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7615229 Mutants of the P4 protein of nontypable Haemophilus influenzae with reduced enzymatic activity  
A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful...
7501131 Haemophilus influenzae type IV pili  
The invention described herein relates to a Haemophilus influenzae ( H. influenzae ) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H....
7449178 Attenuated gram negative bacteria  
Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is...
7429388 Vaccine for nontypeable Haemophilus influenzae infection  
This invention provides a method for identifying strains of nontypeable Haemophilus influenzae that can be used as immunogenic compositions having specificity against a plurality of Haemophilus...
7413743 Active immunization using a siderophore receptor protein  
The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may...
7306805 Nontypeable Haemophilus influenzae virulence factors  
The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi). The invention also relates to the NTHi sap operon genes...
7297340 Vaccine and method for preventing biofilm formation  
The present invention is directed to compounds and methods for immunizing a patient against a biofilm-producing bacterial infection and a vaccine related thereto.
7291722 Polypeptide from haemophilus influenza  
The invention provides BASB203 polypeptides and polynucleotides encoding BASB203 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
7235242 IgA1 protease fragment as carrier peptides  
The present invention is concerned with a fragment of IgA1-protease having 40 to 200 amino acid residues and comprising at least 40 amino acids of an amino acid sequence as shown in SEQ ID NO:1,...
7160549 Methods for making compositions including gram negative microbial polypeptides  
The present invention provides methods for making compositions including siderophore receptor polypeptides and porins from gram negative microbes. The methods include providing a gram negative...
7118749 Transferrin receptor genes  
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic...
7115271 Protein D—an IgD-binding protein of Haemophilus influenzae  
A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular...
7101989 DsrA protein and polynucleotides encoding the same  
DsrA is an outer membrane protein of H. ducreyi that confers serum resistance to the bacteria. Isolated polynucleotides encoding the protein, end expression vectors and host cells encoding the...
7090853 Noscapine derivatives as adjuvant compositions and methods of use thereof  
An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines.
7005129 Non-toxic mutants of pathogenic gram-negative bacteria  
A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen...
6974581 Multi-component vaccine comprising at least two antigens from haemophilus influenzae to protect against disease  
A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae . Such composition comprises at least two different antigens of...
6921537 Preparation and uses of los-depleted outer membrane proteins of gram-negative cocci  
Described herein is a method for removing toxic lipooligosaccharide (LOS) from outer membranes of Gram-negative cocci, such as Neisseria meningitidis . LOS-depleted outer membranes and...
6919080 Polypeptide for Haemophilus paragallinarum and process for preparing the same  
A novel peptide obtained from Haemophilus paragallinarum has been found useful for preventing avian infectious coryza. This polypeptide induces production of hemagglutination-inhibition antibody...
6913753 Incapacitated whole-cell immunogenic bacterial compositions  
The invention features incapacitated whole cell bacterial immunogenic compositions produced by infecting a bacterium with Lys minus bacteriophage, which are deficient in the lysin protein. Lys...
6905691 Vaccines containing attenuated bacteria  
The invention relates to a vaccine comprising a bacterium attenuated by a non-reverting mutation in a gene encoding a protein which promotes folding of extracytoplasmic proteins. Such mutations...
6887484 Vaccine composition containing a promoter peptide  
A vaccine having a good vaccination effect, which comprises an antigen; a peptide selected from the group consisting of a peptide having the amino acid sequence of SEQ ID NO: 1, a peptide having...
6872398 Conjugate vaccine against gram-negative bacterial infections  
The present invention relates to a broadly reactive vaccine against Gram-negative bacteria which is composed of a biological glycan-pilus conjugate. The conjugate core is a common pilus type to...
6858209 Means for detecting bacteria of the taylorella equigenitalis species and their biological applications  
Means for detection of bacteria of the genus Taylorella and biological applications thereof are described. In particular, the detection of T. equigenitalis and the treatment or prevention of...
6814971 Adjuvants for use in vaccines  
The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local...
6793927 Construction of Pasteurella haemolytica vaccines  
Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica . A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the...
6756040 Vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminum phosphate  
The invention relates to a vaccine formulation for the prevention of Haemophilus Influenzae Type B (Hib) infections and where the antigen is adsorbed onto aluminum phosphate. The invention also...
6743607 Production of complex carbohydrates  
Compositions and methods for making complex carbohydrates in a bacterial production cell are disclosed. The complex carbohydrates that can be made include oligosaccharides and polysaccharides of...
6613336 Immunogenic conjugates comprising a group B meningococcal porin and an H. influenzae polysaccharide  
Disclosed is an H. influenzae type b polysaccharide-meningococcal outer membrane protein conjugate, pharmaceutical compositions thereof, and the use thereof to induce an immune response to H....
6607725 Conjugate vaccine for nontypeable Haemophilus influenzae  
A conjugate vaccine for Nontypeable Haemophilus influenzae comprising lipooligosaccharide from which esterified fatty acids have been removed conjugated to an immunogenic carrier. The vaccine is...
6585981 Temperature-sensitive live vaccine for Mycoplasma hyopneumoniae  
The present invention provides a live temperature-sensitive vaccine for Mycoplasma hyopneumoniae . The present invention also provides methods of vaccinating a swine against colonization or...
6562349 Otitis media vaccine  
It has been discovered that a vaccine comprised of fimbrin, a filamentous protein derived from the bacterial surface appendages of non-typable Haemophilus influenzae is useful in studying,...
6544519 Polypeptide originating in haemophilus paragallinarum and process for producing the same  
A novel peptide obtained from Haemophilus paragallinarum has been found useful for preventing avian infectious coryza. This polypeptide induces production of hemagglutination-inhibition antibody...
6410025 Polysaccharide precipitation process  
Bacterial polysaccharides which are used to produced vaccines are isolated then precipitated with a long chain detergent. The precipitated polysaccharides are soluble in organic solvents and can be...
RE37768 DNA encoding the 15 kD outer membrane protein of Haemophilus influenzae  
Murine monoclonal antibodies directed against a novel outer membrane protein (OMP) of Haemophilus influenzae have been isolated and characterized. The gene encoding of the outer membrane protein...
6410021 Vaccines of pasteurellaceae mutants and vaccination method  
A live vaccine of recombinant mutants of a member of the family Pasteurellaceae lacking a rib gene necessary for production of riboflavin as well as a method of vaccination therewith is described....
RE37741 Purified nontypable Haemophilus influenzae P5 protein as a vaccine for nontypable Haemophilus influenzae infection  
The present invention relates to P5 outer membrane protein of the non-typable Haemophilus influenzae bacterial strain and antibodies directed to P5 protein. The invention also relates to a method...
6391316 Vaccine compositions comprising Haemophilus somnus transferrin-binding proteins and methods of use  
Cloning and expression of genes encoding H. somnus transferrin-binding proteins are described. The transferrin-binding proteins can be used in vaccine compositions for the prevention and...
6391313 Multi-component vaccine to protect against disease caused by Haemophilus influenzae and Moraxella catarrhalis  
A multi-valent immunogenic composition confers protection on an immunized host against infection caused by both Haemophilus influenzae and Moraxella catarrhalis . Such composition comprises at...
6379676 Enhancing immune response in animals  
A method for improving the immune response of an animal to a vaccine, comprising: feeding an animal a diet of contamination-resistant feed, and treating said animal with an anti-viral or...
6361779 Transferrin receptor genes  
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic...
6342231 Haemophilus parasuis vaccine and diagnostic  
A cellfree extract of Haemophilus parasuis that exhibits toxic activity is described. The cellfree extract is useful as a vaccine or diagnostic reagent.
6335182 Recombinant Haemophilus influenzae adhesin proteins  
Recombinant production of Hia protein, in full-length and N-terminally truncated forms, of non-typeable strains of Haemophilus influenzae , is described. The nucleic acid and deduced amino acid...
6333036 Vaccine composition containing polyribosylribitol phosphate and method for making same  
Vaccine compositions are disclosed which comprise at least one antigen formed by the capsular polysaccharide of Haemophilus influenzae type b or high molecular weight polyribosylribitol phosphate...
6329512 Immunogenic conjugate molecules  
Immunogenic conjugate molecules comprising at least a portion of a capsular polysaccharide of a Streptococcus strain linked to at least a portion of an outer membrane protein of a Haemophilus...
6299881 Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts  
A method for producing a conjugate vaccine includes mixing a uronium salt reagent with a first moiety (e.g., a polysaccharide). According to the invention, the uronium salt reagent has a chemical...
6290971 Adjuvant compositions comprising a mineral salt and another immunostimulating compound  
Adjuvant compositions for modulating an immune response to an antigen administered to a host comprise a mineral salt adjuvant and at least one other adjuvant. The compositions provide an...
6280741 Equine treatment and method of administering such treatment  
The invention is directed to a novel method for the use of vaccines to be used in the treatment and/or prevention of Navicular Disease in horses. The method comprises administration of a...
6267961 Direct methods for molar-mass determination of fragments of Haemophilus influenzae type b capsular polysaccharides and vaccine preparation  
The invention relates to the accurate and precise direct molar-mass measurement of low-molar-mass fragments of polysaccharides such as Haemophilus influenzae Type b. The methods for obtaining such...
6264954 Haemophilus outer membrane protein  
Purified and isolated nucleic acid from specific strains of Haemophilus influenzae is provided which encodes at least a portion of the D15 outer membrane protein of Haemophilus. The nucleic acid is...
6255050 Dynamic hybridization system  
Rapid methods and means for hybridizing DNA, RNA and analogs thereof are provided. Hybridization occurs on a partition assembly through which nucleobase-containing sequences are driven by a force,...
Matches 1 - 50 out of 146 1 2 3 >