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8444994 |
Multivalent antihelminthic vaccine
A multivalent anthelmintic vaccine targets both hookworm and schistosomiasis. The vaccine includes, at a minimum, a recombinant third-stage larval hookworm antigen, a recombinant adult stage...
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8444991 |
Method of preparing an immunologically-active adjuvant-bound dried vaccine composition
The disclosure provides a method of preparing an immunologically-active adjuvant-bound freeze dried vaccine composition. A specific embodiment provides a stable vaccine composition comprising an...
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8445287 |
Method and apparatus for determining anticoagulant therapy factors
Methods and apparatus are disclosed for determining new anticoagulant therapy factors for monitoring oral anticoagulant therapy to help prevent excessive bleeding or deleterious blood clots that...
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8440233 |
Compositions against rotavirus infection and processes for producing the same
The present inventors discovered that microfiltration retentates of whey, and products obtained by treating whey using centrifugation and/or ammonium sulfate precipitation, have the activity of...
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8440207 |
Live bacterial vaccines for viral infection prophylaxis or treatment
A live bacterium, having a DNA construct stabilized against transduction of other bacteria, having a promoter sequence and encoding a fusion peptide, comprising a bacterial secretion peptide...
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8435533 |
Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of Chlamydia
The instant invention relates to antigens and nucleic acids encoding such antigens obtainable by screening a Chlamydia genome. In more specific aspects, the invention relates to methods of...
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8435520 |
Combinations of immunosuppressive agents for the treatment or prevention of graft rejections
A pharmaceutical composition useful in the treatment or prevention of transgenic xenograft rejection comprising immunosuppressant compounds selected from the group consisting of an IL-2...
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8425920 |
Method for inducing lymphoid tissue and modulating intestinal homeostasis
Methods and products for modulating the lymphoid system, especially intestinal homeostasis between intestinal lymphoid tissues and gut flora using ligands for NOD1 and/or CCR6.
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8425921 |
Lipid raft, caveolin protein, and caveolar function modulation compounds and associated synthetic and therapeutic methods
The present invention is directed to the modulation of lipid rafts, caveolin proteins, or caveolar functions and processes by platinum(IV) compounds. Caveolae and/or lipid rafts are associated with...
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8425915 |
Nanoparticles for providing immune responses against infectious agents
Nanoparticles for providing immune responses for the treatment or prophylaxis of infection by infectious agents such as viruses, parasites, bacteria, prions and fungi are described which comprises...
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8425914 |
Methods for enhanced somatostatin immunogenicity in the treatment of obesity
Compositions and methods are provided for treatment growth hormone and/or insulin-like growth factor 1 deficiency in a patient in need of such treatment. Compositions and methods include novel...
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8415317 |
Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of...
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8414899 |
Vaccines comprising multimeric HSP60 peptide carriers
The present invention provides improved vaccine compositions having enhanced immunogenicity and methods of using same. The compositions and methods include immunogenic conjugates containing peptide...
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8409592 |
Whey and thymus function
The present invention generally relates to the field of nutrition and health. In particular, the present invention provides a composition that can be used to maintain or improve thymus health. One...
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8404251 |
LprG as a chaperone of immune adjuvants
An adjuvant combination that stimulates immune activation or response includes a hydrophobic immune adjuvant and a pathogen derived lipoprotein that chaperones the hydrophobic immune adjuvant to an...
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8404249 |
Compositions and methods for topical application and transdermal delivery of botulinum toxins
A composition for topical application of a botulinum toxin (including botulinum toxin derivatives) comprises a botulinum toxin and a carrier comprising a polymeric backbone comprising a long-chain...
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8404243 |
Peptide adjuvants
Adjuvant compositions comprising specific 5mer polypeptides in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for...
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8398992 |
Methods and compositions for polytopic vaccination
The present invention relates to therapeutic and prophylactic methods for treating or preventing an infectious disease in a subject by stimulating or enhancing an immune response against an...
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8399000 |
Haemophilus influenzae type IV pili
The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type pili from nontypeable H. influenzae...
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8398997 |
Compositions and methods for topical application and transdermal delivery of botulinum toxins
A composition for topical application of a botulinum toxin (including botulinum toxin derivatives) comprises a botulinum toxin and a carrier comprising a polymeric backbone comprising a long-chain...
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8388976 |
Polypeptide specifically binding to vascular endothelial growth factor, fusion protein including polypeptide, and methods therefor
A polypeptide inhibiting binding between a vascular endothelial growth factor and a vascular endothelial growth factor receptor, a fusion protein including the same, and a method of preparing the...
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8388935 |
Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia,...
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8389495 |
Olioodeoxynucleotide and its use to induce an immune response
A substantially pure or isolated oligodeoxynucleotide of at least 10 nucleotides is disclosed, wherein the oligodeoxynucleotide comprised a sequence represented by either formula:...
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8388980 |
Yeast-based therapeutic for chronic hepatitis C infection
Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The...
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8383084 |
Destruction of spores through glycoconjugate enhanced phagocytosis
Methods for enhancing destruction and killing of bacterial spores via phagocytosis, where phagocytosis of bacterial spores is enhanced by using a glycoconjugate. In one embodiment, the method...
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8383767 |
Immunogenic protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain
A protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain. Also described herein is an immunoconjugate containing the protein carrier with an antigen...
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8377869 |
Method of preventing adverse effects by GLP-1
A method for preventing or reducing adverse effects such as profuse sweating, nausea and vomiting, which normally are associated with subcutaneous and intravenous administration of glucagon-like...
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8372413 |
Immunomodulatory polynucleotides and methods of using the same
The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.
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8367070 |
Modified surface antigen
Novel proteins that constitute modified forms of a Neisseria meningitidis surface antigen and encoding nucleic acids are provided. The modified surface proteins are characterized by having...
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8367077 |
Virosomes comprising hemagglutinin derived from an influenza virus produced in a cell line, compositions, methods of manufacturing, use thereof
The present invention relates to virosomes comprising hemagglutinin (HA) with improved fusion activity. Preferably, the HA comprised in said virosomes was derived from influenza virus produced in a...
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8361476 |
Vaccine composition comprising an antigen and a peptide having adjuvant properties
The invention relates to a vaccine which comprises at least one antigen and a peptide comprising a sequence R1—XZXZNXZX—R2, whereby N is a whole number between 3 and 7, preferably 5,X is a pos...
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8361483 |
Epinecidin-1 as a vaccine adjuvant for enhancing immune responses
A method of enhancing a mammalian immune response to a virus is disclosed. The method comprises administering a composition comprising an effective amount of epinecidin (Epi)-1 and the virus to a...
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8361478 |
Recombinant viral-based malaria vaccines
Described are vaccines against malarial infections, which are based on recombinant viral vectors, such as alpha viruses, adenoviruses, or vaccinia viruses. The recombinant viral-based vaccines can...
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8361986 |
Synthetic agonists of TLR9
The invention relates to synthetic chemical compositions that are useful for modulation of Toll-Like Receptor (TLR)-mediated immune responses. In particular, the invention relates to agonists of...
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8357377 |
Cyclodextrin-based materials, compositions and uses related thereto
This application discloses cyclodextrin-modified materials for carrying drugs and other active agents, such as nucleic acids. Compositions are also disclosed of cyclodextrin-modified materials that...
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8357374 |
Conjugates of synthetic TLR agonists and uses therefor
The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.
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8354115 |
CD40 ligand adjuvant for respiratory syncytial virus
The present invention provides methods and adjuvants for enhancing an immune response to RSV in a host, wherein the methods and adjuvants comprise a source of a CD40 binding protein. Preferably,...
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8349292 |
Treatment of allergic otitis media in mammals with Clostridia neurotoxins
A method is disclosed for blocking or reducing physiological reaction in a mammal to the interaction of IgE antibodies present in said mammal upon contact with the corresponding antigen, by the...
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8343497 |
Targeting of antigen presenting cells with immunonanotherapeutics
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...
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8343498 |
Adjuvant incorporation in immunonanotherapeutics
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...
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8343488 |
Diagnosis and treatment of human dormancy-related sequellae
New methods for diagnosis and treatment of human dormancy syndrome-related sequellae are provided. Human dormancy syndrome (HDS) is characterized by elevated serum ratio of rT3/fT3 compared to a...
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8343512 |
Treatment of allergic conditions using a composition containing synthetic adjuvant
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant...
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8343508 |
Botulinum antitoxin compositions and methods
This invention provides botulinum antitoxin compositions and methods of production, and methods of treating animals and humans prophylactically and also those suspected of having contacted botulism...
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8338376 |
Compositions comprising variant LT-B-R-IG fusion proteins
This invention relates to methods of treating disease with soluble inhibitors of the lymphotoxin pathway having improved properties. This invention also relates to improved LTBR-Ig fusion proteins,...
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8333980 |
Methods of modulating an immune response using immunostimulatory sequences and compositions for use therein
The invention provides methods of modulating an immune response to a second antigen which entail administration of a first antigen and an immunostimulatory polynucleotide. Modulation of the immune...
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8329209 |
Encapsulated vaccines for the oral vaccination and boostering of fish and other animals
The invention relates to a composition comprising a pharmaceutically active agent and a bioadhesive delivery system that provides for the oral delivery of a vaccine to animals, particularly aquatic...
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8329197 |
Ex vivo uses of immunostimulatory combinations
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also...
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8323668 |
Prevention and treatment of gram negative, flagellated bacterial infections
The present invention describes a novel mechanism of adhesion by flagellated Gram-negative bacteria such as enterotoxigenic Escherichia coli (ETEC), where the bacteria secretes a protein, EtpA...
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8318438 |
Aptamer-based assays
We describe examples using aptamers for capturing and reporting the presence of a target, such as a pathogen. Examples described here include a set of aptamers that are specific to F. tularensisis....
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8318179 |
Neisserial vaccines
The present invention relates to compositions comprising at least one purified PorA protein antigen and at least one purified FetA protein antigen. In particular, said PorA/FetA antigens are...
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