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7371393 |
Methods for reducing fecal shedding
The present invention provides methods for reducing shedding in an animal. Generally, the method includes administcriirn to an animal a composition including siderophore receptor polypeptides and...
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7351416 |
Vaccines comprising acapsular P. multocida hyaE deletion mutants
Acapsular hyaE deletion mutants of P. multocida can be administered to mammals, particularly ungulates, or birds to provide protective immunity against wild-type P. multocida, e.g., to prevent...
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7341732 |
Methods for treating mastitis in a milk producing animal
The present invention provides methods for treating mastitis in a milk producing animal. The methods include administering compositions including siderophore receptor polypeptides and porins from...
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RE39494 |
Inactivated mycoplasma hyopneumoniae and uses therefor
The invention relates to a method for making an inactivated vaccine of Mycoplasma hyopneumoniae by inactivating the bacteria with Thimerosal. The resulting bacterin is mixed with an adjuvant of...
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7160549 |
Methods for making compositions including gram negative microbial polypeptides
The present invention provides methods for making compositions including siderophore receptor polypeptides and porins from gram negative microbes. The methods include providing a gram negative...
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7144580 |
M. haemolytica outer membrane protein P1pE as a vaccine or vaccine component against shipping fever
Vaccines and methods against M. haemolytica infections in cattle. The vaccine compositions include a recombinant outer membrane protein of M. haemolytica designated PlpE and/or subunits...
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7138124 |
Polypeptides obtained from gram negative microbes
The present invention provides compositions including at least two siderophore receptor polypeptides and at least two porins from a gram negative microbe, and preferably, lipopolysaccharide at a...
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6936262 |
LktA deletion mutant of P. haemolytica
Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be...
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6814971 |
Adjuvants for use in vaccines
The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local...
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6793927 |
Construction of Pasteurella haemolytica vaccines
Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica . A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the...
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6743430 |
Multicomponent vaccine containing clostridial and non-clostridial organisms in a low dose
Disclosed herein is a multicomponent low dose vaccine comprising a safe and immunogenically effective combination of a protective antigen component or components of clostridial organism, a...
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6610506 |
Transferrin binding proteins of Pasteurella haemolytica and vaccines containing same
Novel transferrin binding proteins from Pasteurella haemolytica , and nucleic acid molecules encoding the novel proteins are disclosed. Antibodies against the novel proteins are disclosed. The...
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6610307 |
Immunity against pasteurella haemolytica leukotoxin
Bovine respiratory disease (BRD) complex, shipping fever, or pneumomic pasteurellosis, is a multifactorial disease whereby a combination of viral infection, adverse environment and poor immune...
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6585981 |
Temperature-sensitive live vaccine for Mycoplasma hyopneumoniae
The present invention provides a live temperature-sensitive vaccine for Mycoplasma hyopneumoniae . The present invention also provides methods of vaccinating a swine against colonization or...
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6573093 |
Temperature sensitive plasmids of P. haemolytica
Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be...
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6410021 |
Vaccines of pasteurellaceae mutants and vaccination method
A live vaccine of recombinant mutants of a member of the family Pasteurellaceae lacking a rib gene necessary for production of riboflavin as well as a method of vaccination therewith is described....
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6350454 |
Attenuated Pasteurella piscicida vaccine for fish
Live-attenuated vaccines against Edwardsiella ictaluri or against Pasteurella piscicida are disclosed. Both vaccines are incapable of reversion to virulence, because both are made by deletion...
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6303130 |
Pasteurella haemolytica vaccine inactivated by ultraviolet light
A novel vaccine for immunizing animals against Pasteurella haemolytica infection is disclosed. The vaccine is composed of whole killed cells of P. haemolytica in a dosage effective to immunize an...
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6180112 |
Pasteurella haemolytica vaccine
The present invention is directed to compositions and methods for the production for the prevention of disease due to P. haemolytica. In particular, the present invention provides P. haemolytica...
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6110470 |
Pasteurella multocida toxin derivatives
A vaccine for immunizing animals against diseases caused by microorganisms producing an osteolytic toxin comprising an immunologically effective amount of a recombinant, immunogenic, detoxified...
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6096320 |
Vaccines with chimeric protein comprising gamma-interferon and leukotoxin derived from pasteurella haemolytica
New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are...
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6060068 |
Human IL-2 as a vaccine adjuvant
Methods for enhancing the immune response to vaccination in animals, including humans, comprise administering interleukin-2 (IL-2) as part of the vaccination regimen, preferably for 5 to 14 days...
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6060058 |
Vaccine for conferring bacterial immunity containing lactoferrin receptor protein
A vaccine which provides protective immunity against a bacterial pathogen containing a purified lactoferrin receptor protein is provided.
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6019984 |
Bacterial preparations, method for producing same, and their use as vaccines
Novel bacterial preparations containing one or more isolated and purified strain of a microorganism which produces one or more RTX toxins, and which strain has at least one RTX toxin which is...
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5985289 |
Haemophilus somnus outer membrane protein extract enriched with iron-regulated proteins
New subunit vaccines from Haemophilus somnus are disclosed. The vaccines include an outer membrane protein extract of H. somnus which is enriched with iron-regulated proteins. Additional antigens,...
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5985286 |
Bordetella strains
The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of...
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5985285 |
Vaccines for plague
A method of protecting a human or animal body from the effects of infection with Y. pestis is provided comprising administering to the body a vaccine including Yersinia pestis V antigen and...
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5968525 |
Inactivated Mycolplasma hyopneumoniae and uses therefor
The invention relates to a method for making an inactivated vaccine of Mycoplasma hyopneumoniae by inactivating the bacteria with Thimerosal. The resulting bacterin is mixed with an adjuvant of...
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5951987 |
Polysaccharide vaccine to enhance immunity against brucellosis
A vaccine comprising purified outer-polysaccharide (OPS) is effective for protection against brucellosis. The vaccine is derived from Brucella or a variety of cross reactive bacteria. The vaccine...
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5932705 |
Methods and compositions for the treatment and diagnosis of shipping fever
Novel compositions are disclosed for use in the treatment or diagnosis of bovine pasteurellosis, commonly referred to as Shipping Fever. Cell-free Pasteurella haemolytica supernatants are employed...
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5908630 |
Swine immunization using live, RTX toxin-secreting organisms
An improved method and vaccine is provided for the immunization of swine against infectious diseases caused by RTX toxin-secreting bacteria (e.g., porcine pleuropneumonia) which comprises...
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5885589 |
Pasteurella vaccine
A vaccine for immunizing animals against diseases caused by microorganisms producing an osteolytic toxin is disclosed. The vaccine contains a Pasteurella multocida toxin or derivative thereof that...
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5871750 |
Leukotoxin vaccine compositions and uses thereof
New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit...
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5855894 |
Pasteurella haemolytica type A-1 bacterin-toxoid vaccine
This invention relates to the field of Pasteurella haemolytica vaccines. More particularly, the invention relates to a bacterin-toxoid vaccine capable of inducing immunity in bovine species in one...
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5849531 |
Compositions and treatments for pneumonia in animals
New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit...
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5730989 |
Oral vaccine against gram negative bacterial infection
The present invention concerns an oral preparation useful as an immunizing agent or vaccine against gram negative bacterial infection. This oral preparation can also be used as a treatment for...
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5695769 |
Pasteurella multocida toxoid vaccines
This invention provides vaccine compositions, methods of producing same and methods for protecting porcine animals against disease associated with infection by toxigenic Pasteurella multocida. The...
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5648081 |
Actinobacillus pleuropneumoniae subunit vaccine
The present invention is concerned with vaccines effective in protecting pigs against porcine pleuropneumonia. Said vaccines comprising a hemolysin and/or macrophage toxin and a 42 kD OMP...
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5587166 |
Vaccine against Pasteurella
A vaccine against Pasteurella comprising a proteinaceous material isolated from Pasteurella grown under iron-restricted conditions, but not from Pasteurella grown under normal conditions in vitro,...
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5476657 |
Pasteurella haemolytica leukotoxin compositions and uses thereof
New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit...
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5462735 |
Pasteurella haemolytica subunit vaccine containing capsular polysaccharide and muramyl dipeptide
Protection of ruminants against bacterial pneumonia caused by Pasteurella haemolytica has been achieved with a subunit vaccine. The vaccine contains two principle components; capsular...
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5422110 |
Enhanced immunogenicity using leukotoxin chimeras
New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to...
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5378615 |
Process for the production of vaccine for prevention of Pasteurella haemolytica pneumonia in bovine
A serum-free vaccine effective against pneumonic pasteurellosis in cattle comprising a non-toxic leukotoxin specific for ruminant leukocytes is disclosed. The leukotoxin is prepared in a serum-free...
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5352448 |
Oral administration of antigens
An oral vaccine formulation is provided for stimulation of an immune response in gut-associated lymphoid tissues. The formulation comprises an enzymatically degradable antigen in a hydrogel matrix....
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5292869 |
Method for isolating and purifying transferrin and lactoferrin receptor proteins from bacteria and the preparation of vaccines containing the same
The present invention relates to a method for isolating and purifying transferrin and lactoferrin receptor proteins from bacterial pathogens by affinity chromatography and to the preparation of...
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5256415 |
Vaccine against bovine respiratory disease (pasteurellosis)
A vaccine against bovine respiratory disease is provided containing an attenuated strain of Pasteurella haemolytica isolated from an asymptomatic calf. The vaccine effectively triggers an...
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5225194 |
Aqueous diafiltration process for preparing acellular vaccines, against selected bacterial diseases
Immunogenic components are recovered from pathogenic bacteria grown on semi-defined, serum-free media in purified forms that are useful as veterinary acellular vaccines and include both...
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5210035 |
Non-reventing live vaccines
Live vaccines are provided and methods for preparing the live vaccines for protection of a host from a pathogenic microorganism. The vaccines are prepared by introducing at least one modification...
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5165924 |
Serum-free, cell-free vaccine effective against pneumonic pasteurellosis in cattle
A serum-free vaccine effective against pneumonic pasteurellosis in cattle comprising a non-toxic leukotoxin specific for ruminant leukocytes is disclosed. The leukotoxin is prepared in a serum-free...
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5028423 |
Immunogenic conjugates comprising leukotoxin peptide fragments
Conjugate immunogens are disclosed, comprising peptide fragments having substantial homology to the N-terminal region of Pasteurella haemolytica leukotoxins, covalently linked to suitable carrier...
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