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6863896 |
Plant lectins as mucosal adjuvants
The invention provides a method of increasing an immune response in a mammal. The method involves administering to the mammal an admixture comprising an immunogen and a plant lectin. The plant...
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6852705 |
DNA vaccines for farm animals, in particular bovines and porcines
Improved vaccines or immunogenic or immunological compositions, and methods for making and using the same.
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6852324 |
Immunization for ebola virus infection
Ebola virus vaccines comprising nucleic acid molecules encoding Ebola viral proteins are provided. In one embodiment, the nucleic acid molecule encodes the transmembrane form of the viral...
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6849601 |
Peptides
The present invention relates to novel peptides and derivatives thereof useful as selective α 1 -adrenoceptor antagonists which ability of inhibiting the agonist action of agonist noradrenaline on...
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6846489 |
Vaccines containing a saponin and a sterol
A novel adjuvant composition comprising a sterol (e.g., cholesterol, β-sitosterol, stigmasterol, ergosterol, and ergocalciferol) and saponin fraction (e.g., QS 21, also known as QA 21 ) in the...
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6844000 |
Use of Parapox B2L protein to treat cancer and modify immune responses
A purified Parapoxvirus ovis envelope protein termed “B2L” can be used as a monotherapeutic agent. B2L protein also can be used in screening methods to identify potential therapeutic agents...
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6844001 |
Adjuvants and copolymer compositions
The present invention comprises novel polyoxyethylene/polyoxypropylene block copolymer compositions and compounds. The compositions comprise block copolymers that are high molecular weight...
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6841532 |
Peptides and their use to ameliorate cell death
There is disclosed novel peptides, fragments or analogues thereof and polynucleotides encoding the same, obtained from streptokinase suitable for use in the amelioration of cell death and methods...
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6833136 |
Vaccine for preventing pythiosis in humans and animals
The present invention provides antigen vaccines and methods of use thereof for the treatment of Pythium insidiosum infections, as well as prophylaxis against these infections, in humans and...
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6833275 |
Gold conjugates containing detergent
A composition which contains stabilized conjugates composed of colloidal particles and biomolecules is obtained by adding a detergent to a solution containing biomolecules before or/and during...
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6824793 |
Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants
Compositions are provided which include hyaluronic acid derivatives in combination with vaccine antigens, and optionally adjuvants, for mucosal delivery. Also provided are methods of making the...
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6815169 |
Identification and expression of a novel kinesin motor protein
The invention provides isolated nucleic acid and amino acid sequences of TL-γ, antibodies to TL-γ, methods of screening for TL-γ modulators using biologically active TL-γ, and kits for...
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6814971 |
Adjuvants for use in vaccines
The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local...
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6811780 |
Methods of using cytokine antagonists to treat HIV infection and AIDS
The invention is methods of using cytokine antagonists to treat HIV. In particular, the invention is methods of treating HIV using L-4 and IL-13 cytokine antagonists, including cytokine traps and...
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6811788 |
Combinations and methods for treating neoplasms
Methods for treating neoplasms, tumors and cancers, using one or more haptens and coagulation agents or treatments, alone or in combination with other anti-neoplastic agents or treatments, are...
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6809077 |
Cyclosporin analogs for the treatment of autoimmune diseases
The present invention relates to a cyclosporin analog of the following formula (I) or a pro-drug or pharmaceutically acceptable salt thereof: In particular, residue A maybe represented by either...
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6805869 |
Cellular vaccines and immunotherapeutics and methods for their preparation
The present invention provides a method for enhancing the immunogenicity of weakly immunogenic or non-immunogenic cells, resulting in a cellular vaccine that can stimulate T cell activation, which...
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6803035 |
Anti-diarrheal and method for using the same
A food product and method for treating and preventing diarrhea in a subject animal suffering from or susceptible to diarrhea. The method comprises administering an egg product to the subject animal...
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6803044 |
Antimicrobial and anti-inflammatory peptides for use in human immunodeficiency virus
The present invention is directed to a method and pharmaceuticals for treating HIV and secondary infection. One aspect of this invention involves the use of one or more polypeptides with an amino...
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6800291 |
Uro-genital condition treatment system
The present invention is directed to a Lys-Pro-Val dimer, formulations containing the dimer and dimer applicators. The Lys-Pro-Val dimer is an effective anti-pyretic, anti-inflammatory and...
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6800300 |
Method for treating autoimmune and alloimmune diseases
Disclosed is a method for treating a mammalian subject suffering from an autoimmune or alloimmune disease by administering to the subject a drug treatment which results in at least partial...
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6797480 |
Purification of heat shock/stress protein cell surface receptors and their use as immunotherapeutic agents
The present invention relates to receptors for heat shock proteins (HSPs), such as gp96, Hsp70 and Hsp90. The heat shock receptor is associated with the cell membranes of a subset of antigen...
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6797276 |
Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
A transcutaneous immunization system where the topical application of an adjuvant and an antigen or nucleic acid encoding for an antigen, to intact skin induces a ystemic or mucosol antibody...
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6797721 |
Phorboxazole derivatives for treating cancer
Synthetic Phorboxazole A and derivatives thereof for the treatment of cancer, including inhibition of cancer cell growth, induction of apoptosis, and inhibition of metastises.
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6790457 |
Compositions and methods for reducing or preventing fertilization in fish and birds
Disclosed is an immunocontraceptive vaccine composition comprising a teleost homolog of zona pellucida (TH-ZP), together with a pharmaceutically acceptable diluent or carrier, for reducing or...
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6790443 |
Method for treating symptoms of diabetes
The present invention provides a method for treating symptoms of diabetes in a diabetic subject which comprises administering to the subject a therapeutically effective amount of an agent which...
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6790450 |
Use of coxiella bacteria to treat autoimmune disease
Therapeutic compositions including a species of Coxiella or one or more antigenic components therefrom or analogous or homologous components thereof are disclosed. These compositions are useful in...
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6790661 |
System for detecting bacteria in blood, blood products, and fluids of tissues
The invention provides methods for screening for the presence of a clinically relevant amount of bacteria in donor blood or a blood product from a donor mammal, particularly blood or a blood...
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6787154 |
Artificial antigen presenting cells
The present invention is directed to artificial antigen presenting cells and methods of making artificial antigen presenting cells. Such artificial antigen presenting cells may be used in certain...
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6783764 |
Actinobacillus pleuropneumoniae subunit vaccine
The present invention relates to live attenuated bacteria of the genus Actinobacillus pleuropneumoniae that have a mutation in an apxIV gene such that no functional ApxIV toxin can be produced....
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6780420 |
Carrier protein having an adjuvant effect, immunogenic complex containing it, process for their preparation, nucleotide sequence and vaccine
The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40...
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6776993 |
Tuberculosis vaccine
The present invention relates to novel recombinant vaccines providing protective immunity against tuberculosis. Further, the present invention refers to novel recombinant nucleic acid molecules,...
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6773707 |
Heat shock protein-based vaccines and immunotherapies
The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to...
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6770260 |
Method preventing depletion of non-autologous hematopoietic cells and animal model systems for use thereof
The invention provides methods for preventing depletion of non-autologous hematopoietic cells. Animal model systems using the method are also provided as are methods of treatment using...
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6764682 |
Adjuvant compositions containing more than one adjuvant
Adjuvant compositions for modulating an immune response to an antigen administered to a host comprise a mineral salt adjuvant and at least one other adjuvant. The compositions provide an...
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6764688 |
Method for inducing immunosuppressive cells and a culture device to be used therefor
The present invention provides a method for inducing immunosuppressive cells by cultivating human cells with the use of a culture device having an affinity for protein and the culture device to be...
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6764845 |
Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and...
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6764689 |
High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications
A process for producing and purifying peptides and for producing peptide/protein antigens for antibody production is described. The process utilizes fusion proteins and specifically fusion proteins...
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6761914 |
Immunogenic formulations comprising oil bodies
The present invention provides novel adjuvants which comprise oil bodies. The invention also provides vaccine formulations comprising oil bodies and an antigen and methods for preparing the...
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6756044 |
Antigenic complexes and methods
The present invention provides a complex that includes a virion having a ligand that recognizes an epitope present on an immune effector cell surface and at least a first nucleic acid encoding a...
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6756038 |
Agonist and antagonist peptides of carcinoembryonic antigen (CEA)
The present invention relates to the preparation and use of peptides that act as agonists and antagonists of human carcinoembryonic antigen (CEA). Agonists of the CEA peptide, CAP1, are disclosed...
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6752996 |
Use of parapox PP30 protein to modify immune responses to administered antigens
The Parapox B2L virus envelope protein is used as an adjuvant to enhance a subject's response to an administered antigen. Both antibody and cellular immune responses can be modified. B2L protein is...
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6752995 |
Nucleic acid and polypeptide sequences useful as adjuvants
In the present invention parapox genomes were screened using a novel expression strategy to test genes for dendritic cell recruitment activity. One gene was identified, designated as B2WL, that...
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6746676 |
Chlamydia proteins and their uses
Certain Chlamydia proteins have been found to be infection-specific and to be associated primarily with the vegetative Reticulate Body form of Chlamydia rather than with the refractile Elementary...
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6746677 |
Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation
The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a...
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6737513 |
Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same
The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C-C chemokine designated Macrophage Derived Chemokine (MDC), and polypeptide...
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6737066 |
HIV immunogenic compositions and methods
The invention provides immunogenic compositions which enhance β-chemokine levels in a mammal. The immunogenic compositions contain an HIV antigen, an isolated nucleic acid molecule containing an...
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6733764 |
Immunostimulator anti-cancer compounds and methods for their use in the treatment of cancer
The present invention comprises a method for the treatment of cancerous tumors in mammals comprising the administration of an effective amount of an immunostimulator which enhances and potentiates...
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6733763 |
Induction of cytotoxic T-lymphocyte responses
Methods and compositions useful for inducing a cytotoxic T lymphocyte response (CTL) in a human or domesticated or agriculturally important animal. The method includes the steps of providing the...
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6723329 |
Use of parapox B2L protein to modify immune responses to administered antigens
The Parapox B2L virus envelope protein is used as an adjuvant to enhance a subject's response to an administered antigen. Both antibody and cellular immune responses can be modified. B2L protein is...
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