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7384775 |
Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of Streptococcus pneumoniae , wherein the open reading frames encode...
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7348015 |
Antigen modified cancer cell vaccines for cancer therapy
Disclosed are methods for treating cancers, particularly tumorigenic types. Cancer cells are modified to express highly immunogenic antigens so that the cells will generate a defensive response in...
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7338786 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7335368 |
BVH-A2 and BVH-A3 antigens of group B Streptococcus
Group B streptococcus polypeptides and polynucleotides encoding them are disclosed. Said polypeptides may be useful for the prophylaxis, diagnostic and/or therapy of streptococcal infection in...
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7332173 |
Group A streptococcal polysaccharide immunogenic compositions and methods
This invention provides a novel immunogenic composition and vaccine, processes for producing them and methods for immunization against infections and disease caused by group A Streptococci. The...
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7323175 |
Immunogenicity of glucan binding protein
Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in...
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7316910 |
Rapid test for hemolytic streptococcus
A reagent for the detection of an extracellular enzymatically active protein produced by a beta-hemolytic streptococcus bacteria found in a host biological fluid includes a proteinaceous substrate...
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7270827 |
Multivalent streptococcal vaccine compositions and methods for use
Compositions and methods for making and using therapeutic formulations of multivalent hybrid polypeptides comprising immunogenic peptides of M proteins from various different serotypes of group A...
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7258992 |
Immunization of dairy cattle with chimeric GapC protein against Streptococcus infection
The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino...
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7256265 |
Streptococcal C5a peptidase vaccine
Novel vaccines for use against β-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of a variant of streptococcal C5 a peptidase (SCP)....
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7255867 |
Vaccine
Effective stimulation of immune responses is achieved through the use of a group A streptococcal antigen combined with proteosome adjuvant. The compositions are provided in particular for...
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7247308 |
Streptococcus pyogenes antigens
The present invention relates to antigens, more particularly an antigen of Streptococcus pygenes (also called group A Streptococcus (GAS)) bacterial pathogen which is useful as vaccine...
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7235243 |
Immunological combination compositions and methods
Immununological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself...
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7220415 |
Vaccine composition
A polypeptide is described herein which comprises (a) the sequence of SEQ ID No. 2, (b) a variant of (a) which is capable of generating a protective immune response to S. pyogenes , or (c) a...
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7204993 |
Streptococcus agalactiae vaccine
A composition prepared from intact killed cells of isolated β-hemolytic Streptococcus agalactiae and a concentrated extract of a culture of β-hemolytic Streptococcus agalactiae , is effective...
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7189404 |
Strain selection of pneumococcal surface proteins
The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the...
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7189398 |
Broad spectrum pyrogenic exotoxins antagonists and vaccines
The invention relates to peptides having an amino acid sequence substantially homologous to an amino sequence of a domain of a pyrogenic exotoxin, which domain forms a central turn in the exotoxin...
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7163682 |
Glucan binding protein and glucosyltransferase immunogens
Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in...
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7151171 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7147857 |
Methods for treating high somatic cell counts
The present invention provides methods for treating an animal having a high somatic cell count. The methods include administering compositions including siderophore receptor polypeptides and porins...
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7138125 |
Methods for treating an animal for low milk production
The present invention provides methods for treating an animal for low milk production. The methods include administering compositions including siderophore receptor polypeptides and porins from...
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7135560 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7132107 |
Streptococcus pneumoniae proteins and vaccines
The present invention relates to novel immunogenic polypeptides, and fragments thereof, and vaccines for the prevention and treatment of pneumococcal infection, especially by Streptococcus...
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7129340 |
Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7129339 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7128920 |
metRS2
The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred...
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7128919 |
Group B streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof
This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids...
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7128918 |
Streptococcus antigens
Streptococcus proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus ...
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7125548 |
Streptococcus suis vaccines and diagnostic tests
The invention relates to Streptococcus suis infection in pigs, vaccines directed against those infections and tests for diagnosing Streptococcus suis infections. The invention provides an...
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7122194 |
Vaccine compositions comprising Streptococcus pneumoniae polypeptides having selected structural motifs
A vaccine composition is disclosed that comprises polypeptides and fragments of polypeptides containing histidine triad residues or coiled-coil regions, some of which polypeptides or fragments lie...
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7118756 |
Recombinant protective protein from Streptococcus pneumoniae
The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus Pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight...
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7115731 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7109006 |
Virulence of Streptococci
The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention discloses a method for...
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7101562 |
Conjugate vaccines for the prevention of dental caries
The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and...
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7087740 |
Kits for use in detecting resistance to streptogramin A and related compounds
A kit for use in detecting a bacterium having resistance to streptogramin A and related compounds is provided. A kit for use in detecting a bacterium harboring at least one polynucleotide encoding...
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7087235 |
Fusion protein of streptococcal pyrogenic exotoxins
The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an...
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7074416 |
Antigen of hybrid M protein and carrier for group A streptococcal vaccine
Recombinant hybrid streptococcal M protein antigens are provided which elicit protective antibodies against Group A streptococci and prevent rheumatic fever. Recombinant hybrid genes which encode...
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7074415 |
Streptococcus antigens
Streptococcus polypeptides and polynucleotides encoding them are disclosed. The polypeptides may be useful vaccine components for the prophylaxis or therapy of streptococcus infection in...
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7067639 |
Method to provide bacterial ghosts provided with antigens
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
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7063850 |
Protective antigen of group A Streptococci
The present invention provides the discovery of a new Streptococcus protective antigen (herein designated Spa) which has been identified and isolated from Streptococci. Spa is a surface antigen...
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7060277 |
Broad spectrum antagonists and vaccines directed against pyrogenic exotoxins
The invention relates to peptides comprising an amino acid sequence homologous to the amino sequence of a fragment of a pyrogenic exotoxin, and functional derivatives of said peptides, capable of...
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7056697 |
FabK variant
The invention provides FabK polypeptides and polynucleotides encoding FabK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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7056517 |
Glucosyltransferase immunogens
Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a...
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7056510 |
Streptococcus pneumoniae SP036 polynucleotides, polypeptides, antigens and vaccines
The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneunoniae. The invention further relates to isolated nucleic acid molecules...
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7049419 |
Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or “PspC”, different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a...
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7045132 |
Streptococcus pneumoniae 37-kDa surface adhesin a protein
The invention provides a nucleic acid encoding the 37-kDa protein from Streptococcus pneumoniae . Also provided are isolated nucleic acids comprising a unique fragment of at least 10 nucleotides...
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7018637 |
Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
Multivalent immunogenic molecules comprise a carrier molecule containing at least one functional T-cell epitope and multiple different carbohydrate fragments each linker to the carrier molecule and...
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6994997 |
Gram positive bacteria deprived of HtrA protease activity and their uses
The invention concerns bacteria strains, obtained from gram-positive bacteria whereof the genome size is not more than 3.2 Mb, and wherein the HtrA surface protease is inactive. Said strains are...
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6936259 |
CAMP factor of Streptococcus uberis
The CAMP factor gene of Streptococcus uberis ( S. uberis ) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs,...
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6936252 |
Streptococcus pneumoniae proteins and nucleic acid molecules
Novel protein antigens from Streptococcus pneumoniae are disclosed, together with nucliec acid sequences encoding them. Their use in vaccines and in screening methods is also described.
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