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7387894 |
Recombinant viral-based malaria vaccines
The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based...
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7381807 |
Immunostimulatory oligonucleotides and uses thereof
Oligonucleotides containing the non-palindromic sequence motif:
X 1 X 2 X 3 X 4 X 5 X 6 X 7 X 8 ,
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7378096 |
Stress protein compositions and methods for prevention and treatment of cancer and infectious disease
Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or...
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7374765 |
Methods and compositions for diagnosis and treatment of iron misregulation diseases
Methods and compositions are provided for the diagnosis and treatment of iron misregulation diseases, including HFE polypeptides, agonists, and antagonists, and transferrin receptor agonists and...
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7371734 |
Oligonucleotide compositions and their use for the modulation of immune responses
The present invention relates to 3′-OH, 5′-OH polynucleotide sequence compositions and methods for activating an immune response in an individual, and more preferably, for activating antigen...
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7371395 |
Vaccine formulations
The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified or...
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7371392 |
Cd40 ligand adjuvant for respiratory syncytial virus
The present invention provides methods and adjuvants for enhancing an immune response to RSV in a host, wherein the methods and adjuvants comprise a source of a CD40 binding protein. Preferably,...
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7368119 |
Compositions and methods for WT1 specific immunotherapy
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
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7365172 |
Loop peptide and TGFα for stimulating stem cell proliferation and migration
There is disclosed a novel genus of small peptides, much smaller than human TGFα, was discovered as having TGFα biological activity and therefore are useful as pharmacologic agents for the same...
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7361348 |
Immunogenic glycopeptides, screening, preparation and uses
The invention concerns immunogenic glycopeptides derived from pathogenic microorganisms, useful for vaccination and diagnosis of infections caused by said pathogenic microorganisms (bacteria or...
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7361331 |
Plant bioreactors
A plant expressing a cytokine and an autoantigen is disclosed. An example of a cytokine is a contra-inflammatory cytokine, for example IL-4 and IL-10, and an example of autoantigen is GAD. A novel...
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7357936 |
Adjuvant systems and vaccines
The present invention provides vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed onto a particle of metal salt and the resulting...
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7351435 |
Deglycosylated ricin toxin a-chain vaccine
The present invention relates to a vaccine comprising deglycosylated ricin toxin A-chain and method for making and using the composition.
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7351413 |
Stabilized HBc chimer particles as immunogens for chronic hepatitis
A method of treating chronic hepatitis B is disclosed that comprises administering a T cell-stimulating amount of a vaccine to a patient. The vaccine comprises an immunogenic amount of chimeric,...
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7341733 |
Compositions exhibiting ADP-ribosyltransferase activity and methods for the preparation and use thereof
Compositions characterized by ADP-ribosyltransferase activity are useful in promoting prophylactic and/or therapeutic responses as are promoted by, e.g., pertussis toxin but directed against...
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7335637 |
Biglycan and related therapeutics and methods of use
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with...
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7335354 |
Methods for the reduction of malignant tumors by an eosinophil/helminth therapy
The invention is a method of reducing malignant tumor sizes in mammals by eliciting activated eosinophils to infiltrate the tumor by using helminth excretory and secretory antigens, helminth ova,...
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7329410 |
Compositions and method for WT1 specific immunotherapy
A method for enhancing or inducing an immune response to WT1 is disclosed. In particular, the method comprises administering to a patient an immunogenic composition comprising an isolated...
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7323183 |
Vaccine compositions including chitosan for intranasal administration and use thereof
There is provided vaccine compositions for intranasal administration, which compositions comprise one or more antigens and an effective adjuvant amount of a chitosan.
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7323182 |
Oil in water emulsions containing saponins
The present invention relates to an oil in water emulsion vaccine composition. In particular, the present invention relates to a vaccine adjuvant formulation based on oil in water emulsion...
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7320793 |
Molecular antigen array
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7314627 |
Cationic lipid-mediated enhancement of nucleic acid immunization of cats
The present invention relates to a method to introduce a nucleic acid molecule into a felid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of...
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7314626 |
Use of peptide vectors to improve the immune response to antigens
The invention relates to conjugates of an antigen coupled to a linear derivative of a β-stranded antibiotic peptide, which are useful for immunogenic agents to enhance a CTL response. Two groups...
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7297761 |
Pharmaceutical compositions containing exendins
Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist,...
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7291588 |
Immunogenic detoxified mutant E. coli LT-A toxin
An immunogenic detoxified protein is provided which comprises the amino acid sequence of subunit A of an E. coli heat labile toxin (LT-A) or a fragment thereof in which at least amino acid Ala-72...
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7288261 |
Mid-life vaccine and methods for boosting anti-mycobacterial immunity
Vaccine compositions for boosting immunity to mycobacteria when administered in mid-life in a subject who has been vaccinated neonatally or in early childhood with BCG and in whom protective...
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7285289 |
Nanoparticle vaccines
The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed...
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7285282 |
Mucin peptide with immunoenhancing properties
An isolated peptide or polypeptide containing the sequence VSIGLSFPMLP (SEQ ID NO:1), found in the secreted form of human MUC1, that enhances an immune response when administered to a mammal,...
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7279172 |
Treatment of autoimmune conditions with copolymer 1 and related copolymers
The present invention provides heteropolymer compositions and peptide compositions, and methods of making and using therapeutic compositions comprising amino acid heteropolymers for treatment of a...
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7273615 |
Reaction solution for cell-free protein synthesis, method of preparing the same, and protein synthesis method using the same
The present invention provides a cell-free protein synthesis method characterized by a cell-free protein synthesis reaction solution that is weakly reducing and suitable for protein folding,...
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7270820 |
CD4+ T-lymphocyte-specific hepatitis C virus epitopes
The invention relates to hepatitis C virus epitopes which are CD4 + T-lymphocyte specific, and to vaccines containing these epitopes.
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7267822 |
Cytomodulating lipophilic peptides for modulating immune system activity and inhibiting inflammation
Novel oligonucleotides comprising a sequence derived by a computer program are provided for inhibiting cytotoxic activity of lymphocytic cells, inhibiting production of inflammatory cytokines and...
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7262014 |
Immune responses against HPV antigens elicited by compositions comprising an HPV antigen and a stress protein or an expression vector capable of expression of these proteins
This document describes compositions and methods for inducing an immune response (e.g., a cellular response such as a cell-mediated cytolytic immune response) to a human papillomavirus (HPV)...
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7259136 |
Compositions and methods for treating peripheral vascular disease
The present invention relates to methods of treating intermittent claudication comprising administering glucagon-like peptide-1 (GLP-1) molecules to subjects suffering therefrom.
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7244818 |
Interferon alpha responsive protein
The present invention relates to identification of a gene upregulated by interferon-α administration corresponding to the cDNA sequence set forth in SEQ ID NO: 1. Determination of expression...
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7244438 |
Uses for polycationic compounds
The invention relates to the use of a polycationic compound for the preparation of a medicament with retarded in vivo release.
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7244425 |
Acid- and bile salt-resistant Lactobacillus isolates having the ability to lower and assimilate cholesterol
Disclosed are acid- and bile salt-resistant Lactobacillus isolates having the ability to lower cholesterol. The present Lactobacillus isolates or their sub-cultured offspring or mutants derived...
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7244412 |
Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood...
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7241867 |
Polypeptide encoded by a nucleotide sequence of a nontypeable strain of Haemophilus influenzae genome
The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also...
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7229818 |
Formulations to increase in vivo survival of probiotic bacteria and extend their shelf-life
Disclosed is a formulation for preserving the life of probiotic bacteria during passage through the stomach, while permitting their release in the intestine, and which has a low water activity and...
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7229646 |
Methods and compositions for modulating immune response and for the treatment of inflammatory disease
Compositions and methods for treating inflammatory disease and for modulating the immune system are described. The compositions and methods pertain to the use of a combination of...
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7229628 |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is...
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7229621 |
Method to enhance the immunogenicity of an antigen
The present invention is related to a method for enhancing the immunogenicity of an antigen in a mammal by introducing into the mammal an antigen or a portion thereof and administering to the...
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7223739 |
Adjuvanted genetic vaccines
Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for...
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7223391 |
Method for treating mammals with modified mammalian blood
An improved method for treating or preventing a pathological condition in a mammalian subject in which modified mammalian blood is administered to the subject. The method comprises administering to...
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7217700 |
Chemokines as adjuvants of immune response
Dendritic cells play a critical role in antigen-specific immune responses. Materials and methods are provided for treating disease states, including cancer and autoimmune disease, by facilitating...
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7214788 |
Insect inhibitory Bacillus thuringiensis proteins, fusions, and methods of use therefor
Novel insect inhibitory proteins are disclosed comprising two different components, both of which are required for biological activity. Various methods of linking both components together, so that...
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7208167 |
Treatment of hepatitis C with thymosin and peptide combination therapy
A method and pharmaceutical combination for treating hepatitis C by administering to a hepatitis C patient an effective amount of at least one alpha thymosin peptide, in combination with...
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7195763 |
Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences...
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7192927 |
Peptides
Isolated peptides that are fragments of protein products arising from frameshift mutations in genes associated with cancer are disclosed. The isolated peptides of the invention are capable of...
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