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6602709 |
Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells
This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells....
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6596485 |
Green fluorescent protein fusions with random peptides
The invention relates to the use of fluorescent proteins, particularly green fluorescent protein (GFP), in fusion constructs with random and defined peptides and peptide libraries, to increase the...
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6596278 |
Immunological response potentiation process
An immunological response potentiation process is disclosed for synthetic or genetically engineered antigens having low immunogenicity. The antigen is embedded into biodegradable microparticles,...
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6592844 |
Preparation of protein microspheres, films and coatings
A process is described for preparing microspheres, films and coatings from protein or modified protein in which the protein product is stabilized by carrying out the preparation in the presence of...
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6590076 |
Compositions for the treatment and diagnosis of breast cancer and methods for their use
Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor antigen. Vaccines...
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6572867 |
Inhibition of xenoreactive antibodies
One aspect of the present invention relates to methods and compositions for attenuating xenograft rejection by administering, to an animal receiving the xenograft, an amount of a...
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6572866 |
Nerve growth factor as a vaccine adjuvant
A vaccination method utilizes a pharmaceutical combination for enhancing vaccine effectiveness. The method utilizes an immune response-triggering vaccine capable of stimulating production in an...
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6566386 |
Immunomodulating and antiinflammatory agent
In the present invention, pharmaceutical compositions containing a histamine-added gamma-globulin as an effective component are used as an immunomodulating agent, a suppressive agent for...
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6565858 |
Human ADAMTS-1 protein and pharmaceutical composition
A human ADAMTS-1 protein, a gene encoding the same, a pharmaceutical composition containing the protein as an active ingredient, and a method for immunologically analyzing the human ADAMTS-1...
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6562347 |
Chemokine-tumor antigen fusion proteins as cancer vaccines
The present invention provides a fusion polypeptide comprising a chemokine and either a tumor or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune...
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6558670 |
Vaccine adjuvants
The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an...
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6555346 |
Protein expression in baculovirus vector expression systems
The invention relates to a method to increase protein expression in baculo vector virus expression systems. The invention provides a method to produce a recombinant protein in insect-cell culture...
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6551600 |
Immunological adjuvant compounds compositions and methods of use thereof
The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant...
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6544518 |
Vaccines
The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an...
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6544529 |
Isolated strains of Staphylococcus aureus and vaccines manufactured therefrom
The invention provides antigenic compositions for the vaccination of an animal against bovine mastitis caused by infection with Staphylococcus aureus. The invention also provides methods for...
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6541000 |
Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response
A method for generating antigen-sensitized Ig-A-producing lymphoblasts in a mammal, using an immunogen comprising an antigen or antigen mixture in association with hydroxylated calcium phosphate...
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6540999 |
Immunomodulatory methods using Lewisx oligosacchardies
Methods for modulating immune responses are provided. The methods involve contacting an immune cell with an agent that modulates interaction of a compound comprising a Lewis antigen with the immune...
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6537552 |
Vaccine adjuvant
The invention features fusion agents such as fusion proteins that are useful for the treatment of and prevention from diseases that are susceptible to the effects of cellular (Th1 type) immune...
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6534067 |
Rotavirus enterotoxin adjuvant
This invention relates to a method of potentiating an immune response by administering a viral enterotoxin or derivative as an adjuvant. More particularly it relates to administering a viral...
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6534036 |
Biological materials and methods useful in the diagnosis and treatment of diseases
The present invention relates to a method of making a β-form of a prion protein which preferably has more β-sheet than α-helix structure and is soluble in the absence of a denaturant and/or is...
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6528058 |
Saponin adjuvant composition
Art adjuvant composition for stimulating an effective immune resposne to an antigenic substance when co-administered to an animal with said antigenic substance, comprising: (a) a saponin with...
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6528051 |
Methods and compositions for enhancing immune response
The methods and compositions of the present invention are directed to enhancing an immune response and increasing vaccine efficacy through the simultaneous or sequential targeting of specific...
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6528065 |
Attenuated dengue-3 virus vaccine
The present invention provides immunogenic compositions of attenuated dengue-1 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides...
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6524587 |
Hyperthermia and immunotherapy for leukemias lymphomas, and solid tumors
An improved method of inducing whole-body hyperthermia and enhanced anti-tumor immune response through inoculation of a fever virus with nil mortality and subsequent injection of irradiated tumor...
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6524584 |
Saponin compositions and uses thereof
The present invention is in the field of medicinal chemistry. In particular, the invention is related to vaccines comprising novel combinations of saponin adjuvants, to pharmaceutical compositions...
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6524592 |
Veterinary vaccines
The invention relates to vaccines which are suitable for the prevention of clostridial diseases of sheep (and lambs), providing an effective immunity for up to a year or more following a single...
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6524586 |
Enhancement of oligomeric viral immunogenicity
A method and structure for forming a viral-physiological structure. A naked virus having a capsid is provided. A linker molecule having a covalently attached polymer is covalently bonded to the...
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6514503 |
Antigen delivery system
Adjuvants for administration, particularly for mucosal administration, of an antigen, are described, as well as compositions comprising the described adjuvant in combination with an antigen and a...
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6506384 |
Early detection of mycobacterial disease
A number of protein and glycoprotein antigens secreted by Mycobacterium. tuberculosis (Mt) have been identified as “early” Mt antigens on the basis early antibodies present in subjects...
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6506386 |
Vaccine comprising an iscom consisting of sterol and saponin which is free of additional detergent
The present invention provides an improved adjuvant formulation and a process for producing said adjuvant. The adjuvant comprises an ISCOM structure comprising a saponin, said ISCOM structure being...
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6495521 |
Combination therapy method for treating chronic hepatitis B
The present invention is aimed at augmenting the success rate of using thymosin in treatment of chronic hepatitis B, by employing a combination therapy using thymosin with antiviral agents which...
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6491921 |
Avian polyomavirus vaccines in psittacine birds
The invention provides a nucleic acid vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order comprising a...
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6491914 |
Anti-idiotypic monoclonal antibodies, their use in the active immunotherapy of malignant tumors, and compositions including the anti-idiotypic monoclonal antibodies
An anti-idiotypic monoclonal antibody that is specific against the N-glycolyl residues of gangliosides, particularly those expressed by cancer cells. The monoclonal antibody is useful as an...
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6491925 |
Compositions and methods for cancer prophylaxis and/or treatment
Disclosed are compositions and methods to generate a protective or therapeutic immune response to neoplastic cells (e.g., tumor cells) which, in nature, lack a CoCAM surface molecule essential for...
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6488936 |
Immunogenic composition of interleukin-12 (IL-12), alum, herpes simplex viral (HSV) antigen, and method thereof
This invention pertains to vaccine compositions comprising a mixture of antigen, such as a herpes simplex virus antigen, and the interleukin IL-12, which may be adsorbed onto a mineral in...
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6482925 |
Mutants of the LAG-3 proteins and nucleotides encoding LAG-3 mutants
The invention concerns a purified polypeptide corresponding to a mutated form of the soluble LAG-3 protein or of one of its fragments comprising the extra-cellular domain D1 and D2.
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6471966 |
Type 1 and type p fimbriae-adhesins isolated from novel e. coli strains, process for their preparation and uses thereof
Fimbriae adhesins have a molecular weight of 2×10 5 and 2×10 7 Da, and are comprised of 90-95% protein and 1-3% sugar. Type 1 fimbriae include five different protein fractions of 14-20 kDa,...
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6464976 |
Methods and compositions for reducing immune response
The present invention provides an apparatus and method to diminish the pre-existing immune response to the administration of a therapeutic virus by the selective elimination of antiviral antibodies...
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6458369 |
Composition comprising tumor cells and extracts and method of using thereof
The present invention is directed to compositions containing hapten-modified tumor cells and extracts and methods of treating cancer by administering a therapeutically effective amount of a...
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6458367 |
Method for detecting the presence of a mycobacterium species and a kit and antibodies for use therein
The invention relates to a diagnostic test for the detection and identification of Mycobacterium species in biological specimens of human and animal origin. The test is based on the immunological...
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6455050 |
Production of virus and purfication of viral envelope proteins for vaccine use
Immunogenic envelope glycoproteins are produced from enveloped virus, such as of the paramyxoviridae family, particularly PIV-3 and RSV, by culturing the virus in the substantial absence of...
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6455046 |
Use of mCRP to enhance immune responses
The invention provides a method of enhancing an immune response to an immunogen in an animal. The method comprises administering to the animal an effective amount of the immunogen and an effective...
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6451325 |
Adjuvant formulation comprising a submicron oil droplet emulsion
An adjuvant composition, comprising a metabolizable oil and an emulsifying agent, wherein the oil and the detergent are present in the form of an oil-in-water emulsion having oil droplets...
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6451324 |
Ryegrass pollen allergen
The present invention provides a nucleic acid sequences coding for the ryegrass pollen allergens Lol pIa and Lol pIb, purified Lol pIa and Lol pIb protein and fragments thereof, methods of...
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6444210 |
Bacterial and synthetic polysaccharide immunomodulators that enhance general immunity
The present invention relates to the effects of bacterial polysaccharides on cell mediated immunity in animals. Polysaccharides of the present invention comprise the outer polysaccharides (OPS)...
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6444448 |
Production of β-glucan-mannan preparations by autolysis of cells under certain pH, temperature and time conditions
There is provided a method of production of an immunostimulatory β-glucan-mannan preparation, comprising the step of autolysis of cells of a microorganism at a pH of 5 to 6 and a temperature of 35...
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6440423 |
Mutant enterotoxin effective as a non-toxic oral adjuvant
Methods and compositions are provided herein for the se of a novel mutant form of E. coli heat-labile enterotoxin which has lost its toxicity but has retained its immunologic activity. This...
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6436367 |
Aerosol formulations for buccal and pulmonary application
A mixed micellar aerosol pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal lauryl sulphate, at least three micelle forming compounds, a phenol and a...
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6436411 |
Cancer treatment method
Treatment of tumors, including their metastases, is described. Retrieved cytokines and other molecules from the growth medium of human monocytes stimulated ex vivo with gamma globulin, or other...
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6436391 |
Use of interferon (IFN)-α8 and -α14 as vaccine adjuvants
The use of IFN-α subtypes as vaccine adjuvants is disclosed, together with vaccine compositions comprising them. Methods of vaccinating a subject comprising co-administration of IFN-α subtypes...
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