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6544288 |
Biocompatible titanium implant for medical use
A biocompatible implant for medical use having a layer of titanium or titanium alloys on its surface. The implant is electrochemically treated by using it for an anode in an electrolyte solution...
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6544543 |
Periodic constriction of vessels to treat ischemic tissue
Brief periods of occlusion of blood flow in an otherwise open target vessel adjacent to vessels supplying blood to an ischemic region are caused by periodic administration of a therapeutically...
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6541040 |
Mixture for use as wound dressing
The invention relates to a mixture for use as wound dressing, which comprises: a) paraffins complying with DAB and/or synthetic waxes selected from the group consisting of montan waxes, petroleum...
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6541023 |
Use of collagen of aquatic origin for the production of supports for tissue engineering, and supports and biomaterials obtained
Use of collagen of aquatic origin for the production of supports for tissue engineering is disclosed. The collagen may be obtained from fish skin, preferably in its native form. Novel tissue...
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6541021 |
Devices and methods for pain management
The invention features devices and methods for the systemic delivery of fentanyl or a fentanyl congener (e.g., sufentanil) to treat pain. In the present invention, a drug formulation comprising...
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6541022 |
Mineral and cellular patterning on biomaterial surfaces
Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant...
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6537567 |
Tissue-engineered tubular construct having circumferentially oriented smooth muscle cells
Improved methods for the production of tissue-engineered constructs, including muscular tissue constructs such as vascular constructs, are disclosed. The methods include the use of improved...
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6537589 |
Calcium phosphate artificial bone as osteoconductive and biodegradable bone substitute material
An artificial bone promotive of osteoanagenesis comprising a calcium phosphate cement and a linear polyphosphate, wherein the calcium phosphate cement comprises β-tricalcium phosphate, monocalcium...
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6537565 |
Filamentous porous films and methods for producing the same
The invention is directed to a filamentous porous film that can act as a support for cellular attachment, growth and organization. The film is formed from filaments which define a matrix structure...
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6538026 |
Compositions useful for remodeling body spaces
A composition comprising of a monomer component comprised of at least one alkyl cyanoacrylate and at least one inhibitor, and a second component comprised of a resultant aggregate structure formed...
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6533820 |
Biomaterials for bone replacements
The present invention involves compositions for use as granular bone replacements. The compositions of the present invention are comprised of hyaluronic acid esters or salts of hyaluronic acid in...
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6534080 |
Method for administering camptothecins via injection of pharmaceutical composition comprising coated particles of a camptothecin
A method for administering a camptothecin to a patient comprising: injecting into a patient a pharmaceutical composition comprising an aqueous suspension of solid particles suitable for intravenous...
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6527810 |
Bone substitutes
A strong, porous article useful as a bone substitute material. The article comprises a continuous strong framework structure having struts defining interstices which interconnect throughout the...
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6524622 |
Method of controlling the working time of a gypsum composition in the bone treatment
A method is designed to control the working time, setting time and the semi-solidification time of a gypsum composition in a bone restoration operation. The method involves a preparation of the...
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6521244 |
Body filling material
A body filling agent is formed of a collagen in the form of powder, fiber or gel, and at least one kind of implantable particles selected from a group consisting of implantable polymer and...
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6521736 |
Amphiphilic polymeric materials
The invention is based in part on the discovery of polymers that can complex with certain types of therapeutic drugs and transport those drugs across cell membranes in cell cultures with...
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6521264 |
Method for preparing a biomaterial based on hydroxyapatite, resulting biomaterial and surgical or dental use
A solid powder product with a Ca/P ratio of between 1.40 and 1.90 is prepared from tricalcium phosphate and tetracalcium phosphate. An aqueous solution containing calcium ions and phosphate ions...
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6521223 |
Single phase gels for the prevention of adhesions
Single phase gels for preventing the formation of surgical adhesions are disclosed. The gels are prepared by reacting an aqueous solution of a polyanionic polysaccharide, such as hyaluronic acid or...
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6521245 |
Treatment with recombinant human erythropoietin of bleeding in patients with normal and abnormal hemostasis
Recombinant human Erythropoietin is used in a method as a hemostatic agent for the treatment or prevention of bleeding from any organ or body part involved with benign or malignant lesions,...
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6517857 |
Bioactive product and its use
A porous textile product made from bioactive glass fibers. The fibers in the product are of at least two types, fiber A and fiber B, with fiber A being made from a bioactive glass, and fiber B...
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6514514 |
Device and method for regeneration and repair of cartilage lesions
Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating...
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6511958 |
Compositions for regeneration and repair of cartilage lesions
Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating...
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6509026 |
Osteopontin coated surfaces and methods of use
A novel osteopontin containing implant which increases the rate of osseointegration and the percentage of bone apposition is described. The implant of the invention includes a material suitable for...
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6509145 |
Process for reducing mineralization of tissue used in transplantation
A method of making a tissue-derived implantable medical device that includes contacting the tissue with a composition comprising at least one oxidizing agent prior to implantation of the medical...
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6509031 |
System for polymerizing collagen and collagen composites in situ for a tissue compatible wound sealant, delivery vehicle, binding agent and/or chemically modifiable matrix
This invention relates to materials and methods for crosslinking, in situ, proteins, including collagen, with peroxidase, including horseradish peroxidase, to from biocompatible semi-solid gels...
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6509325 |
Method for inhibiting melanogenesis and uses thereof
The present invention provides a method for treating a subject infected with a mammalian pathogenic fungus which uses melanin in virulence, by administering to the subject an amount of glyphosate...
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6509039 |
Crosslinked products of biopolymers containing amino groups
The invention relates to cross linked products of chitosan or gelatin and of a carboxylic acid di- or polyanhydride. These products form hydrogels with a wide variety of applications, preferably in...
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6509027 |
Injectable pharmaceutical composition comprising coated particles of camptothecin
A pharmaceutical composition is provided which comprises an aqueous suspension of solid particles, the solid particles comprising a camptothecin, the solid particles having mean diameters between...
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6506399 |
Biodegradable botulinum toxin implant
A controlled release system for multiphasic, in vivo release of therapeutic amounts of botulinum toxin in a human patient over a prolonged period of time. The controlled release system can comprise...
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6506217 |
Moldable post-implantation bone filler and method
Methods for correcting defects at bone repair sites are provided, which use a moldable, post-implantable bone conforming material. The method includes the steps of preparing a bone conforming...
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6506398 |
Device for treating diabetes and methods thereof
A vascular graft comprising Vascular Endothelial Growth Factor (VEGF) and/or Platelet Derived Growth Factor (PDGF) for enhanced site-specific angiogenesis and methods thereof are disclosed. At...
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6506390 |
Progestogen-anti-progestogen regimens
A contraceptive and/or HRT (hormone replacement therapy) kit comprising sequential daily dosage units each containing as the sole contraceptively effective ingredient a progestogen, or as the...
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6503954 |
Biocompatible carrier containing actinomycin D and a method of forming the same
A biocompatible carrier and a composition for forming the carrier are disclosed. The carrier is made from an ethylene vinyl alcohol copolymer which can serve as a reservoir, allowing for the local...
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6504079 |
Terminally sterilized osteogenic devices and preparation thereof
Disclosed are terminally sterilized osteogenic devices for implantation into a mammal. The devices contain a combination of a biologically active osteogenic protein and an insoluble carrier which...
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6500464 |
Bilayered collagen construct
This invention describes a collagen construct uniquely suited as a substrate for production of biologically active wound dressings, skin equivalents or skin substitutes. The collagen construct of...
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6500448 |
Composition for sustained release of human growth hormone
A pharmaceutical composition for the sustained release of human growth hormone from a polymer matrix is disclosed. The pharmaceutical composition comprises a biocompatible polymer, particles of...
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6497906 |
Dietary supplements comprising soy hypocotyls containing at least one isoflavone
Composition enriched with natural phyto-estrogens or analogs thereof selected from Genistein, Daidzein, Formomometin, and Biochanin A. These may be used as food additives, tablets, or capsules for...
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6497729 |
Implant coating for control of tissue/implant interactions
A tissue/implant interface, comprising an implant and a bioactive polymer layer adjacent at least a portion of the outer surface of the implant, wherein the polymer layer contains at least one...
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6497901 |
Resorbable matrices for delivery of bioactive compounds
This invention relates generally to the production and use of inorganic-conditioning agent complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used...
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6495154 |
On demand administration of clomipramine and salts thereof to treat premature ejaculation
A method is provided for delaying the onset of ejaculation in an individual. The method involves systemic and on demand administration to an individual of a pharmaceutical formulation containing an...
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6495127 |
Compositions and systems for forming high strength medical sealants, and associated methods of preparation and use
The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally...
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6495155 |
Injectable opioid partial agonist or opioid antagonist microparticle compositions and their use in reducing consumption of abused substances
An injectable slow-release partial opioid agonist or opioid antagonist formulation is provided comprising a partial opioid agonist or opioid antagonist in a poly(D,L-lactide) excipient with a small...
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6491942 |
Suppositories
The present invention provides a suppository comprising a hydrophobic hydroxypropyl methylcellulose. The present invention is useful as a suppository base which has little interaction with a drug...
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6485751 |
Resorbable calcium phosphate-based bio-compound particles and the manufacturing procedure thereof
This specification discloses resorbable calcium phosphate-based bio-compound particles and the manufacturing method thereof. Through the manufacturing process control, collagen has sufficient time...
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6485754 |
Bone cement paste containing an antibiotic
The invention relates to an injectable curable bone cement paste based on bioresorbable hydroxyapatite-like compounds comprising calcium phosphate, which contains a cationic antibiotic in the form...
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6485721 |
Biologically active substance-secreting hybrid gel
The present invention provides a biologically active substance secreting hybrid gel, which consists essentially of a biopolymeric gel and cells containing an expression vector with a gene encoding...
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6485735 |
Multilayer thermoset polymer matrix and structures made therefrom
A composite thermoset polymer matrix structure having a plurality of homogeneously bonded thermoset polymer layers and a method of forming the same is disclosed. Each of the layers is formed from...
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6479066 |
Device having a microporous membrane lined deformable wall for implanting cell cultures
A device and method of using the device are provided for implanting cell cultures in a host. The device is formed of a deformable body, a microporous membrane and a sealable port. The shape of the...
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6479063 |
Therapeutic uses of hormonal manipulation using combinations of various agents to treat atherosclerosis
A method of decreasing atherosclerosis and its complications involving administering to a human or animal various combinations of medications with Finasteride, Bicalutamide, Flutamide and Nilutamide.
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6478790 |
Implant device and dosage form employable therein
An implant device comprises a tubular member having a bore, a charging end and a pointed elongated annular concavely beveled implanting end. A rod is removably insertable within the bore for...
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