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5855894 |
Pasteurella haemolytica type A-1 bacterin-toxoid vaccine
This invention relates to the field of Pasteurella haemolytica vaccines. More particularly, the invention relates to a bacterin-toxoid vaccine capable of inducing immunity in bovine species in one...
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5855902 |
Method of administering a vaccine comprising tritrichomonas foetus membrane surface antigens between 45 and 300 kilopaltons
A subunit vaccine for Tritrichomonas foetus and method for preparing such vaccine for use in immunizing and treating animals is provided. The method disclosed involves separating out the antigens...
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5854069 |
GD2 anti-idiotypic antibodies and uses thereof
Three murine monoclonal anti-idiotype antibodies which functionally mimic GD2 are described. These antibodies are useful in compositions for inducing a CD4 T cell response to cancers characterized...
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5853737 |
Method for inducing a CD1-restricted immune response
The present invention is based on the observation that CD1 functions to present foreign and autoimmune antigens to a select subpopulation of T-cells. Based on this observation, the present...
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5851786 |
Product and process to regulate actin polymerization
The present invention relates to methods useful for identifying compounds capable of specifically regulating actin polymerization, stress fiber formation or focal adhesion assembly by regulating G...
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5849859 |
Polyesters
A biodegradable and biocompatible polyester comprising (C 3 -10) alkylene carbonic acid ester units, each alkylene group being a C 3 -alkylene group having 1 oxy substituent or a (C 4 -10)...
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5849307 |
Vaccine adjuvant
There is disclosed an adjuvant composition for potentiating the immunogenicity of an antigen, comprising water or an aqueous solution and hemozoin or β-hematin.
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5846548 |
Combined administration of mitogenic immumo stimulator and a thymomimetic
A method of tumor therapy involves controlling the immune system by co-administration of a mitogenic immuno-stimulating substance and a thymomimetic substance.
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5846933 |
CD-4 derived peptides that inhibit immune responses
The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4 + T cell immune responses by identifying compounds that block the interaction of CD4 and...
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5840318 |
Methods and compositions for modulating immune systems of animals
Methods and compositions for modulating the immune system of animals by activating macrophages to release cytokines and down-regulating their sensitivity to bacterial endotoxin and to conversion to...
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5840770 |
Method of killing tumor cells
This invention provides an immunoenhancement or immune-potentiation therapy comprising administration of potassium, insulin, glucose and, optionally, thyroid, a cholinergic agent and bicarbonate....
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5840835 |
Inhibitors of peptide binding to MHC class II proteins
Compounds of the formula ##STR1## are inhibitors of peptide binding to major histocompatibility complex type II proteins and may be used in the treatment and prevention of autoimmune diseases...
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5837269 |
Vaccine compositions and method for enhancing an immune response
The invention relates to a vaccine which comprises an antigen and an immune response augmenting agent. The immune response augmenting agent is capable of enhancing T cell lymphokine production....
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5837250 |
Adjuvant compositions
Adjuvant compositions for modulating an immune response to an antigen administered to a host comprise a mineral salt adjuvant and at least one other adjuvant. The compositions provide an...
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5837229 |
Uses of recombinant colony stimulating factor-1
A colony stimulating factor, CSF-1, is a lymphokine useful in treating or preventing bacterial, viral or fungal infections, neoplasms, leukopenia, wounds, and in overcoming the immunosuppression...
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5833996 |
Treatment of psoriasis using dead cells of Mycobacterium vaccae
Immunoregulatory material derived from Mycobacterium vaccae, especially dead cells of M. vaccae, are useful for the treatment of pathological conditions (other than mycobacterial disease and...
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5830464 |
Compositions and methods for the treatment and growth inhibition of cancer using heat shock/stress protein-peptide complexes in combination with adoptive immunotherapy
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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5831068 |
Method to increase the density of antigen on antigen presenting cells
Disclosed is a method for presenting an antigen in the form of a peptide on the surface of a cell. The method involves inhibiting the activity of an MHC class I pathway-associated component (e.g.,...
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5824322 |
Compositions and methods for growth promotion
The present invention includes compositions and methods using biologically active nonionic reverse block copolymers. The reverse copolymers have an inner core of polyoxypropylene (POP) that is...
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5820861 |
Sperm antigen corresponding to a sperm zona binding protein autoantigenic epitope
The present invention involves DNA encoding a mammalian Sp 17 protein, particularly human Sp17 protein, or antigenic peptides which are fragments thereof, along with said antigenic fragments. These...
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5820880 |
Liposomal formulation
Depending on the antigen encapsulated, liposomal formulations are subject to instability in the presence of alum. Formulations containing a nonionic detergent as a stabilizing agent avoid this...
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5817757 |
Inhibitors of peptide binding to MHO class II proteins
Compounds of the formula ##STR1## are inhibitors of peptide binding to major histocompatibility complex type II proteins and are useful in the treatment and prevention of autoimmune diseases...
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5817320 |
In ovo immunization of avian embryos with oil-emulsion vaccines
Avian diseases, particularly those which threaten birds early in life, are controlled by embryonal vaccination using water-in-oil-in-water emulsion vaccines. The site of inoculation is the albumin...
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5814321 |
Oil adjuvant vaccine and method for preparing same
A water-in-oil type oil adjuvant vaccine comprises 20 to 90% by weight of an oil phase A) which is in a liquid state at ordinary temperature; 0.5 to 30% by weight of an emulsifying agent comprising...
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5811231 |
Methods and kits for eukaryotic gene profiling
This invention provides methods and diagnostic kits for identifying and characterizing toxic compounds. These methods and diagnostic kits measure transcription or translation levels from genes...
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5811099 |
Method and composition for preserving antigens and process for utilizing cytological material produced by same
A method and composition for fixing and stabilizing tissues, cells, and cell components such that the antigenic sites are preserved for a useful period of time is provided. The fixative employs a...
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5811105 |
Vaccines containing bacteria attenuated by mutations in two genes of the aromatic amino acid biosynthetic pathway
An attenuated microorganism harboring two mutated genes, each of which is located in the organisms aromatic pathway is provided. These organisms can usefully form the basis of a vaccine. They can...
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5807559 |
Compositions for generating T cell immunity against carbohydrate structures
The present invention relates to a novel class of immunologically active compounds, to processes for their production and to their use in therapy. In particular, the invention provides immunogenic...
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5807830 |
Method for treatment of purulent inflammatory diseases
This invention provides methods of treating purulent inflammatory diseases by administering L-Glu-L-Trp or a salt thereof.
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5804191 |
Sperm as immunogen carriers
Vaccine compositions, contraceptives, and gene therapy delivery vectors are disclosed in which sperm cells or components thereof are used to deliver immunogens or selected gene sequences to target...
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5801157 |
Composition comprising a recombinant plasmid and its uses as vaccine and medicament
A composition containing a recombinant plasmid which includes an exogenous nucleotide sequence capable of expressing a compound including an amino acid sequence in a host organism. The composition...
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5792452 |
Live salmonella vaccine having an increased stability
A live Salmonella vaccine having an increased stability is disclosed. Further, immunization methods of a host such as chickens against Salmonella diseases are carried out by the use of the vaccine....
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5788985 |
Vaccine composition for eliciting an immune response against N-glycolylated gangliosides and its use for cancer treatment
The invention provides novel uses for n-glycolylated gangliosides, or derivatives and/or oligosaccharides thereof. The invention further provides methods of obtaining such gangliosides, as well as...
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5785975 |
Adjuvant compositions and vaccine formulations comprising same
The present invention relates to phospholipid-polysaccharide adjuvant compositions and to vaccine formulations comprising same, as well as to methods of making and using such adjuvants and vaccines.
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5786334 |
Hexapeptide having immunostimulatory activity
The hexapeptide Phe--Leu--Gly--Phe--Pro--Thr, which is derived from a myelopeptide, exhibits immunostimulatory activity when administered to a mammal.
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5783193 |
Oral administration of therapeutic proteins for treatment of autoimmune disease, transplant rejection and infectious disease
An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and...
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5780034 |
Diagnosis and treatment of insulin dependent diabetes mellitus using heat shock protein determinents
A 65 KD heat shock protein, proteins cross-reactive therewith, antibodies thereto or T cells specific thereto can be used for detecting in humans the existence of, a tendency to develop, or the...
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5773007 |
Vaccine compositions
Improved vaccine compositions comprising a long chain alkyl compound as an immunoadjuvant in combination with a bacterial polysaccharide protein conjugate. The compositions of the invention are...
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5773011 |
Method of preparing a synergistic immunological adjuvant formulation
The improved method uses N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) or N-acetylglucosaminyl-N-acetyl-muramyl-L-alanyl-D-isoglutamin
e (GMDP) in low dose ranges in a combination with...
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5770214 |
Vaccines containing salmonella bacteria attenuated by mutations in two genes of the aromatic amino acid biosynthetic pathway
An attenuated microorganism harbouring two mutated genes, each of which is located in the organisms aromatic pathway is provided. These organisms can usefully form the basis of a vaccine. They can...
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5766593 |
Anti-inflammatory CD14 peptides
The invention relates to anti-inflammatory peptides that are based on peptide regions 7-10, 11-14, and 57-64 of CD14.
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5762904 |
Oral delivery of vaccines using polymerized liposomes
Polymerized liposomes, methods of preparing the polymerized liposomes and incorporating biologically active substances within the polymerized liposomes, and methods of administering polymerized...
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5759572 |
Liposome with oligosaccharide on surface
There are provided liposomes as an adjuvant which is effective for cellular immunity, has low toxicity and antigenicity, and may be administered to humans. The liposomes have oligosaccharide on...
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5753237 |
Method for augmenting immunological responses
Methods for augmenting immune responses in immunodeficient individuals are disclosed. The methods utilize steroid hormones, particularly DHEA, its prohormones (particularly DHEA-S), and...
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5753234 |
Single-shot vaccine formulation
A microparticle having a particle size ranging from 0.5 to 300 μm, which is prepared by dissolving an antigen or a mixture of antigens in an aqueous solution, adding a water-soluble substance...
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5747024 |
Vaccine adjuvant comprising interleukin-15
Methods of enhancing a mammal's immune response to a vaccine antigen are disclosed. Interleukin-15 can be used as a vaccine adjuvant to enhance or potentiate the immune response to a vaccine....
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5747653 |
Method of producing of an antimeningococcic hyperimmune gamma globulin and gamma globulin produced by method
A vaccine effective against infection caused by group B Nesseria meningitidis microorganism is provided which comprises a purified protein antigenic complex weighing from 65 to 95 kDa, vesicles,...
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5744354 |
Calcineurin inhibitory compounds and anchoring protein to induce IL-2 gene expression
The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are...
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5741493 |
Vaccine composition against influenza, with synergic effects, containing influenza virus core as an additive
The use, when preparing a vaccine composition containing a standard influenza virus vaccine, of an additive which consists of a core or core fraction of at least one influenza virus, especially a...
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5741495 |
Glucan drug delivery system and adjuvant
The invention describes a whole β-glucan drug delivery vehicle that non-specifically enhances the immune response, and is safe for human use. A drug is incorporated into a whole β-glucan...
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