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6231879 |
Biocompatible devices with foam scaffolds
This invention is directed to methods of manufacturing implantable biocompatible cell encapsulation devices, wherein the cell encapsulation devices have a jacket made of a permeable, biocompatible...
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6228836 |
Permucous preparation
A composition for permucosal administration characterized by containing Antago-3 or a physiologically acceptable salt thereof, and a sucrose fatty acid ester. With the composition for permucosal...
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6224892 |
Polyesterhydrogels
Novel cross-linked polyesters of pyromellitic anhydride and a polyhydroxy compound containing more than two hydroxyl groups are highly water absorbent, and biodegradable, water swellable. The...
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6218016 |
Lubricious, drug-accommodating coating
A coating is provided for a substrate comprising a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable...
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6216388 |
Dissolving polymer plug for introducing nutrients and medicinal materials into tree trunks
A method of introducing treatment agents comprising medicine or nutrients into a tree, involving the boring of holes above ground into the trunk of the tree. Homogeneous plugs of solidified...
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6217896 |
Conjunctival inserts for topical delivery of medication or lubrication
The present invention provides an improved conjunctival insert for topical delivery of medication or lubrication into the conjunctival spaces and upon the ocular surface of human eye. Specifically,...
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6217911 |
sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
A controlled release microcapsule pharmaceutical formulation for burst-free, sustained, programmable release of a non-steroidal, antiinflammatory drug over a duration from 24 hours to 2 months,...
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6214379 |
Maximizing effectiveness of substances used to improve health and well being
The present disclosure relates to novel dosage forms, drug delivery regimens, methods and pharmaceutical compositions which optimize the therapeutic effects of active therapeutic substances through...
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6211152 |
Formulations for peptide release
A pharmaceutical and/or veterinary formulation comprising deslorelin and an excipient, the formulation being characterised in that, in vitro, it releases deslorelin into phosphate buffered saline,...
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6211146 |
60A protein-induced morphogenesis
Disclosed are methods of utilizing a morphogenically active fragment of 60A protein to induce tissue morphogenesis, including methods for increasing a progenitor cell population in a mammal,...
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6207718 |
Pharmaceutical compositions containing hedgehog protein
A composition of a hedgehog protein which includes as an additive cyclodextrin, a non-ionic detergent, an anionic saccharide and/or ionic salt containing zinc ions, magnesium ions, calcium ions...
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6203813 |
Pharmaceutical delivery device and method of preparation therefor
The present invention provides an opiate antagonist implant which is an admixture of an opiate antagonist, in either acid or base form, and a pharmaceutically acceptable carrier. The admixture is...
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6200557 |
Method of treating HIV by a topical composition
A solution or gel composition containing activated stabilized chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium...
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6200600 |
Controlled delay release device
Novel devices for the controlled release of active materials especially pharmaceuticals comprise a capsule formed from two separable pieces at least part of the capsule walls is water permeable....
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6197337 |
Therapeutic uses of abarelix
A method of decreasing atherosclerosis and its complications including but not limited to myocardial infarction, stroke and peripheral vascular disease wherein the method involves administering to...
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6197935 |
Prion-free collagen and collagen-derived products and implants for multiple biomedical applications; methods of making thereof
The use of collagen as a biomedical implant raises safety issues towards viruses and prions. The physicochemical changes and the in vitro and in vivo biocompatibility of collagen treated with heat,...
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6197344 |
Butorphanol sustained release formulations
Controlled, sustained release formulations of butorphanol are provided. Such formulations can be an aqueous suspension of butorphanol freebase or an oil suspension of a butorphanol salt. Processes...
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6194000 |
Analgesic immediate and controlled release pharmaceutical composition
Disclosed is a method for the therapeutic treatment of pain related to wind up in a human or animal. The method of the invention is practiced by administering to the subject an effective amount of...
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6194384 |
Long-acting galenical formulation for GRF peptides
The present invention relates to a long-acting galenical formulation of GRF peptides, GRF and/or analogs thereof which comprises about 1 to about 100 mg of a GRF peptide, fragment or analog thereof...
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6193991 |
Biodegradable delivery systems of biologically active substances
Biodegradable delivery systems of physiologically, pharmacologically and biologically active substance(s) (BAS) are provided. These systems are obtained by incorporating the BAS into a blend of...
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6187333 |
Method for treating, controlling, and preventing diabetes mellitus
This invention pertains to a method that can control, treat, and prevent Diabetes Mellitus. The method includes means of administering a potent product, including mainly the active ingredient...
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6187332 |
Acidic buffered nasal spray
Disclosed herein are buffered flowable nasal sprays having a pH of between 4.0 and 5.0. They are primarily water and a citrate (or citrate/phosphate) buffer. They may also contain sodium chloride,...
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6184266 |
Medical devices comprising cross-linked hydrogels having improved mechanical properties
Shaped medical devices, e.g. stents, having improved mechanical properties and structural integrity are disclosed. The devices comprise shaped polymeric hydrogels which are both ionically and...
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6180606 |
Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
Osteogenic compositions, and methods for preparing same, which compositions comprise a porous or semi-porous matrix, an osteogenic factor and an agent such as growth factors, nutrient factors,...
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6180129 |
Polyurethane-containing delivery systems
A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the...
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6180605 |
Composition with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
The present invention provides improved osteogenic compositions having enhanced by the sorption of growth factors, of nutrient factors, or drugs onto or into the compositions. Compositions may...
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6174529 |
Oral therapy for the treatment of allergies and method of manufacture
An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and...
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6165496 |
Keratin-based sheet material for biomedical applications and method of production
A sheet wound dressing formed of cross linked keratin. An insoluble, largely Beta keratin fraction from human hair is acidified to a low pH, preferably less than about 3, which partially...
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6165486 |
Biocompatible compositions and methods of using same
Blends of biodegradable polymers, preferably poly(caprolactone) and poly(D,L-lactic-co-glycolic) acid are discussed as well as their applications in the medical field, particularly with regard to...
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6166184 |
Process for making a bioprosthetic device
Methods for making bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods include blocking at least a portion of...
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6166159 |
High-strength degradable materials and molded articles for implantation into human and animal organisms
Described are high-strength materials which are degradable and resorbable in the human and animal organisms and shaped articles manufactured therefrom, such as implants, based on cured...
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6162247 |
Vascular graft impregnated with a heparin-containing collagen sealant
A heparin-collagen dispersion is provided for impregnating a vascular prosthesis with heparin and collagen. The dispersion is prepared at an alkaline pH to allow the addition of heparin without...
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6159488 |
Intracoronary stents containing quinazolinone derivatives
The invention provides an intracoronary stent coated with a quinazolinone derivative of formula (I), wherein n is 1 or 2, R 1 is a member of the group consisting of hydrogen, halogen, nitro,...
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6159495 |
Porous and bulk keratin bio-polymers
Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages...
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6156293 |
Moistening preparation
The present invention relates to preparations alleviating the symptoms caused by drying of the mucous membranes of the body. The preparations contain trimethylglycine as an active agent. The...
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6153210 |
Use of locally delivered metal ions for treatment of periodontal disease
Periodontal disease can be treated by the administration of metal ions, preferably silver ions, to the site where the microorganisms that cause this disease reside. Administration can be to...
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6149921 |
Vaccine compositions for eliciting an immune response against N-acetylated gangliosides and their use for cancer treatment
The invention provides novel uses for n-glycolylated gangliosides and N-acetylated gangliosides, or derivatives and/or oligosaccharides thereof The invention further provides methods of obtaining...
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6146653 |
Pharmaceutical preparation and a method for the treatment of diabetes
A method of treatment of humans suffering from diabetes which involves transplantation into the human of viable porcine islets capable of producing insulin within its host. The invention also...
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6143037 |
Compositions and methods for coating medical devices
Compositions and methods for coating medical devices with pharmaceutical agents and devices coated with the compositions. The coated devices provide controlled or sustained release of...
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6142972 |
Method and apparatus for the delivery of elongate solid drug compositions
The invention features an implantable device for the automatic delivery of an active ingredient according to an adjustable delivery profile. The device includes a housing; a reservoir operatively...
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6139863 |
Suppositories
The inventor provides suppositories comprising as the active ingredient 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl) benzimidazole (I). These suppositories are expected to exert drug...
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6136336 |
JM216 formulations
Novel suppository pharmaceutical formulations of the platinum antitumor agent, JM216, are provided. Such dosage forms provide an alternative to the oral form currently available and offer improved...
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6132420 |
Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
The present invention relates to an osmotically driven agent delivery system for delivering a beneficial agent. The osmotic delivery system includes an osmotic agent which operates by imbibing...
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6132751 |
O/W emulsion composition for eye drops
An O/W emulsion composition for eye drops comprises a drug selected from the group consisting of fluorometholone, clobetasone butyrate and clobetasol propionate; a phospholipid; liquid paraffine;...
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6129934 |
Modification of animal lung surfactant for treating respiratory disease due to lung surfactant deficiency or dysfunction
The present invention relates to the method of using a composition of matter that maintains the biophysical and physiological characteristics of natural surfactant, including the rapid and...
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6129925 |
Container filled with infusion liquids and infusion preparation
An object of the present invention is to provide an infusion preparation set (a container filled with infusion liquids) useful for preparation of an infusion liquid containing sugars, amino acids,...
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6126958 |
Intravaginal rings with insertable drug-containing core
Disclosed is a vaginal ring intended for the release of at least one drug over a prolonged time period. The vaginal ring contains a ring body made of a first polymeric material having at least one...
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6126955 |
Apo-transferrin as a potent inhibitor of bacterial adhesion to biomaterials
Methods of inhibiting bacterial adhesion to medical implants and reducing device-associated infection are effectuated by administering an effective amount of apo-transferrin to an individual with...
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6124265 |
Method of making and cross-linking keratin-based films and sheets
Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages...
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6118043 |
Bone replacement material with FGF
The invention relates to a bone replacement material which comprises one or more polypeptides having the biological action of fibroblast growth factors in a porous matrix. The healing-in properties...
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