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7618643 Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease  
The present invention features hydrogel drug delivery systems and methods of producing and using such systems for the treatment of wounds. The systems are based on a hydrogel into which a low...
7615235 Film-shaped or wafer-shaped pharmaceutical preparation with masked taste  
The invention relates to thin film-shaped or wafer-shaped pharmaceutical preparations for oral administration of active substances. The preparations contain at least one matrix-forming polymer...
7608640 Glycine betaine and its use  
The present invention provides pharmaceutical uses of betaines, and especially glycine betaine, such as for the treatment of thromboses not induced by hyperhomocystenemia or homocystinuria, of...
7608454 Vascularization enhanced graft constructs  
A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement...
7605138 Nucleic acid compositions for stimulating immune responses  
The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
7604816 Bio-absorbable collagen-based wound dressing  
A collagen-based bio-absorbable wound dressing which contains a linear polymer biguanide and/or a water-soluble salt thereof. The biguanide is preferably polyhexamethylene biguanide. The...
7601363 Sustained-release drug formulations  
The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled releases of active ingredients. The formulation comprises one of...
7601361 Process for providing antimicrobial surfaces  
Processes for providing durable antimicrobial surfaces are disclosed that comprise treating a polymer substrate surface with formaldehyde followed by treatment with an antimicrobial peptide....
7595062 Joint resurfacing orthopaedic implant and associated method  
An orthopaedic implant includes a porous structure made of a type I collagen matrix having at least one sheet of a naturally occurring extracellular matrix secured thereto. Methods of making and...
7589157 Multi-arm block copolymers as drug delivery vehicles  
The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a...
7589107 Amelioration of vitrectomy-induced cataracts  
Methods to prevent, inhibit, or slow the development of vitrectomy-induced cataracts are disclosed. The methods comprise administering to the eye of a subject a composition comprising an...
7582309 Cohesive demineralized bone compositions  
Demineralized bone matrix fibers and a demineralized bone matrix composition are provided. The demineralized bone matrix fibers have an average fiber length in the range from about 250 μm to about...
7579381 Treatment of bioprosthetic tissues to mitigate post implantation calcification  
The present invention provides methods for treating tissue to inhibit post-implant calcification of a biological tissue. In one method of this invention, a tissue is immersed in or otherwise...
7579189 Aligned scaffolds for improved myocardial regeneration  
The present invention relates to a biocompatible, three-dimensional scaffold useful to grow cells and to regenerate or repair tissue in predetermined orientations. The scaffold is particularly...
7579077 Nanofiber surfaces for use in enhanced surface area applications  
This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates, as well as methods and uses for such substrates.
7575740 Compositions for tissue augmentation  
Methods for making biomaterials for augmentation of soft and hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The...
7571727 Molded foam mouthguard  
A mouthguard includes two sections, a vertical component and a horizontal component. The foam is molded into a configuration such that the vertical component curves around the anterior section of...
7569233 Hybrid biologic-synthetic bioabsorbable scaffolds  
A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion.
7563824 Clathrate complexes formed by hyaluronic acid derivatives and use thereof as pharmaceuticals  
A clathrate formed by: a hyaluronic acid derivative (a), a hyaluronic acid derivative (b 1 ) different from (a), and being able to form a clathrate with (a) and/or a component (b 2 ) not containing...
7563454 Coatings for implantable medical devices  
Coatings for implantable medical devices comprising non-fouling moieties or polymers chemically bonded to the surface of the device via chelating structures, and methods of fabricating the coatings...
7560492 Polysulfone block copolymers as drug-eluting coating material  
A polymeric composition comprising a polysulfone polymer and an elastomeric polymer for use as a coating composition for coating an implantable device, such as a DES, and methods of making and...
7556827 Implantable active ingredient depot  
The invention relates to an implantable active ingredient depot for therapeutically active substances. The fields of application are in medicine and the pharmaceutical industry. The implantable...
7556822 Biomedical compositions  
A method of preparing intraocular lenses in situ is disclosed. The method involves the injection of an unsaturated macromonomer of Formula I: The macromonomer is then polymerized to give a...
RE40786 Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres  
This invention relates to parenteral and mucosal vaccines against diseases caused by intercellular pathogens using antigens encapsulated within a biodegradable-biocompatible microspheres(matrix).
7547471 Material for implantation  
The present invention relates to a material for implantation, which is characterised in that the surface of the material partially comprises at least one area of an inorganic, catalytical substance...
7547447 Bioartificial lacrimal gland  
The present invention provides a bioartificial lacrimal gland which contains at least one unit that includes (a) a permeable housing having an interior and an exterior; (b) an outlet connecting the...
7547446 Dry hemostatic compositions and methods for their preparation  
Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain...
7547445 Crosslinkable macromers  
A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue...
7541049 Bioactive and biodegradable composites of polymers and ceramics or glasses and method to manufacture such composites  
Surgical osteosynthesis composite material which has three components: biodegradable polymer reinforcement, bioceramic or bioglass filler reinforcement and biodegradable polymer matrix. This...
7534854 Apparatus and method for oxidation and stabilization of polymeric materials  
An apparatus for treating polymeric materials comprises a treatment chamber adapted to maintain a selected atmosphere; a means for supporting the polymeric material within the chamber; and, a...
7534451 Bone restorative carrier mediums  
Biocompatible bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.
7531190 Porous ceramic structure containing biologics  
A ceramic scaffold operable to support a defect in bone and a surrounding healthy tissue comprising a ceramic body having a plurality of pores, the pores having a bioactive material incorporated...
7531004 Pliable conformable bone restorative  
A pliable bone restorative having an osteoconductive foam that at least partially surrounds a biocompatible mesh and the foam comprises a biocompatible, resorbable polymer and calcium phosphate.
7521233 Methods and devices for promoting endothelial morphogenesis  
In one aspect the present invention provides methods for promoting endothelial morphogenesis. The methods of this aspect of the invention include the step of providing to one or more endothelial...
7521231 Method for preparing engineered tissue  
A method for preparing a human or animal tissue by applying a compressive force to a stack of sheets of living tissue thereby inducing adjacent layers to fuse or adhere to each other. The force is...
7521064 Non-hormonal vaginal contraceptive  
The present invention relates to a non-hormonal, biocompatible, and biodegradable intravaginal device for the delivery of spermiostatic, spermicidal and anti-infectious agents. The present...
7517539 Method of preparing a poorly crystalline calcium phosphate and methods of its use  
The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In...
7510724 Medical apparatus  
The invention relates to a medical apparatus having a special coating on its surface, notably its surface facing the surroundings. The coating has germ and/or dirt-repellant and/or bactericidal...
7510603 Tattooing ink  
The invention relates to a tattooing ink containing water, colored pigments, and a binding agent for binding the colored pigments with the water. Said tattooing ink also contains another...
7507422 Urinary tract tissue graft compositions and methods for producing same  
A method for repairing damaged or diseased urinary tract tissue includes providing a urinary tract tissue graft composition that includes a distal ileal segment of small intestinal submucosa. The...
7507394 High viscosity embolizing compositions  
Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.
7504113 Heparin-like compounds, their preparation and use to prevent arterial thrombosis associated with vascular injury and interventions  
The present invention is related to heparin-like compounds characterized by their capacity of inhibiting collagen-induced platelet aggregation in flowing whole blood and their use for prophylactic...
7501133 Light-activated adhesive composite, system, and methods of use thereof  
The present invention provides a light-activated adhesive composite suitable for medical and surgical applications. The composite includes a scaffold and a light-activated adhesive, such as a laser...
7501018 Chemically bonded biomaterial with tailored properties  
A chemically bonded biomaterial element composed of an inorganic cement, exhibiting minimal dimensional changes upon hardening and long-time use, improved mechanical properties and improved...
7498042 Stent for blood vessel and material for stent for blood vessel  
A luminal stent, implanted and implanted and left in the blood vessel, is disclosed. By permitting a stent ( 1 ), formed of a biodegradable polymer material ( 2 ), to be swollen, and by...
7498041 Composition for repair of defects in osseous tissues  
Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues. The compositions can be used in the form of an...
7498040 Compositions for repair of defects in osseous tissues, and methods of making the same  
Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can...
7494950 Bone cement compositions having fiber-reinforcement and/or increased flowability  
The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of...
7491408 Polymer, bioabsorbable material and film for preventing tissue fusion  
A novel A 1 -B-A 2 polymer having a number average molecular weight of 10000 to 100000 is provided that has excellent bioabsorbability so as to disappear in a predetermined period of time even...
RE40640 Injectable microfoam containing a sclerosing agent  
Injectable microfoam for scleroteraphy. The sclerotherapy of varices is based on the injection of liquid substances capable of suppressing them. The present invention relates to the preparation of...