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7361359 |
Neospora caninum isolate
The present invention relates to a novel Neospora caninum isolate from Nowra and extracts thereof. The strain is useful in the development of diagnostic assays for the detection of parasites in...
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7273709 |
Detection of sarcocystis neurona
A gene encoding a 29 kilodalton protein found on the surface of merozoite stage S. neurona has been cloned and sequenced. The protein encoded by this gene, termed SnSAG-1, is an immunodominant...
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7250173 |
Use of parasitic biological agents for prevention and control of autoimmune diseases
The invention relates to a method of treating an excessive immune response including an aberrant/enhanced Th1 response by administering a helminthic parasite preparation in an amount sufficient to...
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7238347 |
Suicidal mutant Leishmania vaccine
The present invention discloses the use of a mutant Leishmania as a suicidal vaccine wherein the mutant Leishmania is responsive to external signals to become porphyric and commit suicidal...
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7189399 |
Chimeric gene formed of the DNA sequences that encode the antigenic determinants of four proteins of L. infantum, useful for serologic diagnosis of canine leishmaniosis and protein obtained
Chimeric gene formed by the DNA sequences that encode the antigenic determinants of four proteins of L. infantum , useful for the serological diagnosis of canine Leishmaniosis and protein...
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7179615 |
Method of prophylaxis and treatment
The present invention relates generally to a method for the prophylaxis and treatment of parasitic infections in animals and birds. More particularly, the present invention contemplates a method...
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7169398 |
Equine protozoal myeloencephalitis vaccine
The present invention provides an immunogenically active component comprising inactivated Sarcocystis neurona cells and/or inactivated Neospora hughesi cells; antigens derived therefrom; DNA...
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7166290 |
Methods for producing oocysts
The present invention provides improved methods and compositions for producing oocysts. The oocysts produced according to the invention find use in the manufacture of vaccines. In preferred...
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7150873 |
Coccidiosis vaccines
The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers...
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7141245 |
Process for preparation of a microbial agent
A method of killing mosquito larvae and particularly the species comprising Culex tritaeniorhynchus, Cx. pseudovishnui, Cx . ( Cx ) sp., Cx . ( Lutzia ) sp. and Anopheles hyrcanus group which...
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7094576 |
Methods and compositions for detecting larval Taenia solium with a cloned diagnostic antigen
Compositions and methods for the detection of Taenia solium and the diagnosis of T. solium infection are described. The nucleotide and amino acid sequences of the antigenic T. solium ...
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7078044 |
Anti-amoebic vaccine
The invention relates to an anti-amoebic vaccine containing an oligopeptide which can be obtained from the microorganism Entamoeba histolytica or synthesized by known methods. The anti-amoebic...
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7071296 |
Plasmodium falciparum antigens inducing protective antibodies
The present invention relates to immunogenic compositions comprising as an immunogen a long synthetic or recombinant peptide of a merozoite surface protein 3b (MSP-3b) peptide, an MSP-3c peptide...
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7067315 |
Identification of anti-protozoal agents
The present invention provides novel assay systems and methods for monitoring cell invasion by protozoal parasites. The present invention further provides methods of using these assays systems to...
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7063848 |
Lipoglycan compositions and methods of treating parasitic infections
A composition for and a method of eliciting in a vertebrate a protective immune response against an eukaryotic parasite are disclosed. The method includes administering to the vertebrate a...
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7022511 |
Process for the isolation and acclimatization of bacteria for lignin degradation
The invention provides a novel process of lignin degradation using a consortium of bacteria. To date, biodegradation of lignin has been centered to fungi only. Degradation of lignin by bacteria...
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7018640 |
In ovo vaccination against coccidiosis
The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immnunizing dose of live Eimeria sporozoites or merozoites,...
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7008774 |
Practical serological assay for the clinical diagnosis of leishmaniasis
Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are...
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6998126 |
Selection of poultry Eimeria strains through extra-intestinal sporozoites
A method for obtaining an immunogenic strain useful for producing a vaccine against Coccidiosis comprises the cycle of infecting at least one first group of specific pathogen-free donor birds with...
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6994861 |
Attenuated live neospora vaccine
The present invention provides attenuated live cultures of the pathogenic protozoan parasite, Neospora , and live vaccines against neosporosis prepared therefrom which are useful in the prevention...
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6936263 |
Th1 inducing natural adjuvant for heterologous antigens
The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates...
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6891024 |
Monoclonal antibodies to Sarcocystis neurona and uses therefor
The present invention is directed to particular monoclonal antibodies that find use in the identification and purification of Sarcocystis neurona and related antigens. In particular, these...
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6890542 |
Leishmania vaccine
The present invention relates to the use of a live mutant Leishmania in the preparation of a vaccine and to vaccine formulations for use in immunizing mammals, such as dogs and/or humans. The...
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6890527 |
Methods of treatment
A method of producing active immunity against a bacterial or protozoal disease in a subject comprises administering to the subject a vaccine conjugate comprising a live bacteria or protozoa and a...
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6855537 |
Macrophage-infecting parasites expressing a granulocyte macrophage colony stimulated factor
Strains of Leishmania and other macrophage-infecting parasites are provided which express the GM-CSF gene which are useful in treating hosts infected by the parasite and in protecting hosts against...
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6787146 |
Neospora vaccine
The present invention provides an homogenate prepared from cells of Neospora, and vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion...
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6783765 |
Process for the preparation of a vaccine for the treatment of tuberculosis and other intracellular infections diseases and the vaccine produced by the process
The present invention relates to a process for the preparation of a vaccine against tuberculosis and other intracellular pathogens, this vaccine is targeted against intracellular pathogens, more...
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6780415 |
Animal model for infection by an apicomplexan parasite
An animal model for CNS infection by Apicomplexan parasites was produced by inoculating a homologous cell or other type of cell with the merozoite stage of the Apicomplexan parasite and inoculating...
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6756043 |
Compositions and methods for detecting adult Taenia solium
Compositions and methods for the detection of adult Taenia solium and the diagnosis and treatment of T. solium infection are described. The compositions contain one or more adult T. solium ...
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6730307 |
Anti-cryptosporidium parvum preparations
Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum . A high molecular weight glycoprotein antigen isolated from C. parvum , capable of binding...
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6710166 |
41 kDa Cryptosporidium parvum oocyst wall protein
Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against Cryptosporidium...
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6709661 |
Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at...
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6682746 |
Adjuvanted vaccine which is substantially free of non-host albumin
Disclosed herein is a serum-based adjuvanted vaccine which is substantially free of non-host albumin and the use thereof in reducing or preventing post-vaccination systemic reactions.
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6673351 |
Compositions and methods for the treatment and clinical remission of psoriasis
Polypeptides comprising amino acid sequences of particulate antigens isolated from various species of Leishmania protozoa, or immunogenic variants thereof, are disclosed for the treatment and...
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6660840 |
Methods for enhancement of protective immune responses
Methods for eliciting or enhancing immune responses to antigens, including tumor antigens, and/or DNA vaccines are provided. The methods employ polypeptides or nucleic acid compositions that...
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6652847 |
Attenuated strains of leishmania and uses thereof
Attenuated strains of Leishmania are provided in which at least one gene contributing to virulence of the strain and expressed in both the promastigote and amastigote forms of the strain is...
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6525186 |
Chimeric gene formed of the DNA sequences that encode the antigenic determinants of four proteins of L. infantum, useful of serologic diagnosis of canine leishmaniosis and protein obtained
A chimeric polypeptide encoded by a chimeric gene formed by DNA sequences that encode four antigenic determinants of L. infantum is disclosed. These antigenic determinants are obtained from...
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6491922 |
Methods and compounds for treating autoimmune and vascular disease
The present invention relates to methods of treating inflammatory diseases, inhibiting production of adhesion molecules on endothelial cells, inhibiting production of nitric oxide synthase by...
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6491920 |
Polypeptides and DNA encoding same
Proteins from the merozoite stage of the malaria parasite, fragments and derivatives thereof, DNA coding for the said proteins, and processes for the preparation of the proteins and plasmid and...
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6476192 |
Recombinant antigens useful for the serodiagnosis of neosporosis
Antigens for the detection of antibodies to Neospora parasites for the diagnosis of neosporosis have been identified. Recombinant antigens may be produced by expression of DNA sequences derived...
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6458922 |
Antigens and immunoassays for diagnosing Chagas' disease
Transfusion of contaminated blood has become the major route of transmission for Chagas' disease. Current screening tests are insensitive and yield conflicting results, while confirmatory assays do...
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6451338 |
Liposomes containing particulate materials
A method is provided for the formation of liposomes of 0.1 μm to 50 μm in diameter having unilamella or multilamella structure and containing water insoluble or undissolved particulate materials...
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6432671 |
Tryparedoxin, expression plasmid, process of production, method of use, test kit, and pharmaceutical composition
The present invention provides novel enzymes, tryparedoxins, their isolation from Crithidia fasciculata, a method for the production thereof in genetically transformed bacteria, and their use as...
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6419933 |
Compounds and methods for the detection and prevention of T.cruzi infection
Compounds and methods are provided for diagnosing Trypanosoma cruzi infection. The disclosed compounds are polypeptides, or antibodies thereto, that contain one or more epitopes of T. cruzi ...
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6410250 |
Sustained delivery device and methods of making and using the same
Disclosed herein are novel medical devices, particular well-suited for sustained delivery of therapeutically-significant substances. Also disclosed are methods of making and using these delivery...
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6403576 |
Antifungal and antiparasitic compounds
Novel antiparasitic and antifungal compositions are disclosed. The antiparasitic and antifungal compositions are useful for human and veterinary therapy for the treatment and/or prevention of...
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6392014 |
Cloning of gene encoding the GP28.5 protein of Toxoplasma gondii; peptide fragments of said protein and their applications
The invention relates to cloning of the gene for the toxoplasma GP28.5 antigen. It also encompasses purified GP28.5 antigen preparations and antigenic polypeptides derived from said antigen, and...
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6391569 |
Method to detect Dirofilaria immitis infection
The present invention includes a method to detect D. immitis infection in a host animal using a D. immitis Di33 protein to detect anti- D. immitis Di33 antibodies in a bodily fluid of the...
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6383498 |
Compositions for vaccines
Neuraminidase and galactose oxidase together are a vaccine adjuvant.
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6342230 |
Materials and methods for prevention or reduction of the severity of heartwater
The present invention pertains to materials and methods for preventing, or reducing the severity of, heartwater disease in animals. One aspect of the invention is a vaccine against heartwater...
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