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7344873 |
Methods of adenovirus production
A simple yet effective method of increasing production of a thermo-stable virus, such as adenovirus and picornavirus, is presented. The method entails a temperature shift strategy whereby the...
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7335353 |
Porcine cells comprising an adenovirus E3 gene region
The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells...
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7326555 |
Methods of adenovirus purification
A process for purifying virus particles, especially recombinant adenovirus vector particles, is presented. The process relies on various combinations of cell lysis, detergent-based precipitation of...
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7323177 |
Recombinant porcine adenovirus vector
This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The...
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7291452 |
Erythrovirus and its applications
The invention concerns nucleic acids derived from human V9 erythrovirus, fragments thereof, encoded polypeptides, and applications as diagnostic reagents and as immunogenic agents.
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7267825 |
Parvovirus vectors and their use
This invention relates to a parvovirus vector having a parvovirus DNA excisable from the vector DNA in a parvovirus-permissive cell, the parvovirus DNA having a left terminus which comprises a...
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7264958 |
Method for obtaining a purified viral preparation
The invention concerns a method for purifying a crude viral preparation containing viral, in particular adenoviral, particles of interest. The invention is characterised in that it comprises a step...
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7264818 |
BAV packaging regions and E1 transcriptional control regions
The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and E1 transcriptional control regions. The present invention provides adenovirus...
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7259151 |
AAV virions with decreased immunoreactivity and uses therefor
Methods of making and using recombinant AAV virions with decreased immunoreactivity are described. The recombinant AAV virions include mutated capsid proteins or are derived from non-primate...
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7252997 |
Structural protein of adeno-associated virus with modified antigenicity, its production and its use
The invention relates to a structural protein of adeno-associated virus (AAV) that contains at least one modification that reduces the antigenicity of the virus. The invention further relates to...
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7241447 |
Adeno-associated virus vectors and uses thereof
The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated...
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7238493 |
Acetylation of pRb by p300 assay method for compounds which modulate this process
The present invention is based upon the finding that the protein p300 has acetylation activity which is directed to the retinoblastoma tumour suppressor protein pRb by the presence in the cell of...
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7208315 |
Compositions and methods for efficient AAV vector production
The present invention provides packaging cell lines for the efficient production of an Adeno-associated virus (AAV) vector which does not require “helper” virus function for the replication and...
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7172899 |
Methods to culture circovirus
The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in...
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7148341 |
AAV DNA comprising helper virus sequences
The present invention relates to an AAV DNA having helper virus sequences which are necessary for developing AAV viral particles, a system containing such a DNA and the use of both.
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7135187 |
System for production of helper dependent adenovirus vectors based on use of endonucleases
The present invention relates to methods for efficient and reliable construction of adenovirus vectors which contain and express foreign DNA and are useful for gene transfer into mammalian cells,...
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7135180 |
Preservation of bioactive materials by freeze dried foam
This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at...
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7132280 |
Recombinant protein production in a human cell
Methods and compositions for the production of recombinant proteins in a human cell line. The methods and compositions are particularly useful for generating stable expression of human recombinant...
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7125706 |
Method for the production and purification of adenoviral vectors
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of...
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7115582 |
HoxD3 and HoxA3 compositions and methods for improved wound healing
The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving...
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7109025 |
Viral vectors and viral vaccines based on recombinant porcine adenoviruses
An in vivo replicative and recombined porcine adenovirus characterized in that it comprises a heterologous nucleotide sequence inserted into the porcine adenovirus in conditions enabling the latter...
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7078028 |
Anti-neoplastic viral agents
A viral DNA construct, and virus encoded thereby, is provided having one or more tumour specific transcription factor binding sites in place of one or more wild type transcription factor binding...
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7071172 |
Secretion signal vectors
The present invention provides delivery vectors for transferring a nucleic acid sequence to a cell in vitro, ex vivo or in vivo. The delivery vector comprises a segment encoding a secretory signal...
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7037506 |
Vaccine accelerator factor (VAF) for improvement of vaccinations in poultry
The present invention provides a vaccine accelerator factor (VAF) which is an in ovo nucleotide immuno-stimulant. The VAF contains one or more DNA constructs, each having a DNA molecule and a...
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7022496 |
Use of gene product of adenovirus early region 4 ORF-6 to inhibit repair of double-strand breaks in DNA
The present invention provides a modified adenovirus comprising genomic adenoviral DNA which has been modified so that (i) the only gene product of the early region (E4) that is expressed is open...
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6967076 |
Method for producing recombinant cells for detecting HIV
Recombinant expression vectors and methods are provided for detecting HIV and monitoring HIV drug resistance. The method comprises: taking a culture of cells; adding a recombinant viral vector into...
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6964843 |
Methods and reagents for the detection of antibodies to adenovirus
The present invention provides methods and reagents for detecting antibodies to adenovirus. In a preferred embodiment, the present invention is useful for detecting antibodies to adenovirus...
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6964762 |
Composition and method for stimulating immune response to pathogen using complex adenoviral vector
Genetic vaccines and methods are provided for enhancing the immunity of a host such as a human to one or more pathogens. In one aspect, a method of enhancing the immunity of a host to a pathogen is...
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6943153 |
Use of recombinant gene delivery vectors for treating or preventing diseases of the eye
Gene delivery vectors, such as, for example, recombinant adeno-associated viral vectors, and methods of using such vectors are provided for use in treating or preventing diseases of the eye.
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6921663 |
Adenovirus vector
The present invention provides a method for constructing a fiber-mutant adenovirus vector in which a foreign peptide is introduced by a simple system into the fiber HI loop-coding gene of...
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6908762 |
Method of preparing a eukaryotic viral vector
The inventive method of producing a eukaryotic viral vector comprises contacting a eukaryotic cell, which comprises a unique enzyme that nicks or cleaves a DNA molecule, with a recombinant phage...
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6900010 |
Compositions and methods for detecting human immunodeficiency virus
Methods are provided for screening natural and synthetic anti-HIV agents using recombinant cells that are rendered susceptible to productive infection of various strains, subtypes or clades of HIV...
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6890528 |
Cells for the production of helper dependent adenoviral vectors
The present invention relates to cells for the production of helper dependent adenoviral vectors, including at least the following genic units: a first genic unit comprising an adenovirus defective...
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6875612 |
Monocyte-specific particulate delivery vehicle
The inventive vector specifically directs entry into a cell of monocytic origin. The vector is composed of a nucleic acid component, a lysosome evading component and a particle that can be...
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6849446 |
Modified bovine adenovirus having altered tropism
The present invention provides modified bovine adenoviruses comprising a modification in a capsid protein wherein said protein is associated with adenovirus tropism and wherein said modification is...
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6841158 |
Recombinant celo virus and celo virus DNA
Recombinant CELO virus or CELO virus DNA with a deletion at the right end of the viral genome that allows insertion of large pieces of foreign DNA. The virus is useful as a vaccine for animals, in...
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6821777 |
Cell line preparing and producing ovine adenovirus vectors
The invention relates to the ovine embryo cell line HVO-156 (DSM ACC2440), or to cell lines derived therefrom, and to their use for preparing and propagating ovine adenoviruses, in particular...
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6793926 |
Methods for production of a recombinant adeno-associated virus
This invention relates to novel nonmammalian carrier vectors and viruses useful in the production of high titers of recombinant viruses which may contain foreign DNA inserts or which may be...
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6773909 |
Concentration and lysis of adenovirus-infected cells in a single unit operation
A method is described to prepare intracellular biological entities (e.g. organisms, such as, e.g., viruses, particularly Adenoviruses; organelles, or biological molecules), comprising subjecting...
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6756044 |
Antigenic complexes and methods
The present invention provides a complex that includes a virion having a ligand that recognizes an epitope present on an immune effector cell surface and at least a first nucleic acid encoding a...
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6743772 |
Use of parovirus capsid particles in the inhibition of cell proliferation and migration
The invention described herein relates to the discovery of methods and compositions for the inhibition of growth and/or migration of cells that have the P antigen, including but not limited to,...
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6740515 |
Recombinant adenovirus
Recombinant adenoviruses comprising the following sequences in the genome: (1) a left inverted terminal repeat: (2) a packaging signal: (3) a recombinase recognition sequence located at a region in...
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6730306 |
Parvovirus vaccine as viral coat protein fusions
The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in...
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6726907 |
Purified adenoviral compositions
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of...
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6692956 |
Recombinant adenoviral vectors
The present invention concerns a recombinant adenoviral vector derived from an adenovirus genome in which at least a part of the E3 region is deleted or is non functional, wherein said adenoviral...
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6669942 |
Defective adenoviruses including a therapeutic gene and an immunoprotectove gene
Novel adenovirus-derived viral vectors, the preparation thereof, and the use of such vectors in gene therapy, are disclosed. In particular, defective adenoviruses having a genome that includes a...
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6663872 |
Hemorrhagic enteritis virus DNA sequences, proteins encoded thereby and various uses thereof
The present invention relates to a DNA sequence comprising a nucleotide sequence encoding Hemorrhagic Enteritis virus. It is well known to the man of the art that determining the complete sequence...
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6635472 |
Retrovirus and viral vectors
This invention relates to the fields of genetic engineering, virus replication and gene transfer. More specifically, this invention relates to polynucleotide construct, recombinant virus,...
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6630299 |
Fluorescence detection
The present invention provides methods of detecting and/or characterizing the viral vector particle content of a medium. A medium is provided and contacted with an excitation energy such that, if a...
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6627617 |
Temperature-sensitive regulation of viral vector production
The present invention provides temperature-sensitive (ts) adeno-associated virus (AAV) Rep78 and Rep68 proteins. In preferred embodiments, the ts AAV Rep78 and Rep68 proteins have missense...
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