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6890528 |
Cells for the production of helper dependent adenoviral vectors
The present invention relates to cells for the production of helper dependent adenoviral vectors, including at least the following genic units: a first genic unit comprising an adenovirus defective...
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6875612 |
Monocyte-specific particulate delivery vehicle
The inventive vector specifically directs entry into a cell of monocytic origin. The vector is composed of a nucleic acid component, a lysosome evading component and a particle that can be...
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6849446 |
Modified bovine adenovirus having altered tropism
The present invention provides modified bovine adenoviruses comprising a modification in a capsid protein wherein said protein is associated with adenovirus tropism and wherein said modification is...
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6841158 |
Recombinant celo virus and celo virus DNA
Recombinant CELO virus or CELO virus DNA with a deletion at the right end of the viral genome that allows insertion of large pieces of foreign DNA. The virus is useful as a vaccine for animals, in...
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6821777 |
Cell line preparing and producing ovine adenovirus vectors
The invention relates to the ovine embryo cell line HVO-156 (DSM ACC2440), or to cell lines derived therefrom, and to their use for preparing and propagating ovine adenoviruses, in particular...
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6793926 |
Methods for production of a recombinant adeno-associated virus
This invention relates to novel nonmammalian carrier vectors and viruses useful in the production of high titers of recombinant viruses which may contain foreign DNA inserts or which may be...
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6773909 |
Concentration and lysis of adenovirus-infected cells in a single unit operation
A method is described to prepare intracellular biological entities (e.g. organisms, such as, e.g., viruses, particularly Adenoviruses; organelles, or biological molecules), comprising subjecting...
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6756044 |
Antigenic complexes and methods
The present invention provides a complex that includes a virion having a ligand that recognizes an epitope present on an immune effector cell surface and at least a first nucleic acid encoding a...
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6743772 |
Use of parovirus capsid particles in the inhibition of cell proliferation and migration
The invention described herein relates to the discovery of methods and compositions for the inhibition of growth and/or migration of cells that have the P antigen, including but not limited to,...
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6740515 |
Recombinant adenovirus
Recombinant adenoviruses comprising the following sequences in the genome: (1) a left inverted terminal repeat: (2) a packaging signal: (3) a recombinase recognition sequence located at a region in...
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6730306 |
Parvovirus vaccine as viral coat protein fusions
The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in...
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6726907 |
Purified adenoviral compositions
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of...
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6692956 |
Recombinant adenoviral vectors
The present invention concerns a recombinant adenoviral vector derived from an adenovirus genome in which at least a part of the E3 region is deleted or is non functional, wherein said adenoviral...
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6669942 |
Defective adenoviruses including a therapeutic gene and an immunoprotectove gene
Novel adenovirus-derived viral vectors, the preparation thereof, and the use of such vectors in gene therapy, are disclosed. In particular, defective adenoviruses having a genome that includes a...
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6663872 |
Hemorrhagic enteritis virus DNA sequences, proteins encoded thereby and various uses thereof
The present invention relates to a DNA sequence comprising a nucleotide sequence encoding Hemorrhagic Enteritis virus. It is well known to the man of the art that determining the complete sequence...
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6635472 |
Retrovirus and viral vectors
This invention relates to the fields of genetic engineering, virus replication and gene transfer. More specifically, this invention relates to polynucleotide construct, recombinant virus,...
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6630299 |
Fluorescence detection
The present invention provides methods of detecting and/or characterizing the viral vector particle content of a medium. A medium is provided and contacted with an excitation energy such that, if a...
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6627617 |
Temperature-sensitive regulation of viral vector production
The present invention provides temperature-sensitive (ts) adeno-associated virus (AAV) Rep78 and Rep68 proteins. In preferred embodiments, the ts AAV Rep78 and Rep68 proteins have missense...
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6596270 |
Methods of administering adenoviral vectors
The present invention provides methods for administering an adenoviral gene transfer vector comprising an exogenous gene to an animal. One method involves utilizing systemic neutralizing antibodies...
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6565853 |
Recombinant virus
An adenovirus which encodes a polypeptide which produces a protective immune response against an alpha-virus such as a Venezuelan Equine Encephalitis Virus, in a mammal to which it is administered,...
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6558948 |
Permanent amniocytic cell line, its production and use for the production of gene transfer vectors
The invention relates to a permanent amniocytic cell line comprising at least one nucleic acid which brings about expression of the gene products of the adenovirus E1A and E1B regions. The present...
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6558676 |
Parvovirus capsids
The present invention relates to a method of producing non-infections parvovirus capsids and to diagnostic assays and vaccines utilizing same. The invention further relates to recombinant...
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6544780 |
Adenovirus vector with multiple expression cassettes
Genetic vaccines and methods are provided for enhancing the immunity of a host such as a human to one or more pathogens. In one embodiment, a recombinant benign virus is provided as the genetic...
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6544526 |
Equine herpesvirus glycoproteins
A vaccine for the selective immunization of horses against EHV4 and/or EHV1 is provided comprising at least one of (i) EHV4 virus wherein a portion of the gG gene of the EHV4 virus that elicits a...
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6541012 |
System for the production of AAV vectors
The invention concerns a system comprising an AAV vector, which contains a foreign DNA, and rep 68/78 sequences of AAV with delayed expression, these sequences being present (a) in cis or (b) in...
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6521426 |
Preparation of recombinant adenovirus carrying a rep gene of adeno-associated virus
Adenoviral particles are produced by incubating cells containing a helper adenovirus vector and a helper-dependent adenoviral vector including an Adeno-Associated Virus (AAV) rep gene, such as rep...
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6511845 |
Methods for producing an immune response against HIV-1
This invention provides a method of protecting a primate from an infectious organism by stimulating the production of antibodies or cell mediated immunity to the infectious organism which comprises...
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6464976 |
Methods and compositions for reducing immune response
The present invention provides an apparatus and method to diminish the pre-existing immune response to the administration of a therapeutic virus by the selective elimination of antiviral antibodies...
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6458578 |
Recombinant cell line produces adenoviral gene products E1 and DEF-A, and/or DEF-B
The present invention provides a recombinant cell line, specifically one that produces adenoviral E1 and DEF-A and/or DEF-B gene products.
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6458362 |
Recombinant VP2 parvoviral pseudo-particles encoding CTL or T-helper cell epitopes
Attempts to generate modified viral pseudo-particles that are capable of stably incorporating heterologous antigenic determinants has encountered a number of difficulties including inhibition of...
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6458586 |
Bovine cells expressing adenovirus essential functions for propagation of recombinant adenoviral vectors
The invention provides cell lines capable of supporting the replication of a defective recombinant virus vector. In one aspect, bovine cell lines expressing adenovirus E1 functions are provided....
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6451319 |
Recombinant and mutant adenoviruses
The present invention provides novel viral vectors. In one embodiment, the present invention provides mutant and recombinant bovine adenoviruses having a deletion and/or insertion of DNA in the...
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6447995 |
Utilizing intrinsic fluorescence to detect adenovirus
The present invention provides methods of detecting and/or characterizing the viral vector particle content of a medium. A medium is provided and contacted with an excitation energy such that, if a...
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6432700 |
Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same
Replication-competent adenovirus vectors specific for target cells and methods of use of such viruses are provided. These adenoviruses comprise a first adenoviral gene under control of a cell...
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6410013 |
Viral vectors for use in monitoring HIV drug resistance
Recombinant expression vectors and methods are provided for detecting HIV and monitoring HIV drug resistance. The method comprises: taking a culture of cells; adding a recombinant viral vector into...
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6406861 |
Methods of enhancing effectiveness of therapeutic viral immunogenic agent administration
Methods of reducing pre-existing humoral immunity to a viral immunogenic therapeutic agent such as adenovirus, using immunoapheresis are disclosed. Antibodies specific for the viral immunogenic...
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6335016 |
Chicken embryo lethal orphan (CELO) virus
A CELO virus obtained by in vitro manipulation of a plasmid-cloned CELO virus DNA is suitable for the production of vectors for gene therapy and as a vaccine against infectious diseases in humans...
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6296852 |
Recombinant avian adenovirus vector
This invention relates to a recombinant vector comprising a recombinant avian adenovirus incorporating, and capable of expression of at least one heterologous nucleotide sequence. The nucleotide...
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6291437 |
Methods and compositions for retarding the development of atherosclerotic lesions
A method for preventing or retarding the development atherosclerotic lesions or restenosis involves administering to a subject, preferably a human, an effective amount of an anti-viral composition...
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6287571 |
Replication-defective adenovirus human type 5 recombinant as a vaccine carrier
A replication defective recombinant adenovirus is provided which contains a complete deletion of its E1 gene and at least a partial deletion of its E3 gene, said virus containing in the site of the...
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6241991 |
Aviadenovirus
The invention relates to a new aviadenovirus which was isolated from a pigeon. The aviadenovirus according to the present invention comprises group-I specific antigen and cannot be neutralized by...
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6211160 |
Method for tolerizing a mammalian patient to administration of gene therapy virus vectors
A method for tolerizing a mammalian subject to administration of a live virus carrying a gene for delivery to a cell of the subject is disclosed. The method entails administering to the subject a...
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6193983 |
Equine herpesvirus glycoproteins
A vaccine for the selective immunization of horses against EHV4 and/or EHV1 is provided comprising at least one of (i) EHV4 virus wherein a portion of the gG gene of the EHV4 virus that elicits a...
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6156567 |
Truncated transcriptionally active cytomegalovirus promoters
Recombinant adenoviruses, methods of making them, uses for them, including in immunological, immunogenic, vaccine or therapeutic compositions, or, as a vector for cloning, replicating or expressing...
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6113913 |
Recombinant adenovirus
The present invention provides a recombinant adenovirus having a genome with a deficiency in the E1 region and a mutation in the MLP. The invention also provides stocks of such viruses and...
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6090393 |
Recombinant canine adenoviruses, method for making and uses thereof
Disclosed and claimed are recombinant adenoviruses, methods of making them, uses for them (including in immunological, immunogenic, vaccine or therapeutic compositions, or, as a vector for cloning,...
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6086890 |
Bovine adenovirus expression vector system
The present invention relates novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted...
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6063385 |
DNA vaccine for parvovirus
Disclosed herein are methods for vaccinating mammals against parvovirus. In one form, a recombinant, replication incompetent vector containing DNA coding for canine parvoviral capsid protein is...
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5998131 |
Screening methods for the identification of compounds capable of abrogating BaK-BHRF-1 protein interactions
The present invention provides methods for screening potential anti-viral therapeutic agents by monitoring their ability to disrupt the interaction between the BAK protein and a viral protein.
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5985283 |
Adenovirus E1A-Associated protein BS69, inhibitor of E1A-transactivation
The present invention relates to a transcription inhibiting factor, designated BS69. The factor can bind to both the 243R and 289R E1A adenovirus proteins, inhibiting the transactivating activity...
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