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7132512 |
Medicament for the treatment of chlamydial infection
The present invention concerns treatment, prevention and diagnosis of infection due to Chlamydia pneumoniae and, in particular, to the prevention and treatment of atherosclerosis, including...
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7129339 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7128910 |
Moraxella catarrahalis outer membrane protein-106 polypeptide, gene sequences and uses thereof
The invention discloses the Moraxella catarrhalis outer membrane protein-106 (OMP106) polypeptide, polypeptides derived therefrom (OMP106-derived polypeptides), nucleotide sequences encoding...
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7129340 |
Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7125696 |
Method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent
A invention concerns a novel method for preparing a polypeptide soluble in an aqueous solvent in the absence of detergent, and polypeptides obtainable by said method. The invention also concerns...
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7122194 |
Vaccine compositions comprising Streptococcus pneumoniae polypeptides having selected structural motifs
A vaccine composition is disclosed that comprises polypeptides and fragments of polypeptides containing histidine triad residues or coiled-coil regions, some of which polypeptides or fragments lie...
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7122197 |
Compounds from Moraxella catarrhalis
The invention provides BASB020 polypeptides and polynucleotides encoding BASB020 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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7122196 |
Compounds and methods for diagnosis of tuberculosis
Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins,...
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7118758 |
Transformed bacteria producing CS6 antigens as vaccines
Disclosed herein are antigens that stimulate protective antibodies against enterotoxigenic Escherichia coli . Also disclosed herein are proteins encoded by cssA and cssB genes as well as...
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7118749 |
Transferrin receptor genes
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic...
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7118756 |
Recombinant protective protein from Streptococcus pneumoniae
The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus Pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight...
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7118757 |
Meningococcal class 1 outer-membrane protein vaccine
Outer-membrane vesicles, Class 1 outer membrane proteins of Neisseria meningitidis , fragments or oligopeptides containing epitopes of the Class I OMP can be used to immunize against meningococcal...
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7118888 |
Gene expression vaccine
An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to...
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7115731 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7115269 |
Attenuated Salmonella strain used as a vehicle for oral immunization
The present invention is directed to an attenuated Salmonella comprising a eukaryotic expression vector for delivery of the eukaryotic expression vector to a eukaryotic cell. Delivery may be to...
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7115268 |
Peptides useful for reducing symptoms of toxic shock syndrome and septic shock
This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates...
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7112332 |
Oral or intranasal vaccines using hydrophobic complexes having proteosomes and lipopolysaccharides
An immunogenic complex, essentially consisting of neisserial outer membrane protein proteosomes hydrophobically complexed to native purified bacterial lipopolysaccaride and formulated in accordance...
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7108853 |
Surface protein of Leptospira
The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
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7108854 |
Surface proteins of Leptospira
The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
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7105169 |
Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use
The present invention provides, among other things, methods of removing virus from a sample, a composition comprising a solid support matrix to which is attached a cyanovirin, a conjugate...
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7105170 |
Latent human tuberculosis model, diagnostic antigens, and methods of use
Provided herein is an in vitro granuloma model and methods of its use. Methods of detecting and/or diagnosing latent tuberculosis in a subject are also provided, as are latency-specific antigens...
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7105171 |
Porin B (PorB) as a therapeutic target for prevention and treatment of infection by Chlamydia
The present invention features peptides of a PorB polypeptide, which PorB peptides are useful in production of antibodies that bind the full-length PorB polypeptide and as a therapeutic agent. In...
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7101989 |
DsrA protein and polynucleotides encoding the same
DsrA is an outer membrane protein of H. ducreyi that confers serum resistance to the bacteria. Isolated polynucleotides encoding the protein, end expression vectors and host cells encoding the...
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7101558 |
High yield pertussis vaccine production strain and method for making same
The present invention provides a vaccine production strain of Bordetella bronchiseptica that produces a pertussis toxin in high yield. The present invention provides a method for creating a ...
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7101562 |
Conjugate vaccines for the prevention of dental caries
The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and...
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7094391 |
Compositions and methods for administering Borrelia burgdorferi antigens
Mucosal administration of OspA and compositions therefor are disclosed and claimed. More particularly, oral administration of OspA and compositions therefor for eliciting an immunological response...
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7094403 |
Mycobacterium tuberculosis superoxide dismutase
The invention relates to Mycobacterium tuberculosis superoxide dismutase antibodies, methods of using them for detection of M. tuberculosis , methods of testing for an inhibitor of an M....
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7090856 |
Anti-fouling exopolysaccharides isolated from cultures of Vibrio alginolyticus and Vibrio proteolyticus
An anti-fouling agent derived by culturing Vibrio alginolyticus in a suitable aqueous solution as well as a newly isolated strain of V. alginolyticus (DSM 15590) for producing the anti-fouting...
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7090853 |
Noscapine derivatives as adjuvant compositions and methods of use thereof
An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines.
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7090980 |
Method of detecting acid-fast bacteria using ribosomal RNA as target
A method of detecting a specific acid-fast bacterium, wherein primers having nucleotide sequences homologous or complementary to the specific regions in the rRNAs of the specific acid-fast...
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7087235 |
Fusion protein of streptococcal pyrogenic exotoxins
The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an...
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7087236 |
Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
A method of inducing either a T H 1 polarized immune response, a T H 2 polarized immune response or a combined T H 1 and T H 2 response to an antigen and associated vaccine formulations are...
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7087372 |
Compositions and methods for detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies
The invention provides methods and compositions for the detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies and antibody fragments.
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7087740 |
Kits for use in detecting resistance to streptogramin A and related compounds
A kit for use in detecting a bacterium having resistance to streptogramin A and related compounds is provided. A kit for use in detecting a bacterium harboring at least one polynucleotide encoding...
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7087410 |
Systems for expression of heterologous proteins in M. capsulatus
The present invention relates to an expression system for the expression of proteins and peptides in a methanotrophic bacterium, preferable the M. capsulatus . Further, the invention relates to...
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7083796 |
Fusion proteins of mycobacterium tuberculosis
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The...
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7083797 |
32-kDa protein derived from Mycobacterium tuberculosis and related peptides
The invention relates to recombinant polypeptides and peptides and particularly to the polypeptide containing in its polypeptidic chain the following amino acid sequence: the one extending from the...
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7083792 |
Immunologically active proteins from Borrelia burgdorferi
Various immunologically active proteins from Borrelia burgdorferi have been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from a B....
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7083798 |
Method of immunomodulatory treatment of insulin dependent diabetes mellitus using mycobacterial cell wall compositions
The present invention relates generally to a method of immunomodulating therapy and pharmaceutical compositions useful for same. More particularly, the present invention provides a method of...
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7081244 |
Neisserial vaccine compositions and methods
Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria . Further...
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7074416 |
Antigen of hybrid M protein and carrier for group A streptococcal vaccine
Recombinant hybrid streptococcal M protein antigens are provided which elicit protective antibodies against Group A streptococci and prevent rheumatic fever. Recombinant hybrid genes which encode...
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7074415 |
Streptococcus antigens
Streptococcus polypeptides and polynucleotides encoding them are disclosed. The polypeptides may be useful vaccine components for the prophylaxis or therapy of streptococcus infection in...
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7070779 |
POLYPEPTIDES CONTAINING POLYMORPHISMS OF THE REPEATED REGIONS OF PERTACTIN IN BORDETELLA PERTUSSIS, BORDETELLA PARAPERTUSSIS, AND BORDETELLA BRONCHISEPTICA, THEIR USE IN DIAGNOSTICS, AND IN IMMUNOGENIC COMPOSITIONS
Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella ...
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7070791 |
Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunoassay
A new recombinant form of the plasmid-encoded protein pgp3 from C. trachomatis , serotype D, was purified by ion exchange column chromatography and shown to be suitable for quantitative immunoassy...
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7070781 |
Nontoxic mucosal adjuvant
A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic...
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7067122 |
Modified live Edwardsiella tarda vaccine for aquatic animals
A safe and effective live vaccine against Edwardsiella tarda in fish was created through the induction of rifampicin resistance in a native Edwardsiella tarda isolate. Single immersion exposure...
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7067136 |
Method of screening anti-mycobacterial molecules
This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic...
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7067639 |
Method to provide bacterial ghosts provided with antigens
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
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7063974 |
Baroduric bacterium from Indian Ocean
Accordingly the present invention provides a process for the preparation an alcoholic extract with Carotenoids, UV absorption, antibacterial and pH indicating properties from a deep-sea bacterium...
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7063846 |
Outer membrane protein of Ehrlichia canis and Ehrlichia chaffeensis
Diagnostic tools for for serodiagnosing ehrlichiosis in mammals, particularly in members of the Canidae family and in humans are provided. The diagnostic tools are a group of outer membrane...
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