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9034337 Treatment and delay of outset of synucleinopathic and amyloidogenic disease  
The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such...
9034313 Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same  
Nucleic acid molecules comprising a nucleotide sequence encoding RANTES and fragments and variants thereof are disclosed. Additionally, nucleic acid molecules and compositions comprising the...
9029079 Method of biotechnological production of bovine hemoderivative  
A method of biotechnological production of a bovine hemoderivative comprising the steps of: freshly acquired animal blood matter is first fermented in several phases, the blood fermentation...
9028845 Chimeric immunomodulatory compounds and methods of using the same-IV  
The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
9028839 Stabilizing excipient for inactivated whole virus vaccine  
The invention relates to a vaccine composition comprising: a) inactivated whole virus, andb) a stabilizing excipient which comprises: i. a buffer solution,ii. a mixture of essential and...
9017699 Adjuvancy and immune potentiating properties of natural products of Onchocerca volvulus  
The present invention relates to a method for potentiating a specific immune response to an antigen in a mammal in need thereof. The method comprises administering to the mammal an effective...
9017697 Compositions and methods for modulating immune responses  
This invention discloses methods and compositions for modulating immune responses, which involve particulate delivery of agents to immune cells, wherein the agents comprise an inhibitor of the...
9006406 EGFR-homing double-stranded RNA vector for systemic cancer treatment  
An epidermal growth factor receptor (EGFR)-homing vector comprising a double-stranded RNA (dsRNA) molecule with an EGFR-binding peptide or polypeptide, is disclosed for use in combination with...
9005626 Liquid compositions capable of foaming and including active agents, and methods for making or developing same  
A liquid composition suitable for topical use comprising is provided that includes a phospholipid foaming agent and at least one solvent; and a pharmaceutically acceptable active agent; wherein...
8999353 Method of eliciting an immune response against pandemic influenza virus  
A method for eliciting or inducing a protective immune response in a subject against a pandemic subtype of influenza virus comprises administering to the subject a composition comprising (i) at...
8993624 Method of preventing and treating inflammatory diseases and disorders with abscisic acid  
The present invention relates to the use of a therapeutically effective amount of abscisic acid (ABA) or its analogs to treat or prevent inflammation induced by exposure to lipopolysaccharide...
8986708 Combinations of gene deletions for live attenuated Shigella vaccine strains  
Shigella vaccine strains whose primary attenuating feature is deletion of the virG(icsA) gene and additional two or more deletions in setAB(shET1), senA(shET2), senB(shET2-2), stxAB, and msbB2...
8980283 C. perfringens alpha toxoid vaccine  
The present invention describes vaccines that comprise C. perfringens Type alpha toxoids, antigenic fragments thereof, inactivated antigenic fragments of C. perfringens Type alpha toxins, or any...
8980289 Intestine immunomodulator  
The purpose of the present invention is to provide a better intestine immunomodulator. The intestine immunomodulator of the present invention comprises bacterial cells or a bacterial component of...
8980288 Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase  
Emulsion vaccine formulations containing an antigen and an adjuvant in the aqueous phase are used for the vaccination of animals wherein the adjuvant is an acrylic polymer and/or dimethyl...
8968746 Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation  
The present invention is directed to a polymeric carrier cargo complex, comprising as a cargo at least one nucleic acid (molecule) and disulfide-crosslinked cationic components as a (preferably...
8968744 Aqueous composition comprising a biological antigen and an acrylic acid polymer  
The current invention pertains to an aqueous composition containing a biological antigen and an acrylic acid polymer, wherein the composition comprises an electrolyte to provide an osmolarity...
8961957 Therapy and method for intratumorally introducing cytotoxic T lymphocyte and/or NKT cell with anti-TNF and/or anti-IL-10  
The invention relates to therapy and methods of applying the therapy to cancer patients. The invention includes introducing intratumorally cytotoxic T lymphocyte and/or NKT cells, and prior to,...
8961983 Mucosal vaccine using cationic nanogel  
A mucosal vaccine for the prevention or treatment of microbial infections is described that is capable of inducing vaccine antigen-specific immune responses in an organism without the addition of...
8956627 Method of inducing antibodies to human immunodeficiency virus involving the administration of MPER peptide-liposome conjugates  
The present invention relates to a method of inducing the production in a patient of anti-HIV antibodies. The method comprises administering to a patient in need thereof an amount of at least one...
8951532 A25 bacteriophage lysin  
The invention relates to the identification, sequencing, and isolation of an A25 bacteriophage lysin gene that expresses a protein involved in the lysis of bacterial cells during the phage life...
8951529 Methods of using small compounds to enhance myeloid derived suppressor cell function for treating autoimmune diseases  
Methods for enhancing the suppressive function of myeloid derived suppressor cells (MDSCs) for the treatment of autoimmune diseases using small compounds are disclosed. In certain aspects, the...
8951538 Exopolysaccharide of Shigella sonnei bacteria, method for producing same, vaccine and phamaceutical composition containing same  
For the first time, an O-specific polysaccharide antigen that is a Shigella sonnei, phase I, exopolysaccharide has been produced and characterized, said exopolysaccharide being an authentic...
8951531 Modified Streptococcus pneumonia pneumolysin (PLY) polypeptides  
This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against...
8945591 Methods and compositions involving immunostimulatory oligodeoxynucleotides  
Described is an immunostimulatory oligodeoxynucleic acid molecule (ODN) having the structure according to formula (I), wherein any NMP is a 2′ deoxynucleoside monophosphate or monothiophosphate,...
8946175 Stabilized immunomodulatory oligonucleotides  
The invention provides immunostimulatory oligonucleotides having at least one CpG dinucleotide and a secondary structure at the 5′- or 3′-end. These oligonucleotides have either reduced or...
8945590 Enhancement of an immune response by administration of a cationic lipid-DNA complex (CLDC)  
This invention relates to a method for vaccination which is effective for eliciting an enhanced antigen-specific immune response in a mammal, fish or bird. The method is particularly effective for...
8945587 Synthetic lipid biology for combinatorial engineering of endotoxin  
The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure relates to genetic engineering of Gram-negative bacteria expressing different...
8945566 Methods for improving the bioactivity of therapeutic IgE antibodies for the treatment of disease  
The invention provides a method for increasing the bioactivity (e.g. the biosafety and efficacy) of a therapeutic IgE antibody of the invention in the treatment of a patient. Methods of the...
8940310 Methods of treatment using TLR7 and/or TLR9 inhibitors  
The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory...
8936789 Immunoenhancer-linked oligomeric HIV envelope peptides  
Provided herein are immunogenic compositions comprising fusion proteins, the fusion proteins comprising lentivirus gp41 or a fragment thereof, a trimerization or oligomerization motif and an...
8936793 Synthetic archaeal glycolipid adjuvants  
Archaeal lipid adjuvants are synthesized by chemically coupling various carbohydrates or anionic polar groups to the free hydroxyl(s) of archaeal lipid cores. Chemically stable lipid cores such as...
8933011 Treatment of preterm labor with toll-like receptor 9 antagonists  
The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a...
8932595 Nicotine immunonanotherapeutics  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...
8933029 Antimicrobial and anti-inflammatory peptides  
Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or...
8932594 Adjuvants and methods of use  
Compositions comprising NKT cell agonist compounds and a physiologically acceptable vehicle are provided. Methods of stimulating an NKT cell and enhancing an immune response are also disclosed....
8932846 Unmarked recombinant intracellular pathogen immunogenic compositions expressing high levels of recombinant proteins  
Recombinant immunogenic compositions, and methods for the manufacture and use, are provided for the prevention and treatment of intracellular pathogen diseases in humans and animals. The...
8926961 HPV E6 protein T cell epitopes and uses thereof  
The present invention is directed to the examination of the pattern of immunodominant T cell epitopes in the E6 protein of Human Papilloma virus and its further characterization in terms of its...
8926995 Adjuvant  
The present invention relates, in general, to human immunodeficiency virus (HIV-1) and, in particular, to a method of enhancing an immune response to an HIV-1 immunogen, and to compounds and...
8926983 Method for improving memory in AD patients  
The present invention comprises novel compositions and methods for eliciting high immune responses, of great specifity yielding conformationally sensitive antibodies. These antibodies recognize...
8921311 Method for treating hyperglycemia  
A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting...
8920774 Drug having regulatory cell ligand contained in liposome  
A liposome containing a regulatory cell ligand such as α-galactosyl ceramide or β-galactosyl ceramide is employed as the active ingredient of a drug for preventing or treating immune diseases etc.
8920809 Chimera comprising bacterial cytotoxin and methods of using the same  
This invention provides, a recombinant polypeptide encoding a chimera. The chimera includes a DNase I fragment or a homologue thereof and a Cdt fragment or a homologue thereof. Further, the...
8916164 Methods of enhancing adjuvaticity of vaccine compositions  
The immunogenicity of vaccines is enhanced by co-administering a synthetic glycolipid, designated PBS-57, with the vaccine. PBS-57 has the ability to stimulate both a cell-mediated and humoral...
8916173 Acellular pertussis vaccine  
Described are acellular pertussis (aP) vaccine compositions comprising Bordetella pertussis antigens pertussis toxoid (PT), filamentous hemagglutinin (FHA), and fimbriae types 2 and 3 (FIM), and...
8911749 Vaccine delivery via microneedle arrays  
A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have...
8911748 Cholera toxin chimera and its use as a staph vaccine  
The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of...
8906381 Immunonanotherapeutics that provide IGG humoral response without T-cell antigen  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune...
8906374 Combination therapy with CD4 lymphocyte depletion and mTOR inhibitors  
The invention provides methods for treating a malignant neoplastic cell proliferative disorder or disease, comprising administering to a subject in need thereof an effective amount of an mTOR...
8906380 Fungal immunostimulatory compositions  
Methods are disclosed which are useful in increasing maturation of dendritic cells from CD14+ mononuclear cells, by contact with a composition comprising a fucose-containing glycoprotein fraction...