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7384627 |
Antitumor agents with the use of HSV
It is intended to provide highly safe antitumor agents which exhibit an antitumor effect on human remote tumors such as metastatic tumors too and by which an antitumor immune reaction enabling an...
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7323178 |
Method of identification of equine herpes virus type 1 causing neurological disease, method of producing a vaccine against neurological disease caused by equine herpes virus type 1, and vaccine against neurological disease caused by equine herpes virus type 1
Equine herpesvirus type 1 (EHV-1) causes abortion and respiratory infection in horses. Only certain strains of EHV-1 cause encephalitis. Vaccination of horses with live attenuated or inactivated...
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7318928 |
Molecular vaccine linking intercellular spreading protein to an antigen
Superior molecular vaccines comprise nucleic acids, including naked DNA and replicon RNA, that encode a fusion polypeptide that includes an antigenic peptide or polypeptide against which an immune...
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7309598 |
gM-negative EHV-mutants
This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of...
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7297533 |
Recombinant feline herpesvirus type 1 and polyvalent vaccine using the same
An attenuated feline recombinant herpesvirus 1 (FHV-1), which is prepared by identifying gene regions in the genome wherein inserted foreign genes can be expressed without affecting the replication...
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7285289 |
Nanoparticle vaccines
The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed...
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7279168 |
Recombinant virus expressing foreign DNA encoding feline CD86 and uses thereof
The present invention involves a recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign...
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7264817 |
Immunogenic composition based on a truncated derivative of a membrane bound protein and process for making it
Disclosed is an invention related to the preparation and use of vaccines against pathogenic organisms, such as herpes virus. The vaccines hereof are based upon the use of truncated, membrane-free...
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7264814 |
Composition and method for treating cancer using herpes virus
The present invention provides a herpes virus in which a non-essential gene for replication is inactivated More particularly, the present invention provides a herpes virus in which a non-essential...
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7226604 |
Equine herpesvirus vaccine
A vaccine for protecting a horse against diseases associated with EHV-1 and/or EHV-4 is provided. The vaccine commonly includes inactivated EHV-1 (e.g., chemically inactivated EHV-1 KyA virus) and...
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7223411 |
Herpesvirus replication defective mutants
A herpesvirus vaccine comprising a mutated herpesvirus suspended in a pharmaceutically acceptable carrier. The mutated herpesvirus is capable of infecting cells of the mammal to be vaccinated, but...
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7163685 |
Human cytomegalovirus antigens expressed in MVA and methods of use
DNA and protein constructs useful in producing vaccines against human cytomegalovirus contain optionally N-end modified and N-terminal ubiquitinated human cytomegalovirus antigenic proteins,...
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7141243 |
gM-negative EHV-mutants without heterologous elements
The present invention relates to the field of animal health and in particular of Equine Herpes Viruses (EHV) wherein the gene encoding the protein gM is absent, and which is free of heterologous...
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7118755 |
Herpes viruses for immune modulation
An attenuated herpes virus which lacks a functional vhs gene or a functional equivalent thereof, but which has a functional UL43 gene or functional equivalent thereof, stimulates an immune response...
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7078041 |
Rapid, efficient purification of HSV-specific T-lymphocytes and HSV antigens identified via same
Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific...
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7063851 |
Herpes viruses for immune modulation
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes virus which:
...
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7060282 |
Attenuated equine herpesvirus
The present invention relates to novel Equine herpesvirus (EHV) mutants comprising one or more deletions, substitutions, or insertions in the endogenous promoter region of an essential viral gene,...
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7045598 |
Recombinant infectious laryngotracheitis virus and uses thereof
The present invention provides recombinant and/or isolated infectious laryngotracheitis virus glycoproteins, including gD, gl, gG and gE.
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7041813 |
Canine herpes virus alpha transinducing factor nucleic acid molecules
The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid...
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7037509 |
Immunologically significant herpes simplex virus antigens and methods for using same
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic...
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7037506 |
Vaccine accelerator factor (VAF) for improvement of vaccinations in poultry
The present invention provides a vaccine accelerator factor (VAF) which is an in ovo nucleotide immuno-stimulant. The VAF contains one or more DNA constructs, each having a DNA molecule and a...
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6946448 |
In utero oral nucleic acid immunization
Methods of nucleic acid immunization comprising the in utero delivery of nucleic acid molecules that encode one or more selected antigens to a vertebrate fetus are disclosed.
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6942863 |
Gamma herpesvirus DNA and methods of use
Isolated polynucleotides and polypeptides derived from the genome of swine gamma-herpesviruses are disclosed, including recombinant cells and vectors encoding such polypeptides and expressing such...
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6932972 |
Combined vaccine compositions
Novel combined vaccine composition preferentially for administration to adolescents are provided, comprising a hepatitis B viral antigen and a herpes simplex viral antigen and optionally in...
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6926899 |
Glycoprotein peptide of the human herpesvirus-7 for use in particular in an elisa serologic test
The invention concerns an immunogenic peptide comprising at least six consecutive amino acids of a hydrophilic region of the glycoprotein B (gB) of the human herpesvirus-7 (HIV-7), and reacting...
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6911206 |
Fusion proteins comprising carriers that can induce a dual immune response
The subject invention provides a fusion protein for producing a dual immune response in a vertebrate, which fusion protein comprises: (a) a first proteinaceous portion analogous to all or part of a...
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6890538 |
Immunization against herpes simplex virus
The invention relates to a vaccine against herpes simplex virus (HSV) comprising an invasive but attenuated or non-pathogenic bacterium, which bacterium comprises a coding sequence encoding a HSV...
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6887484 |
Vaccine composition containing a promoter peptide
A vaccine having a good vaccination effect, which comprises an antigen; a peptide selected from the group consisting of a peptide having the amino acid sequence of SEQ ID NO: 1, a peptide having...
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6867000 |
Method of enhancing immune responses to herpes
A method for inducing and enhancing protective and/or therapeutic immunity in a mammal to HSV includes the steps of at least one immunization with an effective amount of a DNA vaccine composition...
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6866854 |
Spliced gene of KSHV/HHV8, its promoter and monoclonal antibodies specific for LANA2
This invention provides an isolated nucleic acid which encodes a Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 2 polypeptide (LANA2) or a fragment thereof and also...
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6866852 |
Recombinant herpesvirus of turkeys and use thereof
The present invention provides a recombinant herpesvirus of turkeys modified by the presence of cDNA encoding the F protein of Newcastle disease virus under the control of a promoter. The poultry...
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6846670 |
Genetically engineered herpes virus for the treatment of cardiovascular disease
The present invention provides methods of expressing a nucleic acid or producing a proteinaceous composition encoded by a nucleic acid in vascular and cardiovascular cells by administration of a...
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6843991 |
Use of the M3 protein of MHV68 to block binding of a chemokine to its receptor
A pharmaceutical composition comprises M3 protein as encoded by virus MHV 68, or a homologue of said M3 protein, for use in binding to a chemokine or a chemokine analogue in vivo, or to block...
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6713067 |
Herpes viruses for immune modulation
An attenuated herpes virus which lacks a functional vhs gene or a functional equivalent thereof, but which has a functional UL43 gene or functional equivalent thereof, stimulates an immune response...
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6669939 |
(Poly)peptides which represent the epitopes of the human herpes virus type 8
The present invention relates to (poly)peptides, which are recognized by anti-HHV8 antibodies of HHV-8 infected patients, whereby these (poly)peptides are not naturally occurring HHV-8 proteins....
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6653465 |
Spliced gene of KSHV / HHV8, its promoter and monoclonal antibodies specific for LANA2
This invention provides an isolated nucleic acid which encodes a Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 2 polypeptide (LANA2) or a fragment thereof and also...
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6641818 |
Cellular proteins which mediate herpesvirus entry
A cellular herpesvirus entry protein, or a mutant, a homolog, a derivative, a variant or a biologically active fragment thereof, suspended in a pharmaceutically active carrier in an amount...
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6635258 |
Herpes simplex virus VP22 vaccines and methods of use
Vaccines containing herpes simplex virus (HSV) VP22 polypeptides capable of eliciting a cellular immune response and methods for treating and preventing HSV infections using the vaccines are...
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6632664 |
Avian infectious herpesvirus recombinants and recombinant vaccines prepared with the use of the same
An avian infectious recombinant herpesvirus is prepared by inserting a foreign gene, in particular a heterologous antigen gene, into an insertion site in an untranslated genetic region in the...
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6596282 |
Treatment of chronic viral infections with M. vaccae
The present invention provides the use of an M. vaccae preparation for the manufacture of a medicament for use in the treatment of a chronic viral infection, excluding an HIV infection. Chronic...
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6573090 |
Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors
The present invention relates to an enhanced and simplified herpes virus amplicon packaging system. The packaging system comprises a herpes virus amplicon vector and a packaging vector. In one...
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6551598 |
Vaccination against canine herpesvirosis and vaccines therefor
Use of a CHV antigen for the preparation of a vaccine against canine herpesvirosis, which is intended to be administered to gestating bitches as close as possible to whelping, preferably during the...
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6544526 |
Equine herpesvirus glycoproteins
A vaccine for the selective immunization of horses against EHV4 and/or EHV1 is provided comprising at least one of (i) EHV4 virus wherein a portion of the gG gene of the EHV4 virus that elicits a...
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6544518 |
Vaccines
The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an...
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6541009 |
Viral vaccines
A mutant virus for use as a vaccine, wherein the genome of the virus is defective in respect of a gene essential for the production of infectious virus. In one aspect the mutant virus is capable of...
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6534064 |
Stabilized protein particles for inducing cellular immune responses
A method for producing a cellular immune response in a vertebrate subject comprising administering to the vertebrate subject a vaccine composition comprising a protein particle antigen and a...
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6531313 |
Invasive bacterial vectors for expressing alphavirus replicons
The present invention is directed to a bacterial delivery system for delivering alphavirus replicon DNA into an animal or animal cells with the replicon encoding one or more heterologous genes to...
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6531136 |
Equine rhinovirus 1 proteins
A determination of the nucleotide sequence for the genome of Equine rhinovirus 1 (ERhV1), a horse-respiratory pathogen of heretofor uncertain taxonomic status, reveals a structure and predicted...
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6521236 |
Vector vaccine of recombinant feline herpesvirus
The present invention is concerned with a Feline Herpesvirus (FHV) mutant comprising a heterologous gene or foreign DNA inserted into a section of the FHV genome. The invention also relates to a...
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6516246 |
Method and system for determining native neurological dominant hemisphere
A method and system for determining the dominant cerebral hemisphere of a subject. There is further provided a method and system for using information obtained regarding hemisphere dominance for...
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