Matches 101 - 150 out of 202 < 1 2 3 4 5 >
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6713444 Buforin I as a specific inhibitor and therapeutic agent for botulinum toxin B and tetanus neurotoxins  
The compounds of the invention are generally described by the formula: X 1 X 2 B 3 X 4 B 5 X* 6 X 7 X 8 B 9 X 10 B 11 X 12 B 13 X 14 B 15 X 16 B 17 X* 18 X* 19 B 20 X 21 X 22 X 23 Q 24 F 25 Z* 26...
6683049 Method for treating a cholinergic influenced sweat gland  
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
6645496 Method for treating tardive dyskinesia with Botulinum toxin type B  
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
6641820 Clostridial toxin derivatives and methods to treat pain  
Methods for treating a bone tumor, in particular pain associated with bone tumor, by administration to a patient of a therapeutically effective amount of an agent are disclosed. The agent may...
6635260 Methods and compositions for prevention and treatment of Clostridium difficile-associated diseases  
This invention provides methods and compositions for preventing and treating Clostridium difficile -associated disease in a subject, wherein the subject is either a human or non-human animal. The...
6635247 Hypoparathyroid therapy  
A method for treating hypoparathyroidism and/or hypocalcemia by local administration of a neurotoxin, such as a botulinum toxin, to a parathyroid gland, thereby reducing an inhibitory effect upon...
6632433 Method for treating cervical dystonia with botulinum toxin type B  
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
6632431 Anti-idiotypic antibody against FimH adhesion of uropathogenic type I-fimbriated Escherichia coli, compositions containing same and method for using same  
The present invention relates to an anti-idiotypic antibody or antigen-binding fragment against FimH adhesin of uropathogenic Type I-fimbriated Escherichia coli and an immunizing composition...
6632440 Methods and compounds for the treatment of mucus hypersecretion  
A method of treating mucus hypersecretion, the causative factor in chronic obstructive pulmonary disease (COPD), asthma and other clinical conditions involving COPD, comprises administering a...
6620415 Parkinson's disease treatment  
Methods for treating a movement disorder by intracranial administration to a human patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A.
6610300 Clostridium perfringens vaccine  
The present invention relates to detoxified immunogenic derivatives of Clostridium perfringens β-toxin or an immunogenic fragment thereof that have as a characteristic that they carry a mutation...
6585970 Method for treating hypothyroidism  
A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method...
6585993 Controlled release neurotoxin system  
A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer,...
6573241 Therapeutic agent for the suppression of snoring noises  
In a method of manufacturing a therapeutic agent to be administered intramuscularly for suppressing snoring noises a high-purity Clostridium toxin BoNT/A or TeNT or at least one of a high-purity...
6573003 Identification of neutralizing epitopes of toxin A and toxin B for the treatment of C. difficile disease  
The present invention includes methods for generating neutralizing antitoxin directed against clostridial toxins. In particular, the antitoxin directed against these toxins is produced in avian...
6524580 Method for treating thyroid disorders  
A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method...
6495315 Channel forming toxins as antiviral agents  
The infectivity of a population of enveloped viruses which comprise a glycosylphosphatidylinositol-anchored protein in their membrane can be reduced by employing certain toxins such as aerolysin,...
6465435 Treatment of C. difficile toxin B associated conditions  
This invention relates to prevention and/or treatment of antibiotic associated diarrhea, including Clostridium difficile associated diarrhea (CDAD), pseudomembranous colitis (PMC) and other...
6458365 Method for treating headache  
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
6455673 Multi-mutant diphtheria toxin vaccines  
Disclosed are diphtheria toxin polypeptides having multiple mutations, which render the polypeptides useful as vaccines.
6447785 Method for treating hypercalcemia  
A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A...
6447787 Methods for enhancing wound healing  
A method for treating a patient having a wound is described. The method includes administering an amount of a chemodenervating agent such that healing of the wound is enhanced. The method is...
6444209 Hybrid botulinal neurotoxins  
A hybrid botulinal neurotoxin is disclosed. In one embodiment, the neurotoxin comprises a combination of a botulinal neurotoxin heavy chain and light chain, wherein the light chain and heavy chain...
6423319 Methods for treating muscle injuries  
Methods for treating an injured muscle by local administration of a neurotoxin, such as a botulinum toxin, to promote healing and/or to reduce the pain associated with an injured muscle.
6416765 Neurotoxin therapy for diabetes  
The invention encompasses a method for treating hyperinsulinemic type 2 diabetes by local administration of a neurotoxin, such as a botulinum toxin, into the pancreas, thereby reducing insulin...
6403094 Clostridium perfringens vaccines  
The present invention provides proteins for use in vaccines which are capable of inducing protective antibodies directed against C. perfringens epsilon toxin when administered to animals or man...
6372221 Immunogenic constructs comprising flaviviruses or flavivirus derivatives  
The invention concerns an immunogenic construct comprising as components (i) an inactive flavivirus or a derivative thereof, and (ii) at least one immunogenic component which is bonded to the...
6372225 Tetanus toxin functional fragment antigen and tetanus vaccine  
Disclosed is a tetanus toxin functional fragment antigen (FFA), comprising at least one fragment which is substantially the same as that obtained by a process comprising the steps of splitting at...
6368605 Method for treating cancer with a neurotoxin to improve patient function  
A method for reducing a catecholamine secretion from a cholinergically innervated, functional chromaffin body, such as a paraganglioma or hyperplasic adrenal medulla, by direct, local...
6365158 Methods for producing neutralizing antitoxin to C. difficile toxin B  
The present invention includes methods for generating neutralizing antitoxin directed against clostridial toxins. In particular, the antitoxin directed against these toxins is produced in avian...
6358513 Method for treating Hashimoto's thyroiditis  
Methods for treating the hypothyroidism of Hashimoto's thyroiditis by local administration of a neurotoxin, such as a botulinum toxin, to the thyroid gland of a patient, thereby reducing an...
6350455 Method for treating a catecholamine secretion  
A method for reducing a catecholamine secretion from a cholinergically innervated, functional chromaffin body, such as a paraganglioma or hyperplasic adrenal medulla, by direct, local...
6337075 Methods for treating diabetes  
The invention encompasses a method for treating hyperinsulinemic type 2 diabetes by local administration of a neurotoxin, such as a botulinum toxin, into the pancreas, thereby reducing insulin...
6328977 Method for treating hyperparathyroidism  
A method for treating hypoparathyroidism and/or hypocalcemia by local administration of a neurotoxin, such as a botulinum toxin, to a parathyroid gland, thereby reducing an inhibitory effect upon...
6319505 Method for treating dystonia with botulinum toxin types C to G  
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
6306403 Method for treating parkinson's disease with a botulinum toxin  
Methods for treating a movement disorder by intracranial administration to a human patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A.
6299881 Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts  
A method for producing a conjugate vaccine includes mixing a uronium salt reagent with a first moiety (e.g., a polysaccharide). According to the invention, the uronium salt reagent has a chemical...
6287566 Protective peptides neurotoxin of C. botulinum  
Methods for developing vaccines to protect from neurotoxins of C. botulinum have been developed. Truncated BoNT/A proteins of about 15-30 kDa in size produced immune responses that provided...
6265379 Method for treating otic disorders  
Methods for treating otic disorders by local administration of a neurotoxin. A botulinum toxin can be administered to myoclonic middle ear muscles and to inner ear efferent and/or afferent nerves...
6261572 Method for treating a pancreatic disorder with a neurotoxin  
A method for treating a pancreatic disorder by local administration of a therapeutic amount of a neurotoxin, such as a botulinum toxin, into or onto the body of the pancreas of a human patient,...
6203794 Modification of clostridial toxins for use as transport proteins  
A chemical conjugate for treating a nerve cell related disorder is provided. The conjugate includes an active or inactive Clostridial toxin having specificity for a target nerve cell. The toxin is...
6143306 Methods for treating pancreatic disorders  
A method for treating a pancreatic disorder by local administration of a neurotoxin, such as a botulinum toxin, into a cholinergic influenced, exocrine pancreas or endocrine pancreas, thereby...
6139845 Method for treating cancer with a neurotoxin  
A method for reducing a catecholamine secretion from a cholinergically innervated, functional chromaffin body, such as a paraganglioma or hyperplasic s adrenal medulla, by direct, local...
6136551 Assay for detecting the presence of botulinum toxin neutralizing antibodies in a patient serum sample  
An assay for the identification of neutralizing botulinum antibodies in sera is provided which includes the steps of separating non-sodium dodecyl sulfate, non-trypsinized complex botulinum toxin...
6060067 Process for the preparation of tetanus toxoid vaccine  
6051239 Compositions and methods for systemic delivery of oral vaccines and therapeutic agents  
Compositions and methods of oral delivery of an antigen or therapeutic agent to the general circulation using a modified botulinum toxin which is capable of translocating from the gut to the...
6036953 Heterologous antigens in live cell V. cholerae strains  
Disclosed is a V. cholerae cell containing a DNA encoding a fusion polypeptide that includes a heterologous antigenic polypeptide sequence such as a portion of C. difficile toxin A. The fusion...
5919463 Clostridium difficle toxins as mucosal adjuvants  
The invention features methods and compositions for inducing protective and/or therapeutic immune responses to an antigen in a mammal. In these methods, an antigen is administered to the mammal...
5917017 Diphtheria toxin vaccines bearing a mutated R domain  
Diphtheria toxin polypeptides comprising a mutant R binding domain exhibit reduced target cell binding and may be used as vaccines to immunize a mammal against infection by Corynebacterium diphtheria.
5897867 Efficacious vaccines against Bordetella pertussis comprising a combination of individually purified pertussis antigens  
This invention is directed to a vaccine for the prevention of disease caused by Bordetella pertussis which comprises the pertussis antigens filamentous hemagglutinin, detoxified lymphocytosis...
Matches 101 - 150 out of 202 < 1 2 3 4 5 >