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6936258 |
Staphylococcus antigen and vaccine
A negatively-charged Staphylococcus antigen contains amino acids and a N-acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of ...
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6929799 |
D-alanine racemase mutants of mycobacteria and uses therefore
The present invention is directed to D-alanine racemase mutants of mycobacterial species. The D-alanine racemase gene (alrA) is involved in the systhesis of D-alanine, a basic component of...
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6929794 |
IL-12 as an adjuvant for Bordetella pertussis vaccines
This invention provides a composition of at least one Bordetella antigen and an effective adjuvant amount of interleukin-12 (IL-12), and uses thereof as a vaccine against Bordetella infection....
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6923963 |
Diagnosis of ehrlichia canis and ehrlichia chaffeensis
Diagnostic tools for for serodiagnosing ehrlichiosis in mammals, particularly in members of the Canidae family and in humans are provided. The diagnostic tools are a group of outer membrane...
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6924118 |
Recombinant intracellular pathogen immunogenic compositions and methods for use
Immunogenic compositions comprising recombinant attenuated intracellular pathogens that have been transformed to express recombinant immunogenic antigens of the same or other intracellular...
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6921538 |
Therapeutic treatments for neuropsychiatric disorders
Methods for treating psychiatric disorders include intracranial administration of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A, to a human patient.
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6921536 |
Lawsonia intracellularis vaccine
The present invention relates i.a. to nucleic acid sequences encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live...
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6921537 |
Preparation and uses of los-depleted outer membrane proteins of gram-negative cocci
Described herein is a method for removing toxic lipooligosaccharide (LOS) from outer membranes of Gram-negative cocci, such as Neisseria meningitidis . LOS-depleted outer membranes and...
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6916478 |
Vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, and methods for preparing same
The invention relates to novel vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, methods for preparing same, and their use in the prevention and treatment of...
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6913756 |
Monoclonal antibodies specific for anthrax and peptides derived from the antibodies thereof
The present invention provides monoclonal antibodies which are highly specific for Bacillus spores. Also provided are peptides derived from those monoclonal antibodies. Both the antibodies and...
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6913753 |
Incapacitated whole-cell immunogenic bacterial compositions
The invention features incapacitated whole cell bacterial immunogenic compositions produced by infecting a bacterium with Lys minus bacteriophage, which are deficient in the lysin protein. Lys...
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6908619 |
Camp factor of streptococcus uberis
The CAMP factor gene of Streptococcus uberis ( S. uberis ) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the...
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6908994 |
Collagen-binding proteins from enterococcal bacteria
A collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM from Staphylococcus aureus ,...
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6908739 |
Diagnostic assays for detection of Giardia lamblia
This invention provides methods, reagents, and kits that are useful for diagnosing infection by Giardia lamblia . The methods are based on the discovery of binding agents, including recombinant...
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6905691 |
Vaccines containing attenuated bacteria
The invention relates to a vaccine comprising a bacterium attenuated by a non-reverting mutation in a gene encoding a protein which promotes folding of extracytoplasmic proteins. Such mutations...
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6896888 |
Treatment of papilloma virus infection using a mycobacterium
Disease cased by papilloma virus is treated by applying an effective amount of Mycobacterium to the region of infection. Specifically, condylomata acuminata are caused by human papilloma virus...
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6896887 |
Bacterial ghosts provided with antigens
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
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6887481 |
Bacterial-derived molecules and therapeutic and diagnostic uses therefor
The present invention relates generally to molecules derived from a Mycobacterium species and recombinant, synthetic, derivative, homologue and analogue forms of said molecules. The molecules of...
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6887482 |
Antigenic iron repressible proteins from N. meningitidis related to the hemolysin family of toxins
An isolated, antigenic polypeptide comprises a segment having at least fifty amino acid residues. The amino acid sequence of the segment is present in N. meningitidis , and is different from, but...
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6887480 |
Streptococcus pneumoniae proteins and vaccines
The present invention relates to novel immunogenic polypeptides, and fragments thereof, and vaccines for the prevention and treatment of pneumococcal infection, especially by Streptococcus...
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6884423 |
Antimicrobial histone H1 compositions, kits, and methods of use thereof
The invention includes antibiotic pharmaceutical compositions comprising eukaryotic histone H1 protein and methods of using eukaryotic histone H1 protein to kill or to inhibit the growth of...
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6881411 |
Method of stimulating an immune response by administration of host organisms that express intimin alone or as a fusion protein with one or more other antigens
This invention satisfies needs in the art by providing intimin, the Enterohemorrhagic Escherichia coli (EHEC) adherence protein, alone or as a fusion protein with one or more other antigens,...
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6881410 |
Treatment of E. faecium infection
The present invention provides bacterial and fungal ABC transporter proteins, immunogenic fragments thereof, neutralising agents specific thereto and binding agents specific thereto for therapeutic...
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6881412 |
Modified live Flavobacterium columnare against columnaris disease in fish
Safe and effective live vaccines against Flavobacterium columnare of fish were created through the induction of rifampicin resistance in a native Flavobacterium columnare isolate; these...
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6878377 |
Mycobacterium vaccae for down-regulation of the Th2 activity of the immune system
Antigenic and/or immunogenic material derived from Mycobacterium vaccae is used to down-regulate Th2 activity of the immune system without up-regulation of Th1 activity. Disorders such as Chronic...
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6872550 |
Immunogenic formulation of OspC antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens
A novel approach to Borrelia vaccine formulation taking into account serological, genotypic and epidemiological information by which OspC proteins from different strains of B. burgdorferi are...
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6872394 |
Non-toxic immune stimulating enterotoxin compositions
Pyrogenic toxins, such as staphylococcal enterotoxins, modified in the disulfide loop region are provided. The modified toxins retain useful biological properties but have substantially reduced...
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6872397 |
Method for treating neuromuscular disorders and conditions with botulinum toxin types A and B
A method of treating a patient suffering from a disease, disorder or condition includes the administration to the patient of a therapeutically effective amount of botulinum toxin of a selected...
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6867024 |
Ubiquinone composition and methods related thereto
A composition is provided that includes an ubiquinone, such as CoQ 10 , bound by a glycoprotein matrix. A method is also provided for the manufacture of a composition of the invention. The...
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6861507 |
Screening of neisserial vaccine candidates and vaccines against pathogenic neisseria
Methods of screening for vaccine candidates, vaccines against pathogenic neisscria and intermediaries for such vaccines have been developed. Two vaccine candidates TspA and TspB have been...
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6861247 |
Salmonella secreted proteins and uses thereof
Substantially pure Salmonella secreted proteins (Ssp), the sercetion of which is dependent upon the expession of PrgH; methods of diagnosing Salmonella infection; and live attenuated vaccine...
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6858209 |
Means for detecting bacteria of the taylorella equigenitalis species and their biological applications
Means for detection of bacteria of the genus Taylorella and biological applications thereof are described. In particular, the detection of T. equigenitalis and the treatment or prevention of...
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6846477 |
One dose vaccination with Mycoplasma hyopneumoniae
The present invention relates to methods for treating or preventing a disease or disorder in an animal caused by infection by Mycoplasma hyopneumoniae ( M. hyo ) by administering to the animal at...
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6841159 |
Rapid lateral flow assay for determining exposure to Mycobacterium tuberculosis and other mycobacteria
An assay method and kit is disclosed for detecting the presence of at least one predesignated, target antibody to a mycobacterium in a sample selected from one or more patient bodily fluids. The...
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6841156 |
Method for treating muscle spasm with botulinum toxin type B
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
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6841155 |
Immunization against and treatment for infection by H. pylori
Methods for treating and/or protecting H. pylori infection are described. The methods utilize non-mucosal administration of an effective amount of one or more H. pylori antigens.
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6838247 |
Test for lyme disease
The present invention provides an accurate method to identify and quantify the Borrelia burgdorferi (Bb) antigen, the cause of Lyme Disease, in a sample of whole blood, body tissues and fluids of...
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6838089 |
Antigen delivery system and method of production
The present invention concerns polymer particle vaccine delivery systems in which a water insoluble protein antigen, e.g. a lipidated HpaA protein, is incorporated with particles comprising a...
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6827936 |
Synthetic peptide vaccines for dental caries
Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a...
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6824997 |
Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies
A process is disclosed for obtaining a C-polysaccharide cell wall antigen containing not more than about 10% protein from Streptococcus pneumoniae bacteria. The antigen thus obtained is...
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6821520 |
Clostridial toxin therapy for Hashimoto's thyroiditis
Methods for treating the hypothyroidism of Hashimoto's thyroiditis by local administration of a Clostridial toxin, such as a botulinum toxin, to the thyroid gland of a patient.
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6822075 |
Protein L and hybrid proteins thereof
The invention relates to sequences of protein L which bind to light chains of immunoglobulins. The invention also relates to hybrid proteins thereof which are able to bind to both light and heavy...
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6818221 |
Adjuvants and processes to induce a specific type of immune response
Porphyromanas gingivalis LPS elicits a Th2 immune response. P. gingivalis LPS, detoxified P. gingivalis LPS, derivatives of P. gingivalis LPS, derivatives of detoxified P. gingivalis LPS, ...
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6814971 |
Adjuvants for use in vaccines
The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local...
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6814970 |
Methods and compositions including a 13 kD B. burgdorferi protein
All Borrelia burgdorferi sensu lato isolates characterized to date have one or a combination of several major outer surface proteins (Osp). Mutants of B. burgdorferi lacking Osp proteins were...
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6811787 |
Over-expressing homologous antigen vaccine and a method of making the same
This invention relates to an over-expressing homologous antigen vaccine, a method of producing the same, and use of the vaccine for prophylaxis or treatment of vertebrates at risk of or suffering...
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6808711 |
Immunologically active proteins from Borrelia burgdorferi, nucleic acids which encode them, and their use in test kits and as vaccines
The present invention relates to immunologically active proteins from Borrelia burgdorferi which are present in a form which is free of other proteins derived from Borrelia burgdorferi and...
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6806253 |
Immunodulatory complex and use thereof in helicobacter diseases
A therapeutical vaccine complex having activity specific for Helicobacter bacteria as well as non-specific immunomodulation activity for regulating the natural defenses of the body. The drug is...
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6805868 |
Moraxella catarrhalis antigen, corresponding gene and uses thereof
The invention provides BASB109 polypeptides and polynucleotides encoding BASB109 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6803043 |
Basbo27 proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses
The invention provides BASB027 polypeptides and polynucleotides encoding BASB027 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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