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7264817 |
Immunogenic composition based on a truncated derivative of a membrane bound protein and process for making it
Disclosed is an invention related to the preparation and use of vaccines against pathogenic organisms, such as herpes virus. The vaccines hereof are based upon the use of truncated, membrane-free...
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7118755 |
Herpes viruses for immune modulation
An attenuated herpes virus which lacks a functional vhs gene or a functional equivalent thereof, but which has a functional UL43 gene or functional equivalent thereof, stimulates an immune response...
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7070781 |
Nontoxic mucosal adjuvant
A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic...
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7064111 |
Use of soluble costimulatory factor for tumor immuno-gene therapy
A new gene therapy entails tumor treatment by introducing an expressible nucleotide sequence for a soluble costimulatory factor, thereby enhancing the response of T-cells to a tumor. In vivo...
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7063851 |
Herpes viruses for immune modulation
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes virus which:
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7063835 |
Virus strains
The present invention relates to non-laboratory virus strains, for example of herpes viruses such as HSV, with improved oncolytic and/or gene delivery capabilities as compared to laboratory virus...
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6946448 |
In utero oral nucleic acid immunization
Methods of nucleic acid immunization comprising the in utero delivery of nucleic acid molecules that encode one or more selected antigens to a vertebrate fetus are disclosed.
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6936255 |
Vaccine composition comprising herpes simplex virus and human papilloma virus antigens
Novel combined vaccine compositions are provided, comprising a herpes simplex virus (HSV) antigen and a HPV antigen and optionally in addition one or more of the following: an EBV antigen, a...
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6932972 |
Combined vaccine compositions
Novel combined vaccine composition preferentially for administration to adolescents are provided, comprising a hepatitis B viral antigen and a herpes simplex viral antigen and optionally in...
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6863896 |
Plant lectins as mucosal adjuvants
The invention provides a method of increasing an immune response in a mammal. The method involves administering to the mammal an admixture comprising an immunogen and a plant lectin. The plant...
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6855317 |
Immunological herpes simplex virus antigens and methods for use thereof
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by...
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6841373 |
Herpes virus complementing cell line
The present invention is directed to a cell line capable of supporting replication of a growth-defective Herpes Simplex Virus strain; specifically a replication-defective HSV-2 double mutant....
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6821519 |
Compositions and methods for the diagnosis and treatment of herpes simplex virus infection
Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA...
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6734167 |
Uses of transport proteins
This invention relates to uses of transport-active proteins, particularly of proteins and fusion polypeptides with the function of VP22, for control of the cell cycle, particularly in the reduction...
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6723316 |
Herpes simplex virus-1 Glycoprotein C mutants for treating unwanted hyperproliferative cell growth
The present invention relates to pharmaceutical compositions, kits, and methods of use thereof, comprising, a mutant human herpes simplex virus, which is cytopathic to susceptible target cells,...
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6719982 |
Mutant herpes simplex viruses and uses thereof
The present invention provides a herpes simplex virus strain having a functional ICP27 gene and lacking at lease a functional ICP4 gene and a functional ICP34.5 gene. It also provides the use of a...
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6713067 |
Herpes viruses for immune modulation
An attenuated herpes virus which lacks a functional vhs gene or a functional equivalent thereof, but which has a functional UL43 gene or functional equivalent thereof, stimulates an immune response...
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6699481 |
Peptides for inhibition of herpes simplex virus entry
The invention includes antiherpesviral peptides and method of generating the same.
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6692752 |
Methods of treating human females susceptible to HSV infection
A method of administering a vaccine to females to prevent or treat infections associated with pathogens which cause sexually transmitted diseases is described. The vaccine comprises one or more...
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6673602 |
Herpes simplex virus amplicon vector targeting system and method of using same
The present invention relates to herpes simplex virus (HSV) amplicon vectors, and in particular, HSV-1 amplicon vectors, which have been genetically modified and used alone or with consequent...
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6641817 |
Herpes virus vectors for dendritic cells
An attenuated herpes virus capable of efficiently infecting a dendritic cell without preventing antigen processing occurring within the infected cell. The attenuated herpes virus and dentrictic...
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6635472 |
Retrovirus and viral vectors
This invention relates to the fields of genetic engineering, virus replication and gene transfer. More specifically, this invention relates to polynucleotide construct, recombinant virus,...
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6635258 |
Herpes simplex virus VP22 vaccines and methods of use
Vaccines containing herpes simplex virus (HSV) VP22 polypeptides capable of eliciting a cellular immune response and methods for treating and preventing HSV infections using the vaccines are...
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6613892 |
HSV viral vector
A recombinant herpes simplex virus (HSV) viral vector genome which has substantially lost its transducing properties as a result of a DNA sequence change in the gene coding for Vmw65 protein and...
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6572860 |
Immunogenic conjugated polypeptide for treatment of herpes simplex virus
Peptide constructs chemically synthesized to contain a Herpes Simplex Virus specific antigenic peptide, such as, the 322-332 peptide (H1) from the ICP27 protein of Herpes Simplex Virus (HSV-1) and...
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6544780 |
Adenovirus vector with multiple expression cassettes
Genetic vaccines and methods are provided for enhancing the immunity of a host such as a human to one or more pathogens. In one embodiment, a recombinant benign virus is provided as the genetic...
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6544518 |
Vaccines
The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an...
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6541459 |
Soluble herpesvirus glycoprotein complex vaccine
The invention is directed to a herpes simplex virus vaccine comprising a herpes simplex virus glycoprotein H-glycoprotein L complex. The invention is also directed to a vaccine comprising a DNA...
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6537555 |
Compositions and methods for the diagnosis and treatment of herpes simplex virus infection
Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA...
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6531313 |
Invasive bacterial vectors for expressing alphavirus replicons
The present invention is directed to a bacterial delivery system for delivering alphavirus replicon DNA into an animal or animal cells with the replicon encoding one or more heterologous genes to...
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6509020 |
Replication-competent herpes simplex virus
A promising approach for the therapeutic treatment of brain tumors utilizes replication-competent, neuroattenuated herpes simplex virus-1 (HSV-1) mutants. This approach requires mutation of HSV-1...
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6488936 |
Immunogenic composition of interleukin-12 (IL-12), alum, herpes simplex viral (HSV) antigen, and method thereof
This invention pertains to vaccine compositions comprising a mixture of antigen, such as a herpes simplex virus antigen, and the interleukin IL-12, which may be adsorbed onto a mineral in...
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6471965 |
Vaccine containing whole killed herpes viruses to prevent development of atherosclerotic plaque
A vaccine is disclosed for the prophylaxis against pathogenic development of atherosclerotic plaque in a mammalian subject susceptible thereto which consists essentially of a multiplicity of killed...
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6451320 |
Combined hepatitis and herpesvirus antigen compositions
Novel combined vaccine compositions preferentially for administration to adolescents are provided, comprising a hepatitis B viral antigen and a herpes simplex viral antigen and optionally in...
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6383738 |
Herpes simplex virus ORF P is a repressor of viral protein synthesis
The present invention is directed to methods and compositions relating to the treatment of herpes simplex virus infections and the screening of compounds for activity that inhibit or promote viral...
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6342229 |
Herpesvirus particles comprising fusion protein and their preparation and use
Herpesviral particle preparations, e.g. a preparation of herpesviral particles isolated from the cell culture in which such particles were produced, can have at least part of the VP22 tegument...
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6337074 |
Anti-herpesviral agent
An antiviral agent capable of disrupting the association of two viral proteins required for DNA replication in herpesviruses. The agents disrupt the association of UL8 and POL in HSV-1 or the...
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6319703 |
Recombinant virus vectors
A mutant herpesvirus that can be used a recombinant virus vector includes (a) a mutation such that the mutant virus has a reduced ability in comparison with a parent type to cause lysis of an...
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6299874 |
Method of treatment
A method of producing active immunity against a viral disease in an animal subject comprises administering to the subject a vaccine conjugate consisting essentially of a live virus and a...
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6267967 |
Virus preparations and methods
Herpesvirus preparations, e.g. cultured HSV type 2, e.g. genetically disabled virus for vaccine use, can be purified, e.g. for subsequent pharmaceutical formulation, with solid phase affinity...
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6207168 |
Vaccine composition for herpes simplex virus and methods of using
The present invention discloses a new vaccine composition for Herpes Simplex comprising a whole live HSV-2 virus having the oncogene deleted. Methods of using the vaccine composition are also...
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6200577 |
Anti-herpesviral agents and assays therefor
There is described an antiviral agent capable of disrupting the association of two viral structural proteins required for maturation, replication and infection of herpesviruses. The agents are...
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6193984 |
Pharmaceutical composition of herpes simplex virus typ-1 (HSV-1) glycoproteins
The present invention relates to the field of infectious diseases and ophthalmology. More particularly, the invention relates to compositions and methods for vaccination against Herpes Simplex...
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6126944 |
Baculovirus expression vectors and recombinant antigens for detecting type-specific antibodies to herpes simplex virus
Novel baculovirus expression vectors and recombinant antigens for detecting, type-specific herpes simplex virus (HSV) infection have been made. Diagnostic kits and assays for detecting...
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6120773 |
Recombinant herpes simplex viruses vaccines and methods
A recombinant herpes simplex virus genome having modified γ 1 34.5 genes incapable of expressing an active ICP34.5 gene product, vaccines comprising the recombinant herpes simplex virus genome...
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6083505 |
1H-imidazo[4,5-C]quinolin-4-amines as vaccine adjuvants
An immunogen/vaccine adjuvant composition containing an immunogen in an amount effective to stimulate an immune response and as a vaccine adjuvant a 1H-imidazo[4,5-c]quinolin-4-amine in an amount...
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6051428 |
Rapid production of autologous tumor vaccines
An autologous vaccine to tumor cells is produced by transducing the tumor cells with a herpes simplex virus amplicon containing the gene for an immunomodulatory protein to provide transient...
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6051238 |
Stabilizers for lyophilized mumps vaccines
Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric...
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6027730 |
Herpes simplex vaccine comprising HSV glycoprotein GD and 3 deacylated monophosphoryl lipid A
Novel herpes simplex (HSV) vaccine formulations are provided. These comprise HSV glycoprotein gD or immunological fragments in conjunction with 3 Deacylated monophosphoryl lipid A.
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5994116 |
Herpesvirus pre-(viral DNA replication) enveloped particles
This invention is directed toward a new type of herpesvirus particle (e.g., HSV-1), herein designated pre-viral DNA replication enveloped particles (PREPS), and methods of preparing said particles....
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