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7354594 |
Merozoite surface protein 1 lacking glycosylation sites
The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is...
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7332595 |
DNA sequences encoding peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
The invention discloses isolated DNA sequences encoded by polypeptides characterized by the presence in their structure of one or more sequences bearing all or part of one or more T epitopes, and...
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7306806 |
Recombinant P. falciparum merozoite protein-142 vaccine
In this application is the expression and purification of a recombinant Plasmodium falciparum (3D7) MSP-1 42 . The method of the present invention produces a highly purified protein which retains...
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7256281 |
Recombinant P. falciparum merozoite protein-142 vaccine
In this application is described the expression and purification of a recombinant Plasmodium falciparum (FVO) MSP-1 42 . The method of the present invention produces a highly purified protein...
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7198791 |
Compositions and methods for the generation of protective immune responses against malaria
The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory...
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7179615 |
Method of prophylaxis and treatment
The present invention relates generally to a method for the prophylaxis and treatment of parasitic infections in animals and birds. More particularly, the present invention contemplates a method...
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7125958 |
Malaria polypeptides
The present invention relates to carbohydrates capable of acting as receptors for malaria antigens present on the surfaces of malaria infected erythrocytes. The receptors according to the invention...
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7101556 |
Preparation and usage of plasmodium fusion antigen
The invention provides a fusion protein comprising the Plasmodium merozoite surface protein-1 (MSP1) and the Plasmodium apical membrane antigen 1 (AMA-1), the encoding DNA sequence, the vector...
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7078507 |
Synthetic genes for malarial proteins and methods of use
Synthetic gene sequences encoding erythrocyte binding protein of a malaria pathogen for the expression of the erythrocyte binding protein. The codon composition of the synthetic gene sequences...
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7078043 |
Malaria vaccine
A non-naturally occurring variant of a C-terminal fragment of a Plasmodium merozoite surface protein-1 (MSP-1) wherein said variant has (i) a reduced affinity, compared with a naturally occurring...
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7071296 |
Plasmodium falciparum antigens inducing protective antibodies
The present invention relates to immunogenic compositions comprising as an immunogen a long synthetic or recombinant peptide of a merozoite surface protein 3b (MSP-3b) peptide, an MSP-3c peptide...
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7067315 |
Identification of anti-protozoal agents
The present invention provides novel assay systems and methods for monitoring cell invasion by protozoal parasites. The present invention further provides methods of using these assays systems to...
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7056518 |
Malarial pre-erythrocytic stage polypeptide molecules
Polypeptide molecules containing at least 10 consecutive amino acids of the amino acid sequence shown in FIG. 2, representing the LSA3 antigen, the following peptides being excluded:
...
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7029685 |
Plasmodium falciparum AMA-1 protein and uses thereof
In this application is described the expression and purification of a recombinant Plasmodium falciparum (3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified...
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6942866 |
Malaria immunogen and vaccine
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid protein (HBc) is disclosed that contains an immunogen for inducing the production of antibodies to malarial proteins. An...
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6855322 |
Isolation and purification of P. falciparum merozoite protein-142 vaccine
This application is the expression and purification of a recombinant Plasmodium falciparum (3D7) MSP-1 42 . The method of the present invention produces a highly purified protein which retains...
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6815183 |
Plasmodium sp. chitinase
The present invention is directed to isolated nucleic acid molecules encoding Plasmodium sp. chitinases . Expression vectors and host cells comprising the nucleic acid molecules are also...
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6783765 |
Process for the preparation of a vaccine for the treatment of tuberculosis and other intracellular infections diseases and the vaccine produced by the process
The present invention relates to a process for the preparation of a vaccine against tuberculosis and other intracellular pathogens, this vaccine is targeted against intracellular pathogens, more...
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6780417 |
Transmission blocking immunogen from malaria
The present invention relates to transmission blocking vaccines against malaria. Vaccines of the present invention contain a recombinant virus encoding all, or a unique portion, of the 25 kDa...
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6593463 |
Modified MSP-1 nucleic acid sequences and methods for increasing MRNA levels and protein expression in cell systems
The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is...
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6491920 |
Polypeptides and DNA encoding same
Proteins from the merozoite stage of the malaria parasite, fragments and derivatives thereof, DNA coding for the said proteins, and processes for the preparation of the proteins and plasmid and...
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6417341 |
Malaria merozoite antigen subunit vaccine
An immunogenic polypeptide for use in inducing an immune response against Plasmodium infection comprises an amino acid sequence corresponding to a non-full length fragment of the apical membrane...
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6333406 |
Gene encoding protein antigens of Plasmodium falciparum and uses therefor
A Plasmodium falciparum gene encoding immunogenic SERA protein has been isolated by a) systematically screening a lambda gt11 recombinant DNA expression library with a murine monoclonal antibody...
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6316000 |
Cloning and expression of plasmodium falciparum transmission-blocking target antigen, PFS230
Compositions comprising biologically pure Pfs230 and nucleic acids which encode them are provided. The proteins can be used induce transmission blocking immune responses in susceptible hosts.
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6214353 |
Malaria recombinant poxvirus vaccine
What is described is a recombinant poxvirus, such as vaccinia virus, containing foreign DNA from Plasmodium Merozoite Surface Antigen 1. What is also described is a vaccine containing the...
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6120770 |
Plasmodium proteins useful for preparing vaccine compositions
The present invention relates to DNA segments encoding MAEBL, an erythrocyte binding protein of a Plasmodium parasite, to substantially pure MAEBL proteins and to recombinantly or synthetically...
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6113917 |
Modified polypeptides for enhanced immunogenicity
A recombinant polypeptide comprising a polypeptide which has added thereto a glycoxyl-phosphatidylinositol anchor structure, said polypeptide demonstrating a greater immune response than the...
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6100067 |
Molecules containing at least one peptide sequence carrying one or several epitopes characteristic of a protein produced by P. falciparum at the sporozoite stage and in the hepatocytes
The invention relates to a polypeptide characterized in that it contains at least one peptide sequence carrying one or several epitopes characteristic of a protein produced at the sporozoite stage...
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6093406 |
Vaccine for induction of immunity to malaria
Vaccines for the induction of immunity to malaria, based on aluminum hydroxide-treated, lipid A- and malarial antigen-containing liposomes, are described. Vaccines of this sort are useful in both...
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5965142 |
Polypeptides and methods for the detection of L. tropica infection
Compounds and methods for diagnosing Leishmania tropica infection, or for screening for L. tropica infection, are disclosed. The disclosed compounds are polypeptides that contain one or more...
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5928901 |
Molecules containing at least one peptide sequence carrying one or several epitopes characteristic of a protein produced by P. falciparum in hepatocytes and compositions containing them
The invention relates to a molecule comprising one or more peptide sequences of formula: TBL Leu-Ala-Lys-Glu-Lys-Leu-Gln-X-Gln-Gln-Ser-Asp-Leu- Glu-Gln-Glu-Arg in which X is Glu or Gly. It also...
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5911991 |
Malarial binding site in duffy blood group protein
A composition and method for inhibiting binding of malarial Duffy-binding ligand to Duffy blood group antigens on mammalian erythrocytes is disclosed. The composition includes a Duffy-related...
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5853739 |
Transmission-blocking vaccine against malaria
The present invention relates to transmission-blocking vaccines against malaria. Vaccines of the present invention contain a recombinant Pfs25 Plasmodium falciparum protein produced by yeast cells...
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5814617 |
Protective 17 KDA malaria hepatic and erythrocytic stage immunogen and gene
An IgG1 monoclonal antibody, Navy Yoelii Liver Stage 3 (NYLS3) does not recognize sporozoites, but recognizes P. yoelii liver stage parasites within 6 hours of invasion of mouse hepatocytes, and...
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5811106 |
Plasmodium falciparum thrombospondin-related anonymous proteins (TRAP), fragments and functional derivatives
Proteins, fragments and functional derivatives of a Plasmodium falciparum merozoite-stage thrombospondin-related anonymous protein (TRAP) and pharmaceutical compositions comprising said products.
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5798106 |
Protein
This invention relates to a novel protein capable of inducing an immune response protective against human malarial infection caused by Plasmodium falciparum, and to the cloning and expression of a...
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5766597 |
Malaria recombinant poxviruses
What is described is a recombinant poxvirus, such as vaccinia or canarypox virus, containing foreign DNA from Plasmodium such as coding for at least one of CSP, PfSSP2, LSA-1, LSA-1-repeatless,...
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5753238 |
Target antigens of transmission blocking antibodies for malaria parasites
The present invention relates novel methods and compositions for blocking transmission of Plasmodium spp. which cause malaria. In particular, P28 proteins are disclosed which, when administered to...
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5609872 |
Peptides comprising a protective epitope from blood stages of plasmodium falciparum
A peptide comprising the amino acid sequence: U-O-X-glu-Z or O-X-glu-Z-ala-glu, wherein: U is an amino acid residue selected from val and ile; O is an amino acid residue selected from ala and thr:...
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5602031 |
DNA encoding molecules containing at least one peptide sequence carrying one or several epitopes characteristic of a liver stage antigen produced by p. falciparum in hepatocytes and compositions containing them
The invention relates to a molecule comprising one or more peptide sequences of formula: Leu-Ala-Lys-Glu-Lys-Leu-Gln-X-Gln-Gln-Ser-Asp-Leu-Glu-Gln-Gl
u-Arg in which X is Glu or Gly. It also...
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5599543 |
Immunogenic four amino acid epitope against Plasmodium vivax
An agent and pharmaceutical formulations of the agent containing a synthetic peptide of the human malaria Plasmodium vivax, containing at least one repeat of a synthetic peptide having the amino...
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5589343 |
Antibodies which bind to molecules containing at least one peptide sequence carrying one or several epitopes characteristic of a liver stage antigen produced by P. falciparum in hepatocytes
The invention relates to a molecule comprising one or more peptide sequences of formula: Leu-Ala-Lys-Glu-Lys-Leu-Gln-X-Gln-Gln-Ser-Asp-Leu-Glu-Gln-Gl
u-Arg in which X is Glu or Gly. It also...
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5573943 |
Cloning and expression of a rhoptry associated protein of P. falciparum
A synthetic or recombinant polypeptide displaying the antigenicity of the 42 kDa rhoptry-associated protein (RAP-2) of P.falciparum or an antigenic fragment thereof, and recombinant DNA molecules,...
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5456911 |
Synthetic malarial antigens and uses thereof
The present invention includes novel peptides GQDEGEENEG, SEQ. ID NO:1 GRNGLGANTDQDDQLEDE, SEQ. ID NO:2 DQFFDANPNLFQLLEPVEFDED, SEQ. ID NO:3 and LVFLVQQPFLFVLWDQNEKFPVFMGVYDP SEQ. ID NO:3. Such...
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5393523 |
Plasmodium falciparum vaccine comprising a recombinant histidine-rich protein-HRP-II
Recombinant histidine-rich protein of Plasmodium falciparum, its preparation and use. It was possible, by screening two different Plasmodium falciparum cDNA gene banks with an antiserum against a...
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5376370 |
Monoclonal antibody - specific merozoite antigens
Disclosed herein is a P. falciparum merozoite antigenic polypeptide of approximate molecular weight 185,000. The polypeptide and processing fragments are specific to, and isolable using, a...
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5286483 |
50 kilodalton antigen obtained from the intraerythrocytic phase of plasmodium falciparum
The invention concerns antigens from the intraerythrocytic phase of Plasmodium falciparum, namely: a protein of 50 kDa with an isoelectric point of 5.5 and a protein of 65 kDa separated by...
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5229110 |
Process for preparing a vaccine against malaria
A process for preparing a vaccine against malaria comprising at least one polypeptide extracted from a schizont form of a strain of Plasmodium containing polypeptides antigenic to malaria. The...
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5225534 |
Recombinant malarial polypeptides
The invention provides polypeptides which correspond in at least one specific epitope with a plasmodium falciparum merozoite antigen having a molecular weight of about 41,000 Daltons, and a process...
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5118501 |
Polypeptidic composition useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of antimerozoite antibodies
Immunologically active polypeptide composition constituted by polypeptides having the formula: H--(Glu--Glu--Asn--Val--Glu--His--Asp--Ala) n --OH wherein Glu=Glutamic Acid; Asn=Asparagine; ...
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