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7381807 Immunostimulatory oligonucleotides and uses thereof  
Oligonucleotides containing the non-palindromic sequence motif: X1X2X3X4X5X6X7X8, wherein X1 is C,T,G or A (preferably T or C); wherein X2 is C,T,G or A; wherein X7 is C,T,G or A (preferably G); at...
7378096 Stress protein compositions and methods for prevention and treatment of cancer and infectious disease  
Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or...
7374765 Methods and compositions for diagnosis and treatment of iron misregulation diseases  
Methods and compositions are provided for the diagnosis and treatment of iron misregulation diseases, including HFE polypeptides, agonists, and antagonists, and transferrin receptor agonists and...
7371734 Oligonucleotide compositions and their use for the modulation of immune responses  
The present invention relates to 3′-OH, 5′-OH polynucleotide sequence compositions and methods for activating an immune response in an individual, and more preferably, for activating antigen pre...
7371392 Cd40 ligand adjuvant for respiratory syncytial virus  
The present invention provides methods and adjuvants for enhancing an immune response to RSV in a host, wherein the methods and adjuvants comprise a source of a CD40 binding protein. Preferably,...
7371395 Vaccine formulations  
The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified or...
7368119 Compositions and methods for WT1 specific immunotherapy  
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
7365172 Loop peptide and TGFα for stimulating stem cell proliferation and migration  
There is disclosed a novel genus of small peptides, much smaller than human TGFα, was discovered as having TGFα biological activity and therefore are useful as pharmacologic agents for the same i...
7361348 Immunogenic glycopeptides, screening, preparation and uses  
The invention concerns immunogenic glycopeptides derived from pathogenic microorganisms, useful for vaccination and diagnosis of infections caused by said pathogenic microorganisms (bacteria or...
7361331 Plant bioreactors  
A plant expressing a cytokine and an autoantigen is disclosed. An example of a cytokine is a contra-inflammatory cytokine, for example IL-4 and IL-10, and an example of autoantigen is GAD. A novel...
7357936 Adjuvant systems and vaccines  
The present invention provides vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed onto a particle of metal salt and the resulting...
7358229 Deuterated cyclosporin analogs and their use as immunomodulating agents  
Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The...
7351688 Compositions and methods for less immunogenic protein formulations  
Methods and composition are described for low immunogenic protein, polypeptide or peptide formulations. The method comprises forming complexes of the protein, polypeptide or peptide with a binding...
7351435 Deglycosylated ricin toxin a-chain vaccine  
The present invention relates to a vaccine comprising deglycosylated ricin toxin A-chain and method for making and using the composition.
7351413 Stabilized HBc chimer particles as immunogens for chronic hepatitis  
A method of treating chronic hepatitis B is disclosed that comprises administering a T cell-stimulating amount of a vaccine to a patient. The vaccine comprises an immunogenic amount of chimeric,...
7341733 Compositions exhibiting ADP-ribosyltransferase activity and methods for the preparation and use thereof  
Compositions characterized by ADP-ribosyltransferase activity are useful in promoting prophylactic and/or therapeutic responses as are promoted by, e.g., pertussis toxin but directed against...
7339037 Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins  
The invention provides a method of inhibiting prophylactically or therapeutically an influenza viral infection in a host. The method comprises instilling into or onto a host a cell producing an...
7335354 Methods for the reduction of malignant tumors by an eosinophil/helminth therapy  
The invention is a method of reducing malignant tumor sizes in mammals by eliciting activated eosinophils to infiltrate the tumor by using helminth excretory and secretory antigens, helminth ova,...
7329410 Compositions and method for WT1 specific immunotherapy  
A method for enhancing or inducing an immune response to WT1 is disclosed. In particular, the method comprises administering to a patient an immunogenic composition comprising an isolated...
7323183 Vaccine compositions including chitosan for intranasal administration and use thereof  
There is provided vaccine compositions for intranasal administration, which compositions comprise one or more antigens and an effective adjuvant amount of a chitosan.
7323182 Oil in water emulsions containing saponins  
The present invention relates to an oil in water emulsion vaccine composition. In particular, the present invention relates to a vaccine adjuvant formulation based on oil in water emulsion...
7320793 Molecular antigen array  
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
7314626 Use of peptide vectors to improve the immune response to antigens  
The invention relates to conjugates of an antigen coupled to a linear derivative of a β-stranded antibiotic peptide, which are useful for immunogenic agents to enhance a CTL response. Two groups ...
7314627 Cationic lipid-mediated enhancement of nucleic acid immunization of cats  
The present invention relates to a method to introduce a nucleic acid molecule into a felid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of...
7297761 Pharmaceutical compositions containing exendins  
Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist,...
7291588 Immunogenic detoxified mutant E. coli LT-A toxin  
An immunogenic detoxified protein is provided which comprises the amino acid sequence of subunit A of an E. coli heat labile toxin (LT-A) or a fragment thereof in which at least amino acid Ala-72...
7288261 Mid-life vaccine and methods for boosting anti-mycobacterial immunity  
Vaccine compositions for boosting immunity to mycobacteria when administered in mid-life in a subject who has been vaccinated neonatally or in early childhood with BCG and in whom protective...
7285282 Mucin peptide with immunoenhancing properties  
An isolated peptide or polypeptide containing the sequence VSIGLSFPMLP (SEQ ID NO:1), found in the secreted form of human MUC1, that enhances an immune response when administered to a mammal,...
7285289 Nanoparticle vaccines  
The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed...
7279172 Treatment of autoimmune conditions with copolymer 1 and related copolymers  
The present invention provides heteropolymer compositions and peptide compositions, and methods of making and using therapeutic compositions comprising amino acid heteropolymers for treatment of a...
7273615 Reaction solution for cell-free protein synthesis, method of preparing the same, and protein synthesis method using the same  
The present invention provides a cell-free protein synthesis method characterized by a cell-free protein synthesis reaction solution that is weakly reducing and suitable for protein folding,...
7270820 CD4+ T-lymphocyte-specific hepatitis C virus epitopes  
The invention relates to hepatitis C virus epitopes which are CD4+ T-lymphocyte specific, and to vaccines containing these epitopes.
7267822 Cytomodulating lipophilic peptides for modulating immune system activity and inhibiting inflammation  
Novel oligonucleotides comprising a sequence derived by a computer program are provided for inhibiting cytotoxic activity of lymphocytic cells, inhibiting production of inflammatory cytokines and...
7262167 Drug, in particular for modulating the immunological response for the control of viruses, tumors, bacteria and parasites  
A method of treating tumors and other conditions in a patient is provided. The method involves administering to the patient a treatment medicament. The medicament contains a first component and a...
7262014 Immune responses against HPV antigens elicited by compositions comprising an HPV antigen and a stress protein or an expression vector capable of expression of these proteins  
This document describes compositions and methods for inducing an immune response (e.g., a cellular response such as a cell-mediated cytolytic immune response) to a human papillomavirus (HPV)...
7259137 Peptides and related molecules that bind to TALL-1  
The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4...
7259136 Compositions and methods for treating peripheral vascular disease  
The present invention relates to methods of treating intermittent claudication comprising administering glucagon-like peptide-1 (GLP-1) molecules to subjects suffering therefrom.
7244438 Uses for polycationic compounds  
The invention relates to the use of a polycationic compound for the preparation of a medicament with retarded in vivo release.
7244412 Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia  
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood...
7244818 Interferon alpha responsive protein  
The present invention relates to identification of a gene upregulated by interferon-α administration corresponding to the cDNA sequence set forth in SEQ ID NO: 1. Determination of expression ...
7244425 Acid- and bile salt-resistant Lactobacillus isolates having the ability to lower and assimilate cholesterol  
Disclosed are acid- and bile salt-resistant Lactobacillus isolates having the ability to lower cholesterol. The present Lactobacillus isolates or their sub-cultured offspring or mutants derived...
7241867 Polypeptide encoded by a nucleotide sequence of a nontypeable strain of Haemophilus influenzae genome  
The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also...
7229621 Method to enhance the immunogenicity of an antigen  
The present invention is related to a method for enhancing the immunogenicity of an antigen in a mammal by introducing into the mammal an antigen or a portion thereof and administering to the...
7229628 Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling  
T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is...
7229646 Methods and compositions for modulating immune response and for the treatment of inflammatory disease  
Compositions and methods for treating inflammatory disease and for modulating the immune system are described. The compositions and methods pertain to the use of a combination of...
7223739 Adjuvanted genetic vaccines  
Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for...
7223391 Method for treating mammals with modified mammalian blood  
An improved method for treating or preventing a pathological condition in a mammalian subject in which modified mammalian blood is administered to the subject. The method comprises administering to...
7217700 Chemokines as adjuvants of immune response  
Dendritic cells play a critical role in antigen-specific immune responses. Materials and methods are provided for treating disease states, including cancer and autoimmune disease, by facilitating...
7208167 Treatment of hepatitis C with thymosin and peptide combination therapy  
A method and pharmaceutical combination for treating hepatitis C by administering to a hepatitis C patient an effective amount of at least one alpha thymosin peptide, in combination with...
7195763 Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them  
Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences...