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8784843 Stabilizers for freeze-dried vaccines  
The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the present invention relates to stabilizers for freeze-dried live attenuated...
8784825 Modulators of MYC, methods of using the same, and methods of identifying agents that modulate MYC  
Disclosed herein are methods of modulation of the viability of a cell. Further disclosed herein are methods of modulating an immune response. Further disclosed herein are methods of identifying...
8784844 Arabinogalactan for enhancing the adaptive immune response  
The present invention discloses a composition containing Arabinogalactan for enhancing the adaptive immune response in subjects to foreign antigen(s) by administering said composition prior, during...
8784839 Attenuated live vaccines  
Disclosed is an attenuated flavivirus live vaccine comprising a flavivirus mutant, characterized in that the flavivirus mutant has a deletion in the capsid protein of at least more than 4...
8778384 Compositions and methods for encapsulating vaccines for the oral vaccination and boostering of fish and other animals  
The invention relates to a composition comprising a pharmaceutically active agent and a bioadhesive delivery system that provides for the oral delivery of a vaccine to animals, particularly aquatic...
8771727 Microfluidized oil-in-water emulsions and vaccine compositions  
This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions...
8765148 1C31 nanoparticles  
The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKL5KLK and an oligodeoxynucleotide with the nucleic acid sequence (dIdC)13 and...
8759310 Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8  
The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based...
8758775 Pharmaceutical composition including clinoptilolite  
The invention is for a method of potentiating clinoptilolite, the method including the steps of: providing fresh or spent clinoptilolite; exposing the clinoptilolite to a saline solution having a...
8758759 Transmucosal administration of aggregated antigens  
The present invention relates to modulation of the immune response in a mammal. In particular, the invention relates to methods of inducing oral tolerance and systemic immunity in a mammal. The...
8758766 Modified Streptococcus pneumoniae pneumolysin (PLY) polypeptides  
This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against...
8758829 Reduced fluoride content phospholipids/peptide complex meal  
The present invention relates to a process for removing fluorine from krill material by subjecting the krill to disintegration and to an enzymatic hydrolysis process prior to or simultaneously with...
8758772 Peptides and methods for the detection of lyme disease antibodies  
The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences...
8753651 Capsular polysaccharide solubilisation and combination vaccines  
Precipitated bacterial capsular polysaccharides can be efficiently re-solubilized using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide,...
8741869 Oligodeoxynucleotide and its use to induce an immune response  
A substantially pure or isolated oligodeoxynucleotide of at least 10 nucleotides is disclosed, wherein the oligodeoxynucleotide comprised a sequence represented by either formula: 5′ N...
8741313 Polypeptide vaccine and vaccination strategy against mycobacterium  
A vaccine is provided wherein a polypeptide or combination of peptides from M. tuberculosis is administered to a subject to elicit an immune response. The polypeptide vaccine is administered as...
8741303 Immunogenic LHRH compositions and methods relating thereto  
The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino...
8734807 Preventing and curing Schistosomiasis mansoni by inhibiting Trk receptors on female Schistosoma  
Schistosomiasis mansoni is caused by flukes called Schistosoma(es) that enters the human body through the skin in Schistosoma infested waters. The Schistosomes travel from the skin into human blood...
8729126 Use of pufas for treating skin inflammation  
The present invention provides a compound which is a polyunsaturated fatty acid (PUFA) derivative of formula (I), or a pharmaceutically acceptable salt, or solvate thereof, for use in treating...
8728489 Immunotherapy for chronic hepatitis C virus infection  
Disclosed are uses of immunotherapeutic compositions in combination with Standard of Care (SOC), or interferon therapy combined with anti-viral therapy, for the improved treatment of chronic...
8722055 Synthetic Streptococcus pneumoniae vaccine  
Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R2i or R22...
8722064 Synthetic glucopyranosyl lipid adjuvants  
Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: or a pharmaceutically acceptable salt thereof, wherein L1, L2, L3, L4, L5,...
8722030 Composite vaccine adjuvant  
The invention provides a composite vaccine adjuvant, which is comprised of sodium ferulate and zinc hydroxide in a mass ratio of 10:1˜50:1. When the composite vaccine adjuvant and vaccine used in ...
8715620 Treatment of asthma in mammals with clostridia neurotoxins  
A method is disclosed for blocking or reducing physiological reaction in a mammal to the interaction of IgE antibodies present in said mammal upon contact with the corresponding antigen, by the...
8715649 Compositions and methods of use for alpha-1 antitrypsin having no significant serine protease inhibitor activity  
Embodiments herein illustrate methods and compositions for treating medical disorders. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating graft rejection,...
8715654 Methods of modulating the negative chemotaxis of immune cells  
The current invention is directed to methods of inducing migration of an immune cell toward a cancer cell comprising inhibiting the activity of a chemorepellant released from the cancer cell.
8716253 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes  
The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing...
8715697 Genes associated with Leishmania parasite virulence  
The invention relates to the field of combating leishmaniases. Said invention results from the isolation, from wild isolates of Leishmania major, of a protein-coding gene known as LmPDI which has...
8709405 Cancer vaccines containing epitopes of oncofetal antigen  
Disclosed are fragments of oncofetal antigen, otherwise known as immature laminin receptor protein that specifically stimulate one T cell subclass. The fragments may be formulated into compositions...
8709448 Anti-infective agents and uses thereof  
The present invention is concerned with novel immunostimulant microparticle compositions and their use as anti-infective agents in the treatment of bacterial and viral infections.
8709447 Compositions and methods for activating innate and allergic immunity  
Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be...
8703095 Immuno-adjuvant emulsion  
The invention relates to an oil-in-water adjuvant emulsion which comprises at least: squalene,an aqueous solvent,a polyoxyethylene alkyl ether nonionic surfactant,a hydrophobic nonionic surfactant,...
8703142 Methods to bypass CD4+ cells in the induction of an immune response  
Embodiments of the invention disclosed herein relate to methods and compositions for bypassing the involvement of CD4+ cells when generating antibody and MHC class I-restricted immune responses,...
8703924 Chitosan composition  
This invention relates to a cross-linkable chitosan composition comprising chitosan having a degree of deacetylation between 30 and 75%, wherein the chitosan is randomly deacetylated, and a...
8703152 Methods of treating inflammatory intestinal disease and managing symptoms thereof  
Methods and products are disclosed for treating an inflammatory intestinal disease in a mammalian subject in need thereof, or preventing or reducing a symptom of inflammatory intestinal disease....
8703154 Adjuvant for the preparation of vaccine compositions intended for the prevention of coccidiosis  
A vaccine adjuvant which, based on the 100% mass thereof, includes between 10% and 95% of a mineral oil containing: between 0.05 mass-% and 10 mass-% hydrocarbon chains having less than 16 carbon...
8697633 Dissolution of arterial plaque  
Embodiments of methods of treating atherosclerosis are described. In some embodiments an emulsifier is provided to achieve levels in the systemic circulation that are effective to solubilize...
8697093 Vaccine composition based on sticholysin encapsulated into liposomes  
The present invention relates to the field of biotechnology applied to human health. The invention describes a vaccine vehicle which toxins from eukaryotic organisms are encapsulated in liposomes...
8691234 Vaccine formulation potentiated by the combination of DNA and an antigen  
Formulation of vaccine antigens, containing as main components: a—) one or several DNA expressing one or several proteins in the immunized individuals and b—) a viral antigen, in appropriate pro...
8685939 Vaccine targeting cellular death receptor DR5  
The invention provides therapeutics and methods to induce a mammalian host, including a human, to produce antibodies, which agonize death receptors and cause the apoptotic death of target cells...
8679471 Modulation of regulatory T cells by human IL-18  
The present invention relates to compositions and methods for modulating the presence and/or activity of regulatory T cells in a subject.
8673296 Method and composition for producing a cellular allogeneic vaccine  
The present invention relates to a method for the production of a cellular allogeneic vaccine, which is based upon an allogeneic APC, comprising the following steps: isolation of an APC from a...
8673313 Cell penetrating peptides and its use fused to biomolecules with therapeutic action  
The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention ...
8673321 Cyclophosphamide in combination with anti-idiotypic vaccines  
The present invention relates to methods of treating a cancer and in particular, a B-cell derived cancer, using a lymphocytotoxic but hematopoeitic cell sparing high-dose pulsed amount of an...
8663646 P53 peptide vaccine  
The invention relates to a peptide derived from p53 that could be used as a vaccine against cancer.
8663650 Methods and compositions comprising supramolecular constructs  
The present invention comprises novel compositions and methods for eliciting high immune responses, of great specifity yielding conformationally sensitive antibodies. These antibodies recognize...
8652439 Compositions of HSP60 peptides and viral antigens for vaccination and diagnosis  
The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where...
8652487 Tolerogenic synthetic nanocarriers for inducing regulatory B cells  
Disclosed are synthetic nanocarrier methods, and related compositions, comprising B cell and/or MHC Class II-restricted epitopes and immunosuppressants in order to generate tolerogenic immune...
8652482 HPV E6 protein T cell epitopes and uses thereof  
The present invention is directed to the examination of the pattern of immunodominant T cell epitopes in the E6 protein of Human Papilloma virus and its further characterization in terms of its...
8652481 Mycoplasma bovis vaccine and methods of use thereof  
The present invention relates to new attenuated M. bovis bacteria strains. Moreover, the present invention also provides immunogenic compositions comprising live bacteria of an of those attenuated...