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6368604 |
Non-pyrogenic derivatives of lipid A
The present inventors have found that certain preparations containing LPS and/or lipid A variants, derivatives, and/or analogs demonstrate non-pyrogenic properties and exhibit anti-viral...
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6365158 |
Methods for producing neutralizing antitoxin to C. difficile toxin B
The present invention includes methods for generating neutralizing antitoxin directed against clostridial toxins. In particular, the antitoxin directed against these toxins is produced in avian...
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6365159 |
Spo-rel
spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such...
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6361776 |
Compounds isolated from M. vaccae and their use in modulation of immune responses
Polypeptides and polynucleotides isolated from Mycobacterium vaccae are provided, together with compositions comprising such polypeptide and polynucleotides and methods for their use in the...
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6355777 |
P43 antigen for the immunodiagnosis of canine ehrlichiosis and uses thereof
Canine monocytic ehrlichiosis, caused by Ehrilichia canis is a potentially fatal disease of dogs that requires rapid and accurate diagnosis in order to initiate appropriate therapy leading to a...
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6353093 |
gidB
The invention provides gidB polypeptides and polynucleotides encoding gidB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6350454 |
Attenuated Pasteurella piscicida vaccine for fish
Live-attenuated vaccines against Edwardsiella ictaluri or against Pasteurella piscicida are disclosed. Both vaccines are incapable of reversion to virulence, because both are made by deletion...
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6350455 |
Method for treating a catecholamine secretion
A method for reducing a catecholamine secretion from a cholinergically innervated, functional chromaffin body, such as a paraganglioma or hyperplasic adrenal medulla, by direct, local...
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6348579 |
FtsL
The invention provides FtsL polypeptides and DNA (RNA) encoding FtsL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FtsL...
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6348578 |
Apt
The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt...
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6348342 |
Compounds
The invention provides secA2 polypeptides and DNA (RNA) encoding secA2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing...
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6348198 |
Lactoferrin receptor protein
An isolated and purified lactoferrin receptor protein is isolated and purified from bacterial pathogens, including Moraxella and Neisseria, and has a molecular weight of between about 70,000 and...
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6346608 |
MecB
The invention provides mecB polypeptides and polynucleotides encoding mecB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6344540 |
PAI
The invention provides pai polypeptides and DNA (RNA) encoding pai polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pai...
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6342230 |
Materials and methods for prevention or reduction of the severity of heartwater
The present invention pertains to materials and methods for preventing, or reducing the severity of, heartwater disease in animals. One aspect of the invention is a vaccine against heartwater...
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6342231 |
Haemophilus parasuis vaccine and diagnostic
A cellfree extract of Haemophilus parasuis that exhibits toxic activity is described. The cellfree extract is useful as a vaccine or diagnostic reagent.
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6340455 |
Testkit and method
Skin prick test for the determination of the predisposition of an individual to develop marginal periodontitis, said kit comprising: (a) a first reagent containing a known quantity of a surface...
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6340463 |
Identification of antigenic peptide sequences
Identification of linear amino acid antigenic sequences for the production of both polyclonal and monoclonal antibodies to defined antigenic domains is described. Also described are antigenic...
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6335424 |
ribG
The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6328989 |
Use of bicozamycin for the manufacture of a medicament for treating infections with enterohemorrhagic e. coli
The present invention relates to the use of bicozamycins for the prophylaxis and treatment of infections with a verotoxin-producing E. coli, as well as for eradicating verotoxin-producing E. coli...
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6328978 |
Methods for the treatment of immunologically-mediated skin disorders
Methods for the treatment of skin disorders, including psoriasis, atopic dermatitis, allergic contact dermatitis, alopecia areata and skin cancers are provided, such methods comprising...
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6328972 |
Compositions and methods for inducing cytotoxic T lymphocyte responses by immunization with protein antigens
The invention provides compositions and methods for inducing MHC class I-restricted cytotoxic T lymphocyte responses in a mammalian host by immunization with non-replicating protein antigens. The...
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6326462 |
RibH
The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6316005 |
Borrelia burgdorferi bacterin
A bacterin including effective immunizing amounts of two non-crossprotective isolates of inactivated Borrelia burgdorferi, an adjuvant in an amount effective to enhance the immunogenicity of the...
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6312700 |
Method for enhancing an antigen specific immune response with OX-40L
Compositions and methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the surface of T-cells are disclosed, comprising administering to the mammal a...
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6307022 |
Def
The invention provides def polypeptides and DNA (RNA) encoding def polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def...
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6303129 |
Production of borrelia burgdorferi vaccine, product produced thereby and method of use
A process for the preparation of a vaccine from substantially viable spirochetal bacteria of Borrelia, preferably Borrelia burgdorferi having immunogenic or therapeutic properties and capable of...
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6303124 |
Compounds
The invention provides lysS polypeptides and DNA (RNA) encoding lysS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lysS...
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6300101 |
Methods and compositions including a 13kD B. burgdorferi protein
All Borrelia burgdorferi sensu lato isolates characterized to date have one or a combination of several major outer surface proteins (Osp). Mutants of B. burgdorferi lacking Osp proteins were...
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6299880 |
Cell surface protein compounds
Novel cell surface protein polypeptides and DNA (RNA) encoding such novel cell surface protein and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed...
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6299883 |
Tarf
The invention provides tarF polypeptides and DNA (RNA) encoding tarF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tarF...
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6296851 |
Integral membrane proteins of Staphylococcus aureus
The invention provides integral membrane protein polypeptides and DNA (RNA) encoding integral membrane protein polypeptides and methods for producing such polypeptides by recombinant techniques....
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6296855 |
17-KDA Brucella abortus antigen, recombinant polypeptides, nucleic acids coding for the same and use thereof in diagnostic and prophylactic methods and kits
The present invention relates to an isolated 17-kDa Brucclla antigen characterized by an amino acid sequence having at least 60% homology, preferably at least 70% homology, more preferably having...
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6296849 |
Methods and compositions including a 13kDa B. burgdorferi protein
All Borrelia burgdorferi sensu lato isolates characterized to date have one or a combination of several major outer surface proteins (Osp). Mutants of B. burgdorferi lacking Osp proteins were...
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6290962 |
Urease-based vaccine and treatment for helicobacter infection
Method of eliciting in a mammalian host a protective immune response to Helicobacter infection and treatment of Helicobacter infection by administering to the host an immunogenically effective...
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6290970 |
Transferrin receptor protein of Moraxella
An isolated and purified non-denatured transferrin receptor protein of a Moraxella strain, particularly M. catarrhalis, has an apparent molecular mass of about 80 to about 90 kDa, as determined by...
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6287575 |
Vaccine against papillomatous digital dermatitis (PDD)
This invention relates to the diagnosis and prevention of ungulate diseases caused by the spirochete bacteria Treponema. The invention specifically relates to isolated cultures of this spirochete...
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6287573 |
Method and vaccine for treatment of Pythiosis insidiosi in humans and lower animals
A method and vaccine for treatment of pythiosis in humans and animals is described. In particular a vaccine comprising a mixture of extracellular and intracellular proteins is described. The...
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6287555 |
Method and vaccine for prevention of over-production of acid in the rumen or gut of animals
The present invention is directed to a method of preventing the over-production of acid in an animal comprising administering to the animal a vaccine including an acid producing microorganism...
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6284238 |
Cell lines infected with granulocytic ehrlichia, vaccines, diagnostics and methods
The present invention relates, in general, to granulocytic Ehrlichia. In particular, the present invention relates to a human promyelocytic leukemia cell line infected with granulocytic Ehrlichia,...
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6280741 |
Equine treatment and method of administering such treatment
The invention is directed to a novel method for the use of vaccines to be used in the treatment and/or prevention of Navicular Disease in horses. The method comprises administration of a...
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6277379 |
Use of purified invaplex from gram negative bacteria as a vaccine
A novel composition comprising Invaplex from gram-negative bacteria is described and is effective as a vaccine against gram-negative bacterial infection.
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6274144 |
Method for generating antibodies to saccharide fragments
A method for depolymerizing polysaccharides containing into saccharide fragments using ozonolysis is described.
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6270777 |
Conserved metalloprotease epitopes
The present invention provides immunogenic compositions comprising peptides derived from the amino acid sequence of P. aeruginosa for protecting susceptible hosts against diseases caused by...
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6267961 |
Direct methods for molar-mass determination of fragments of Haemophilus influenzae type b capsular polysaccharides and vaccine preparation
The invention relates to the accurate and precise direct molar-mass measurement of low-molar-mass fragments of polysaccharides such as Haemophilus influenzae Type b. The methods for obtaining such...
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6264952 |
Method for protecting a mammalian host against infection by Brucella
Vaccines against facultative intracellular pathogens are disclosed. A host is vaccinated with non-viable but metabolically active agents. The non-viable agents produce immunogenic components that...
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6264954 |
Haemophilus outer membrane protein
Purified and isolated nucleic acid from specific strains of Haemophilus influenzae is provided which encodes at least a portion of the D15 outer membrane protein of Haemophilus. The nucleic acid is...
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6262029 |
Chemically modified saponins and the use thereof as adjuvants
The present invention is directed to novel bidesmosidic saponin derivatives comprising a triterpene aglycone core substituted at positions 3 and 28 with a monosaccharide or an oligosaccharide which...
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6255097 |
Two-phase system for the production and presentation of foreign antigens in hybrid live vaccines
The present invention relates to a genetic engineering process for the optimal production and exposure to the immune system of additional antigen coded for by a live vaccine. The genetic...
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6254874 |
Attenuated auxotrophic microorganisms having a combination of non-attenuating mutations and method for making same
A live non-virulent vaccine composition and method for preparing the same comprising a virulent microorganismal strain which contains at least two mutations, wherein the first mutation results in...
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