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5897867 |
Efficacious vaccines against Bordetella pertussis comprising a combination of individually purified pertussis antigens
This invention is directed to a vaccine for the prevention of disease caused by Bordetella pertussis which comprises the pertussis antigens filamentous hemagglutinin, detoxified lymphocytosis...
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5837265 |
Chemically-modified clostridiatoxin with improved properties
The invention consists of modified Clostridium neurotoxin compounds, pharmaceutical compositions containing such compounds and methods for preparing such compounds. In particular, the compounds of...
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5766605 |
Treatment of autonomic nerve dysfunction with botulinum toxin
There is disclosed according to the present invention a method for the control of autonomic nerve function in a mammal comprising administering a therapeutically effective amount of botulinum toxin...
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5601826 |
Peptide which produces protective immunity against tetanus
The invention provides an immunogen against tetanus toxin including a peptide having a single, linear, antigenic, tetanus-toxin-specific epitope. The epitope is derived from the heavy chain C...
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5571694 |
Expression of tetanus toxin fragment C in yeast
Expression of tetanus toxin fragment C is accomplished employing a DNA coding sequence having a (G+C)-content that has been increased in the region from nucleotide 410 to the 3' end of the coding...
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5562907 |
Method to prevent side-effects and insensitivity to the therapeutic uses of toxins
Human-derived or human-compatible antitoxins are administered is an adjunct to therapy with a toxin, such as botulinum toxin or an immunotoxin, or as an adjunct to therapy with a combination of...
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5538733 |
Method of priming an immune response in a one-day old animal
The invention provides a method of priming an immune response in the presence of maternal antibody in a young animal by administering to a 1-90 day old animal, a biocompatible and non-toxic solid...
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5494807 |
NYVAC vaccinia virus recombinants comprising heterologous inserts
What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential...
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5484773 |
Treatment of antibiotic associated diarrhea
This invention relates to treatment of antibiotic associated diarrhea, including Clostridium difficile associated diarrhea (CDAD) and pseudomembranous colitis (PMC), using oligosaccharide...
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5437291 |
Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction
Direct injection of sphincteric botulinum toxin is disclosed as an effective, safe and simple method of treatment for disorders of gastrointestinal muscle or smooth muscles elsewhere in the body,...
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5139776 |
Method for culturing Bordetella pertussis, a pertussis toxoid and a pertussis vaccine
There is disclosed a method for culturing Bordetella pertussis in the presence of a cellulose and/or cellulose derivatives. The present method is useful for obtaining a mixed antigen comprising...
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5110794 |
Method of immunization with partially cationized substances and said partially cationized substances
A partially cationized protein-containing substance that exhibits enhanced immunogenicity as compared to the native protein-containing substance and is useful in mammalian immunization by oral or...
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5097020 |
Immunogenic conjugates
An immunogenic conjugate which is the reductive amination product of an immunogenic capsular polymer fragment having at least one reducing group and derived from a bacterial capsular polymer of a...
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4762713 |
Boosting of immunogenic conjugate vaccinations by unconjugated bacterial capsular polymers
This invention relates to immunogenic conjugates of capsular polymers or polymer fragments from bacterial pathogens and bacterial toxins, toxoids or subunits. The invention also relates to methods...
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4751064 |
Synthetic chollera vaccine
A synthetic vaccine against cholera and against heat-labile toxin of E. coli comprising a conjugate of a high-molecular weight carrier with a synthetic polypeptide corresponding to part of the...
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4713240 |
Vaccines based on insoluble supports
The present invention relates to vaccine compositions which comprise at least one antigen chemically linked to a water-insoluble support combined with a pharmaceutically acceptable carrier. It also...
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4711779 |
Glycoproteinic conjugates having trivalent immunogenic activity
Glycoproteinic conjugates having trivalent immunogenic activity obtained by binding, by a covalent bond, to a protein selected among CRM 197, tetanus toxoid, and pertussis toxin, at least an...
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4705686 |
Process for the preparation of acellular Bordetalla pertussis vaccine
This invention discloses a process for preparing an acellular Bordetella pertussis vaccine by passing culture supernatants or cellular extracts of B. pertussis through a column containing an ion...
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4619828 |
Polysaccharide exotoxoid conjugate vaccines
A water-soluble covalent polysaccharide-antigen conjugate having a molecular size between 140,000 and 4,500,000 dalton and a nominal polysaccharide/protein ratio between 0.25 and 2, capable of...
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4578270 |
Process for the preparation of lyophilized, adsorbed polyvalent vaccines
The invention relates to the preparation of lyophilized, absorbed polyvalent vaccines. According to the invention tetanus, diphtheria, pertussis and optionally typhus antigens concentrated to 5 to...
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4455142 |
Method of coadministering an antigen and an immunopotentiator
A method is disclosed for potentiating the immune response of an animal. The method consists in administering an antigen and an immunopotentiator in effective low dose, at a controlled rate, and...
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4396630 |
Process for preparing lipoid-biologically active particles
Adjuvant particles are prepared from lipoid-soluble substances, and compositions comprising the particles and biologically active substances adsorbed thereon are provided. The adjuvant systems are...
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4372883 |
Process for the production of vaccine
The present invention relates to a process for the production of vaccine, characterized by covalent attachment of a biologically toxic substance to a saccharide both to form a biologically toxic...
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4292307 |
Vaccine and method for prophylaxis and treatment of clostridioses of animals and poultry
A vaccine for prophylaxis and treatment of clostridioses of animals and poultry is provided which comprises toxoids of Clostridium perfringens types A, B and D, Cl. oedematiens, and Cl. septicum,...
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4264588 |
Vaccine for Clostridium perfringens type E enterotoxemia of rabbits
A vaccine for Clostridium perfringins type E enterotoxemia of rabbits is produced by harvesting (or centrifuging) an actively growing culture of the bacterium and subjecting the supernatant to a...
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4258029 |
Synthetic adjuvants for stimulation of antigenic responses
Long chain alcohol esters of amino acids are used as adjuvants in vaccines to provide an improved antigenic capability when compared with conventional adjuvants.
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4200627 |
Atoxic, immunogenic product of tetanus toxin
What is disclosed is a method for obtaining an atoxic, immunogenic product from tetanus toxin by treating tetanus toxin with a proteinase. The product, which is different from known fragment C of...
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4172126 |
Method for the inactivation of microbial toxins and attenuation of vaccines
A method for the inactivation of microbial toxins and attenuation of vaccines by treating the toxin or vaccine with a tannin, especially a condensed tannin derived from fruit of the genus...
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4029765 |
Derivatives of the tetanus toxin, process for their preparation and agents containing them
The present invention relates to derivatives of tetanus toxin, a process for their preparation by treating an aqueous solution of tetanus toxin with an aliphatic mono- or dialdehyde, reacting the...
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4021364 |
Microcapsules in the nanometric range and a method for their production
The present invention is concerned with novel synthetic capsules which are colloid soluble in water or suspendible or colloid soluble in hydrophobic media and consist of compatible polymeric...
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4016252 |
Calcium phosphate gel for adsorbing vaccines
An improved aqueous gel of calcium phosphate, useful for preparation of adsorbed vaccines, prepared by contacting an antigen with an aqueous gel obtained by reacting an aqueous solution of dibasic...
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4007265 |
Method for treating tetanus toxin with a proteinase to produce an atoxic immunogenic product
An atoxic, immunogenic product obtained by treating tetanus toxin with a proteinase, a process for its manufacture and a tetanus vaccine containing as the essential ingredient said atoxic...
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3968202 |
Tetanus antigen and process for its manufacture
Tetanus antigen which contains a tetanus toxin inactivated with oxymethane sulfinate and a process for the manufacture of this tetanus antigen by the inactivation of a tetanus toxin which comprises...
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3920811 |
Adjuvant compositions
Acrylic acid polymer adjuvant compositions comprising a mixture of an acrylic acid polymer cross-linked with a polyallylsaccharide and a physiologically acceptable electrolyte have properties which...
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3919411 |
Injectable adjuvant and compositions including such adjuvant
A medicinal composition comprising an injectable active substance or agent combined with a novel adjuvant therefor capable of enhancing the effect of the agent. The adjuvant in its preferred form...
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3869546 |
Adjuvant compositions and medicinal mixtures comprising them
Acrylic acid polymer adjuvant compositions comprising a mixture of an acrylic acid polymer crosslinked with a polyallylsaccharide and a physiologically acceptable electrolyte have properties which...
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3542920 |
TETANUS VACCINE AND PROCESS FOR PREPARING IT
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3531565 |
STABLE ADJUVANT EMULSION COMPOSITIONS COMPRISING HYDRATED SALTS OF A POLYVALENT METALLIC CATION AND A HIGHER FATTY ACID
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3522347 |
TOXOID COMPOSITIONS
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3429966 |
VACCINES AND ADJUVANTS THEREFOR
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3415804 |
Fractionation of mixtures of proteinaceous substances using polyethylene glycol
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3384544 |
Injectable solutions or suspensions of antigens in optically clear colloidal solutions
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3322632 |
Process for stabilizing biologically active materials with modified collagen hydrolyzate
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3288680 |
Stabilized clostridium perfringens beta-toxoid vaccine
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3269912 |
Aluminum oxide depot vaccines
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3234199 |
Ion exchange process for separating proteins
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3184394 |
Process for the preparation of enzymes, toxins and toxoids
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3178350 |
Biologic antigens adjuvanted with a colloidally water-soluble polymer of acrylic acidcrosslinked with polyallyl sucrose or polyallyl pentaerythritol
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3100178 |
Vaccine products and method of preparing same
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2952585 |
Immunizing against and treatment of diseases
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