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7390496 |
Therapeutic treatments for repetitive hand washing
Methods for treating a hand washing disorder by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration...
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7381700 |
Methods for treating pain associated with arthritis
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
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7375079 |
Previns as specific inhibitors and therapeutic agents for botulinum toxin B and tetanus neurotoxins
The compounds of the invention are generally described by the formula:
B 1 Z* 2 B 3 Z* 4 X* 5 Q 6 F 7 X 8 X 9 X 10 X 11 , ...
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7374769 |
Method for treating a trigeminal neuralgia by peripheral administration of a neurotoxin
Methods for treating a trigeminal neuralgia by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7361358 |
Treatment of a facial pain by peripheral administration of a neurotoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7357934 |
Intracranial botulinum toxin therapy for focal epilepsy
Methods for treating and/or curing epilepsy by intracranial administration of a botulinum toxin.
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7354740 |
Animal product free system and process for purifying a botulinum toxin
Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.
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7341829 |
In situ growth, freezing and testing of cultured cells
The present invention provides methods and compositions for the in situ growth, freezing and testing of cultured cells. In particular, the present invention provides methods and compositions for...
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7335367 |
Treatment of chronic chalazion and hordeolum with botulinum toxin
Chalazia and hordeola are the most common lesions occurring in the human eyelid, and often recurrences are managed by surgical intervention to remove fatty inclusions within the lid with associated...
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7323179 |
Methods and compositions for the treatment and prevention of Staphylococcus and other bacterial infections
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, certain species of bacteria, including in particular bacteria in...
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7294339 |
Method for treating allodynia by peripheral administration of a neurotoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7291344 |
Method for treating phantom pain by peripheral administration of a neurotoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7288260 |
Method for treating pain by peripheral administration of a neuroptoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7288259 |
Treatment of holocrine gland dysfunction with clostridia neurotoxins
Methods of using clostridial toxins and other biological agents to control holocrine gland dysfunction in humans is provided. In preferred embodiments the methods provide beneficial effects in...
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7279169 |
Mucosal DTPa vaccines
Mucosal DTPa vaccines, especially intranasal vaccines, comprising (a) a diphtheria antigen, a tetanus antigen and an acellular pertussis antigen, and (b) a detoxified mutant of cholera toxin (CT)...
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7276245 |
Method for treating hyperalgesia by peripheral administration of a neurotoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7276244 |
Methods of treating abnormalities of the first metatarsophalangeal joint of the foot
Disclosed is a method for treating abnormalities of the first metatarsophalangeal joint of the foot of a mammal comprising administering a therapeutically effective amount of neuromuscular toxin to...
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7270826 |
Methods of using Botulinum toxin for the treatment of hypervolemic lip deformity (lip ectropion)
The present invention uses pharmaceutical preparations of Botulinum toxin to induce neurogenic atrophy to alter muscle volume and subsequently, facial contour. Reduction in lip volume is...
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7270287 |
Botulinum toxin treatment for kinesia
Methods for treating kinesia (motion sickness) by local administration of a Clostridial toxin, such as a botulinum toxin, to a cranial or neck area of a patient susceptible to motion sickness.
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7255866 |
Botulinum toxin therapy for fibromyalgia
Methods for treating fibromyalgia by administering a therapeutically effective amount of a botulinum toxin to a patient with fibromyalgia.
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7255865 |
Methods of administering botulinum toxin
Methods for treating conditions in an animal or human subject. The conditions may be pain, skeletal muscle conditions, smooth muscle conditions, glandular conditions and cosmetic conditions. The...
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7238357 |
Methods for treating ulcers and gastroesophageal reflux disease
Methods for treating peptic ulcers and methods for treating gastroesophageal reflux disease by oral administration of a botulinum toxin.
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7226597 |
Mutants of Clostridium difficile toxin B and methods of use
An active or passive vaccine utilizing purified non-toxic mutant TcdB toxins from Clostridium difficile for humans and animals against infections caused by C. difficile and/or C. sordellii. ...
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7223399 |
Methods for treating restenosis with a botulinum neurotoxin
The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a...
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7211262 |
Burn pain treatment by peripheral administration of a neurotoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7211261 |
Stable liquid formulations of botulinum toxin
The invention includes liquid formulations of botulinum toxin that are stable to storage in liquid form at standard refrigerator temperatures for at least 1–2 years and to storage at higher...
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7208166 |
Use of botuline toxin to obtain a product to be used in articular pathologies, particularly coxarthrosis, epicondylitis and rotator muscle cap pathology
Use of botulin toxin to obtain a product intended to be administered intramuscular with lissive effect in treating articular pathologies, particularly coxarthrosis, or arthrosis of the hip,...
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7192596 |
Recombinant toxin fragments
A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to...
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7189541 |
Botulinum toxin production method
Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can...
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7179474 |
Methods for treating a buttock deformity
Methods for treating a buttock deformity or for preventing development of a buttock deformity by local administration of a Clostridial toxin, such as a botulinum neurotoxin, to a buttock...
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7172764 |
Rescue agents for treating botulinum toxin intoxications
The present invention relates to rescue agents for use in the treatments of toxin intoxication—for example botulinum intoxication, which can result from food poisoning, an act of bioterrorism, or...
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7172763 |
Post-operative pain treatment by peripheral administration of a neurotoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7160699 |
Media for clostridium bacterium and processes for obtaining a clostridial toxin
Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for...
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7153514 |
Use of botulinum toxin therapy for prostatic hyperplasia and related disorders
The present invention relates to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin.
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7148041 |
Animal product free media and processes for obtaining a botulinum toxin
Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can...
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7141428 |
Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof
The present invention provides methods for making, delivering and using formulations that combine a therapeutically active agent(s) (such as for example a Rho antagonist(s)) and a flowable carrier...
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7138127 |
Clostridial toxin derivatives and methods for treating pain
Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a...
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7108857 |
Therapy for injured muscles
Methods for treating an injured muscle by local administration of a neurotoxin, such as a botulinum toxin, to promote healing and/or to reduce the pain associated with an injured muscle.
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7091176 |
Methods for treating arthritis pain
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
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7067137 |
Method for treating post herpetic neuralgia by peripheral administration of a neurotoxin
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7056729 |
Botulinum neurotoxin-substance P conjugate or fusion protein for treating pain
Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a...
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7052702 |
Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics
A class of novel agents that are able to modify nociceptive afferent function is provided. The agents may inhibit the release of neurotransmitters from discrete populations of neurones and thereby...
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7022329 |
Method for treating neurogenic inflammation pain with botulinum toxin and substance P components
The present invention relates to methods for treating neurogenic inflammation pain. The methods include administering an effective amount of a composition which includes a botulinum toxin...
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7001602 |
Use of botulinum toxin therapy for urinary incontinence and related disorders
The present invention relates to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin.
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6977080 |
Intrapericardial botulinum toxin treatment for bradycardia
Methods for treating cardiac muscle disorders, such as cardiac arrhythmias, by administration of a neurotoxin to cardiac muscle are disclosed. Bradycardia can be alleviated for several months by a...
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6974579 |
Methods for treating vascular disorders
The present invention provides methods for improving blood supply through a grafted blood vessel. In some embodiments, the methods comprise the step of locally administering a botulinum toxin to...
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6974578 |
Method for treating secretions and glands using botulinum toxin
Method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of...
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6955813 |
Therapy for injured muscles
Methods for treating an injured muscle by local administration of a neurotoxin, such as a botulinum toxin, to promote healing and/or to reduce the pain associated with an injured muscle.
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6939852 |
Methods and compositions for the treatment of cerebral palsy
The invention provides for the use of a botulinum toxin to treat cerebral palsy in juvenile patients by transdermal administration of the botulinum toxin. The juvenile patients are preferably...
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6921538 |
Therapeutic treatments for neuropsychiatric disorders
Methods for treating psychiatric disorders include intracranial administration of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A, to a human patient.
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