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8858962 Adjuvant or pharmaceutical preparation for transdermal or transmucosal administration  
An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not...
8858952 Methods and materials for generating T cells  
The document provides to methods and materials for generating T cells (e.g., antigen-specific CD4+ T cells). For example, methods and materials for using nested MHC class II epitopes as vaccines to...
8858958 Adjuvant comprising aluminum, oligonucleotide and polycation  
An immunological adjuvant comprises an aluminum salt, an immunostimulatory oligonucleotide and a polycationic polymer, wherein the oligonucleotide and the polymer ideally associate with each other...
8852612 Universal carrier for targeting molecules to Gb3 receptor expressing cells  
The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys,...
8852591 Combination of BLyS and/or APRIL inhibition and immunosuppressants for treatment of autoimmune disease  
The invention relates to novel combination therapies involving BLyS or BLyS/APRIL inhibition and immunosuppressants for the treatment of autoimmune diseases. One preferred method is where the BLyS...
8852607 Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith  
Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and...
8852606 Capsular polysaccharide solubilisation and combination vaccines  
Precipitated bacterial capsular polysaccharides can be efficiently re-solubilized using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide,...
8840906 Methods and compositions related to immunizing against Staphylococcal lung disease and conditions  
Embodiments of the invention include methods and compositions useful in a vaccination strategy capable of neutralizing HIa to provide immunoprotection against S. aureus pneumonia. In certain...
8840908 Vaccine composition containing synthetic adjuvant  
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant...
8834900 Combination motif immune stimulatory oligonucleotides with improved activity  
A class of immunostimulatory nucleic acids having at least two functionally and structurally defined domains is provided. This class of combination motif immunostimulatory nucleic acids activates...
8834889 Antigen presenting composition and use thereof  
An antigen presenting composition comprising a plurality of 2-component MHC class I complexes and a carrier is described. A method for activating a group of antigen-specific CD8+ T cells comprising...
8834891 Immunogenic compositions comprising Lawsonia intracellularis  
The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and...
8834898 Cholera toxin chimera and its use as a staph vaccine  
The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of...
8828403 Anti-tumor immunotherapy  
The present invention relates to the use of telomerase-derived peptides for the treatment of any cancer patients, particularly for the treatment of patients with renal or prostate cancer.
8821892 Yeast-based therapeutic for chronic hepatitis C infection  
Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The...
8821881 Quil A fraction with low toxicity and use thereof  
Fraction A of Quil A can be used together with at least one other adjuvant for the preparation of an adjuvant composition, where the included adjuvant components act synergistically to enhance...
8821884 Compositions and methods using MD-2 mutants and chimeric proteins  
The invention provides compositions and methods for the targeted bacteriostatic and antibacterial agents and for treatment of sepsis caused by infectious diseases, such as bacterial and fungal...
8821885 Immunogenic compositions and methods  
The invention is directed to immunogenic compositions, and methods for their use in the formulation and administration of therapeutic and prophylactic pharmaceutical agents. In particular, the...
8815255 Use of Mycoplasma bovis antigen  
The present invention relates to combination vaccines and/or the combined use of immunogenic compositions for the treatment and/or prophylaxis of cattle against microbiological infections, wherein...
8808703 Compounds (cystein based lipopeptides) and compositions as TLR2 agonists used for treating infections, inflammations, respiratory diseases etc  
The invention provides a novel class of compounds viz. generally lipopeptides like Pam3CSK4, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using...
8809290 Methods and compositions to generate and control the effector profile of T cells by simultaneous loading and activation of selected subsets of antigen presenting cells  
The present invention is directed to novel compositions that cause effective redirection of class I-immunity to Tc1 effectors, that take advantage of the unexpected loading of MHC I by peptide...
8808710 Method of preparing an immunologically-active adjuvant-bound dried vaccine composition  
The disclosure provides a method of preparing an immunologically-active adjuvant-bound freeze dried vaccine composition. A specific embodiment provides a stable vaccine composition comprising an...
8802158 Methods of use of probiotic Lactobacilli for companion animals  
According to the present invention there are provided methods of use in companion animals of probiotic bacteria of the genus Lactobacilli.
8795674 Methods and compositions for modulating immune tolerance  
The instant invention provides methods and compositions for modulation of the immune system. Specifically, the invention provides methods and compositions for increasing T cell mediated immune...
8795653 Methods for repressing B cell autoantibody secretion and for treating autoimmune disorders by administration of hematopoietic stem cells and macrophage-colony stimulating factor  
The invention provides isolated regulatory immune cells as well as cell cultures and conditioned media derived therefrom. Also provided are methods of repressing B cell autoantibody production...
8795678 TLR-2 agonists and methods of use thereof  
Two new TLR2 agonists, VP1 and VP3, which are structural proteins of FMDV. Residues of VP3 responsible for TLR2 activation are identified. In vivo experiments showed that VP3-4xM2e is active as a...
8790664 Multimodular assembly useful for intracellular delivery  
A stabilized multimodular assembly for intracellular delivery comprising a complex of at least one cationic transfection agent and of at least one negatively charged macromolecule, wherein the...
8790655 Conjugates of synthetic TLR agonists and uses therefor  
The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.
8784843 Stabilizers for freeze-dried vaccines  
The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the present invention relates to stabilizers for freeze-dried live attenuated...
8784825 Modulators of MYC, methods of using the same, and methods of identifying agents that modulate MYC  
Disclosed herein are methods of modulation of the viability of a cell. Further disclosed herein are methods of modulating an immune response. Further disclosed herein are methods of identifying...
8784844 Arabinogalactan for enhancing the adaptive immune response  
The present invention discloses a composition containing Arabinogalactan for enhancing the adaptive immune response in subjects to foreign antigen(s) by administering said composition prior, during...
8784839 Attenuated live vaccines  
Disclosed is an attenuated flavivirus live vaccine comprising a flavivirus mutant, characterized in that the flavivirus mutant has a deletion in the capsid protein of at least more than 4...
8778384 Compositions and methods for encapsulating vaccines for the oral vaccination and boostering of fish and other animals  
The invention relates to a composition comprising a pharmaceutically active agent and a bioadhesive delivery system that provides for the oral delivery of a vaccine to animals, particularly aquatic...
8771727 Microfluidized oil-in-water emulsions and vaccine compositions  
This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions...
8765148 1C31 nanoparticles  
The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKL5KLK and an oligodeoxynucleotide with the nucleic acid sequence (dIdC)13 and...
8759310 Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8  
The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based...
8758775 Pharmaceutical composition including clinoptilolite  
The invention is for a method of potentiating clinoptilolite, the method including the steps of: providing fresh or spent clinoptilolite; exposing the clinoptilolite to a saline solution having a...
8758759 Transmucosal administration of aggregated antigens  
The present invention relates to modulation of the immune response in a mammal. In particular, the invention relates to methods of inducing oral tolerance and systemic immunity in a mammal. The...
8758766 Modified Streptococcus pneumoniae pneumolysin (PLY) polypeptides  
This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against...
8758829 Reduced fluoride content phospholipids/peptide complex meal  
The present invention relates to a process for removing fluorine from krill material by subjecting the krill to disintegration and to an enzymatic hydrolysis process prior to or simultaneously with...
8758772 Peptides and methods for the detection of lyme disease antibodies  
The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences...
8753651 Capsular polysaccharide solubilisation and combination vaccines  
Precipitated bacterial capsular polysaccharides can be efficiently re-solubilized using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide,...
8741869 Oligodeoxynucleotide and its use to induce an immune response  
A substantially pure or isolated oligodeoxynucleotide of at least 10 nucleotides is disclosed, wherein the oligodeoxynucleotide comprised a sequence represented by either formula: 5′ N...
8741313 Polypeptide vaccine and vaccination strategy against mycobacterium  
A vaccine is provided wherein a polypeptide or combination of peptides from M. tuberculosis is administered to a subject to elicit an immune response. The polypeptide vaccine is administered as...
8741303 Immunogenic LHRH compositions and methods relating thereto  
The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino...
8734807 Preventing and curing Schistosomiasis mansoni by inhibiting Trk receptors on female Schistosoma  
Schistosomiasis mansoni is caused by flukes called Schistosoma(es) that enters the human body through the skin in Schistosoma infested waters. The Schistosomes travel from the skin into human blood...
8729126 Use of pufas for treating skin inflammation  
The present invention provides a compound which is a polyunsaturated fatty acid (PUFA) derivative of formula (I), or a pharmaceutically acceptable salt, or solvate thereof, for use in treating...
8728489 Immunotherapy for chronic hepatitis C virus infection  
Disclosed are uses of immunotherapeutic compositions in combination with Standard of Care (SOC), or interferon therapy combined with anti-viral therapy, for the improved treatment of chronic...
8722055 Synthetic Streptococcus pneumoniae vaccine  
Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R2i or R22...
8722064 Synthetic glucopyranosyl lipid adjuvants  
Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: or a pharmaceutically acceptable salt thereof, wherein L1, L2, L3, L4, L5,...