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9040069 Process for manufacturing a stationary state of crystalline polymer of a biodegradable polymer matrix carrying an active substance and a polymer matrix produced thereby  
A method for manufacturing a stationary state of polymer crystallinity of an active substance charged polylactide matrix for a stent, comprising the steps of: preparing the active substance...
9040070 Material for induction of hard tissue regeneration  
The present invention relates to a material for induction of hard tissue regeneration, comprising platelet-rich plasma and gelatin β-TCP sponge, which promotes angiogenesis, osteogenesis,...
9034377 Opioid dosage forms having dose proportional steady state Cave and AUC and less than dose proportional single dose Cmax  
The present invention relates to a plurality of dosage forms comprising a first dosage form and second dosage form each comprising a therapeutic agent, such as an opioid; wherein the dosage...
9034355 Materials for modulating biological responses and methods of making  
A polymeric composition capable of releasing nitric oxide and modulating biological responses comprises a biocompatible polymer and S-nitrosated thiol bonded to the biocompatible polymer. The...
9034644 Compositions for repair of defects in osseous tissues, and methods of making the same  
Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can...
9034362 Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens  
A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical...
9028857 Method for preparing porous scaffold for tissue engineering  
The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the...
9023897 Biodegradable drug delivery compositions  
A biodegradable drug delivery compositions comprising a triblock copolymer containing a polyester and a polyethylene glycol and a diblock copolymer containing a polyester and an end-capped...
9023382 Medicament carrier composition and method of forming a film therefrom  
A medicament carrier composition includes a medicament and a polymer component including a polyvinylpyrrolidone having a weight average molecular weight of at least 700,000 g/mol. The medicament...
9023896 Porous silicon drug-eluting particles  
The invention provides a biodegradable drug-eluting particle useful for the delivery of diagnostic or therapeutic agents. In certain embodiments, the drug-eluting particle of the invention...
9017729 Method and composition for hyperthermally treating cells  
A method and composition for hyperthermally treating tumor cells in a patient under conditions that affect tumor stem cells and tumor cells.
9011899 Methods and devices for cellular transplantation  
Devices and methods for transplanting cells in a host body are described. The cell comprises a porous scaffold that allows ingrowth of vascular and connective tissues, a plug or plug system...
9011884 Embolic devices  
Described herein are apparatus, compositions, systems and methods for occluding vascular structures and vascular malformations with radiopaque hydrogel filaments. The filaments can contain no...
9005960 Functionalized membrane for a chamber for encapsulating cells producing at least one substance of therapeutic interest and bioartificial organ comprising such a membrane  
The present invention relates to a functionalized semi-permeable membrane composed of a porous biocompatible support pretreated so as to increase the surface energy thereof and characterized in...
9006182 Light activated composite tissue adhesives  
A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adheives that are...
9005647 Biocompatible material and uses thereof  
The present invention relates to a biocompatible ceramic material comprising Baghdadite (Ca3ZrSi2O9), and a method for its preparation. Preferably the Baghdadite is synthetically prepared. The...
9005646 Compositions for repair of defects in tissues, and methods of making the same  
Tissue repair compositions, particularly bone repair compositions, containing (a) bone fragments and (b) homogenized connective tissue, and methods for making the same are provided. Some of the...
9005943 Bone cell delivery device  
Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to...
9005648 Inorganically surface-modified polymers and methods for making and using them  
In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned)...
8999945 Methods, compositions and systems for local delivery of drugs  
Implantable medical device eluting drug locally and in a prolonged fashion are provided.
8992961 Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles  
This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended...
8992628 Bone delivery system  
A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering...
8992963 Immobilised biological entities  
There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting...
8992613 Unshrunken tissue equivalent and methods for producing such an unshrunken tissue equivalent  
The invention relates to a method for producing an unshrunken tissue equivalent. Said method is comprising in that: a mixture is produced that contains at least one element of an extracellular...
8992967 Poly (diol-co-citrate) hydroxyapatite composite for tissue engineering and orthopaedic fixation devices  
The present invention is directed to a novel poly(diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in...
8992962 Two-piece, internal-channel osmotic delivery system flow modulator  
An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a...
8986724 Nitric oxide generating medical devices  
Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
8986737 Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth  
A method of treating or preventing infection at a surgical site comprising a bony defect and an implanted metal device is disclosed. Biodegradable microspheres are placed at the site and are...
8986726 Biocompatible polyacrylate compositions for medical applications  
A composition comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety...
8980295 Multifunctional in situ polymerized network via thiol-ene and thiol-maleimide chemistry  
Biomaterials that support cell attachment and growth are provided. In one aspect, biomaterials are provided comprising a first polymer matrix comprising reactive amino moieties and a second...
8974808 Elastic implantable composites and implants comprising same  
Described herein are implantable composites, kits comprising the composites, implant devices comprising the composites, and methods of making and using same, including point of use methods.
8974812 Extended release biodegradable ocular implants  
Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a...
8974829 Embolization  
A particle includes a ferromagnetic material, a radiopaque material, and/or an MRI-visible material.
8974813 Hydrophilic polyurethane compositions  
A water-swellable linear polymer is made by reacting together a polyethylene oxide of number average molecular weight less than 4,000, an aliphatic diol, and a difunctional diisocyanate....
8968760 Attachment of a biomaterial to tissue  
A method for attaching an implant to tissue is disclosed. In embodiments, a method includes applying a sprayable material to tissue, the sprayable material possessing functional groups capable of...
8968759 Method of administering an injectable antibiotic to an animal  
A method of administering an antibiotic to an animal in need thereof, including the step of injecting the antibiotic subcutaneously at the junction of a pinna with the cranium of the animal, is...
8968761 Particulate tissue graft with components of differing density and methods of making and using the same  
Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration...
8968417 Bioactive implant for myocardial regeneration and ventricular chamber restoration  
Bioactive implant for myocardial regeneration and ventricular chamber support including an elastomeric microporous membrane. The elastomeric microporous membrane being at least one non-degradable...
8962011 Process and intra-cervical device for the local release of drugs in the local-regional treatment of cervical cancer  
An intrauterine device and more specifically an intracervical device (ICD) for the local release of drugs in the loco-regional treatment of tumours of the uterine cervix comprises an elongated...
8962007 Method of improving absorption of vitamin E by a pet animal  
A method of providing a pet with a benefit relating to effective assimilation of a lipid is described wherein the pet is administered, as a part of, or in addition to its regular diet, an edible...
8962006 Composite mesh including a 3D mesh and a non porous film of oxidized cellulose from bacterial cellulose origin  
The present invention relates to a composite implant comprising: a prosthetic fabric having a first side and a second side, a non-porous film of bacterial cellulose secured to the first side of...
8962023 UV cured gel and method of making  
A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can...
8956638 Biocompatible poly (amic acid) and method of preparation thereof  
A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine...
8956637 Medical device applications of nanostructured surfaces  
This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such...
8956636 Methods and compositions for treating postoperative pain comprosing ketorolac  
Methods and compositions are provided for reducing, treating or preventing postoperative pain or inflammation in a patient in need of such treatment, the methods and compositions comprising...
8956603 Amphiphilic compounds and self-assembling compositions made therefrom  
The present disclosure relates to amphiphilic compounds, self assembling compositions formed from the amphiphilic compounds and methods of making such compositions.
8956639 Multiple drug delivery from a balloon and prosthesis  
System for treating vascular disease comprising a balloon having an outer surface for temporary contact with a vessel wall when in an expanded state, a coating disposed on at least a portion of...
8956643 Porous biodegradable polymer scaffolds for in situ tissue regeneration and method for the preparation thereof  
The present invention relates to an intelligent porous biodegradable polymer scaffold for in situ tissue regeneration in which two kinds of physiologically active substances having high...
8945538 Bone substitute compositions, methods of preparation and clinical applications  
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium...
8945598 Low temperature drying methods for forming drug-containing polymeric compositions  
The present invention relates to a process for reducing solvent contents in drug-containing polymeric compositions. Specifically, the solvent contents in the drug-containing polymeric compositions...