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6986894 Methods for the treatment of coagulation disorders with lipoprotein associated coagulation inhibitor (LACI)  
The present invention related to a method and therapeutic composition for the treatment of coagulation disorders comprising administration of a lipoprotein associated coagulation inhibitor.
6984389 Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality  
The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a n...
6982247 Compounds exhibiting an antibiotic activity  
The present invention relates to compounds having antibiotic activity which are obtained from body fluids of mollusks, namely of certain West-African snails, to therapeutic drugs comprising these...
6982088 Vaccine composition and stabilization method using high molecular weight PVP  
The invention concerns the stabilization of a vaccine composition maintained in liquid state by the use of high molecular weight polyvinylpyrrolidone, hence eliminating the use of albumen. The...
6982248 Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue  
Individuals in need of treatment of ischemia-related reperfusion are treated, preferably intravenously, with a composition which includes a compound which binds to a receptor for the glucagon-like...
6967022 Ganglioside-KLH conjugate vaccines plus QS-21  
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
6964769 Molecular antigen array  
The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the...
6960651 TANGO 332 polypeptides  
The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are...
6951647 T cell binding ligand peptides and method of inducing a cellular immune response  
The present invention is based, in part, on the discovery that a modified version of Peptide G (Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile—SEQ ID NO:2) obtained by replacing Asn w...
6936258 Staphylococcus antigen and vaccine  
A negatively-charged Staphylococcus antigen contains amino acids and a N-acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of...
6932973 Peptides which stimulate the expression of the cytokines of inflammation and promote tissue regeneration  
A pharmaceutical composition for stimulating production of cytokines of inflammation including a peptide corresponding to formula (I) below: (A)n-A1-A1-A2-A1-A3-A4-A1-(A)m in which A is any amino...
6930167 DNA encoding bovine immunoglobulin a inducing protein and uses therefor  
The invention provides an isolated and purified nucleic acid molecule encoding mammalian immunoglobulin A inducing protein (IGIP), and methods of using the IGIP nucleic acid molecule and IGIP.
6929794 IL-12 as an adjuvant for Bordetella pertussis vaccines  
This invention provides a composition of at least one Bordetella antigen and an effective adjuvant amount of interleukin-12 (IL-12), and uses thereof as a vaccine against Bordetella infection....
6927207 Recombinant mistletoe lectines  
The present invention relates to isolated mistletoe lectin polypeptides and the pharmaceutical composition comprising the polypeptides thereof. Also, the present invention relates to processes for...
6927235 Vaccine composition comprising iron phosphate as vaccine adjuvant  
The present invention relates to vaccine compositions comprising iron phosphate as adjuvant. This iron phosphate is in the form of particles, the size of which is between 0.01 μm and 300 μm; it c...
6919080 Polypeptide for Haemophilus paragallinarum and process for preparing the same  
A novel peptide obtained from Haemophilus paragallinarum has been found useful for preventing avian infectious coryza. This polypeptide induces production of hemagglutination-inhibition antibody...
6916476 Ganglioslide-KLH conjugate vaccine plus QS-21  
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
6913767 Compositions for microencapsulation of antigens for use as vaccines  
Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided...
6911429 Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans  
The present invention provides compositions and methods for treating a tissue disorder associated with a response-to-injury process or proliferating cells in a mammal. These tissue disorders are...
6905691 Vaccines containing attenuated bacteria  
The invention relates to a vaccine comprising a bacterium attenuated by a non-reverting mutation in a gene encoding a protein which promotes folding of extracytoplasmic proteins. Such mutations...
6905712 Vaccine adjuvants comprising ginseng plant extract and added aluminum salt  
A composition, which includes ingredients capable of enhancing the immunogenic effect of a vaccine, includes an aluminium salt and at least one ginsenoside, such as a tri-terpenoid glycoside,...
6902744 Exendin agonist formulations and methods of administration thereof  
Novel exendin and exendin agonist compound formulations and dosages and methods of administration thereof are provided. These compositions and methods are useful in treating diabetes and conditions...
6900299 Interrupting the interaction of intercellular adhesion molecule-1 and respiratory syncytial virus for prevention and treatment of infection  
There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention...
6893644 Hepatitis vaccines containing 3-O-deacylated monophoshoryl lipid A  
A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier...
6890541 Method for enhancing production performance in an animal  
The present invention provides methods for activating the immune systems of newborn animals and methods for enhancing the production performance of the animals. More particularly, the methods of...
6887469 Anti-idiotypic antibodies of vascular endothelial growth factor and use thereof as drugs  
An anti-idiotypic vascular endothelial growth factor antibody, an Fab fragment, and pharmaceutical compositions thereof, being ligands of the human KDR receptor or of the murine flk-1 receptor and...
6887484 Vaccine composition containing a promoter peptide  
A vaccine having a good vaccination effect, which comprises an antigen; a peptide selected from the group consisting of a peptide having the amino acid sequence of SEQ ID NO: 1, a peptide having...
6884785 Compositions and methods for the treatment or prevention of autoimmune diabetes  
The present invention provides compostions and methods for the prevention or treatment of autoimmune disorders. In particular, the invention methods utilize genetic material encoding at least a...
6881828 Fusion proteins between antigenic amino acid sequences and beta-2-microglobulin  
A hybrid fusion protein comprising a first antigenic amino acid sequence fused to a second amino acid sequence substantially homologous to B2M or a fragment thereof.
6878377 Mycobacterium vaccae for down-regulation of the Th2 activity of the immune system  
Antigenic and/or immunogenic material derived from Mycobacterium vaccae is used to down-regulate Th2 activity of the immune system without up-regulation of Th1 activity. Disorders such as Chronic...
6875743 Cell adhesion inhibitors  
The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical...
6872700 Methods for glucagon suppression  
Methods for use of an exendin, an exendin agonist, or a modified exendin or exendin agonist having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, for...
6872385 Adjuvant preparation for the induction of specific immunity  
Disclosed are methods and compositions useful in the recruitment, activation and initiation of proliferation of immune cells. The instant invention relates to the discovery that specific insect...
6869607 Vaccine formulations  
A vaccine containing one or more synthetic or highly purified natural peptides or proteins as antigen(s) as well as one or more adjuvants is present in the form of a solution or emulsion which is...
6867292 Characterization of novel gene cbl-SL  
The invention pertains to nucleic acids encoding a cbl-SL protein, including fragments and biologically functional variants thereof. The invention also pertains to therapeutics and diagnostics...
6867000 Method of enhancing immune responses to herpes  
A method for inducing and enhancing protective and/or therapeutic immunity in a mammal to HSV includes the steps of at least one immunization with an effective amount of a DNA vaccine composition...
6866847 Method of delivering a protein to poultry  
A method of delivering a protein to domestic poultry by administering to the poultry by whole body spray an effective amount of a live avirulent derivative of an enteropathogenic bacterium that...
6867283 Peptides capable of binding to MHC molecules, cells presenting such peptides, and pharmaceutical compositions comprising such peptides and/or cells  
A method of identifying peptides originating from a particular cell type and being capable of binding to MHC molecules of a particular haplotype is disclosed. The method comprises obtaining a cell...
6863896 Plant lectins as mucosal adjuvants  
The invention provides a method of increasing an immune response in a mammal. The method involves administering to the mammal an admixture comprising an immunogen and a plant lectin. The plant...
6852324 Immunization for ebola virus infection  
Ebola virus vaccines comprising nucleic acid molecules encoding Ebola viral proteins are provided. In one embodiment, the nucleic acid molecule encodes the transmembrane form of the viral...
6849601 Peptides  
The present invention relates to novel peptides and derivatives thereof useful as selective α1-adrenoceptor antagonists which ability of inhibiting the agonist action of agonist noradrenaline on ...
6846489 Vaccines containing a saponin and a sterol  
A novel adjuvant composition comprising a sterol (e.g., cholesterol, β-sitosterol, stigmasterol, ergosterol, and ergocalciferol) and saponin fraction (e.g., QS21, also known as QA21) in the form ...
6844000 Use of Parapox B2L protein to treat cancer and modify immune responses  
A purified Parapoxvirus ovis envelope protein termed “B2L” can be used as a monotherapeutic agent. B2L protein also can be used in screening methods to identify potential therapeutic agents for mod...
6841533 Conformationally constrained backbone cyclized interleukin-6 antagonists  
Novel peptides which are conformationally constrained backbone cyclized antagonists of IL-6, are disclosed. Methods for synthesizing the IL-6 antagonists are also disclosed. Furthermore,...
6833275 Gold conjugates containing detergent  
A composition which contains stabilized conjugates composed of colloidal particles and biomolecules is obtained by adding a detergent to a solution containing biomolecules before or/and during...
6833136 Vaccine for preventing pythiosis in humans and animals  
The present invention provides antigen vaccines and methods of use thereof for the treatment of Pythium insidiosum infections, as well as prophylaxis against these infections, in humans and...
6824793 Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants  
Compositions are provided which include hyaluronic acid derivatives in combination with vaccine antigens, and optionally adjuvants, for mucosal delivery. Also provided are methods of making the...
6814971 Adjuvants for use in vaccines  
The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local...
6815169 Identification and expression of a novel kinesin motor protein  
The invention provides isolated nucleic acid and amino acid sequences of TL-γ, antibodies to TL-γ, methods of screening for TL-γ modulators using biologically active TL-γ, and kits for scr...
6811780 Methods of using cytokine antagonists to treat HIV infection and AIDS  
The invention is methods of using cytokine antagonists to treat HIV. In particular, the invention is methods of treating HIV using L-4 and IL-13 cytokine antagonists, including cytokine traps and...