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7087573 Methods of inhibiting platelet anti-HLA alloimmune antibody responses with soluble 18 KDa CD40L  
The invention relates to a method for inhibiting an in vivo alloimmune response, and to the use of a soluble recombinant human CD40L protein containing the active binding site with CD40. In...
7083798 Method of immunomodulatory treatment of insulin dependent diabetes mellitus using mycobacterial cell wall compositions  
The present invention relates generally to a method of immunomodulating therapy and pharmaceutical compositions useful for same. More particularly, the present invention provides a method of...
7083787 Yeast-dendritic cell vaccines and uses thereof  
Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral...
7078388 DNA vaccines for farm animals, in particular bovines and porcines  
DNA vaccine against a pathogen affecting farm animals, in particular bovines or porcines, comprising a plasmid containing a nucleotide sequence encoding an immunogen of a pathogen of the animal...
7070781 Nontoxic mucosal adjuvant  
A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic...
7067139 Method for treating autoimmune diseases  
A method of treating patients having rheumatoid arthritis by administering Product R, a peptide-nucleic acid preparation, is disclosed.
7067639 Method to provide bacterial ghosts provided with antigens  
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
7063854 Composition and methods for WTI specific immunotherapy  
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an...
7060453 Method and kit for the determination of analyte concentration in blood  
A method is provided for determining the level of an analyte in the blood of an individual based on determination of the level of the same analyte in non-blood sample (e.g. urine, saliva and hair)...
7056521 Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants  
The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E. coli...
7052701 Inactivated influenza virus vaccine for nasal or oral application  
The invention relates to nasal or oral administration of a compound containing inactivated influenza virus antigen and aluminum as adjuvant for the prophylaxis of influenza virus infections. Said...
7053176 Combination of C1-INH and lung surfactant for the treatment of respiratory disorders  
Pharmaceutical composition for the treatment of infant respiratory distress syndrome and acute lung injury (including adult respiratory distress syndrome) which contains C1 esterase inhibitor...
7048906 Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions  
Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia,...
7049302 Compositions of CPG and saponin adjuvants and uses thereof  
Vaccine compositions of immunostimulatory oligonucleotides and saponin adjuvants and antigens and the use thereof for stimulating immunity, enhancing cell-mediated immunity, and enhancing antibody...
7041301 Interferon immunotherapy  
A method for reducing the recurrence of a resectable malignant tumor includes administering an immunostimulatory dosage of an α-interferon composition, then surgically resecting the malignant ...
7041294 Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects  
A method of eliciting an immune response against an antigen in a vertebrate subject, the method comprising the steps of providing an antigen-adjuvant composition comprising the antigen and a...
7041302 Therapeutic modulation of the tumor inflammatory response  
The invention relates to compositions, kits, and methods for alleviating cancer (i.e., a tumor) in a human patient. The therapeutic modality effected by the invention involves inducing a type 1...
7037500 Method for using phagocytic particles and ATP receptors to deliver antigens to MHC class I receptors to induce immunity against microbial pathogens or tumors or to suppress immunity  
This invention provides methods of delivering an antigen to an Class I or Class II MHC receptors to induce immunity against the antigen in a subject having a disease. This invention also provides...
7037510 Hybrids of M. tuberculosis antigens  
The present invention discloses fusion proteins of the immunodominant antigens ESAT-6 and Ag85B from Mycobacterium tuberculosis or homologues thereof, and a tuberculosis vaccine based on the fusion...
7037501 Myostatin immnoconjugate  
A method to alter the phenotype of animals, e.g., avians, which employs passive and active immunization is provided.
7033591 Immunostimulant bacterial membrane fractions in cancer treatment  
The invention concerns the use of a membrane fraction of gram-negative bacteria, in particular Klebsiella pnemoniae for preparing a pharmaceutical composition that is immunostimulant and/or capable...
7029656 Methods and formulations for the efficient delivery of water-insoluble drugs by nebulizer  
Formulations, methods and devices for producing formulations and methods for nebulizer delivery of formulations of water-insoluble drugs are provided. Also provided are methods for minimizing...
7030219 B7-DC, Dendritic cell co-stimulatory molecules  
A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments,...
7030094 Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and QS-21  
The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising RC-529 (an aminoalkyl glucosaminide phosphate compound) and QS-21 (a...
7026166 Fluorogenic dyes  
The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule.
7022496 Use of gene product of adenovirus early region 4 ORF-6 to inhibit repair of double-strand breaks in DNA  
The present invention provides a modified adenovirus comprising genomic adenoviral DNA which has been modified so that (i) the only gene product of the early region (E4) that is expressed is open...
7014856 Ganglioside-KLH conjugate vaccines plus OS-21  
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
7012129 Antiviral composition comprising glycine amide  
Embodiments relate to the discovery that certain tripeptide amides and glycine amide can be used to inhibit viral infection, including human immunodeficiency virus (HIV) infection. More...
7011836 Mutants of gram negative mucosal bacteria and application thereof in vaccines  
It is possible to inactivate the early stage of lipid A synthesis of mucosal gram negative bacteria without compromising cell viability. In particular the lpxA gene in N. meningitidis was mutated...
7001601 Ganglioside-KLH conjugate vaccine plus QS-21  
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
6987166 Compositions and methods for the treatment of sepsis  
The present invention relates to compositions and methods for the prevention and treatment of blood-borne and toxin mediated diseases, and in particular anti-C5a antibodies for the prevention and...
6986894 Methods for the treatment of coagulation disorders with lipoprotein associated coagulation inhibitor (LACI)  
The present invention related to a method and therapeutic composition for the treatment of coagulation disorders comprising administration of a lipoprotein associated coagulation inhibitor.
6984389 Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality  
The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a n...
6982247 Compounds exhibiting an antibiotic activity  
The present invention relates to compounds having antibiotic activity which are obtained from body fluids of mollusks, namely of certain West-African snails, to therapeutic drugs comprising these...
6982088 Vaccine composition and stabilization method using high molecular weight PVP  
The invention concerns the stabilization of a vaccine composition maintained in liquid state by the use of high molecular weight polyvinylpyrrolidone, hence eliminating the use of albumen. The...
6982248 Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue  
Individuals in need of treatment of ischemia-related reperfusion are treated, preferably intravenously, with a composition which includes a compound which binds to a receptor for the glucagon-like...
6967022 Ganglioside-KLH conjugate vaccines plus QS-21  
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
6964769 Molecular antigen array  
The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the...
6960651 TANGO 332 polypeptides  
The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are...
6951647 T cell binding ligand peptides and method of inducing a cellular immune response  
The present invention is based, in part, on the discovery that a modified version of Peptide G (Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile—SEQ ID NO:2) obtained by replacing Asn w...
6936258 Staphylococcus antigen and vaccine  
A negatively-charged Staphylococcus antigen contains amino acids and a N-acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of...
6932973 Peptides which stimulate the expression of the cytokines of inflammation and promote tissue regeneration  
A pharmaceutical composition for stimulating production of cytokines of inflammation including a peptide corresponding to formula (I) below: (A)n-A1-A1-A2-A1-A3-A4-A1-(A)m in which A is any amino...
6930167 DNA encoding bovine immunoglobulin a inducing protein and uses therefor  
The invention provides an isolated and purified nucleic acid molecule encoding mammalian immunoglobulin A inducing protein (IGIP), and methods of using the IGIP nucleic acid molecule and IGIP.
6929794 IL-12 as an adjuvant for Bordetella pertussis vaccines  
This invention provides a composition of at least one Bordetella antigen and an effective adjuvant amount of interleukin-12 (IL-12), and uses thereof as a vaccine against Bordetella infection....
6927207 Recombinant mistletoe lectines  
The present invention relates to isolated mistletoe lectin polypeptides and the pharmaceutical composition comprising the polypeptides thereof. Also, the present invention relates to processes for...
6927235 Vaccine composition comprising iron phosphate as vaccine adjuvant  
The present invention relates to vaccine compositions comprising iron phosphate as adjuvant. This iron phosphate is in the form of particles, the size of which is between 0.01 μm and 300 μm; it c...
6919080 Polypeptide for Haemophilus paragallinarum and process for preparing the same  
A novel peptide obtained from Haemophilus paragallinarum has been found useful for preventing avian infectious coryza. This polypeptide induces production of hemagglutination-inhibition antibody...
6916476 Ganglioslide-KLH conjugate vaccine plus QS-21  
This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of...
6913767 Compositions for microencapsulation of antigens for use as vaccines  
Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided...
6911429 Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans  
The present invention provides compositions and methods for treating a tissue disorder associated with a response-to-injury process or proliferating cells in a mammal. These tissue disorders are...