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7361348 |
Immunogenic glycopeptides, screening, preparation and uses
The invention concerns immunogenic glycopeptides derived from pathogenic microorganisms, useful for vaccination and diagnosis of infections caused by said pathogenic microorganisms (bacteria or...
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7357936 |
Adjuvant systems and vaccines
The present invention provides vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed onto a particle of metal salt and the resulting...
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7341733 |
Compositions exhibiting ADP-ribosyltransferase activity and methods for the preparation and use thereof
Compositions characterized by ADP-ribosyltransferase activity are useful in promoting prophylactic and/or therapeutic responses as are promoted by, e.g., pertussis toxin but directed against...
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7320793 |
Molecular antigen array
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7294337 |
Use of Lactobacillus farciminis for the prevention or treatment of digestive pathologies
The invention relates to the use of lactic bacteria of the species Lactobacillus farciminis for the treatment or prevention of a pathology of the digestive tube, especially an acute or chronic...
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7291588 |
Immunogenic detoxified mutant E. coli LT-A toxin
An immunogenic detoxified protein is provided which comprises the amino acid sequence of subunit A of an E. coli heat labile toxin (LT-A) or a fragment thereof in which at least amino acid Ala-72...
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7244438 |
Uses for polycationic compounds
The invention relates to the use of a polycationic compound for the preparation of a medicament with retarded in vivo release.
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7204992 |
P153 and P156 antigens for the immunodiagnosis of canine and human ehrlichioses and uses thereof
Sequences encoding two immunoreactive glycoproteins were cloned from Ehrlichia canis (p153 gene) and Ehrlichia chaffeensis (p156 gene). These two glycoproteins are species-specific...
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7189557 |
Process for the intracellular over-production of streptokinase using genetically engineered strain of E. coli
An improved process for the production of streptokinase using a genetically engineered strain of Escherichia coli which overproduces streptokinase intracellularly and more particularly, the...
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7169399 |
Non-toxic double mutant forms of pertussis toxin as adjuvants
The invention relates to the use of an antigen which is a non-toxic double mutant form of pertussis toxin for the manufacture of a vaccine composition for intranasal administration to induce an...
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7163686 |
Protein A based binding domains with desirable activities
Provided are Staphylococcal protein A (SpA) variants for binding immunoglobulin (Ig), comprising a polypeptide which varies by one or more amino acids from the amino acid sequence of a natural...
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7160549 |
Methods for making compositions including gram negative microbial polypeptides
The present invention provides methods for making compositions including siderophore receptor polypeptides and porins from gram negative microbes. The methods include providing a gram negative...
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7157089 |
Immune responses using compositions containing stress proteins
The present invention relates to a vaccine for inducing an immune response to an antigen in a vertebrate (e.g., mammal) comprising an antigen and all or a portion of a stress protein or all or a...
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7153515 |
Method of preventing T cell-mediated responses by the use of the major histocompatibility complex class II analog protein (map protein) from Staphylococcus aureus
A method of immunomodulating the T cell response in Staphylococcal bacteria is provided wherein an effective amount of the Map protein from Staphylococcus aureus is administered to a host to...
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7132102 |
Bacteriocins and novel bacterial strains
Novel bacteriocins and/or the novel lactic acid-producing strains are used for at least reducing the levels of colonization by at least one target bacteria in animals, especially poultry.
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7118749 |
Transferrin receptor genes
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic...
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7105317 |
Immunogenic compositions comprising vrg-gene products from Bordetella extracts
This invention relates to an immunogenic composition comprising a bacterial extract containing at least one expression products of the vrg genes of a strain of Bordetella chosen from B....
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7097845 |
Combinations of antigen and mucosal binding component for inducing specific immunological tolerance
This invention provides combinations of a tolerance-inducing antigen such as insulin and a mucosal binding component that preferably binds ganglioside GM1. The components are present in a...
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7090853 |
Noscapine derivatives as adjuvant compositions and methods of use thereof
An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines.
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7083798 |
Method of immunomodulatory treatment of insulin dependent diabetes mellitus using mycobacterial cell wall compositions
The present invention relates generally to a method of immunomodulating therapy and pharmaceutical compositions useful for same. More particularly, the present invention provides a method of...
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7070781 |
Nontoxic mucosal adjuvant
A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic...
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7067639 |
Method to provide bacterial ghosts provided with antigens
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
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7056521 |
Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E....
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7030094 |
Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and QS-21
The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising RC-529 (an aminoalkyl glucosaminide phosphate compound) and QS-21 (a...
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7014856 |
Ganglioside-KLH conjugate vaccines plus OS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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7011836 |
Mutants of gram negative mucosal bacteria and application thereof in vaccines
It is possible to inactivate the early stage of lipid A synthesis of mucosal gram negative bacteria without compromising cell viability. In particular the lpxA gene in N. meningitidis was mutated...
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7001601 |
Ganglioside-KLH conjugate vaccine plus QS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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6967022 |
Ganglioside-KLH conjugate vaccines plus QS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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6936259 |
CAMP factor of Streptococcus uberis
The CAMP factor gene of Streptococcus uberis ( S. uberis ) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs,...
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6916476 |
Ganglioslide-KLH conjugate vaccine plus QS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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6896888 |
Treatment of papilloma virus infection using a mycobacterium
Disease cased by papilloma virus is treated by applying an effective amount of Mycobacterium to the region of infection. Specifically, condylomata acuminata are caused by human papilloma virus...
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6890541 |
Method for enhancing production performance in an animal
The present invention provides methods for activating the immune systems of newborn animals and methods for enhancing the production performance of the animals. More particularly, the methods of...
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6846488 |
Chimeric antigen-enterotoxin mucosal immunogens
The present invention provides methods of inducing immune responses by recombinant antigen-enterotoxin chimeric mucosal immunogens that contain the A2/B subunits of cholera toxin or heat-labile...
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6827940 |
Immune-stimulating bacterial cell wall extracts
A method of obtaining a pharmacologically active extract of the cell walls of Gram-positive bacteria is disclosed. The method involves the treatment of the bacteria with acid such that the...
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6818221 |
Adjuvants and processes to induce a specific type of immune response
Porphyromanas gingivalis LPS elicits a Th2 immune response. P. gingivalis LPS, detoxified P. gingivalis LPS, derivatives of P. gingivalis LPS, derivatives of detoxified P. gingivalis LPS, ...
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6811788 |
Combinations and methods for treating neoplasms
Methods for treating neoplasms, tumors and cancers, using one or more haptens and coagulation agents or treatments, alone or in combination with other anti-neoplastic agents or treatments, are...
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6806253 |
Immunodulatory complex and use thereof in helicobacter diseases
A therapeutical vaccine complex having activity specific for Helicobacter bacteria as well as non-specific immunomodulation activity for regulating the natural defenses of the body. The drug is...
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6790450 |
Use of coxiella bacteria to treat autoimmune disease
Therapeutic compositions including a species of Coxiella or one or more antigenic components therefrom or analogous or homologous components thereof are disclosed. These compositions are useful in...
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6790446 |
Campylobacter vaccine
The present invention relates to vaccines comprising antiserum raised against a flagellaless Campylobacter strain for the prevention of Campylobacter colonization in animals. The invention also...
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6780420 |
Carrier protein having an adjuvant effect, immunogenic complex containing it, process for their preparation, nucleotide sequence and vaccine
The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40...
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6750028 |
Anti-fibrotic agent assay
A novel method has been developed for screening anti-scarring and anti-fibrotic agents. This method offers simplicity, it is reproducible and could be adopted to screen large numbers of new...
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6743430 |
Multicomponent vaccine containing clostridial and non-clostridial organisms in a low dose
Disclosed herein is a multicomponent low dose vaccine comprising a safe and immunogenically effective combination of a protective antigen component or components of clostridial organism, a...
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6726913 |
Treatment of dermal tumors, warts, and viral infections of the respiratory tract in humans using heat-killed P. acnes
Heat-killed, terminally sterilized saline suspensions of Propionibacterium acnes, Propionibacterium avidum, Propionibacterium lymphophilum, Propionibacterium granulosum, Cornynebacterium parvum, ...
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6723832 |
Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof
The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
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6723327 |
Methods and compounds for the treatment of immunologically-mediated diseases using mycobacterium vaccae
Methods for the prevention and treatment of disorders, including disorders of the skin and respiratory system, such as infection with mycobacteria such as M. tuberculosis or M. avium ,...
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6685935 |
Vectors for the diagnosis and treatment of solid tumors including melanoma
The present invention is directed to the isolation and use of super-infective, tumor-specific vectors that are strains of parasites including, but not limited to bacteria, fungi and protists. In...
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6660267 |
Prevention and treatment of sepsis
Compositions and methods are described for preventing and treating sepsis in humans and animals. Surgical patients, low birth weight infants, and burn and trauma victims can be treated...
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6649170 |
Adjuvant combinations for immunization composition and vaccines
A kit useful for immunization is described. The kit contains an antigenic substance from a Mycobacterium and an adjuvant combination of dimethyl dioctadecyl ammonium bromide and monophosphoryl...
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6638518 |
Method for inhibiting inflammatory responses
The present invention provides methods for treating at least one symptom of an inflammatory response in a mammal by administering a polypeptide to the mammal. The polypeptide can be a microbial...
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6632440 |
Methods and compounds for the treatment of mucus hypersecretion
A method of treating mucus hypersecretion, the causative factor in chronic obstructive pulmonary disease (COPD), asthma and other clinical conditions involving COPD, comprises administering a...
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