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6803042 |
Oral or intranasal vaccines using hydrophobic complexes having proteosomes and lipopolysaccharides
An immunogenic complex, essentially consisting of neisserial outer membrane protein proteosomes hydrophobically complexed to native purified bacterial lipopolysaccharide and formulated in...
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6800734 |
Leptospira vaccine antigens for the prevention of Leptospirosis
Four antigenic preparations are provided, each of which contains a different protein from Leptospira which can be used immunologically in vaccines for leptospirosis caused by this organism. Also...
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6797276 |
Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
A transcutaneous immunization system where the topical application of an adjuvant and an antigen or nucleic acid encoding for an antigen, to intact skin induces a ystemic or mucosol antibody...
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6793925 |
Pseudomycin natural products
The invention relates to pseudomycin natural products including pseudomycins A′ and B′, methods for making such pseudomycins, and methods employing antifungal activity of these pseudomycins....
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6790446 |
Campylobacter vaccine
The present invention relates to vaccines comprising antiserum raised against a flagellaless Campylobacter strain for the prevention of Campylobacter colonization in animals. The invention also...
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6790450 |
Use of coxiella bacteria to treat autoimmune disease
Therapeutic compositions including a species of Coxiella or one or more antigenic components therefrom or analogous or homologous components thereof are disclosed. These compositions are useful in...
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6783765 |
Process for the preparation of a vaccine for the treatment of tuberculosis and other intracellular infections diseases and the vaccine produced by the process
The present invention relates to a process for the preparation of a vaccine against tuberculosis and other intracellular pathogens, this vaccine is targeted against intracellular pathogens, more...
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6783764 |
Actinobacillus pleuropneumoniae subunit vaccine
The present invention relates to live attenuated bacteria of the genus Actinobacillus pleuropneumoniae that have a mutation in an apxIV gene such that no functional ApxIV toxin can be produced....
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6780419 |
Basb029 polynucleotide(s) and polypeptides from neisseria meningitidis
The invention provides BASB029 polypeptides and polynucleotides encoding BASB029 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6780420 |
Carrier protein having an adjuvant effect, immunogenic complex containing it, process for their preparation, nucleotide sequence and vaccine
The invention relates to an adjuvant product which is intended to improve the activity of a molecule when administered to a host, characterized in that it comprises at least one part of the P40...
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6780414 |
METHODS OF IDENTIFYING BACTERIAL GENES THAT ARE INCOMPATIBLE WITH BACTERIAL PATHOGENICITY, AND THE USE OF SUCH GENES, SUCH AS CADA, TO REDUCE PATHOGENICITY IN A BACTERIA OR TO COMBAT PATHOGENIC BACTERIAL INFECTIONS
“Black holes” in the genomes of bacterial pathogens represent deletions of “anti-virulence” genes, i.e. genes that are detrimental to a pathogenic lifestyle. Identification of the missing...
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6776993 |
Tuberculosis vaccine
The present invention relates to novel recombinant vaccines providing protective immunity against tuberculosis. Further, the present invention refers to novel recombinant nucleic acid molecules,...
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6773711 |
Botulinum toxin therapy for Hashimoto's thyroiditis
Methods for treating the hypothyroidism of Hashimoto's thyroiditis by local administration of a neurotoxin, such as a botulinum toxin, to the thyroid gland of a patient.
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6770275 |
Live attenuated RTC-producing bacteria of the family
The present invention relates to live attenuated RTX-toxin producing bacteria of the family Pasteurellaceae, of which the attenuation is due to the fact that they produce RTX toxin in a...
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6770459 |
Immunogenic compounds
The invention provides BASB081 polypeptides and polynucleotides encoding BASB081 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6764686 |
Modified immunogenic pneumolysin compositions as vaccines
This invention relates to modified pneumolysin polypeptides that retain the immunogenic nature of pneumolysin but have reduced or undetectable hemolytic activity compared to native pneumolysin. The...
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6764687 |
Live attenuated bacteria for use in a vaccine
The present invention relates to live attenuated bacteria for use as a medicament. The invention also relates to vaccines based thereon that are useful for the prevention of microbial pathogenesis....
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6764834 |
BASB019 proteins and genes from Moraxella catarrhalis, antigens, antibodies, and uses
The invention provides BASB019 polypeptides and polynucleotides encoding BASB019 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6759241 |
Adjuvant comprising a lipopolysaccharide antagonist
LPS preparations, isolated from gram negative bacterial strains that contain at least one mutation in at least one of the htrB and msbB genes, and methods and therapeutics related thereto. The LPS...
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6756040 |
Vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminum phosphate
The invention relates to a vaccine formulation for the prevention of Haemophilus Influenzae Type B (Hib) infections and where the antigen is adsorbed onto aluminum phosphate. The invention also...
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6756493 |
Nucleic acid sequence and uses thereof
The invention discloses the Neisseria spp. NGSP polypeptide, polypeptides derived therefrom (NGSP-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies that...
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6752993 |
Abundant extracellular product vaccines and methods for their production and use
Vaccines based on majorly abundant extracellular products of pathogens and methods for their use and production are presented. The most prevalent or majorly abundant extracellular products of a...
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6746676 |
Chlamydia proteins and their uses
Certain Chlamydia proteins have been found to be infection-specific and to be associated primarily with the vegetative Reticulate Body form of Chlamydia rather than with the refractile Elementary...
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6746677 |
Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation
The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a...
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6743424 |
Method for treating hyperthyroidism
A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method...
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6740322 |
Immunization of dairy cattle with Mig protein
The Mig protein gene of Streptococcus dysgalactiae , and the correspondingamino acid sequence, is described, as is the use of the Mig protein in vaccine compositions to prevent and treat bacterial...
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6733761 |
Mycobacterial isocitrate lyase gene and uses thereof
The present invention provides a purified and isolated nucleic acid encoding mycobacterial isocitrate lyase, as well as mutated forms of the nucleic acid. Further provided are purified and isolated...
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6733758 |
Fibrinogen binding protein originating from coagulase-negative staphylococcus
A new fibrinogen binding protein or polypeptide originating from coagulase negative staphylococci, biotechnological methods for producing the protein or polypeptide having fibrinogen binding...
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6733760 |
Recombinant toxin A/toxin B vaccine against Clostridium difficile
The present invention relates to the field of medical immunology and further to pharmaceutical compositions, methods of making and methods of use of vaccines. More specifically this invention...
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6723327 |
Methods and compounds for the treatment of immunologically-mediated diseases using mycobacterium vaccae
Methods for the prevention and treatment of disorders, including disorders of the skin and respiratory system, such as infection with mycobacteria such as M. tuberculosis or M. avium ,...
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6722062 |
Capsular polysaccharides from enterococci
The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In...
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6716432 |
Pneumolysin mutants and pneumococcal vaccines made therefrom
Mutants of pneumolysin that are non-toxic by reason of amino acid substitutions have been constructed. These mutants elicit an immune response in animals that is reactive to wild-type pneumolysin....
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6716430 |
Compositions isolated from M. vaccae and their use in the modulation of immune responses
Polypeptides and polynucleotides isolated from Mycobacterium vaccae are provided, together with compositions comprising such polypeptide and polynucleotides, and methods for their use in the...
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6713062 |
Acinetobacter outer membrane protein and gene sequence compositions and methods
Disclosed are new outer membrane proteins and nucleic acids from Acinetobacter and related biological compositions and methods. The biological materials provided are useful in diagnostic,...
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6713071 |
Proteins from actinobacillus pleuropneumoniae
The present invention is directed to five novel, low molecular weight proteins from Actinobacillus pleuropneumoniae ( APP ), which are capable of inducing, or contributing to the induction of, a...
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6713063 |
Broad-spectrum &dgr -endotoxins
Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity and broader insect host range against coleopteran, dipteran and...
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6709660 |
Meningococcal antigens
The invention provides proteins from Neisseria meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The...
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6706271 |
Cloning of BASB023 antigen from Moraxella catarrhalis
The invention provides BASB023 polypeptides encoding BASB023 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and...
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6706494 |
BASB028 polypeptides and polynucleotides encoding therefor from moraxella catarrhalis
The invention provides BASB028 polypeptides and polynucleotides encoding BASB028 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6706269 |
Moraxella catarrhalis PILQ proteins
The invention provides BASB031 polypeptides and polynucleotides encoding BASB031 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6706287 |
Prebiotic and probiotic compositions and methods for their use in gut-based therapies
Microencapsulated and/or enteric coated compositions containing a mixture of probiotics, prebiotics and ammoniaphilic bacteria with high urease activity with or without sorbents with specific...
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6703025 |
Multicomponent vaccines
Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or...
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6699482 |
Leptospira rare outer membrane proteins
The present invention presents novel leptospiral membrane lipoproteins, LipL1 and LipL2, associated with pathogenic strains of Leptospira. LipL1 is of about 35 kDa, and LipL2 is of about 41 kDa....
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6696064 |
Methods of protecting vasculature from damage by diphtheria toxin-and pseudomonas toxin-based immunotoxins during therapy
Vascular damage has proven to be dose limiting in administering immunotoxins into the brain to treat brain tumors. Vascular toxicity of immunotoxins which rely in part on exposure to lowered pH in...
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6693186 |
Neisseria meningitidis polypeptide, nucleic acid sequence and uses thereof
The invention discloses the Neisseria meningitidis NMASP polypeptide, polypeptides derived therefrom (NMASP-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies...
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6689364 |
Borrelia burgdorferi polypeptides and uses thereof
The present invention provides novel polypeptides which are substantially free of a B. burgdorferi spirochete or fragments thereof and which are thus useful in compositions and methods for the...
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6689354 |
Immunogenic preparation and method for improving the productivity of ruminant animals
A method of improving the productivity of a ruminant animal comprising administering to said animal an amount of an immunogenic preparation effective to invoke an immune response to at least one...
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6685949 |
Lipooligosaccharide based vaccine for prevention of moraxella (branhamella)catarrhalis infections in humans
A conjugate vaccine for Moraxella ( Branhamella ) catarrhalis comprising isolated lipooligosaccharide from which esterified fatty acids have been removed, to produce a detoxified...
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6685945 |
Cloned Leptospira outer membrane protein
An antigenic preparation is provided which contains a 31 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism.
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6682746 |
Adjuvanted vaccine which is substantially free of non-host albumin
Disclosed herein is a serum-based adjuvanted vaccine which is substantially free of non-host albumin and the use thereof in reducing or preventing post-vaccination systemic reactions.
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