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7632513 |
Immunogenic detoxified mutants of cholera toxin
An immunogenic detoxified protein comprising the amino acid sequence of subunit A of a cholera toxin (CT-A) or a fragment thereof or the amino acid sequence of subunit A of an Escherichia coli ...
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7632514 |
Universal carrier for targeting molecules to Gb3 receptor expressing cells
The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys,...
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7628992 |
Modification of clostridial toxins for use as transport proteins
A chemical conjugate for treating a nerve cell related disorder is provided. This conjugate includes an active or inactive Clostridial toxin having specificity for a target nerve cell. The toxin is...
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7625559 |
Antibodies against Clostridium difficile toxins and uses thereof
Antibodies that specifically bind to toxins of C. difficile , antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided...
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7622127 |
Clostridial toxin derivatives and methods for treating pain
Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a ...
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7608275 |
Systems and methods for delivery of a therapeutic agent
Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G...
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7597891 |
Synthesis of human secretory IgA for the treatment of Clostridium difficile associated diseases
A composition for treating a subject is provided. The composition includes dimeric or polymeric secretory IgA therapeutic. Formulating agents are mixed with the dimeric or polymeric secretory IgA...
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7585942 |
Diphtheria toxin variant
The present invention relates to methods and compositions of modified variants of diphtheria toxin (DT) that reduce binding to vascular endothelium or vascular endothelial cells, and therefore,...
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7579182 |
Use of cross-protection to identify novel vaccine candidates for infectious agents
This invention discloses methods for identifying Francisella tularensis vaccine candidates. It enables identification of novel vaccine candidates and quality assurance for vaccine batches,...
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7579010 |
Botulinum toxin pharmaceutical compositions with a recombinant human serum albumin
A botulinum toxin pharmaceutical formulation free of animal derived proteins, comprising a botulinum toxin and a recombinant albumin, suitable for therapeutic administration to a human patient, and...
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7579011 |
Exoenzyme toxin of Aeromonas salmonicida, and uses therefor
A novel protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration)...
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7560251 |
Media for Clostridium bacterium
Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for...
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7541040 |
Chimeric molecule for the treatment of th2-like cytokine mediated disorders
The invention provides uses and methods for alleviating respiratory tract symptoms of allergy, asthma, and of viral, bacterial, fungal and parasitic infections by shifting inappropriate TH2...
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7537771 |
Expression system
An immunogenic reagent which produces an immune response which is protective against Bacillus anthracis, said reagent comprising one or more polypeptides which together represent up to three...
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7534857 |
Methods and compositions for the treatment and prevention of staphylococcal infections
A biologically pure RNAIII inhibiting peptide (RIP), that includes five contiguous amino acids of the sequence YX 2 PX 1 TNF, where X 1 is C, W, I or a modified amino acid, and X 2 is K or S is...
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7531183 |
Biologically active hemagglutinin from type A Clostridium botulinum and methods of use
An isolated, biologically active 33 kDa Hemagglutinin purified from the type A Clostridium botulinum neurotoxin complex and its uses are described.
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7527797 |
Vibrio cholerae 0139 conjugate vaccines
The invention pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These...
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7507419 |
Topically applied Clostridium botulinum toxin compositions and treatment methods
Hyperactive glandular conditions are treated using topically formulated botulinum toxin compositions. In the preferred embodiment of the invention, topical botulinum preparations are applied...
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7501130 |
Methods for treating myofascial pain
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
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7494661 |
Methods for using tetanus toxin for beneficial purposes in animals (mammals)
Methods of using tetanus toxin to modulate or control neural functions or nonneural cellular activities at selected sites in animals, particularly in mammals, and more particularly in humans, are...
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7491404 |
Acellular immunogenic compositions and acellular vaccine compositions against Bacillus anthracis
The invention concerns an acellular immunogenic or vaccine composition for producing antibodies against Bacillus anthracis comprising a protective antigen (PA) and killed and optionally purified...
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7485304 |
Non-toxic mucosal adjuvant
A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic...
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7479281 |
Botulinum toxin for treating postherpetic neuralgia
Methods for treating conditions in an animal or human subject. The conditions may be pain, skeletal muscle conditions, smooth muscle conditions, glandular conditions and cosmetic conditions. The...
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7479282 |
Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof
This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate in which the amino acid sequence is set forth in any of SEQ ID...
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7473429 |
Method for treatment of laminitis in animals
The present invention generally relates to methods for treating the sequela of laminitis in hoofed animals. Benefits are obtained by administering to the animals to be treated injections of...
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7470431 |
Use of neurotoxin therapy for treatment of urological-neurological disorders associated with prostate cancer
The present invention related to methods for treating neurological-urological conditions associated with prostate cancer or methods of treatment of prostate cancer, which is accomplished by...
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7468189 |
Neuropathic pain treatment method
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
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7459164 |
Composition for therapeutic and cosmetic botulinum toxin
This invention relates to a composition of botulinum based pharmaceuticals used for therapeutic and cosmetic treatment. This invention offers an improvement on the prior art by eliminating the...
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7455843 |
Adjuvant activities of mutants of LT-IIa and LT-IIb enterotoxin lacking binding to ganglioside
The present invention describes the adjuvant activity of mutants of LT-IIa and LT-IIb enterotoxin which lack ganglioside binding activity. The adjuvant activity of the LT-IIb(T13I) mutant is...
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7455845 |
Use of neurotoxin therapy for treatment of urologic and related disorders related to lowering elevated bladder pressure
The present invention related to methods for treating neurological-urological conditions, including urinary retention. This is accomplished by administration of a botulinum toxin into the lower...
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7452697 |
Chromatographic method and system for purifying a botulinum toxin
Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.
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7452543 |
Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics
A class of novel agents that are able to modify nociceptive afferent function is provided. The agents may inhibit the release of neurotransmitters from discrete populations of neurones and thereby...
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7449192 |
Use of neurotoxin therapy for treatment of urologic and related disorders related to neurogenic bladder dysfunction
The present invention related to methods for treating neurological-urological conditions, including neurogenic bladder dysfunction. This is accomplished by administration of a botulinum toxin into...
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7449310 |
Recombinant Fusobacterium necrophorum leukotoxin vaccine and preparation thereof
The F. necrophorum gene expressing leukotoxin was sequenced and cloned. The leukotoxin open reading frame (lktA) is part of a multi-gene operon containing 9,726 bp, and encoding a protein...
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7445914 |
Animal product free media and processes for obtaining a botulinum toxin
Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can...
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7438921 |
Buttock deformity treatment
Methods for treating a buttock deformity or for preventing development of a buttock deformity by local administration of a Clostridial toxin, such as a botulinum neurotoxin, to a buttock...
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7438914 |
Composition and method for enhancing immune response
A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to...
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7431935 |
Proteins within the type E botulinum neurotoxin complex
The invention features a polypeptide complex synthesized by bacteria of the genus Clostridia that contains the serotype E botulinum neurotoxin and five neurotoxin associated polypeptides having...
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7429386 |
Stretch mark treatment
Methods for treating stretch marks by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a stretch mark.
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7429387 |
Use of botulinum toxin therapy for treatment of recalcitrant voiding dysfunction
The present invention related to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin.
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7425338 |
Clostridial toxin derivatives and methods for treating pain
Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a...
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7422753 |
Methods for treating trichotillomania
Methods for treating trichotillomania by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a low...
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7419675 |
Method for treating peritoneal adhesions
Methods for treating peritoneal adhesions by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a peritoneal adhesion.
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7399470 |
Sandwich immunoassay kits for detecting ciguatoxin CTX3C
A sandwich immunoassay kit for detecting ciguatoxins based on a combination of two anti-ciguatoxin CTX3C monoclonal antibodies produced by hybridomas, 3D11 (deposited at IPOD, AIST under accession...
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7396535 |
Therapy for obsessive compulsive head banging
Methods for treating a head banging disorder by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration...
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7393537 |
Botulinum toxin for treatment of obsessive compulsive finger biting disorder
Methods for treating obsessions and compulsions by local administration of a Clostridial toxin. The obsessions or compulsions can be eye poking, body rocking, finger biting, counting, checking and...
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7393538 |
Clostridial toxin treatment for dermatillomania
Methods for treating a dermatillomania by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a...
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7390496 |
Therapeutic treatments for repetitive hand washing
Methods for treating a hand washing disorder by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration...
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7384918 |
Botulinum toxin for treating muscle contracture
The invention provides for the use of a botulinum toxin to treat contracture, such as muscle contracture, in patients by transdermal administration of the botulinum toxin.
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7378389 |
Botulinum toxin neurotoxic component for treating juvenile cerebral palsy
The invention provides for the use of a presynaptic neurotoxin (for example a bacterial neurotoxin such as botulinum toxin A) for the manufacture of a medicament for the treatment of cerebral palsy...
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