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5738852 |
Methods of enhancing antigen-specific T cell responses
Recombinant polynucleotides are provided that confer at least partial immunity on an individual to an infectious intracellular pathogenic agent. The recombinant polynucleotides encode a...
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5738848 |
Immunosuppressive compounds and method of preparing same
The present invention relates to compounds which have immunosuppressive effects in mammals. In particular, the invention provides a protein which suppresses allograph rejection in a mammalian...
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5736146 |
Conjugates of poorly immunogenic antigens and synthetic peptide carriers and vaccines comprising them
The invention relates to conjugates of poorly immunogenic antigens, e.g. peptides, proteins and polysaccharides, with a synthetic peptide carrier constituting a T cell epitope derived from the...
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5725850 |
Use of CSF-1 to treat tumor burden
A colony stimulating factor, CSF-1, is a lymphokine useful in treating or preventing bacterial, viral or fungal infections, neoplasms, leukopenia, wounds, and in overcoming the immunosuppression...
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5725864 |
Composition for suppressing infection and growth of human immunodeficiency virus
The invention relates to compositions and methods for inhibiting infection or suppressing growth of human immunodeficiency virus. The composition comprises, as an effective component, an...
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5718904 |
Adjuvants for viral vaccines
The present invention discloses mammalian vaccine compositions having an effective amount of an adjuvant, the adjuvant comprising squalene or squlane, glycerol and a surfactant. These compositions...
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5695761 |
Suppression of nitric oxide production by osteopontin
The present invention relates to compositions and methods for inhibition of the vasoactive and signal transduction agent nitric oxide (NO), and to therapeutic treatment of diseases or disorders...
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5696081 |
UVB-induced factor for immunosupression
The present invention comprises the method of selectively suppressing an immune response of a mammal to a particular alloantigen. The method includes several steps. One step is administering to a...
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5693760 |
Method of causing selective immunosuppression using HL-60 related lectins
Pharmaceutical compositions useful in the treatment of autoimmune conditions include as an active ingredient a soluble lectin having a molecular weight of about 14 kilodaltons or a fragment...
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5690934 |
Peptides relating to the extracellular membrane-bound segment of human alpha chain
The invention relates to unique extracellular peptide segments present on B cell-bound but not secreted IgA. These extracellular peptide segments form, entirely or in part, antigenic epitopes...
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5688507 |
Methods and compositions for inhibiting thrombogenesis
Thrombus or clot formation and accretion are inhibited by administering thrombin-displacing substances to a patient. The thrombin-displacing substances comprise either thrombin analogs which bind...
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5688511 |
Cellular protein TDP-43 and regulation of HIV-1 gene expression
Compositions including a polypeptide or nucleic acid sequence encoding a polypeptide that binds TAR DNA (particularly the region -18 to +28 of HIV-LTR DNA) and that does not bind to TAR RNA...
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5679355 |
Vaccines containing non-ionic surfactant vesicles
Non-ionic surfactant vesicles (NSIV) with entrapped antigen act as potent immunological adjuvants and can produce antibody titers of the same order of magnitude as those using Freund's Complete...
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5679354 |
Matrix with immunomodulating activity
The invention claims an iscom matrix which is not a lipid vesicle comprising at least one lipid and at least one saponim but no intentional antigenic determinants and optionally also adjuvants for...
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5679356 |
Use of GM-CSF as a vaccine adjuvant
The present invention is a method for enhancing the immune response of a mammal to a vaccine by administering to such a mammal an effective amount of GM-CSF in conjunction with a vaccine. The...
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5674495 |
Alginate-based vaccine compositions
A vaccine composition including an antigen dispersed in an alginate gel is described. The alginate gel is preferably in the form of discrete particles coated with a polymer. Vaccination of...
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5670157 |
Method for reducing and controlling immunoglobulin concentrations
The present invention provides a method for reducing and controlling antigen-specific immunoglobulin concentrations in a patient. In addition, the present invention provides a method for...
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5662911 |
Benzodiazepine protein conjugates
Benzodiazepine protein conjugates of the formula I ##STR1## wherein R1 is hydrogen, a methyl group or R, R2 is hydrogen, a hydroxyl or an OR group, with R1 or R2 containing an R group, R3 is a...
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5639852 |
Immunostimulatory agents
Compositions and methods are described for the synthesis of novel analogs of cyclosporin A, and the use of those analogs as immunostimulatory agents.
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5635175 |
Use of CSF-1 to treat viral infections
A colony stimulating factor, CSF-1, is a lymphokine useful in treating or preventing bacterial, viral or fungal infections, neoplasms, leukopenia, wounds, and in overcoming the immunosuppression...
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5632995 |
Method for stimulation of reproductive performance
The present invention relates to an immunostimulant composition and method of use that is effective for increasing reproductive performance in an animal or human. More particularly, the present...
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5616329 |
Spray-dried antigenic products
A method is described for preparing an antigenic product which incorporates exposing an aerosol of a microbial suspension to temperatures at which substantially only the heat stable components of...
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5614183 |
Use of CSF-1 to treat bacterial infections
A colony stimulating factor, CSF-1, is a lymphokine useful in treating or preventing bacterial, viral or fungal infections, neoplasms, leukopenia, wounds, and in overcoming the immunosuppression...
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5601828 |
CD8 derivatives and methods of use for cellular modulation and enhancement of cellular engraftment
Specific and nonspecific immunomodulation, enhancement of cellular engraftment, and modulation of nonimmune cells are achieved by using various membrane-binding and soluble CD8 compositions.
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5599788 |
Method for accelerating skin wound healing with H3 protein
A method of producing recombinant transforming growth factor β-induced H3 protein and the use of this protein to accelerate wound healing. H3 promoted adhesion of human dermal fibroblasts to...
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5597572 |
Method of producing Neisseria meningitidis B vaccine, and vaccine produced by method
A vaccine effective against infection caused by Group B Neisseria meningitidis microorganism is provided which comprises a purified protein antigenic complex weighing from 65 to 95 kDa, vesicles,...
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5597563 |
Method induction of antigen-specific immune tolerance
A method for inducing antigen-specific immune tolerance by depletion of resident thymic antigen presenting cells (APCs) and re-population of thymus with new APCs containing the antigen for...
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5591433 |
Oral administration of immunologically active biomolecules and other therapeutic proteins
An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and...
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5587166 |
Vaccine against Pasteurella
A vaccine against Pasteurella comprising a proteinaceous material isolated from Pasteurella grown under iron-restricted conditions, but not from Pasteurella grown under normal conditions in vitro,...
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5583112 |
Saponin-antigen conjugates and the use thereof
Saponin/antigen conjugates and the use thereof for enhancing immune responses in individuals are disclosed. The saponins may be substantially pure or mixtures of saponins.
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5580563 |
Multiple antigen peptide system having adjuvant properties, vaccines prepared therefrom and methods of use thereof
A multiple antigenic peptide system is disclosed that comprises a dendritic core and peptide and a lipophilic anchoring moiety. This particular combination has as an advantage that it eliminates...
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5569457 |
Method of stimulating antibody formation
A method and composition for the enhanced stimulation of antigenic response in animals and humans is disclosed. The method involves administering an effective amount of a compound of formula (I):...
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5565203 |
Hepatitis A virus in a reconstituted influenza virosome and use as a vaccine
Disclosed are immunostimulating reconstituted influenza virosomes (IRIVs) comprising reconstituted functional virus envelopes containing an inactivated hepatitis A virus and an influenza...
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5565548 |
Pre-S gene coded peptide hepatitis B immunogens and synthetic lipid vesicle carriers
A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine...
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5560914 |
Immunopotentiator and method of manufacturing the same
In a method of producing an immunopotentiator, a plant tissue material is extracted with hot water, the insoluble material is filtered, and the filtrate thereof is treated with glucoamylase to...
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5556620 |
Use of recombinant colony stimulating factor-1 to enhance wound healing
A colony stimulating factor, CSF-1, is a lymphokine useful in treating or preventing bacterial, viral or fungal infections, neoplasms, leukopenia, wounds, and in overcoming the immunosuppression...
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5554372 |
Methods and vaccines comprising surface-active copolymers
The present invention comprises adjuvants which, when admixed with an antigen and administered into a human or animal, will induce a more intense immune response to the antigen than when the...
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5547670 |
Recombinant hybrid porin epitopes
The present invention provides a polypeptide that is non-toxic in E. coli. The disclosed polypeptide comprises at least one antigenic sequence present in P.IA of N. gonorrhoeae and at least one...
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5543140 |
Method and use of IL-1α
Methods for stimulating immunity, inhibiting tumor growth, promoting production of a cytokine, and preventing or inhibiting radiation injury by administration of Interleukin-1α (IL-1α)...
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5527524 |
Dense star polymer conjugates
Dense star polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared....
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5519114 |
Retroviral superantigens, superantigen peptides, and methods of use
The subject invention concerns novel superantigen proteins and peptides and methods of use of these superantigens. Specifically exemplified are peptide agonists from mouse mammary tumor virus,...
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5512283 |
Methods for the selective suppression of an immune response to dust mite der Pi
The present invention provides novel compositions and methods useful in the modulation or selective suppression of host immune responses to an immunogen of interest, particularly to immunogens...
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5494895 |
Scorpion peptide margatoxin with immunosuppressant activity
A thirty-nine amino acid peptide, Margatoxin (MgTX), is purified to homogeneity from venom of the scorpion Centruroides margaritatus. The gene encoding MgTX is constructed and this gene is...
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5487895 |
Method for forming controlled release polymeric substrate
A method for forming a controlled release polymeric substrate is provided by contacting a polymeric substrate with a liquid mixture containing a cross-linking agent at least partially soluble...
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5484707 |
Assay for free secretory component and methods for monitoring organ rejection
Methods of monitoring and detecting the early onset of organ injury incident rejection of a organ rejection in an animal are disclosed. The described methods are capable of distinguishing organ...
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5480642 |
Synthetic immunoreglators, and methods of use and preparation
To regulate the immune response to an antigen, a subject with the antigen is injected with polyanionic polysaccharide derivative: (1) having a molecular weight of between 1,000 and 600,000; (2)...
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5476659 |
Cancerous B cell treatment using substituted nucleoside derivatives
Processes for the killing of cancerous B cells, and particularly chronic lymphocytic leukemia (CLL) cells are disclosed. In one process, cancerous B cells that do not proliferate when contacted...
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5468481 |
MHC class II-peptide conjugates useful in ameliorating autoimmunity
The present invention is directed to complexes consisting essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These...
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5424068 |
Method for immunization of mammals against atherosclerosis and pharmaceutical compositions for obtaining said immunization
Pharmaceutical compositions and a method for immunization of mammals against atherosclerosis including steps of a) obtaining blood from a mammal; b) isolating low density lipoprotein from the...
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5424067 |
Injectable multi-phase emulsions
The present invention relates to injectable multi-phase solutions of W/O/W type, usable as vaccines or as vehicles of active substances in human and veterinary medicine, which are pharmaceutically...
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