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7259137 Peptides and related molecules that bind to TALL-1  
The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4...
7259136 Compositions and methods for treating peripheral vascular disease  
The present invention relates to methods of treating intermittent claudication comprising administering glucagon-like peptide-1 (GLP-1) molecules to subjects suffering therefrom.
7244438 Uses for polycationic compounds  
The invention relates to the use of a polycationic compound for the preparation of a medicament with retarded in vivo release.
7244412 Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia  
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood...
7244818 Interferon alpha responsive protein  
The present invention relates to identification of a gene upregulated by interferon-α administration corresponding to the cDNA sequence set forth in SEQ ID NO: 1. Determination of expression ...
7244425 Acid- and bile salt-resistant Lactobacillus isolates having the ability to lower and assimilate cholesterol  
Disclosed are acid- and bile salt-resistant Lactobacillus isolates having the ability to lower cholesterol. The present Lactobacillus isolates or their sub-cultured offspring or mutants derived...
7241867 Polypeptide encoded by a nucleotide sequence of a nontypeable strain of Haemophilus influenzae genome  
The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also...
7229621 Method to enhance the immunogenicity of an antigen  
The present invention is related to a method for enhancing the immunogenicity of an antigen in a mammal by introducing into the mammal an antigen or a portion thereof and administering to the...
7229628 Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling  
T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is...
7229646 Methods and compositions for modulating immune response and for the treatment of inflammatory disease  
Compositions and methods for treating inflammatory disease and for modulating the immune system are described. The compositions and methods pertain to the use of a combination of...
7223739 Adjuvanted genetic vaccines  
Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for...
7223391 Method for treating mammals with modified mammalian blood  
An improved method for treating or preventing a pathological condition in a mammalian subject in which modified mammalian blood is administered to the subject. The method comprises administering to...
7217700 Chemokines as adjuvants of immune response  
Dendritic cells play a critical role in antigen-specific immune responses. Materials and methods are provided for treating disease states, including cancer and autoimmune disease, by facilitating...
7208167 Treatment of hepatitis C with thymosin and peptide combination therapy  
A method and pharmaceutical combination for treating hepatitis C by administering to a hepatitis C patient an effective amount of at least one alpha thymosin peptide, in combination with...
7195763 Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them  
Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences...
7192927 Peptides  
Isolated peptides that are fragments of protein products arising from frameshift mutations in genes associated with cancer are disclosed. The isolated peptides of the invention are capable of...
7189834 Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection  
This invention provides novel methods and compositions for modulating and stimulating the immune system of animals to withstand microbial infections and the lethality of endotoxic shock by feeding...
7182962 Immunostimulator for animals and humans, and method of preventing animal and human infectious diseases and cancer  
The goal of the present invention is to provide substances to prevent diseases by activating inherently possessed functions, for cultured fishes and shellfishes and livestock with tendency of...
7183108 Selection and uses of lactic acid bacteria strains modulating non-specific immunity  
The invention concerns lactic acid bacteria strains capable of regulating the production of NO and inflammatory cytokines by enterocytes, depending on the inflammatory condition of said...
7182948 Topical veterinary compositions and methods for the treatment and prevention of infection  
The present invention provides compositions and methods for the treatment of infection in a subject. More particularly, the invention provides a therapy for the treatment or prevention of mammary...
7179471 Materials and methods relating to fusion proteins an immune response  
A nucleic acid construct is provided for delivery into living cells in vivo for inducing an immune response in a patient to an antigen; the construct directing the expression of a fusion protein,...
7169395 Multivalent immunogenic composition containing RSV subunit composition and influenza virus preparation  
Immunogenic compositions for administration to adults, particularly to the elderly, to protect them against disease caused by infection by respiratory syncytial virus and by influenza virus...
7169399 Non-toxic double mutant forms of pertussis toxin as adjuvants  
The invention relates to the use of an antigen which is a non-toxic double mutant form of pertussis toxin for the manufacture of a vaccine composition for intranasal administration to induce an...
7163703 Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds  
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
7163810 Method for producing target substance  
In a method for producing a target substance by using a microorganism comprising culturing a microorganism having an ability to produce the target substance in a medium to produce and accumulate...
7157092 Acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same  
Compounds of the formula wherein the substitutents are defined as in the specification useful for modulating immune responses in warm-blooded animals.
7153509 Immunogenic peptides comprising a T-helper epitope and a B-cell neutralizing antibody epitope  
The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for...
7147849 Pharmaceutical formulation  
A pharmaceutical formulation containing at least one protein-containing substance and at least one substance selected from the group of compatible solutes.
7147862 Vaccine composition containing adjuvants  
The present invention provides vaccine compositions comprising 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccines compositions are potent inducers of CTL and γ IFN responses.
7129334 Synthetic peptide and uses for same  
Beta taipoxin obtained the taipoxin component of the venom of the taipan snake, Oxyuranus s. scutellatus, was fragmented by trypsin digestion. The fragment which showed the highest activity on skin...
7125556 Nucleic acid molecule comprising a nucleic acid sequence coding for a haemocyanin  
A nucleic acid molecule or construct alone or with a promoter suitable for expression control is contemplated that codes for a haemocyanin, a haemocyanin domain or a fragment thereof with the...
7122191 Microfluidized oil-in-water emulsions and vaccine compositions  
This invention provides submicron oil-in-water emulsions useful as a vaccine adjuvant for enhancing the immunogenicity of antigens. The present invention also provides vaccine compositions...
7122192 Porcine circoviruses, vaccines and diagnostic reagents  
The invention relates to new porcine circovirus strains isolated from pulmonary or ganglionic samples obtained from farms affected by the post-weaning multisystemic wasting syndrome (PMWS). It...
7122620 Haptotactic peptides  
This invention is related to a novel peptide consisting of the amino acid sequence of SEQ ID NO:1, and a pharmaceutical composition comprising the peptide thereof.
7118749 Transferrin receptor genes  
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic...
7118874 Immunogenic formulation and process for preparation thereof  
A process is disclosed for preparation of a immunogenic peptide mixture in a single synthesis. The peptide mixture collectively represents the in vivo variability seen in immunogenic epitopes from...
7115562 Peptides and their use to ameliorate cell death  
The present invention relates to a method of reducing cell death in a warm-blood animal wherein said cell death associated with a neurodegenerative disorder, an immune disease, a neoplastic...
7115579 Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides  
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
7115268 Peptides useful for reducing symptoms of toxic shock syndrome and septic shock  
This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates...
7105162 Pharmaceutical composition for immunomodulation based on peptides and adjuvants  
Pharmaceutical composition containing at least one peptide or protein (fragment) with an immunomodulatory activity together with an adjuvant. The peptide is derived from a pathogenic agent or a...
7101560 Combination vaccine for administration to adolescents  
Novel combined vaccine compositions are provided, comprising a herpes simplex virus (HSV) antigen and a HPV antigen and optionally in addition one or more of the following: an EBV antigen, a...
7097837 Synthetic vaccine agents  
The present invention provides for novel immungens that are comprised of an activated polyhydroxypolymer backbone to which is attached 2 separate antigenic determinants. The 1st antigenic...
7094391 Compositions and methods for administering Borrelia burgdorferi antigens  
Mucosal administration of OspA and compositions therefor are disclosed and claimed. More particularly, oral administration of OspA and compositions therefor for eliciting an immunological response...
7094413 Combined therapy for treatment of HIV infection  
The present invention relates to pharmaceutical preparations and methods for treating individuals infected with the human immunodeficiency virus (HIV). The pharmaceutical preparations comprise an...
7090853 Noscapine derivatives as adjuvant compositions and methods of use thereof  
An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines.
7087573 Methods of inhibiting platelet anti-HLA alloimmune antibody responses with soluble 18 KDa CD40L  
The invention relates to a method for inhibiting an in vivo alloimmune response, and to the use of a soluble recombinant human CD40L protein containing the active binding site with CD40. In...
7083798 Method of immunomodulatory treatment of insulin dependent diabetes mellitus using mycobacterial cell wall compositions  
The present invention relates generally to a method of immunomodulating therapy and pharmaceutical compositions useful for same. More particularly, the present invention provides a method of...
7083787 Yeast-dendritic cell vaccines and uses thereof  
Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral...
7078388 DNA vaccines for farm animals, in particular bovines and porcines  
DNA vaccine against a pathogen affecting farm animals, in particular bovines or porcines, comprising a plasmid containing a nucleotide sequence encoding an immunogen of a pathogen of the animal...
7070781 Nontoxic mucosal adjuvant  
A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic...