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6974594 |
Method of preparing biological materials and preparations produced using same
Methods for preparing products containing moisture-sensitive materials, including biological materials such as proteins, peptides or live cells, comprising at least the steps: (i) providing a...
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6974679 |
Support with collagen base for tissue engineering and manufacture of biomaterials
The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin,...
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6974585 |
Durable multi-component antibiotic formulation for topical use
Disclosed are methods and formulations for the treatment or prevention of infections on mammalian tissues such as skin. Specifically, the methods of this invention involve the in situ formation of...
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6974587 |
Intraruminal device
An intraruminal device is provided for the time release dispensation of a medicament to a ruminant. The device has no metal parts which may damage slaughterhouse equipment or injure a human upon...
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RE38913 |
Biocompatible hydrogel
A BIOCOMPATIBLE HYDROGEL, is provided for use in the treatment of humans for cosmetic and functional defects (e.g. in mammas, vocal cords, penis, etc. as endoprostheses), in the provision of...
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6972130 |
Bioceramic compositions
The present invention provides a synthetic, poorly crystalline apatite (PCA) calcium phosphate containing a biologically active agent and/or cells (preferably tissue-forming or tissue-degrading...
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6969525 |
Surgically implanted time release medication for post-surgical treatment of a patient
A method of administering a medication to a post operative patient with the medication being administered at the site of a surgery performed on the patient. The medication is formed into a time...
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6964781 |
Sustained release drug delivery devices with prefabricated permeable plugs
The present invention is directed to an improved sustained release drug delivery device comprising a drug core, a unitary cup, and a prefabricated permeable plug.
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6960351 |
Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region...
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6958149 |
Repair of larynx, trachea, and other fibrocartilaginous tissues
Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of...
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6955806 |
Ionene polymers and their use as antimicrobial agents
Disclosed are ionene polymers having antimicrobial activity. “Ionene polymers” as used in this invention are cationic polymers in which a substantial proportion of the atoms providing the...
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RE38827 |
Adhesive sealant composition
This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first...
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6953586 |
Growth promoting pharmaceutical implant
A combination growth promoting pharmaceutical pellet system which delivers doses of both a growth stimulating pharmaceutical agent and a supplemental agent that enhances the growth produced by the...
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6946143 |
Medical materials and porous scaffolds for tissue engineering made from the biodegradable glycolide/ε-caprolactone copolymer
Disclosed is a biocompatible medical material and porous scaffold for use in tissue engineering, made from a biodegradable glycolide/ε-caprolactone copolymer having a repeat unit of
wherein x...
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6945949 |
Left ventricular conduits to coronary arteries and methods for coronary bypass
A method of treating a heart may include providing an implant having a first end and a second end, placing the implant in a heart wall between a heart chamber and a blood vessel such that the first...
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6946140 |
Methods and compositions for enhancing fibroblast migration
Methods and compositions for enhancing fibroblast migration at a wound site are disclosed. The method includes contacting the wound site with fibrinogen that is prepared by a process which includes...
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6942877 |
Method for producing antibiotic composites
A method for producing antibiotic composites is described, which is characterized in that a salt, which can be subjected to plastic deformation and which consists of at least one cationic component...
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6939569 |
Medical device having anti-infective and contraceptive properties
There is disclosed a medical device for implantation that acts to prevent transmission of infectious agents. Specifically, the present invention provides implantable devices, such as catheters or...
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6939364 |
Composite tissue adhesive
Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of...
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6936278 |
Microparticles
A process for producing microparticles, in which an aqueous solution of purified amylopectin-based starch of reduced molecular weight is prepared, the solution is combined with biologically active...
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6932978 |
Double-headed, closed-mouth cough suppressant and cold relief device
A double-headed, closed-mouth cough suppressant and cold relief device in which an individual having the symptoms of a cough is able to suppress the cough by inserting the device into an open...
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6929800 |
Nasal passage cleaning composition
A nasal passage cleaning composition according to the invention comprises water and salt as a base, and contains a mucolytic agent such as alum and/or zinc sulphate to shrink the mucosa and allow...
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6923990 |
Stabilized silver-ion amine complex compositions and methods
The present invention relates to new silver-ion super-complex compositions. More particularly, the present invention describes silver-ion super-complex compositions comprising a silver-thiosulfate...
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6923978 |
Multilayer materials
The invention is directed to a composite material, especially a biomedical device, e.g. an ophthalmic device, preferably a contact lens, with one or more wettable surfaces capable of holding a...
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6923988 |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one...
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6923989 |
Method for preparing a calcium phosphate pasty material for injection
A method for preparing a calcium phosphate pasty material for injection which after, setting, is designed to form an apatite material consists in: producing from water and calcium phosphates pasty...
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6916485 |
Prolonged release bioadhesive therapeutic systems
The present invention concerns a prolonged release bioadhesive mucosal therapeutic system containing at least one active principle, with an active dissolution test of more than 70% over 8 hours and...
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6916483 |
Bioabsorbable plugs containing drugs
Bioabsorbable modular drug delivery devices having shapes and sizes adapted to be inserted within a mating receptacle on the surface of an implantable prosthesis are disclosed. The devices may be...
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6911213 |
Pernasally absorbable insulin preparations
An insulin formulation with porous, spherical calcium carbonate composed of trabeculate or needle-shaped crystals, or an aggregation of the parallel intergrowth of these forms, as its carrier, will...
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6908624 |
Coating for implantable devices and a method of forming the same
Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active...
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6899700 |
Therapeutic agent delivery tampon
A tampon adapted to deliver a therapeutic agent includes a body having a proximal end and a distal end. The body includes an absorbency zone adjacent the distal end, wherein the absorbency zone...
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6896884 |
Human chitinase, its recombinant production, its use for decomposing chitin, its use in therapy or prophylaxis against infection diseases
A new human chitinase having an amino acid sequence as shown in FIG. 1 or FIG. 2 . Modified forms of it having a similar chitin-hydrolyzing activity, and antigenic peptides representing one of...
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6893653 |
Chemical cleaning of biological material
The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as...
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6887485 |
Nitric oxide-releasing metallic medical devices
Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian...
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6884427 |
Filamentary means for introducing agents into tissue of a living host
The present invention provides a filamentary structure for the introduction of agents into a living host, comprising a filament comprising a solid core and a porous sheath which coats at least a...
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6884428 |
Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
A biocompatible tissue repair stimulating implant or “scaffold” device is used to repair tissue injuries, particularly injuries to ligaments, tendons, and nerves. Such implants are especially...
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6884518 |
Material suitable for an individual's tissue reconstruction
A material suitable for the reconstruction of an individual's tissue, particularly supportive tissue such as bone tissue, insertable into the tissue. The material is characterized by being composed...
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6881413 |
Humanized biomaterials, a process for their preparation and their applications
The invention relates to humanized biomaterial comprising a porous biocompatible composite material customized and implanted with monocyte derived cells preferably with macrophages.
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6878369 |
Methods for treating urinary incontinence in mammals
Disclosed are methods for treating urinary incontinence in a mammal wherein a composition comprising a biocompatible polymer, a biocompatible solvent, and a contrast agent is delivered to the...
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6878383 |
Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
The invention provides a composition for promoting regeneration of tissue which has degenerated in a subject as a result of a disease or disorder and a method of using the composition is provided....
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6875441 |
Composition for delivery of hematopoietic growth factor
A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition...
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6872576 |
Antigens embedded in thermoplastic
The invention relates to an immunoassays, binding assays, solid phase substrates ( 12 ) and other devices with an antigen or antibody or ligand or receptor ( 11 ) embedded into a solid phase...
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6872195 |
Chlorhexidine-containing medical devices
The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic...
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6872403 |
Polymethylmethacrylate augmented with carbon nanotubes
An augmented synthetic resin is provided. That resin includes carbon nanotubes dispersed in a polymethylmethacrylate matrix. The method of preparing this synthetic resin includes the mixing and...
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6872387 |
Three-dimensional hydrogel/cell system
Methods and compositions are described that provide scaffolds for the support of cells. The scaffolds of the present invention have structural uniformity and desirable mechanical properties that...
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6869976 |
Inorganic-polymer complexes for the controlled release of compounds including medicinals
This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium...
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6869436 |
Surgical clip with a self-releasing fluid reservoir
The present invention generally relates to surgical clips. A surgical clip comprises a first piece comprising a first base and a first projection extending from the first base, a second piece...
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6866864 |
Compositions and methods of use in the treatment of angiogenesis and vascular-related disorders
The present invention provides compositions and method of use for the prevention and treatment of vascular-related disorders such as vascular re-occlusion or restenosis post-coronary intervention...
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6863899 |
Composite shaped bodies and methods for their production and use
Shaped, composite bodies are provided. One portion of the shaped bodies comprises an RPR-derived porous inorganic material, preferably a calcium phosphate. Another portion of the composite bodies...
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6858229 |
In situ forming hydrogels
The invention features materials and methods for the liquid to solid transition of an injectable pre-hydrogel composition to a hydrogel. These methods can be carried out in situ.
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