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8703095 Immuno-adjuvant emulsion  
The invention relates to an oil-in-water adjuvant emulsion which comprises at least: squalene,an aqueous solvent,a polyoxyethylene alkyl ether nonionic surfactant,a hydrophobic nonionic surfactant,...
8703142 Methods to bypass CD4+ cells in the induction of an immune response  
Embodiments of the invention disclosed herein relate to methods and compositions for bypassing the involvement of CD4+ cells when generating antibody and MHC class I-restricted immune responses,...
8703924 Chitosan composition  
This invention relates to a cross-linkable chitosan composition comprising chitosan having a degree of deacetylation between 30 and 75%, wherein the chitosan is randomly deacetylated, and a...
8703152 Methods of treating inflammatory intestinal disease and managing symptoms thereof  
Methods and products are disclosed for treating an inflammatory intestinal disease in a mammalian subject in need thereof, or preventing or reducing a symptom of inflammatory intestinal disease....
8703154 Adjuvant for the preparation of vaccine compositions intended for the prevention of coccidiosis  
A vaccine adjuvant which, based on the 100% mass thereof, includes between 10% and 95% of a mineral oil containing: between 0.05 mass-% and 10 mass-% hydrocarbon chains having less than 16 carbon...
8697633 Dissolution of arterial plaque  
Embodiments of methods of treating atherosclerosis are described. In some embodiments an emulsifier is provided to achieve levels in the systemic circulation that are effective to solubilize...
8697093 Vaccine composition based on sticholysin encapsulated into liposomes  
The present invention relates to the field of biotechnology applied to human health. The invention describes a vaccine vehicle which toxins from eukaryotic organisms are encapsulated in liposomes...
8691234 Vaccine formulation potentiated by the combination of DNA and an antigen  
Formulation of vaccine antigens, containing as main components: a—) one or several DNA expressing one or several proteins in the immunized individuals and b—) a viral antigen, in appropriate pro...
8685939 Vaccine targeting cellular death receptor DR5  
The invention provides therapeutics and methods to induce a mammalian host, including a human, to produce antibodies, which agonize death receptors and cause the apoptotic death of target cells...
8679471 Modulation of regulatory T cells by human IL-18  
The present invention relates to compositions and methods for modulating the presence and/or activity of regulatory T cells in a subject.
8673296 Method and composition for producing a cellular allogeneic vaccine  
The present invention relates to a method for the production of a cellular allogeneic vaccine, which is based upon an allogeneic APC, comprising the following steps: isolation of an APC from a...
8673313 Cell penetrating peptides and its use fused to biomolecules with therapeutic action  
The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention ...
8673321 Cyclophosphamide in combination with anti-idiotypic vaccines  
The present invention relates to methods of treating a cancer and in particular, a B-cell derived cancer, using a lymphocytotoxic but hematopoeitic cell sparing high-dose pulsed amount of an...
8663646 P53 peptide vaccine  
The invention relates to a peptide derived from p53 that could be used as a vaccine against cancer.
8663650 Methods and compositions comprising supramolecular constructs  
The present invention comprises novel compositions and methods for eliciting high immune responses, of great specifity yielding conformationally sensitive antibodies. These antibodies recognize...
8652439 Compositions of HSP60 peptides and viral antigens for vaccination and diagnosis  
The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where...
8652487 Tolerogenic synthetic nanocarriers for inducing regulatory B cells  
Disclosed are synthetic nanocarrier methods, and related compositions, comprising B cell and/or MHC Class II-restricted epitopes and immunosuppressants in order to generate tolerogenic immune...
8652482 HPV E6 protein T cell epitopes and uses thereof  
The present invention is directed to the examination of the pattern of immunodominant T cell epitopes in the E6 protein of Human Papilloma virus and its further characterization in terms of its...
8652481 Mycoplasma bovis vaccine and methods of use thereof  
The present invention relates to new attenuated M. bovis bacteria strains. Moreover, the present invention also provides immunogenic compositions comprising live bacteria of an of those attenuated...
8647642 Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment  
Gram-negative bacteria, and compositions containing the bacteria, resistant to one or more stress conditions, including, but not limited to, CO2, acid pH, and high osmolarity, having reduced...
8647643 Farnesoid-X-receptor antagonist as a vaccine adjuvant  
The invention provides novel adjuvants and pharmaceutical composition comprising of an adjuvant alone. The invention also provides novel vaccine compositions comprising of an antigen and a novel...
8647634 Recombinant avian infectious coryza vaccine and process for preparing same  
A recombinant avian infectious coryza vaccine and a process for preparing the same are provided. A process for preparing a recombinant avian infectious coryza vaccine which comprises step of...
8642027 Compositions and methods for modulating ischemic injury  
The invention is directed to methods of modulating ischemic injury in tissues and organs. The invention is further directed to methods of increasing time to ischemic injury in tissues and organs....
8642011 Tuberculosis vaccine  
The present invention relates to an isolated microorganism belonging to the genus Mycobacterium, characterized in that it comprises inactivating the gene Rv0757 that confers a PhoP− phenotype and i...
8642731 Porphyromonas gingivalis polypeptides and nucleotides  
The present invention relates to isolated Porphyromonas gingivalis polypeptides and nucleotides. The polypeptides include an amino acid sequence selected from the group consisting of: SEQ. ID. NO....
8637028 Adjuvant incorporation in immunonanotherapeutics  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...
8637051 Compositions and methods for treatment of mucosal infections  
The present invention is concerned with novel compositions and vaccines useful for prophylactic an/or therapeutic treatment of mucosal infections, and in particular it is concerned with oral...
8636979 TLR 4 and 9 receptors agonists for preventing septic complications of post-traumatic immunodepression in patients hospitalized for severe traumatic injuries  
The present invention concerns a pharmaceutical composition comprising at least one agonist of at least one Toll Like receptor (TLR) chosen from TLR 4 and 9, for use in the prophylactic treatment...
8632787 Methods using immunomodulatory compounds for treatment of certain leukemias  
Methods of treating, preventing or managing leukemias are disclosed. The methods encompass the administration of an immunomodulatory compound of the invention. The invention further relates to...
8628784 Adjuvant systems and vaccines  
An adjuvant composition comprising monophosphoryl lipid A or a derivative of monophposphoryl lipid A adsorbed onto an aluminium salt particle.
8628809 Method of inducing mucosal immune response to antigen with Dioscorea polysaccharides adjuvant  
A method for inducing mucosal immune responses in a subject in need thereof to an antigen includes administering to the subject a vaccine composition including the antigen and a Dioscorea...
8628786 Polychlorinated biphenyls and squalene-containing adjuvants  
When using squalene in a vaccine adjuvant, there is a possibility of contamination with polychlorinated biphenyls (PCBs). Environmental exposure to PCBs may adversely affect children's immune...
8628785 Method for augmenting the immunogenicity of an antigen  
The present invention relates to a method for augmenting the immunogenicity of an antigen in a mammal, comprising immunizing the mammal with a composition comprising the antigen, and an adjuvant in...
8623349 Systems, methods and microrganisms for antibody production with type III secretion system  
Exemplary embodiments disclosed herein include a microorganism that produces, secretes and injects recombinant antibodies into eukaryote cells said the described microorganisms can be used to...
8623384 Methods using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of acute myelogenous leukemia  
Methods of treating, preventing or managing leukemias are disclosed. The methods encompass the administration of an immunomodulatory compound of the invention known as Revlimid® or lenalidomide. ...
8617520 Cancer therapy  
The present invention relates to a method of preventing, treating or inhibiting the development of tumors or metastases in a subject and to an immunomodulator for use in such therapy, in...
8617621 Composition for enhancing immunity containing plant stem cell line derived from cambium of Panax ginseng including wild ginseng or ginseng as an active ingredient  
The present invention relates to a composition for enhancing immunity, comprising one or more of the following: a homogenous cell line, and a lysate, an extract and a culture medium thereof as an...
8609114 Methods of using a vaccine composition containing synthetic adjuvant  
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant...
8603482 Compositions and methods for cancer immunotherapy  
The invention relates to immunotherapeutic compounds and to methods for stimulating an immune response in a subject individual at risk for developing cancer, diagnosed with a cancer, in treatment...
8597664 Endogenous adjuvant molecules and uses thereof  
Methods of modulating the immune response using pharmaceutical compositions containing crystalline adjuvants are described. In various embodiments the crystalline adjuvants are selected from the...
8598324 Anti-pathogen treatments  
Chimeric molecules that contain at least one pathogen-detection domain and at least one effector domain, and their methods of use in preventing or treating a pathogen infection in a cell or...
8597697 Composition of beta-glucan and ashwagandha  
Compositions including combinations of β-glucan and Withania somnifera for increasing the immune activity of certain target cytokines and phagocytosis, and reducing cortisol or corticosterone. ...
8597665 Chimeric immunomodulatory compounds and methods of using the same-IV  
The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
8591905 Nicotine immunonanotherapeutics  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...
8591919 Synergistic mixture of beta-galacto-oligosaccharides with beta-1,3 and beta -1,4/1,6 linkages  
The present invention relates to a nutritional composition comprising at least two different beta-galacto-oligosaccharides (BGOS) A and B wherein the majority of linkages between two galactose...
8586555 Immunomodulatory compositions, formulations, and methods for use thereof  
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMO/MC)...
8580280 Adjuvant compositions  
This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant...
8574599 Methods and products for inducing mucosal immunity  
The invention relates methods and products for inducing mucosal immunity. In particular, the invention relates to the use of immunostimulatory oligonucleotides containing a CpG motif for inducing...
8568742 Methods and compositions involving immunostimulatory oligodeoxynucleotides  
Described is an immunostimulatory oligodeoxynucleic acid molecule (ODN) having the structure according to formula (I) whereinany NMP is a 2′ deoxynucleoside monophosphate or monothiophosphate, s...
8562998 Targeting of antigen presenting cells with immunonanotherapeutics  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...