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8911748 Cholera toxin chimera and its use as a staph vaccine  
The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of...
8852605 Vibrio cholerae O139 conjugate vaccines  
The disclosure pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These...
8834898 Cholera toxin chimera and its use as a staph vaccine  
The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of...
8758774 Bivalent vaccine for marine fish and method for making the same  
A bivalent vaccine against Scuticociliatosis, Vibriosis and marine ich in zobaidy, sobaity and hamoor includes a formalin killed whole cell Vibrio encapsulated Uronema spp. The vaccine is made by...
8753643 Spray dried compositions and methods of use  
Provided herein are insoluble particles that include polypeptides. The polypeptides may have immunogenicity that is greater than the immunogenicity of the same polypeptides when they are not...
8734814 Recombinant microorganisms and uses thereof  
The present invention relates to recombinant strains of Vibrio spp, which are unable to utilize the amino sugar N-acetylglucosamine (GlcNAc) as a sole carbon source. This inability to utilize...
8728491 Transcutaneous delivery of therapeutic agents  
The present invention provides materials and methods to facilitate the transcutaneous delivery of therapeutic agents. In some embodiments, agonists of tight junctions are used in compositions to...
8647640 Vaccine compositions and methods of use to protect against infectious disease  
The present invention provides a novel immunogenic composition, vaccine and methods for making and using the immunogenic composition and vaccine. The immunogenic composition is capable of...
8642046 Cholera vaccines  
The methods and compositions of the present invention are directed to a vaccine against Vibrio cholerae comprised of V. cholerae outer membrane vesicles (OMVs). Such vaccines are relatively...
8637048 Immunizing compositions and methods of use  
The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccharide at a concentration of no greater...
8535689 Identification of bacterial autoinducer and use in treating bacterial pathogenicity  
A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its...
8425917 Mutant forms of EtxB and CtxB and their use as carriers  
The present invention describes the use of a mutant form of EtxB or CtxB to deliver an agent to a target cell wherein the mutant has GM-1 binding activity; but wherein the mutant has a reduced...
8425916 Immunizing compositions and methods of use  
The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater...
8337865 Modified flagellin improved toll-like receptor 5 stimulating activity  
Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants,...
8337864 Modified flagellin improved toll-like receptor 5 stimulating activity  
Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants,...
8287855 V. cholerae hyperexpressing recombinant cholera toxin B subunit showing dual immunogenicity  
Oral immunogenic compositions imparting dual protection against enterotoxigenic labile toxin (LT)-expressing Escherichia coli (ETEC) and Vibrio cholerae based on the delivery of recombinant...
8282941 Immunizing compositions and methods of use  
The present invention provides compositions including siderophore receptor polypeptides from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about...
8277821 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Immunizing compositions and methods of use
 
The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater...
8236327 Modified flagellin improved toll-like receptor 5 stimulating activity  
Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants,...
8039008 Identification of residues critical for the function of the vibrio cholerae virulence regulator ToxT by scanning alanine mutagenesis  
Disclosed are Vibrio cholerae comprising a mutated transcriptional regulatory protein (ToxT) amino acid sequence, wherein the mutation results in a reduction in the expression of cholera toxin by...
7943151 Immunizing compositions and methods of use  
The present invention provides compositions including siderophore receptor polypeptides from gram negative microbes, and preferably, lipopolysaccharide at a concentration of no greater than about...
7943150 Immunizing compositions and methods of use  
The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater...
7883709 Stabilised compositions  
This invention relates to the stabilization of a bacterial ADP-ribosylating exotoxin class protein (bARE), a method for analysing a bARE class protein, a method for the stabilization of the bARE...
7871629 Delivery of DNA vaccines into fish by immersion  
A method for immunizing fish against pathogenic infection is disclosed. More particularly, this invention provides a method of immunizing fish against bacterial and viral infection which comprises...
7838016 Vibrio cholerae strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof  
Metabolic auxotroph of Vibrio cholerae 0139 synonym Bengal which has a mutation in its hem A gene and which is not capable of synthesizing aminolevulinic acid (ALA) de novo and which is obtained...
7632513 Immunogenic detoxified mutants of cholera toxin  
An immunogenic detoxified protein comprising the amino acid sequence of subunit A of a cholera toxin (CT-A) or a fragment thereof or the amino acid sequence of subunit A of an Escherichia coli...
7592171 Vibrio cholerae with improved biological safety features in freeze dried form  
The present invention discloses new live attenuated strains for oral immunization against cholera that are provided in freeze dried formulations for long term storage and administration to humans....
7527797 Vibrio cholerae 0139 conjugate vaccines  
The invention pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These...
7485304 Non-toxic mucosal adjuvant  
A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic...
7438914 Composition and method for enhancing immune response  
A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response...
7422752 Mutant forms of EtxB and CtxB and their use as carriers  
The present invention describes the use of a mutant form of EtxB or CtxB to deliver an agent to a target cell wherein the mutant has GM-1 binding activity; but wherein the mutant has a reduced...
7384639 Methods of treating or preventing an infectious disease using an immunogenic conjugate of a gram-negative bacterial autoinducer molecule  
The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria The immunogenic conjugate, when combined with a...
7285281 Mutant forms of cholera holotoxin as an adjuvant  
Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid...
7261899 Method of producing thy A-strains of Vibrio cholerae, such strains and their use  
A method of producing a thy A−strain of vibrio cholerae comprising the step of site-directed mutagenesis in the V. cholerae chromosome at the locus of the thy A gene SEQ ID NO: 1 of FIG. 1, is...
7160549 Methods for making compositions including gram negative microbial polypeptides  
The present invention provides methods for making compositions including siderophore receptor polypeptides and porins from gram negative microbes. The methods include providing a gram negative...
7090853 Noscapine derivatives as adjuvant compositions and methods of use thereof  
An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines.
7090856 Anti-fouling exopolysaccharides isolated from cultures of Vibrio alginolyticus and Vibrio proteolyticus  
An anti-fouling agent derived by culturing Vibrio alginolyticus in a suitable aqueous solution as well as a newly isolated strain of V. alginolyticus (DSM 15590) for producing the anti-fouting...
7070781 Nontoxic mucosal adjuvant  
A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic...
7063852 Hybrid LT-A/CT-B holotoxin for use as an adjuvant  
The present invention provides a novel composition which is a hybrid heat labile enterotoxin comprising the A-subunit of the heat labile toxin of Escherichia coli (LT-A) and the B-subunit of the...
7056521 Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants  
The present invention provides parenteral adjuvants comprising detoxified mutants of bacterial ADP-ribosylating toxins, particularly those from pertussis (PT), cholera (CT), and heat-labile E....
7037499 Adjuvant for transcutaneous immunization  
A transcutaneous immunization system delivers antigen to immune cells without perforation of the skin, and induces an immune response in an animal or human. The system uses an adjuvant, preferably...
6913757 Live, avirulent strain of V. anguillarum that protects fish against infection by virulent V. anguillarum and method of making the same  
The present invention comprises the identification, characterization and sequencing of a gene within the V. anguillarum genome, the mugA gene, a live, attenuated strain of V. anguillarum which...
6811787 Over-expressing homologous antigen vaccine and a method of making the same  
This invention relates to an over-expressing homologous antigen vaccine, a method of producing the same, and use of the vaccine for prophylaxis or treatment of vertebrates at risk of or suffering...
6733762 Method of using Zot to inhibit lymphocyte proliferation in an antigen-specific manner  
Methods of using Zot or zonulin as an antigen specific inhibitor of APC activity and lymphocyte proliferation, being primarily useful in the field of immunoregulation and immunotherapy as...
6723323 Vibrio Cholerae vaccine candidates and method of their constructing  
Vibrio cholerae vaccine strains which have a disrupted hap gene and which are tagged with celA coding functions from Clostridium thermocellum are described. A contained, genetically defined thyA...
6613321 Live vaccines against gram-negative pathogens, expressing heterologous O-antigens  
The present invention relates to live attenuated gram-negative vaccine carrier strains which are useful for expression and delivery of heterologous O-antigens (O-PS) from gram-negative pathogens....
6548287 Non-pyrogenic bacterial strains and use of the same  
The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said...
6444210 Bacterial and synthetic polysaccharide immunomodulators that enhance general immunity  
The present invention relates to the effects of bacterial polysaccharides on cell mediated immunity in animals. Polysaccharides of the present invention comprise the outer polysaccharides (OPS)...
6440423 Mutant enterotoxin effective as a non-toxic oral adjuvant  
Methods and compositions are provided herein for the se of a novel mutant form of E. coli heat-labile enterotoxin which has lost its toxicity but has retained its immunologic activity. This...
6426075 Protease-activatable pseudomonas exotoxin A-like proproteins  
This invention provides protease-activatable Pseudomonas exotoxin A-like (“PE-like”) proproteins. The proproteins comprise (1) a cell recognition domain of between 10 and 1500 amino acids that...

Matches 1 - 50 out of 106 1 2 3 >