially composed of calcium-phosphate, methods for preparing the same, and methods of use are disclosed. The particles are obtained by differential immersion...
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6417247 |
Polymer/ceramic composites
The present invention provides a composition which comprises a polymer or polymer solution that forms a gel under controlled parameters and a ceramic matrix, the composition being fluid under...
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6416776 |
Biological disk replacement, bone morphogenic protein (BMP) carriers, and anti-adhesion materials
A BMP carrier is described for use with humans and animals. The carrier includes human hair and a block copolymer of ethylene glycol and propylene glycols that can be implanted into an...
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6413538 |
Bioactive glass or ceramic substrates having bound cell adhesion molecules
Non-crystalline, porous bioactive glass and ceramic materials are prepared that permit in vitro formation of bone tissue when exposed to a tissue culture medium and inoculated with cells. The...
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