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7387886 |
Prion protein dimers useful for vaccination
Described is a prion protein, wherein said prion protein is a homodimer or heterodimer. The prion protein dimers are highly immunogenic capable of inducing an immune response in a mammal, thus...
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7387773 |
Vaccine
The invention provides a vaccine comprising secreted protein derived from Mycobacterium avium subsp paratuberculosis ( M. ptb ) substantially free of whole organisms of that species either dead...
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7364740 |
Molecular differences between species of the M. tuberculosis complex
Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared...
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7361348 |
Immunogenic glycopeptides, screening, preparation and uses
The invention concerns immunogenic glycopeptides derived from pathogenic microorganisms, useful for vaccination and diagnosis of infections caused by said pathogenic microorganisms (bacteria or...
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7344703 |
Mycobacterial sulfation pathway proteins and methods of use thereof
Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid...
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7335480 |
Enriched antibody for detecting mycobacterial infection, methods of use and diagnostic test employing same
The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is...
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7335369 |
Fusion proteins of mycobacterium tuberculosis antigens and their uses
The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M....
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7332340 |
Process for identifying a novel target for use for the development of therapeutic modalities and drugs effective against tuberculosis
The present invention relates to a process for identifying a novel target for use for the development of therapeutic modalities and drugs effective against tuberculosis comprising testing M....
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7288261 |
Mid-life vaccine and methods for boosting anti-mycobacterial immunity
Vaccine compositions for boosting immunity to mycobacteria when administered in mid-life in a subject who has been vaccinated neonatally or in early childhood with BCG and in whom protective...
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7279170 |
32-kDa protein derived from Mycobacterium tuberculosis and related peptides
The invention relates to recombinant polypeptides and peptides and particularly to the polypeptide containing in its polypeptidic chain the following amino acid sequence: the one extending from the...
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7276350 |
Method for diagnosing infectious diseases
A method for diagnosing the presence in an animal of an infection due to a microorganism in which a test sample obtained from the animal is exposed to a population of the microorganism and the...
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7261897 |
Fusion proteins of mycobacterium tuberculosis
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The...
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7238359 |
Antigen ORF Rv2430c and a method thereof
The present invention relates to a PPE family antigenic protein Rv2430c of SEQ ID No. 1; a set of three high antigenic index peptides of SEQ ID Nos. 2 to 4; an antigenic ORF Rv2430c of SEQ ID No. 5...
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7238358 |
Compounds and methods for immunotherapy and diagnosis of tuberculosis
Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more ...
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7160548 |
Mycobacterium strains with modified erp gene and vaccine composition containing same
Mycobacterium strains in which the erp gene is modified, and vaccine compositions comprising such Mycobacterium strains are provided. The modification of the erp gene may decrease the virulence...
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7135280 |
Assay to determine efficacy of treatment for mycobacterial infection
Method of determining the efficacy of treatment for mycobacterial infection in an individual comprising determining in samples from the individual whether the level of T cells specific for a...
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7122196 |
Compounds and methods for diagnosis of tuberculosis
Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins,...
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7122195 |
Mutant mycobacteria for use in therapy
This invention relates to recA mutant mycobacteria, particularly mutants of mycobacterial species which are members of the Mycobacterium tuberculosis complex, such as M. bovis BCG and M....
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7105170 |
Latent human tuberculosis model, diagnostic antigens, and methods of use
Provided herein is an in vitro granuloma model and methods of its use. Methods of detecting and/or diagnosing latent tuberculosis in a subject are also provided, as are latency-specific antigens...
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7094403 |
Mycobacterium tuberculosis superoxide dismutase
The invention relates to Mycobacterium tuberculosis superoxide dismutase antibodies, methods of using them for detection of M. tuberculosis , methods of testing for an inhibitor of an M....
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7090980 |
Method of detecting acid-fast bacteria using ribosomal RNA as target
A method of detecting a specific acid-fast bacterium, wherein primers having nucleotide sequences homologous or complementary to the specific regions in the rRNAs of the specific acid-fast...
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7087713 |
Compounds and methods for diagnosis and immunotherapy of tuberculosis
Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one...
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7083798 |
Method of immunomodulatory treatment of insulin dependent diabetes mellitus using mycobacterial cell wall compositions
The present invention relates generally to a method of immunomodulating therapy and pharmaceutical compositions useful for same. More particularly, the present invention provides a method of...
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7083797 |
32-kDa protein derived from Mycobacterium tuberculosis and related peptides
The invention relates to recombinant polypeptides and peptides and particularly to the polypeptide containing in its polypeptidic chain the following amino acid sequence: the one extending from the...
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7083796 |
Fusion proteins of mycobacterium tuberculosis
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The...
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7067136 |
Method of screening anti-mycobacterial molecules
This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic...
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7064195 |
Fusion proteins of mycobacterium tuberculosis antigens and their uses
The present invention relates to fusion proteins of Mycobacterium tuberculosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis...
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7037510 |
Hybrids of M. tuberculosis antigens
The present invention discloses fusion proteins of the immunodominant antigens ESAT-6 and Ag85B from Mycobacterium tuberculosis or homologues thereof, and a tuberculosis vaccine based on the...
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7026467 |
High resolution typing system for pathogenic Mycobaterium tuberculosum
MLVA methods for strain discrimination among Mycobacterium tuberculosum strains are disclosed. Nine VNTR loci have been identified from genomic sequences of Mycobacterium tuberculosum strains...
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7022320 |
Mycobacterium tuberculosis immunization
Recombinant nucleic acid molecules are described. The molecules have a sequence or sequences encoding at least two M. tuberculosis antigens. Vectors and compositions containing these molecules...
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7018616 |
Rapid serological test for paratuberculosis using fluorescence polarization technology
The present invention provides an assay for detection of serum antibodies to M. paratuberculosis . A tracer, comprising a carbohydrate antigen isolated from M. paratuberculosis that is...
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7002002 |
Abundant extracellular products and methods for their production and use
Vaccines based on one or more combinations of majorly abundant extracellular products of pathogens and methods for their use and production are presented. The most prevalent or majorly abundant...
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6995255 |
Cellular delivery agent
One aspect of the present invention relates to a nucleic acid construct which includes a first nucleic acid and a second nucleic acid operatively coupled to the first nucleic acid. The first...
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6991797 |
M. tuberculosis antigens
The present invention is based on the identification and characterization of a number of novel M. tuberculosis derived proteins and protein fragments. The invention is directed to the...
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6989146 |
Stress proteins and peptides and methods of use thereof
Provided are HLA pan DR peptides and methods of using such peptides to modulate, block, or inhibit immune responses in treatment of immune-mediated diseases and conditions, such as inflammatory and...
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6982085 |
TB diagnostic based on antigens from M. tuberculosis
The present invention is based on the identification and characterization of a number of novel M. tuberculosis derived proteins and protein fragments. The invention is directed to the...
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6979450 |
Method and compositions for detection and diagnosis of infectious diseases
Methods and compositions for the detection and diagnosis of infectious diseases are provided. In particular, efficient and sensitive methods and compositions for the detection of active...
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6977075 |
Photosensitizer conjugates for targeting intracellular pathogens
The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention...
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6949345 |
Identification and cloning of a mycobacterial antigen corresponding to a heparin-binding haemagglutinin
The present invention relates to peptide sequences enabling mycobacteria to adhere to host cells (e.g., epithelial cells). More particularly, the invention relates to a mycobacterial...
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6949246 |
Compounds and methods for diagnosis of tuberculosis
Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins,...
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6936263 |
Th1 inducing natural adjuvant for heterologous antigens
The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates...
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6936260 |
Vaccine composition
A tuberculosis (TB) vaccine composition is disclosed. The composition comprises, as adjuvant, one or more substances selected from a) monoglyceride preparations having at least 80% monoglyceride...
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6929799 |
D-alanine racemase mutants of mycobacteria and uses therefore
The present invention is directed to D-alanine racemase mutants of mycobacterial species. The D-alanine racemase gene (alrA) is involved in the systhesis of D-alanine, a basic component of...
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6927235 |
Vaccine composition comprising iron phosphate as vaccine adjuvant
The present invention relates to vaccine compositions comprising iron phosphate as adjuvant. This iron phosphate is in the form of particles, the size of which is between 0.01 μm and 300 μm; it...
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6924118 |
Recombinant intracellular pathogen immunogenic compositions and methods for use
Immunogenic compositions comprising recombinant attenuated intracellular pathogens that have been transformed to express recombinant immunogenic antigens of the same or other intracellular...
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6896888 |
Treatment of papilloma virus infection using a mycobacterium
Disease cased by papilloma virus is treated by applying an effective amount of Mycobacterium to the region of infection. Specifically, condylomata acuminata are caused by human papilloma virus...
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6890541 |
Method for enhancing production performance in an animal
The present invention provides methods for activating the immune systems of newborn animals and methods for enhancing the production performance of the animals. More particularly, the methods of...
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6890540 |
Vaccine formulation
A vaccine formulation against a microorganism is disclosed. The formulation comprises: as adjuvant, one or more substances selected from a) monoglyceride preparations having at least 80%...
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6887481 |
Bacterial-derived molecules and therapeutic and diagnostic uses therefor
The present invention relates generally to molecules derived from a Mycobacterium species and recombinant, synthetic, derivative, homologue and analogue forms of said molecules. The molecules of...
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6878377 |
Mycobacterium vaccae for down-regulation of the Th2 activity of the immune system
Antigenic and/or immunogenic material derived from Mycobacterium vaccae is used to down-regulate Th2 activity of the immune system without up-regulation of Th1 activity. Disorders such as Chronic...
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