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6649145 |
Compositions and method of tissue superoxygenation
Disclosed are methods and compositions for increasing tissue oxygen levels by administration of superoxygenated compositions of tissue surfaces. The methods are applicable to treatment of a wide...
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6649183 |
Methods for treating apnea and apnea disorders using optically pure R(&plus ) ondansetron
Methods for the treatment, management, or prevention of apnea and apnea disorders, or symptoms thereof, using a therapeutically effective amount of substantially optically pure R(+) ondansetron, or...
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6648872 |
Circumferential compression device for intracavernosal anesthesia and method for using same
A preferred embodiment of the device of the invention, which is adapted to be applied circumferentially about a phallus, having a perimeter, and to facilitate intracavernosal anesthesia, generally...
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6645517 |
Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
A thermally sensitive polymer-particle composite that absorbs electromagnetic radiation, and uses the absorbed energy to trigger the delivery of a chemical is disclosed. Metal nanoshells are...
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6645518 |
Uses for medical devices having a lubricious, nitric oxide-releasing coating
Methods are provided for delivering nitric oxide to the vascular tissue of a patient to inhibit or prevent restenosis or improve vascular function following various surgical procedures or...
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6641842 |
Thermoplastic articles exhibiting high surface-available silver
Improvements in increasing the amount of surface-available silver in thermoplastic articles comprising certain silver-containing antimicrobial agents. Such an invention requires the incorporation...
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6641611 |
Therapeutic coating for an intravascular implant
The invention relates to a coating for an intravascular implant that prevents hyperproliferative vascular disease after a mechanical injury, such as angioplasty. The coating includes first and...
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6641831 |
Medical products with sustained pharmacological activity and process for producing them
A non-degradable medical product comprising at least two substances or groups of substances, of which a first substance is referred to as substance A and a second is referred to as substance B,...
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6641834 |
Compositions containing alpha-2-adrenergic agonist components
Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid...
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6641833 |
Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
Biodegradable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described, wherein the polymer compositions provide extended...
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6635267 |
Hyaluronic acid gel, process for the preparation thereof and medical materials containing the same
A gel made of hyaluronic acid alone which is hardly soluble in a neutral aqueous solution and has fluidity enough to be easily ejectable from an injector.
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6635268 |
Sustained delivery of an active agent using an implantable system
The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber...
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6635242 |
Broad spectrum microbicidal and spermicidal compositions, devices, and methods
Microbicidal and spermicidal devices, methods, and compositions containing sodium dodecyl sulfate or related anionic surfactants as active ingredients for the prevention and control of pregnancy...
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6635272 |
Wound dressing and drug delivery system
A dressing and method of treating wounds is provided. The dressing can comprise water-soluble or swellable polymers capable of forming viscous aqueous or non-aqueous solution and form a gel, and...
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6635263 |
Beauty method
The present invention relates to a beauty method in which a sound skin condition can be maintained or created and/or deep relaxation can be appreciated, wherein a comfort-stimulating means capable...
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6632450 |
Adherable biomaterial patches and methods for producing and for using same
This invention relates to a method for producing an adherable biomaterial patch. The subject patch is capable of being joined onto a tissue substrate. The invention is also directed to the patch...
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6632431 |
Anti-idiotypic antibody against FimH adhesion of uropathogenic type I-fimbriated Escherichia coli, compositions containing same and method for using same
The present invention relates to an anti-idiotypic antibody or antigen-binding fragment against FimH adhesin of uropathogenic Type I-fimbriated Escherichia coli and an immunizing composition...
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6632446 |
Coating substrates by polymerizing macromers having free radical-polymerizable substituents
Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions...
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6632423 |
Viscoelastics for use in middle ear surgery
Disclosed are viscoelastic compositions and methods of their use in surgical and non-surgical packing and in effecting drug delivery, especially in conjunction with trauma to of disorders of the ear.
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6632805 |
Methods for using water-stabilized organosilanes
A method of dyeing and treating a substrate using a water-stabilized organosilane. A method of antimicrobially treating a food article. A method of antimicrobially coating a fluid container. A...
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6630155 |
Controlled release liquid delivery compositions with low initial drug burst
The invention provides a controlled release polymeric composition which includes a base polymer or copolymer, an organic solvent, a polymeric controlled release additive, and a biologically active...
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6630171 |
Particles based on polyamino-acid(s) and methods for preparing same
The invention concerns delivery particles (DP's) for active principles (AP's) based on linear amphiphilic polyamino-acids (PAA's), with α-peptide chains, capable of being spontaneously formed by...
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6630153 |
Manufacture of bone graft substitutes
The present invention is directed to methods and compositions for manufacturing a bone graft substitute. A powder compaction process is utilized to generate a shaped product comprised of a...
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6630148 |
Compositions comprising hedgehog proteins
The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning...
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6626873 |
Tricolosan-containing medical devices
The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic...
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6627210 |
Compositions containing α-2-adrenergic agonist components
Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid...
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6627600 |
Compressed microparticles for dry injection
The invention relates to a pharmaceutical implant for controllably releasing a drug in a subject and methods for manufacturing and administering the implant. The implant is made of associated...
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6624138 |
Drug-loaded biological material chemically treated with genipin
A method for treating tissue of a patient comprising, in combination, mixing a drug with a solidifiable biological material, chemically treating the drug with the biological material with a...
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6623752 |
Patch for transdermal application for pergolid
The invention relates to a patch for transdermal application of pergolid and its pharmaceutically acceptable salts.
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6623760 |
Method of preparing particles for agglomeration
Methods of preparing particulates for agglomeration, having a specified particle size distribution and desired convertible amorphous content, are described. The method involves a plurality of...
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6623730 |
Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate
Oligomers and polymer compositions are provided which comprise GHB and produce GHB after administration in vivo. Devices for the storage and delivery of these polymers and oligomers are also...
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6623748 |
Reverse phase connective tissue repair composition
A biocompatible connective tissue repair composition which comprises a therapeutic material and a carrier comprising a means for achieving reverse phase characteristics, and methods for using said...
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6623749 |
Medical device containing polyhydroxyalkanoate treated with oxidizing agent to remove endotoxin
Polyhydroxyalkanoate (PHA) that contains a pyrogen such as an endotoxin due to a process of producing the PHA is treated to remove the pyrogen by a process that does not affect the inherent...
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6620423 |
Use for pain management
The present invention is directed to the intramuscular use of ropivacaine for the manufacture of a medicament for use in the treatment of muskuloskeletal pain, in particular myofascial pain and...
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6620422 |
Compositions containing a peptide and polylactic-glycolic acid suitable for preparing subcutaneous implants with an extended release period
Compositions comprising a peptide and polylactic-glycolic acid (PLGA) wherein the distribution of the size of the particles of the peptide in the PLGA results highly heterogeneous, suitable to the...
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6616912 |
Bi-component microporous hollow fiber membrane structure for in vivo propagation of cells
A bi-component microporous hollow fiber membrane structure is provided for in vivo propagation of cells and use in testing of the effect of medical treatments on cells within the structure. The...
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6617307 |
Peptide and osteogenetic accelerator
A peptide has any one of the sequences SEQ ID NO.1 to SEQ ID NO.8, or has a sequence derived from any one of the sequences SEQ ID NO.1 to SEQ ID NO.8 by substitution, deletion or addition of one or...
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6617314 |
Injectable formulations of avermectins and milbemycins
The present application relates to injection formulations of avermectins and milbemycins based on a solvent mixture comprising sesame oil, medium-chain triglycerides, glycol esters or fatty acid...
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6613735 |
Composition for polypeptide transfer to cells
The present invention is directed to a composition for gene transfer which composition contains a quaternary ammonium salt represented by formula (1): (wherein each of R 1 , R 2 , R 3 , R 4 ,...
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6613325 |
Prevention of post surgical adhesions using a fibrin monomer sealant
In accordance with the present invention it has been found that a fibrin polymer film formed by applying materials most closely resembling the natural clotting materials to a surgical adhesion...
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6613332 |
Oral administration of therapeutic proteins
An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and...
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6608040 |
Chemical modification of biomedical materials with genipin
Biocompatible cross-linked materials, suitable for use in implants, wound dressings, and blood substitutes, are described. The materials are prepared by cross-linking biological substances, such as...
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6602963 |
Polyesters containing (meth)acrylate end groups
The invention describes polyesters containing (meth)acrylate end groups, of the general formula (I) CH 2 ═CRCOO—PE—OCOCR═CH 2 where R=CH 3 or H, where PE=[—A—OCO—B—COO—] m...
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6602516 |
Antibiotic/medicated gutta percha point
The ability to incorporate iodoform, tetracycline and a combination of iodoform/tetracycline into root canal gutta percha points is described. The iodoform, tetracycline and iodoform/tetracycline...
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6602519 |
Oxidized thymosin β4
The present invention relates to the use of oxidized thymosin β4 in therapy, more particularly in the treatment of diseases or conditions associated with an inflammatory response of septic shock.
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6599275 |
Implantable medical device
An implantable medical device 10 such as a catheter with a pharmacologically active ingredient layered between outer and inner elongated member tubes 11 and 13 for minimizing the risk of...
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6599526 |
Pericardial anti-adhesion patch
The present invention is directed to an anti-adhesion patch, which is constructed using a tissue equivalent technique. The anti-adhesion patch comprises a collagenous material and at least one...
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6599519 |
Biodegradable poly(alkylene oxide)-poly(p-dioxanone) block copolymer soluble in organic solvents, and drug delivery composition comprising same
The present invention relates to a biocompatible and biodegradable block copolymer of poly(alkylene oxide) and poly(p-dioxanone), which is soluble in organic solvents, and a drug delivery...
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6599521 |
Absorbent articles for the inhibition of exoprotein production from Gram positive bacteria
An absorbent article for inhibiting the production of exoproteins from Gram positive bacteria, such as potentially harmful proteins produced by Staphylococcus species, is described. The absorbent...
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6599517 |
Bone tissue restoring composition
A composition suitable for restoring bone tissue in a human or animal body, which comprises a solid, preferably particulate, calcium phosphate as a biocompatible bone tissue substitute material...
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