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7368119 |
Compositions and methods for WT1 specific immunotherapy
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
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7285282 |
Mucin peptide with immunoenhancing properties
An isolated peptide or polypeptide containing the sequence VSIGLSFPMLP (SEQ ID NO:1), found in the secreted form of human MUC1, that enhances an immune response when administered to a mammal,...
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7279172 |
Treatment of autoimmune conditions with copolymer 1 and related copolymers
The present invention provides heteropolymer compositions and peptide compositions, and methods of making and using therapeutic compositions comprising amino acid heteropolymers for treatment of a...
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7270808 |
Cyclodextrin-based polymers for therapeutics delivery
The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical...
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7255868 |
Chimeric immunomodulatory compounds and methods of using the same—I
The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
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7244438 |
Uses for polycationic compounds
The invention relates to the use of a polycationic compound for the preparation of a medicament with retarded in vivo release.
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7220717 |
Interleukin-18 binding proteins, their preparation and use
Interleukin-18 binding proteins which are capable of binding IL-18 and of modulating and/or blocking IL-18 activity are provided. Methods for the isolation and recombinant production, DNAs encoding...
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7217781 |
Polyphosphazenes including ionic or ionizable moieties and fluorine-containing moieties
A polyphosphate polymer which includes both (i) ionic or ionizable moieties; and (ii) fluorine-containing moieties. Such polymers may be used as matrices for pharmaceuticals, as multilayer coatings...
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7166302 |
Complexing agents for compositions containing inclusion complexes
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the...
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7141246 |
Lubricious coating
A lubricant coating vehicle for medical devices used to reduce the coefficient of friction of such devices upon exposure thereof to moisture. The lubricant coating vehicle allows the introduction...
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7115579 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
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7105495 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
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7105162 |
Pharmaceutical composition for immunomodulation based on peptides and adjuvants
Pharmaceutical composition containing at least one peptide or protein (fragment) with an immunomodulatory activity together with an adjuvant. The peptide is derived from a pathogenic agent or a...
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7087236 |
Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
A method of inducing either a T H 1 polarized immune response, a T H 2 polarized immune response or a combined T H 1 and T H 2 response to an antigen and associated vaccine formulations are...
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7081495 |
Cationic compounds and their use as macro molecular carriers
Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C 6-24 -alkyl group containing α-amino acyl groups,...
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7029755 |
Silane copolymer compositions containing active agents
The invention is drawn to silane copolymers prepared from the reaction of one or more polyisocyanates with one or more lubricious polymers having at least two functional groups, which may be the...
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7014856 |
Ganglioside-KLH conjugate vaccines plus OS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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7001601 |
Ganglioside-KLH conjugate vaccine plus QS-21
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
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6870012 |
Chain-extended peo/ppo/peo block copolymer, optionally with polyester blocks, combined with cellular or bioactive material
A composition exhibiting reverse thermal gellation properties comprises a block polymer having the structure:
{[A n (BCB)A n ]} m...
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6844001 |
Adjuvants and copolymer compositions
The present invention comprises novel polyoxyethylene/polyoxypropylene block copolymer compositions and compounds. The compositions comprise block copolymers that are high molecular weight...
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6656459 |
Compositions of non-ionic block copolymers to treat autoimmune and inflammatory diseases, and to reduce graft/implantation, and methods of use thereof
Compositions comprising non-ionic block copolymers are useful for the treatment of autoimmune, inflammatory and proliferative diseases and for reducing graft/implantation rejection. The present...
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6649170 |
Adjuvant combinations for immunization composition and vaccines
A kit useful for immunization is described. The kit contains an antigenic substance from a Mycobacterium and an adjuvant combination of dimethyl dioctadecyl ammonium bromide and monophosphoryl...
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6610310 |
Polyanionic polymers as adjuvants for mucosal immunization
Mucosal adjuvants for vaccines contain water-soluble polyanionic polymers which have anionic constitutional units obtained from acids such as acrylic acid, methacrylic acid, maleic acid, fumaric...
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6596278 |
Immunological response potentiation process
An immunological response potentiation process is disclosed for synthetic or genetically engineered antigens having low immunogenicity. The antigen is embedded into biodegradable microparticles,...
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6572867 |
Inhibition of xenoreactive antibodies
One aspect of the present invention relates to methods and compositions for attenuating xenograft rejection by administering, to an animal receiving the xenograft, an amount of a...
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6528058 |
Saponin adjuvant composition
Art adjuvant composition for stimulating an effective immune resposne to an antigenic substance when co-administered to an animal with said antigenic substance, comprising: (a) a saponin with...
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6524586 |
Enhancement of oligomeric viral immunogenicity
A method and structure for forming a viral-physiological structure. A naked virus having a capsid is provided. A linker molecule having a covalently attached polymer is covalently bonded to the...
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6512072 |
Fast cure film forming formulation
A formulation for depositing a film on a substrate comprising 5 to79.9 wt. % of an alkylene trialkoxy terminated polysiloxane; 0.01 to 5 wt. % of a catalyst; 20 to 94.99 to wt % of a volatile...
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6471968 |
Multifunctional nanodevice platform
The present invention relates to novel therapeutic and diagnostic arrays. More particularly, the present invention is directed to dendrimer based multifunctional compositions and systems for use in...
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6458355 |
Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
Provided are methods for treating inflammatory diseases in a patient comprising administering to the patient an effective amount of a conjugate consisting essentially of one or more antibody...
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6447777 |
Polymerized staphylococcal protein a for treatment of diseases
Polymers and polymer conjugates comprising crosslinked Staphylococcal protein A, or crosslinked protein A-superantigen, or crosslinked functional derivatives thereof ranging in size from 12kDa to...
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6416947 |
Vaccine adjuvant and vaccine method
The present invention includes novel polyoxyethylene/polyoxypropylene block copolymers as well as methods for making the block copolymers. The block copolymers are high molecular weight molecules...
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6375951 |
Therapeutic suppression of specific immune response by administration of oligomeric forms of antigen of controlled chemistry
The invention features a non-immunogenic construct for reducing a non-primary antibody response to an epitope of a T-dependent antigen. The construct is free of high molecular weight...
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6340464 |
Adjuvants for vaccines
Vaccine adjuvants comprising a liquid medium contain polymers with anionic constitutive repeating units and hydrophobic constitutive repeating units. Advantageously, the adjuvants are aqueous...
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6340461 |
Superantigen based methods and compositions for treatment of diseases
The present invention relates to therapeutic methods and compositions employing superantigens. Methods and compositions employing superantigens and immunotherapeutic proteins in combination with...
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6299881 |
Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
A method for producing a conjugate vaccine includes mixing a uronium salt reagent with a first moiety (e.g., a polysaccharide). According to the invention, the uronium salt reagent has a chemical...
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6290962 |
Urease-based vaccine and treatment for helicobacter infection
Method of eliciting in a mammalian host a protective immune response to Helicobacter infection and treatment of Helicobacter infection by administering to the host an immunogenically effective...
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6287854 |
Diagnosis of susceptibility to cancer and treatment thereof
A method for determining the susceptibility of a patient to cancer comprising the steps (i) obtaining a sample containing nucleic acid derived from the patient; and (ii) contacting the said nucleic...
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6258362 |
Stabilization of herpes virus preparations
Stabilized dried pharmaceutical compositions dispersible in aqueous liquid or injection comprise (i) virus e.g. for use as a vaccine or vector, preferably a herpesvirus, e.g. attenuated or...
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6245752 |
Compositions and methods for tolerization in immune complex-mediated disease progression
Methods and compositions are provided for tolerizing shed antigen-specific B cells involved in an immune complex-mediated disease progression. The composition comprises a substantially...
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6228374 |
Peptides with immunomodulatory effects
Novel homodimers that include cysteine-containing peptides having 4-15 amino acid residues can be administered to modulate the immune response in an animal.
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6207171 |
Polyphosphazene microspheres
A soluble polyphosphazene polyelectrolyte immunoadjuvant is disclosed. In one embodiment, the polymeric adjuvant is poly[di(carboxylatrophenoxy)phosphazene] which is in the form of a microsphere...
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6149922 |
Vaccine adjuvant and vaccine
The present invention includes novel polyoxyethylene/polyoxypropylene block copolymers as well as methods for making the block copolymers. The block copolymers are high molecular weight molecules...
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6149911 |
Method for enhancing the immunogenicity of an immunogenic compound or hapten, and use thereof for preparing vaccines
The present invention relates to a process for improving the immunogenicity of an immunogen, an antigen or a hapten, when it is administered to a host, independently of the mode of administration,...
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6139862 |
Pharmaceutical dipeptide compositions and methods of use thereof
Methods are provided for the therapy of immunodeficient, immunodepressed or hyperactive immune states and for the prevention and treatment of opportunistic infections in such states comprising...
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6113902 |
Immunogenic compositions comprising peptides from β-2-microglobulin
An immunogenic composition for treating and/or preventing infectious diseases where the infectious agent has at least one intracellular phase in the host during its multiplication cycle, is...
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6093699 |
Method for gene therapy involving suppression of an immune response
A method for specifically suppressing the capacity of a mammal receiving gene therapy to mount an immune response to a given expressed gene of the deficient gene in question, which response is...
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6017537 |
Formyl methionyl peptide vaccine adjuvant
The present invention relates to immunological adjuvants comprised of the N-formyl methionyl peptide fMLP. FMLP, when used as an adjuvant in accordance with the present invention, provides for an...
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6015563 |
Polyphosphazene polyelectrolyte immunoadjuvants
A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or...
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5998588 |
Interactive molecular conjugates
The combination of the capabilities of stimuli-responsive components such as polymers and interactive molecules to form site-specific conjugates which are useful in a variety of assays,...
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