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7628995 |
Outer membrane vesicles and uses thereof
The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of...
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7618636 |
Antigenic meningococcal peptides
WO99/36544 discloses a large number of proteins from Neisseria Meningitidis . The present invention relates to fragments of those proteins which comprise at least one antigenic determinant....
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7604810 |
Conserved Neisserial antigens
To ensure maximum cross-strain recognition and reactivity, regions of proteins that are conserved between different Neisserial species, serogroups and strains can be used. The invention provides...
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7585510 |
Vaccine
The invention relates to a vaccine for the treatment of disease caused by Neisseria , the vaccine including one or more immunogenic components for Neisseria serogroups, as well as antibodies to...
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7524509 |
Proteosome-liposaccharide vaccine adjuvant
An adjuvant complex composed of bacterial outer membrane protein proteosomes complexed to bacterial liposaccharide is prepared to contain the component parts under a variety of conditions. The...
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7521549 |
Compounds
The invention provides BASB041, 43, 44 and 48 polypeptides and polynucleotides encoding BASB041, 43, 44 and 48 polypeptides and methods for producing such polypeptides by recombinant techniques....
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7504111 |
Gonococcal proteins and nucleic acids
The invention provides proteins from gonococcus ( Neisseria gonorrhoeae ), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The...
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7485304 |
Non-toxic mucosal adjuvant
A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic...
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7422754 |
Neisseria meningitidis compounds and anti-infection applications thereof
The invention provides novel Neisseria meningitides (Nm) polypeptides and polynucleotides which cover the Nm genetic diversity, and which correspond to polypeptide of Nm outer membrane and/or...
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7399840 |
Proteosome influenza vaccine
Improved forms of vaccines which comprise proteosomes and protein antigens are described. Vaccines which contain influenza HA as the antigen are used for illustration as to demonstrate efficacy....
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7384645 |
Outer membrane vesicles from gram negative bacteria and use as a vaccine
A composition is prepared from a mixture of different vesicles, such as outer membrane vesicles (OMVs) and vaccines are based thereon. Another composition comprises in a single vesicle a...
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7357932 |
Surface protein of Neisseria bacteria
Present invention provides a monoclonal antibody binding to Neisseria bacteria and its target antigen Ag473, which include the sequences of its polynucleotide and its amino acid, wherein the ...
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7273611 |
Proteinase K resistant surface protein of neisseria meningitidis
The identification of a highly conserved, immunologically accessible antigen on the surface of Neisseria facilitates treatment, prophylaxis, and diagnosis of Neisseria diseases. This antigen is...
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7250172 |
Vaccine and compositions for the prevention and treatment of neisserial infections
The present invention is directed to novel polypeptides, polynucleotides and vaccines for use against Neisseria gonorrhoeae colonization or infection. The vaccines contain an immunogenic amount...
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7235242 |
IgA1 protease fragment as carrier peptides
The present invention is concerned with a fragment of IgA1-protease having 40 to 200 amino acid residues and comprising at least 40 amino acids of an amino acid sequence as shown in SEQ ID NO:1,...
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7189405 |
Peptide mimics of conserved gonococcal epitopes and methods and compositions using them
The present invention relates to peptide mimics of a conserved gonococcal epitope of Neisseria gonorrhoeae , which epitope is not found on human blood group antigens. This invention also relates...
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7112332 |
Oral or intranasal vaccines using hydrophobic complexes having proteosomes and lipopolysaccharides
An immunogenic complex, essentially consisting of neisserial outer membrane protein proteosomes hydrophobically complexed to native purified bacterial lipopolysaccaride and formulated in accordance...
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7081244 |
Neisserial vaccine compositions and methods
Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria . Further...
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7070781 |
Nontoxic mucosal adjuvant
A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic...
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7018637 |
Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
Multivalent immunogenic molecules comprise a carrier molecule containing at least one functional T-cell epitope and multiple different carbohydrate fragments each linker to the carrier molecule and...
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6994860 |
Neisseria meningitidis antigenic polypeptides, corresponding polynucleotides and protective antibodies
The invention provides Neisseria meningitidis BASB030 polypeptides and polynucleotides encoding BASB030 polypeptides and methods for producing such polypeptides by recombinant techniques. Also...
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6936261 |
Vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis
The present invention generally provides methods and vaccines for the prevention of diseases caused by Neisseria meningitidis bacteria, particularly serogroup B strains.
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6913753 |
Incapacitated whole-cell immunogenic bacterial compositions
The invention features incapacitated whole cell bacterial immunogenic compositions produced by infecting a bacterium with Lys minus bacteriophage, which are deficient in the lysin protein. Lys...
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6887482 |
Antigenic iron repressible proteins from N. meningitidis related to the hemolysin family of toxins
An isolated, antigenic polypeptide comprises a segment having at least fifty amino acid residues. The amino acid sequence of the segment is present in N. meningitidis , and is different from, but...
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6835384 |
Nucleic acids and polypeptides specific of the neisseria genus pathogenic strains
The invention concerns nucleic acids coding for polypeptides specific of the Neisseria genus pathogenic strains, the corresponding polypeptides, and their diagnostic and therapeutic applications.
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6821521 |
Multicomponent meningococcal vaccine
A composition comprising Transferrin binding proteins A and B is described (TbpA and TbpB). The composition is suitable for use in vaccines and for treatment of Gram negative bacterial infection,...
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6803042 |
Oral or intranasal vaccines using hydrophobic complexes having proteosomes and lipopolysaccharides
An immunogenic complex, essentially consisting of neisserial outer membrane protein proteosomes hydrophobically complexed to native purified bacterial lipopolysaccharide and formulated in...
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6797273 |
Neisseria meningitidis antigen
The invention provides BASB053 polypeptides and polynucleotides encoding BASB053 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6770284 |
Polypeptides and polynucleotides BASB040 from neisseria meningitidis and vaccine comprising said polypeptides and polynucleotides
The invention provides BASB040 polypeptides and polynticleotides from Neisseria meningitidis encoding BASB040 polypeptides and methods for producing such polypeptides by recombinant techniques....
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6756493 |
Nucleic acid sequence and uses thereof
The invention discloses the Neisseria spp. NGSP polypeptide, polypeptides derived therefrom (NGSP-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies that...
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6743607 |
Production of complex carbohydrates
Compositions and methods for making complex carbohydrates in a bacterial production cell are disclosed. The complex carbohydrates that can be made include oligosaccharides and polysaccharides of...
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6709660 |
Meningococcal antigens
The invention provides proteins from Neisseria meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The...
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6664094 |
Neisserial vaccine free of immunologically functional PIII or class 4 proteins
This invention relates to mutants of Neisseria useful for vaccine preparation. Specifically this invention relates to mutants of Neisseria containing mutations in a major outer membrane protein...
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6613336 |
Immunogenic conjugates comprising a group B meningococcal porin and an H. influenzae polysaccharide
Disclosed is an H. influenzae type b polysaccharide-meningococcal outer membrane protein conjugate, pharmaceutical compositions thereof, and the use thereof to induce an immune response to H....
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6558677 |
Vaccine against gram negative bacteria
A mucosal vaccine for Neisseria based on native outer membrane vesicles (NOMV) prepared from genetically engineered vaccine strain and unexposed to detergents is described. Methods for extending...
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6548287 |
Non-pyrogenic bacterial strains and use of the same
The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said...
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6544518 |
Vaccines
The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an...
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6476201 |
Methods for the production of non-covalently complexed and multivalent proteosome sub-unit vaccines
A continuous method for preparing proteosome-amphiphilic determinant vaccines for parenteral or mucosal administration using diafiltration or ultrafiltration technology. The amphiphilic...
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6348198 |
Lactoferrin receptor protein
An isolated and purified lactoferrin receptor protein is isolated and purified from bacterial pathogens, including Moraxella and Neisseria, and has a molecular weight of between about 70,000 and...
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6348332 |
DNA molecule encoding gonorrhoeal hybrid PIA/PIB protein
The present invention relates to a gene sequence coding for hybrid Protein I of Neisseria gonorrhoeae, and cloning vector and host organisms containing same. Also disclosed are oligonucleotides...
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6277382 |
Hemoglobin receptors from neisseriae
The present invention relates to novel bacterial hemoglobin receptor proteins and genes that encode such proteins. The invention is directed toward the isolation, characterization, diagnostic and...
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6277379 |
Use of purified invaplex from gram negative bacteria as a vaccine
A novel composition comprising Invaplex from gram-negative bacteria is described and is effective as a vaccine against gram-negative bacterial infection.
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6210663 |
Methods of augmenting mucosal immunity through systemic priming and mucosal boosting
A method for inducing and enhancing mammalian mucosal immunity includes the steps of first administering to a mammal via a non-mucosal route a suitable amount of a priming vaccine composition which...
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6180111 |
Vaccine delivery system
The invention relates to a hyperblebbing strain of Neisseria gonorrhoeae which produces large amounts of blebs useful for production of blebosomes containing antigens for use as a vaccine delivery...
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6146635 |
System for the expression of heterologous antigens as fusion proteins
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6086896 |
Antigenic iron repressible protein from N. meningitidis related to the hemolysin family of toxins
An isolated, antigenic polypeptide comprises a segment having at least fifty amino acid residues. The amino acid sequence of the segment is present in N. meningitidis, and is different from, but...
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6060058 |
Vaccine for conferring bacterial immunity containing lactoferrin receptor protein
A vaccine which provides protective immunity against a bacterial pathogen containing a purified lactoferrin receptor protein is provided.
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6045805 |
Oligosaccharide derived from an antigenic polysaccharide obtained from a pathogenic agent
An oligosaccharide derived from an antigen polysaccharide obtained from a pathogenic agent, a method for its preparation, and its use particularly as a vaccinal agent. The oligosaccharide is...
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6013267 |
Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular,...
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5997881 |
Method of making non-pyrogenic lipopolysaccharide or A
The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said...
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