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6491924 |
Chlamydia pneumoniae antigenic polypeptide
Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding the...
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6486132 |
Immunomodulator, immunomodulator food and immunomodulator feed
To provide an immunomodulator in which DNA can be administered orally or percutaneously, not through injection, or can be taken daily like a food, or an immunomodulator food or feed. DNA derived...
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6479056 |
Live vaccine constituting minor risk for humans
A salmonella live vaccine produced from at least one attenuated immunologic live vaccine strain, characterized in that the vaccine strain has an envelope marker which results in an increased...
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6475492 |
Peptides and assays for the diagnosis of lyme disease
A peptide consisting of an invariable 26-amino-acid-long region, named IR 6 , which is antigenically conversed among strains and species of the B. burgdorferi sensu lato complex, and...
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6476201 |
Methods for the production of non-covalently complexed and multivalent proteosome sub-unit vaccines
A continuous method for preparing proteosome-amphiphilic determinant vaccines for parenteral or mucosal administration using diafiltration or ultrafiltration technology. The amphiphilic...
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6472183 |
Immunity against Actinobacillus pleuropneumoniae's RTX toxins APX
Disclosed herein is a modified microorganism which produces an RTX toxin, wherein said RTX toxin is partially or fully inactivated. Also disclosed is a modified microorganism wherein an RTX toxin...
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6471966 |
Type 1 and type p fimbriae-adhesins isolated from novel e. coli strains, process for their preparation and uses thereof
Fimbriae adhesins have a molecular weight of 2×10 5 and 2×10 7 Da, and are comprised of 90-95% protein and 1-3% sugar. Type 1 fimbriae include five different protein fractions of 14-20 kDa,...
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6471967 |
Recombinant intracellular pathogen vaccines and methods for use
Vaccines and immunotherapeutics for preventing intracellular pathogen diseases in mammals are provided that consist of recombinant attenuated intracellular pathogens that have been transformed to...
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6464979 |
Chlamydial vaccines and methods of preparation thereof
Immunogenic compositions including vaccines are described that comprise an outer membrane antigen extract of a strain of Chlamydia and are effective in protection against disease caused by...
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6464985 |
Compositions and methods using the borreliacidal epitope(s) of Borrelia burgdorferi outer surface protein C (OspC) for the diagnosis and prevention of lyme disease
An OspC Dra fragment fusion peptide isolated from Borrelia burgdorferi is described herein for the prevention, treatment and early diagnosis of Lyme disease in humans and other animals. This...
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6461614 |
Fibronectin binding proteins
The invention provides Fibronectin Binding Protein polypeptides and DNA (RNA) encoding Fibronectin Binding Protein polypeptides and methods for producing such polypeptides by recombinant...
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6458367 |
Method for detecting the presence of a mycobacterium species and a kit and antibodies for use therein
The invention relates to a diagnostic test for the detection and identification of Mycobacterium species in biological specimens of human and animal origin. The test is based on the immunological...
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6458368 |
Attenuated microorganism strains expressing HPV proteins
Attenuated strain of a prokaryotic microorganism, being an attenuated strain of Salmonella suitable for use in a live vaccine for administration to a human or animal, in which the microorganism is...
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6455052 |
Enteric coating, comprising alginic acid, for an oral preparation
A composition for forming an enteric coating on a tablet, capsule or pellet for oral ingestion includes a liquid mixture of alginic acid particles dispersed in an aqueous solution of a binding...
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6451338 |
Liposomes containing particulate materials
A method is provided for the formation of liposomes of 0.1 μm to 50 μm in diameter having unilamella or multilamella structure and containing water insoluble or undissolved particulate materials...
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6448230 |
Testis expressed polypeptide
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
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6444448 |
Production of β-glucan-mannan preparations by autolysis of cells under certain pH, temperature and time conditions
There is provided a method of production of an immunostimulatory β-glucan-mannan preparation, comprising the step of autolysis of cells of a microorganism at a pH of 5 to 6 and a temperature of 35...
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6440426 |
Antigen-containing formulation and methods of use thereof
An antigen-containing formulation is provided, comprising: (a) an antigen; (b) a TH1-inducing adjuvants; and (c) a sparingly soluble amino acid or a derivative thereof. The adjuvants may be, for...
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6440423 |
Mutant enterotoxin effective as a non-toxic oral adjuvant
Methods and compositions are provided herein for the se of a novel mutant form of E. coli heat-labile enterotoxin which has lost its toxicity but has retained its immunologic activity. This...
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6436407 |
Mutant enterotoxin effective as a non-toxic adjuvant
Methods and compositions are provided herein for the use of a novel mutant form of E. coli heat-labile enterotoxin which has lost its toxicity but has retained its immunologic activity. This...
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6423320 |
Inhibitor of immunoglobulin E antibody production
A polysaccharide and fragments thereof derived from Klebsiella oxytoca or Klebsiella pneumonia inhibit the IgE antibody production and response and, therefore, are useful in the prophylaxis...
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6416976 |
TrpS
The invention provides trpS polypeptides and DNA (RNA) encoding trpS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing trpS...
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6413523 |
Pharmaceutical composition of escherichia coli heat-labile enterotoxin adjuvant and methods of use
Novel immunoregulatory utilities of Escherichi coli heat-labile enterotoxin (LT) are disclosed. This enterotoxin can be used in combination with an unrelated antigen to achieve a higher immune...
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6410688 |
Def1
The invention provides Def1 polypeptides and DNA (RNA) encoding Def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Def1...
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6406703 |
Treatment of H. pylori associated gastroduodenal disease
The application discloses a method for the treatment of Heliobacter infection in a mammalian host, which comprises administration to said infected host of an immunologically effective amount of one...
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6406887 |
Compositions for diagnosing Rochalimaea henselae and Rochalmaea quintana infection
Fusion protein compositions containing the sequence of a 17 kilodalton antigenic polypeptide of Rochalimaea (SEQ ID NO:12) are disclosed for diagnosis of cat scratch disease and bacillary...
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6403093 |
Methods to detect granulocytic ehrlichiosis
An isolated nucleic acid molecule associated with human granulocytic ehrlichiosis is provided. Also provided are methods to detect the presence of the nucleic acid molecule, and antibodies specific...
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6403100 |
Method of attenuating pathogenic mycobacteria and strains of mycobacteria so attenuated
This invention provides for novel attenuated strains of Mycobacterium tuberculosis and M. bovis. Attenuation is achieved by eliminating or by downregulating the expression of the α-crystallin...
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6403094 |
Clostridium perfringens vaccines
The present invention provides proteins for use in vaccines which are capable of inducing protective antibodies directed against C. perfringens epsilon toxin when administered to animals or man...
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6399070 |
Methods and compositions for eliciting an immune response with hsp90-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6399069 |
Prevention of infectious diseases with hsp70-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6395282 |
Immunogenic conjugates of Gram-negative bacterial autoinducer molecules
The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a...
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6391306 |
Treatment of infectious diseases with hsp90-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6391570 |
Methods and compositions for the detection of bacterial endotoxins
The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for...
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6391313 |
Multi-component vaccine to protect against disease caused by Haemophilus influenzae and Moraxella catarrhalis
A multi-valent immunogenic composition confers protection on an immunized host against infection caused by both Haemophilus influenzae and Moraxella catarrhalis . Such composition comprises at...
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6387372 |
Polypeptides from mycrobacterium paratuberculosis
The invention relates to a polypeptide containing in its polypeptidic chain: the amino acid sequence of 101 amino acids of FIG. 8, or a fragment of this sequence, this fragment being such that it...
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6387665 |
Method of making a vaccine for anthrax
A method of making a vaccine for anthracis that inolves a bacterial expression system and production and use of protective antigen (PA) against Bacillus anthracis . The PA immunogen is useful in a...
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6383491 |
Prevention of infectious diseases with hsp90-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6383492 |
Treatment of infectious diseases with gp96-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6383498 |
Compositions for vaccines
Neuraminidase and galactose oxidase together are a vaccine adjuvant.
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6383494 |
Methods and composition for eliciting an immune response with gp96-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6379676 |
Enhancing immune response in animals
A method for improving the immune response of an animal to a vaccine, comprising: feeding an animal a diet of contamination-resistant feed, and treating said animal with an anti-viral or...
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6379677 |
Streptococcus iniae vaccine
Safe and effective mono and polyvalent vaccines against Streptococcus iniae may be prepared from formalin-killed cells and concentrated extracellular products of Streptococcus iniae which include...
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6379672 |
Prevention of infectious diseases with gp96-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6375953 |
Treatment of infectious diseases with HSP70-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6375954 |
Size-variable strain-specific protective antigen for potomac horse fever
An isolated and purified antigen which is expressed by a wild-type E. risticii strain and is specific to the strain. The present invention also relates to nucleic acid constructs which encode the...
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6372225 |
Tetanus toxin functional fragment antigen and tetanus vaccine
Disclosed is a tetanus toxin functional fragment antigen (FFA), comprising at least one fragment which is substantially the same as that obtained by a process comprising the steps of splitting at...
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6372222 |
Antigenic group B Streptococcus type II and type III polysaccharide fragments having a 2, 5-anhydro-D-mannose terminal structure and conjugate vaccine thereof
The process for depolymerizing Group B Types II and III Streptococcal Polysaccharide is disclosed which results in polysaccharide fragments having a reducing end suitable for conjugating to...
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6368605 |
Method for treating cancer with a neurotoxin to improve patient function
A method for reducing a catecholamine secretion from a cholinergically innervated, functional chromaffin body, such as a paraganglioma or hyperplasic adrenal medulla, by direct, local...
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6368603 |
Lyme combination compositions and uses
Disclosed and claimed are compositions containing a Borrelia burgdorferi antigen, and methods for making and using them. The antigen can be OspA. The compositions can contain at least one...
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