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6333046 |
Transmucous absorption enhancer
To provide a transmucous absorption enhancer comprising a medium-chain fatty acid salts or a bile acid salt and a glycyrrhizic acid salts capable of sustaining the effect of the absorption enhancer...
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6331309 |
Hydrogel compositions for the controlled release administration of growth factors
Compositions and methods are disclosed for the controlled release delivery of polypeptide growth factors. The compositions of the invention are hydrogels which comprise: a polypeptide growth factor...
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6331313 |
Controlled-release biocompatible ocular drug delivery implant devices and methods
Controlled release devices are disclosed which are biocompatible and can be implanted into the eye. The devices have a core comprising a drug and a polymeric outer layer which is substantially...
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6331312 |
Bioresorbable ceramic composites
A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The poorly crystalline apatitic calcium...
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6328989 |
Use of bicozamycin for the manufacture of a medicament for treating infections with enterohemorrhagic e. coli
The present invention relates to the use of bicozamycins for the prophylaxis and treatment of infections with a verotoxin-producing E. coli, as well as for eradicating verotoxin-producing E. coli...
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6328990 |
Bioactive, degradable composite for tissue engineering
Bioactive, degradable composite material and composite material microspheres were produced using a new solid-in-oil-in-water method. Compositions and methods for tissue engineering and drug...
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6326406 |
Clear, injectable formulation of an anesthetic compound
The present invention is directed to a clear, injectable, pharmaceutical composition including propofol, a pharmaceutically acceptable salt of a bile and a lecithin. The present invention is...
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6326019 |
Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries
A method for making, storing and using a surgical graft from human amniotic membrane; the resulting graft; and the storage solution. The amniotic membrane is obtained from human placenta, from...
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6325991 |
Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2
The present invention relates to methods of treating periodontal disease in a mammal. The methods include administering to an animal an s effective amount of an inhibitor of sPLA 2 . The inhibitors...
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6326017 |
Methods for the localized delivery of agents to blood vessels
Methods for the localized delivery of agents to blood vessels are disclosed. The methods of the present invention provide advantages over existing methods for treating, diagnosing, or preventing,...
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6319512 |
Implants for controlled release of pharmaceutically active principles and method for making same
The present intention relates to an implant for the controlled release of at least one pharmaceutically active principle comprising a core containing at least one active principle and a sheath...
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6319492 |
Copolymers of tyrosine-based polyarylates and poly(alkylene oxides)
Implantable medical devices and drug delivery implants containing polyarylate random block copolymers are disclosed, along with methods for drug delivery and for preventing the formation of...
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6312708 |
Botulinum toxin implant
A controlled release system for multiphasic, in vivo release of therapeutic amounts of botulinum toxin in a human patient over a prolonged period of time. The controlled release system can comprise...
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6312706 |
Prepolymers useful in biomedical devices
A novel polyurethane based prepolymer useful in biomedical devices which provides high oxygen permeability and superior physical properties.
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6310036 |
High strength, Bio-compatible tissue adhesive and methods for treating vigorously bleeding surfaces
Disclosed is a novel tissue adhesive technology comprising a combination of ultrasonically treated proteins including collagen and albumin which form a viscous material that develops adhesive...
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6306419 |
Medical uses of styrene sulfonate polymers
Wound dressings and coated implantable medical devices include a styrene sulfonate polymer. Organic and inorganic therapeutic agents may be incorporated in the copolymer. Inorganic therapeutic...
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6306491 |
Respiratory aids
The present invention is directed to materials that assist respiration of living cells contained in cell-containing systems. The materials form air-filled conduits or channels through which gases,...
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6306845 |
Method for treating demyelinating disease
The present invention provides a method for treating a demyelinating disease in a subject which includes administering to the subject a therapeutically effective amount of a high affinity...
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6306423 |
Neurotoxin implant
A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer,...
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6306424 |
Foam composite for the repair or regeneration of tissue
The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition...
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6306420 |
Methods and apparatus for the delivery of solid drug compositions
The invention features an implantable device for the automatic delivery of an active ingredient according to an adjustable delivery profile. The device includes a housing; a reservoir operatively...
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6303138 |
Endothelin-based compositions for enhancing connective tissue repair
The present invention is directed to bioactive composition that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in...
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6299894 |
Drug delivery device, especially for the delivery of gestodene
The invention relates to a delivery device for the controlled release of the therapeutically active agent gestodene, over a prolonged period of time, at a release rate of 0,1-300 μg/day, said...
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6299898 |
Methods and compositions for the treatment of wounds
Devices and methods for enhancing the healing of wounds, especially chronic wounds (e.g., diabetic wounds), involving the use of keratinocytes are described. Keratinocytes are grown on a...
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6299893 |
Method to reduce hair loss and stimulate hair regrowth
This invention is a method for reduction of hair loss and stimulation of hair growth on the scalp of a human patient. The method comprises the step of administering a presynaptic neurotoxin into...
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6294190 |
Antiobestic agent containing procyanidin as the active ingredient
An antiobestic agent of the present invention having antiobestic effect, carbohydrase inhibitory effect, blood sugar increase inhibitory effect, monosaccharide absorption inhibitory effect, cholic...
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6294187 |
Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
A load-bearing osteoimplant, method of making the osteoimplant and method for repairing bone using the osteoimplant are provided. The osteoimplant comprises a shaped, compressed composition of bone...
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6291428 |
Peptides which promote bone-forming cell attraction and adhesion
Peptides are provided with the properties of enhancing the migration and adhesion of bone-forming cells to a substrate, useful for promoting bone mineralization and osseointegration in the healing...
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6287601 |
Topical nitric oxide donor compositions
Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID...
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6280957 |
Costimulatory blockade and mixed chimerism in allo-transplantation
Use of the blockade of costimulation and hematopoietic stem cells in allograft transplantation.
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6280760 |
Peptide-coated implants and methods for producing same
The invention describes the possibility of the biofunctionalization of biomaterials, in particular implants, by their made-to-measure coating with synthesized cell- or tissue-selective RGD peptides...
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6280744 |
Use of inorganic aerogels in pharmacy
The invention relates to the use of inorganic aerogels as an auxiliary and/or excipient for pharmaceutical active compounds and/or preparations.
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6277394 |
Collagen-polymer matrices with differential biodegradability
The current invention is a biomedical implant comprising a biomedical matrix material and a biodegradable porosifying agent. As the porosifying agent degrades in situ, an implant with an...
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6277390 |
UHMW polyethylene for implants
UHMW polyethylene for implants which are intended for a sterilization by means of γ rays or electron beams are doped with vitamin E during the manufacture, which binds off the free radicals faster...
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6270789 |
Base for suppository
The present invention provides a base for suppository comprising oily or fatty base and polyethlene. The suppository prepared by the use of the base of the present invention has superior heat...
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6267981 |
Method of producing sustained-release preparation
This invention provides a sustained-release preparation comprising a biodegradable polymer metal salt and broactive polypeptide, with enhanced entrapment of the bioactive polypeptides, a...
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6261585 |
Generating blood vessels with angiogenic material containing a biocompatible polymer and polymerizable compound
An angiogenic material is provided which promotes extensive vascularization when implanted in animal tissue. The angiogenic material contains a biocompatible polymer and a vascularizing...
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6262127 |
Polymeric matrices and their uses in pharmaceutical compositions
This invention provides pharmaceutical compositions comprising polymeric matrices, especially those comprising IL-6 as an active ingredient. Specific novel poly(ethylene carbomate) polymers are...
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6261586 |
Bone graft composites and spacers
A bone graft substitute including a composition of natural selectively deactivated bone material which has been processed to remove associated non-collagenous bone proteins, said bone material...
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6261583 |
Moldable solid delivery system
The invention provides an implant composition for sustained delivery of a biologically active agent. The implant composition includes a biologically active agent, a thermoplastic polymer, an...
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6258856 |
Method for preventing or controlling cataract
A method for preventing or treating pathological changes which occur in association with cataract formation in the mammalian eye by protecting lens cells against the cataractogenic effects of...
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6258371 |
Method for making biocompatible medical article
A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using...
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6253443 |
Method of forming a stent
Expandable intraluminal stents are provided as well their method of manufacture. These stents are made of metal, the metal characterized by a desired porosity, with a drug compressed into the pores...
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6251419 |
Membrane system for controlled tissue regeneration in cases of diseases of the periodontium
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6251137 |
Synthetic triglyceride filler material for surgically implanted prostheses
A filler material for a surgically implantable prosthesis comprised of a synthetic triglyceride having a viscosity substantially greater than that of naturally occurring triglycerides is provided....
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6248344 |
Composite and its use
A porous composite suitable for filling a recess or a through-passing hole in an implant. The composite includes particles A prepared from a bioactive material and particles B prepared from a...
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6245537 |
Removing endotoxin with an oxdizing agent from polyhydroxyalkanoates produced by fermentation
Polyhydroxyalkanoate (PHA) that contains a pyrogen such as endotoxin due to a process of producing the PHA is treated to remove the pyrogen by a process that does not affect the inherent chemical...
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6245057 |
Device for treating malignant, tumorous tissue areas
A device (1) functions for treating malignant, tumorous tissue areas. The device has at least one measuring sensor for determining chemical or physical signal patterns in the immediate vicinity of...
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6238688 |
Method for repairing blood vessel system
The present invention generally relates to thermally responsive polymer gel compositions that have enhanced temperature-dependent shrinking rates, increased strength, and improved pliability over...
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6238702 |
High load formulations and methods for providing prolonged local anesthesia
A formulation for inducing sustained local anesthesia in a patient comprising a substrate comprising a high load of local anesthetic by weight and an effective amount of a biocompatible, controlled...
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