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6719993 |
Calcium phosphate cements prepared from silicate solutions
Methods are provide for producing flowable compositions, e.g. pastes, that set into calcium phosphate products. In the subject methods, dry reactants that include a calcium source and a phosphate...
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6719991 |
Combination of antimicrobial agents and bacterial interference to coat medical devices
This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a...
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6719987 |
Antimicrobial bioabsorbable materials
The invention provides bioabsorbable materials with antimicrobial coatings or powders which provide an effective and sustainable antimicrobial effect. Specifically, this invention provides...
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6713081 |
Ocular therapeutic agent delivery devices and methods for making and using such devices
Ocular implant devices for the delivery of a therapeutic agent to an eye in a controlled and sustained manner. Dual mode and single mode drug delivery devices are illustrated and described....
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6713079 |
Methods for increasing vascularization and promoting wound healing
The present invention provides a method of stimulating vascularization at a site in a mammal, said method comprising contacting said site with a matrix comprising gelatin and a nitric oxide...
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6713527 |
Anaesthetic bone cement
The invention relates to surgical bone cement compositions and more particularly to bone cement compositions having aneasthetic properties, and to methods for producing analgesia.
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6709674 |
Injectable pamidronate disodium
The invention includes a packaged liquid composition of a pamidronate alkaline salt in a sealed storage vessel having an inner surface which is non-reactive with the pamidronate alkaline salt...
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6706024 |
Triclosan-containing medical devices
The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic...
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6706274 |
Differential delivery of nitric oxide
This invention relates to devices and methods for the local, differential delivery of nitric oxide within the body. The devices include devices having at least two differing nitric oxide donor...
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6706273 |
Composition for implantation into the human and animal body
Compositions for implantation into the human and animal body as bone replacement contain inter alia calcium and phosphorus and consist in particular of mixtures of powders and admixing liquids....
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6703037 |
Biodegradable macromers for the controlled release of biologically active substances
A method for delivering a biologically active substance including the steps of: (a) combining said biologically active substance with a macromer; (b) forming a mixture of the combination formed in...
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6703039 |
Reversible gelling system for ocular drug delivery
The invention provides an ophthalmic aqueous composition for topical administration, comprising: (a) a block copolymer of propylene oxide and ethylene oxide in concentration sufficient to provide...
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6703047 |
Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize...
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6699492 |
Quinolone carboxylic acid compositions and related methods of treatment
The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release...
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6699490 |
Aqueous prolonged release formulation
Prolonged parenteral release into the circulatory system of a cow of a bioactive bovine somatotropin at desirably effective levels can be achieved using novel compositions in which the bovine...
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6699484 |
Fibrin sealants or adhesives comprising a hyaluronic acid derivative material
An especially useful fibrin glue composition comprises a biocompatible, bioabsorbable hyaluronic acid derivative material, upon which are applied or chemically bonded fibrinogen and thrombin, along...
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6699505 |
Method of increasing the efficacy of antibiotics by compexing with cyclodextrins
The present invention provides methods of increasing the biological activity of a bioactive agent by complexing the bioactive agent with a complexing agent. In one preferred embodiment, the...
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6699494 |
Pharmaceutical composition and method for treating premature labor
The present invention teaches a composition comprising a β-adrenergic agonist in a bioadhesive carrier. Preferably, the composition comprises terbutaline in polycarbophil. The present invention...
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6696072 |
Methods for treatment of male erectile dysfunction
Improved drug compositions and methods useful in the treatment of male erectile dysfunction. An optimized mixture of the drugs phentolamine mesylate, papaverine hydrochloride, and alprostadil in a...
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6696073 |
Shaped load-bearing osteoimplant and methods of making same
A load-bearing osteoimplant, methods of making the osteoimplant and method for repairing hard tissue such as bone and teeth employing the osteoimplant are provided. The osteoimplant comprises a...
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6696075 |
Liquid crystalline polymers
Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from...
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6692758 |
Insertion stabilizers for implants
The present invention relates to an implant attachment stabilizer having, as an effective component, a methanebisphosphonic acid derivative represented by general formula (I) [where, in the...
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6692760 |
Polymeric material for artificial bone
A novel polymeric material for artificial bones, comprising a solid or gel-form base containing, as the main component, either a polysaccharide having carboxyl groups or their derivatives, or a...
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6689380 |
Remote and local controlled delivery of pharmaceutical compounds using electromagnetic energy
The present invention provides a method/system for remote and local controlled delivery of pharmaceutical compounds or biomolecule collection using electromagnetic energy. Controlled...
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6689373 |
Devices and methods for pain management
The invention features devices and methods for the systemic delivery of fentanyl or a fentanyl congener (e.g., sufentanil) to treat pain. In the present invention, a drug formulation comprising...
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6685951 |
Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
The present invention is an improvement in the treatment of migraine headaches. By administering dihydroergotamine as a sublingual spray or aerosol, major limitations of past treatments are...
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6682760 |
Cross-linked collagen matrices and methods for their preparation
A method for preparing cross-linked collagen and cross-linked collagen products. The method includes incubating collagen in a solution including water, at least one polar solvent and at least one...
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6682753 |
Methods for promoting weight gain using GPE-related compounds
Weight gain in a mammal, especially a human, having a condition that leads to decreased weight gain or weight loss, such as AIDS, brain trauma, a chronic neurodegenerative disease such as...
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6682754 |
Ovo delivery of an immunogen containing implant
The disclosure provides a method for administering an agent to an avian species by in ovo delivery of an implant releasably containing the agent. In one embodiment, the method is particularly...
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6682522 |
Valve for osmotic devices
An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule having a beneficial agent reservoir, an osmotic agent which expands on contact with fluid...
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6680063 |
Biocompatible albumin lamina and method
The present invention provides a denatured albumin lamina, useful for repairing lesions on solid visceral organs. The lamina comprises human serum albumin, formed into a thin, pliant sheet and...
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6680065 |
Shaped bodies which release agrochemical active substances
The present invention relates to shaped articles which release agrochemical active compounds, are used for treatment of woody plants and are employed in a hollow preformed in the woody plant, are...
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6676970 |
Subcutaneous osteoporosis compositions
The invention is concerned with a pharmaceutical preparation for subcutaneous, parenteral administration, which contains bisphosphonic acids or their salts as the active substance, as well as the...
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6676956 |
Oil-in-water emulsion for protecting human organs against peroxidation
The invention relates to an oil-in-water emulsion comprising, as an active ingredient, α-tocopherol or the stereoisomers thereof and comprising, as an emulsifier, phospholipids. The inventive...
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6676971 |
Embolic compositions
Embolic compositions comprising macromers having a backbone comprising a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure, such as polyvinyl alcohol, and pendant chains...
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6673767 |
Gel composition and methods
Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, compositions having burst indices of 8 ...
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6673338 |
Nitric oxide-releasing imidate and thioimidate diazeniumdiolates, compositions, uses thereof and method of making same
The invention provides NO— or NO − -releasing imidate, thioimidate, and amide diazeniumdiolates, in which the N 2 O 2 − functional group is bonded to a carbon atom. The invention also...
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6673843 |
Curcumin and curcuminoid inhibition of angiogenesis
Methods for treating diseases or disorders of the skin which are characterized by angiogenesis have been developed using curcumin and curcumin analogs. Based on the results obtained with curcumin,...
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6673361 |
Polymer, in vivo degradable material, and use
A polymer having a satisfactory balance between in vivo degradability and satisfactory mechanical properties, which is an A 1 BA 2 type polymer comprising a segment A 1 and a segment A 2 each...
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6669959 |
Modulated release particles for lung delivery
A polymeric construct is disclosed. The construct comprises a biodegradable ABA block copolymer having a selected medicament associated therewith. The medicament thus present is provided in a slow...
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6663878 |
Anti-inflammatory bioactive glass particulates
Compositions and methods for systemically minimizing the inflammatory effects of TNF-α are disclosed. The compositions include particles of bioactive glass with a particle size less than about 20...
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6663879 |
Injectable compositions
A stable injectable composition includes a non-aqueous parasitic agent in a therapeutically effect amount, chosen from the group of avermectin, ivermectin, doramectin, abamectin, milbemycin and...
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6660301 |
Injectable microspheres for dermal augmentation and tissue bulking
The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions...
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6660279 |
Stability for injection solutions
A primary package containing a low molecular weight peptide-based thrombin inhibitors which package is sealed with a rubber stopper or plunger containing bromobutyl rubber.
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6656496 |
Porous tissue scaffolding materials and uses thereof
A biodegradable scaffold includes a protein, a cross-linking agent, 10 to 50 percent by volume porosity imparting polymeric beads and a modifying agent. A method for the use of the biodegradable...
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6652883 |
Tissue bulking and coating compositions
Compositions comprising macromers having a backbone comprising units having a 1,2-diol and/or 1,3-diol structure for tissue bulking and coating. Such polymers include poly(vinyl alcohol) (PVA) and...
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6653291 |
Composition and method for production of transformed cells
A composition useful for the production of transformed eukaryotic cells is described. The composition comprises submucosal tissue and a nucleic acid sequence. The nucleic acid sequence is typically...
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6652886 |
Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
A biodegradable, novel cationic coopolymer comprising a a poly(alkylenimine)(PAI), a hydrophilic polymer, and a biodegradable linker, wherein the biodegradable linker covalently links the PAI and...
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6652884 |
Method for the treatment of solid tumors by albumin microparticles incorporating paclitaxel
The invention concerns a method for the treatment of tumors sensitive to Paclitaxel, by intra-arterial injections of dispersions of microparticles of albumin incorporating Paclitaxel in...
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6653288 |
Injectable anthelmintic compositions and methods for using same
Injectable compositions containing a liquid solvent free of solid polymers, anthelmintic agent(s)and hormonal growth promoter(s), where the anthelmintic agent(s) and the hormonal growth promoter(s)...
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