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7371390 |
Vaccine against HBV and HPV
Novel combined vaccine compositions are provided, comprising a hepatitis B viral antigen and optionally in addition one or more of the following: an EBV antigen, a hepatitis A antigen or...
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7368118 |
Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus
Peptides are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against hepatitis B virus antigens. The peptides are derived from regions of HBV envelope, and are...
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7357936 |
Adjuvant systems and vaccines
The present invention provides vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed onto a particle of metal salt and the resulting...
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7351413 |
Stabilized HBc chimer particles as immunogens for chronic hepatitis
A method of treating chronic hepatitis B is disclosed that comprises administering a T cell-stimulating amount of a vaccine to a patient. The vaccine comprises an immunogenic amount of chimeric,...
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7320795 |
Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof
The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core...
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7313357 |
Method for typing and detecting HBV
The present invention relates to a method for detection and/or genetic analysis of HBV in a biological sample, comprising hybridizing the polynucleic acids of the sample with a combination of at...
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7285289 |
Nanoparticle vaccines
The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed...
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7279555 |
Advanced antigen presentation platform
The present invention provides particles for the presentation of haptens for the purpose of eliciting an immune response. The amino acid sequences of the monomers which make up the particles are...
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7226603 |
HBV core antigen particles with multiple immunogenic components attached via peptide ligands
This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core...
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7105165 |
Mutant human hepatitis B viral strain and uses thereof
This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-‘S’-133 Oon Strain (Methionine to Threonine) which constituent viral genome is...
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7101555 |
Mycobacterial proteins, microorganisms producing them and their use for vaccines and the detection of tuberculosis
Mycobacterium tuberculosis protein having a molecular weight of 28 779 Da, and hybrid proteins containing at least portions of its sequence. These proteins may in particular be used in vaccines...
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7038035 |
Vaccine-induced hepatitis B viral strain and uses thereof
This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-'Ś-145 Singapore Strain (Glycine to Arginine) which constituent viral genome is...
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7034108 |
Mimotopes of hypervariable region 1 of the E2 glycoprotein of HCV and uses thereof
Peptides which are mimotopes of the hypervariable region 1 (HVR1) of the putative envelope protein E2 of hepatitis C virus (HCV) are provided, useful in obtaining antibodies and raising an immune...
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7029680 |
Delivery of immunogenic molecules vis HBsAg particles
Compositions of HBsAg particles having biologically active molecules contained in the particles, and methods of their use, e.g. in stimulating enhanced immune responses, are described. Antigenic...
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6946448 |
In utero oral nucleic acid immunization
Methods of nucleic acid immunization comprising the in utero delivery of nucleic acid molecules that encode one or more selected antigens to a vertebrate fetus are disclosed.
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6942866 |
Malaria immunogen and vaccine
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid protein (HBc) is disclosed that contains an immunogen for inducing the production of antibodies to malarial proteins. An...
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6932972 |
Combined vaccine compositions
Novel combined vaccine composition preferentially for administration to adolescents are provided, comprising a hepatitis B viral antigen and a herpes simplex viral antigen and optionally in...
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6921534 |
Hepatitis B virus treatment
The invention relates to HBV antigen-containing compositions that are useful in treating or preventing HBV infection. The content of the compositions can vary, as described herein, but the...
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6905677 |
Combined hepatitis B treatment
The invention relates to a method of treating patients infected with hepatitis B virus comprising the adminstration of both a nucleoside analogue and interferon-α over a prolonged period of time.
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6893644 |
Hepatitis vaccines containing 3-O-deacylated monophoshoryl lipid A
A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier...
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6827937 |
HBV capsid-binding peptide immunogens
This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core...
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6787142 |
Mutant human hepatitis B viral strain and uses thereof
This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-‘S’-133 Oon Strain (Methionine to Threonine) which constituent viral genome is...
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6756040 |
Vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminum phosphate
The invention relates to a vaccine formulation for the prevention of Haemophilus Influenzae Type B (Hib) infections and where the antigen is adsorbed onto aluminum phosphate. The invention also...
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6680059 |
Vaccines containing ribavirin and methods of use thereof
The present invention relates to compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans. More particularly, the use of...
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6676945 |
Mycobacterial proteins, microorganisms producing them and their use for vaccines and for the detection of tuberculosis
Mycobacterium tuberculosis protein having a molecular weight of 28.779 Da, and hybrid proteins containing at least portions of its sequence. These proteins may in particular be used in vaccines...
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6649172 |
Amphipathic aldehydes and their uses as adjuvants and immunoeffectors
This invention relates to novel aldehyde containing compounds and their uses as adjuvants and immunoeffectors.
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6620414 |
Hepatitis vaccines containing 3-0-deacylated monophoshoryl lipid A
A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier such as alum in...
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6589534 |
Hepatitis B virus binding proteins and uses thereof
An isolated nucleic acid, a recombinant protein encoded thereby and uses thereof. The isolated nucleic acid including (a) a polynucleotide at least 60% identical to SEQ ID NOs:1, 3, 5 or portions...
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6589530 |
Hepatitis B surface antigen vaccine
HBV surface antigen particles, prepared by recombinant DNA technology are described, said particles being composed of epitopes from the group of surface peptides and/or core peptide of non-A, non-B...
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6565849 |
Methods of enhancing activity of vaccines and vaccine compositions
Disclosed are methods for vaccine priming, using co-treatment, at a temporally similar or at a previous time, with a priming antibody capable of priming, or enhancing, or potentiating the effects...
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6544780 |
Adenovirus vector with multiple expression cassettes
Genetic vaccines and methods are provided for enhancing the immunity of a host such as a human to one or more pathogens. In one embodiment, a recombinant benign virus is provided as the genetic...
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6531313 |
Invasive bacterial vectors for expressing alphavirus replicons
The present invention is directed to a bacterial delivery system for delivering alphavirus replicon DNA into an animal or animal cells with the replicon encoding one or more heterologous genes to...
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6488934 |
Hepatitis B vaccine
A novel vaccine formulation is provided, comprising a hepatitis B component, particularly hepatitis B surface antigen, in combination with aluminum phosphate and 3 de-O-acylated monophosphoryl...
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6468534 |
Methods for obtaining transfer factor from avian sources, compositions including avian-generated transfer factor, and methods of use
A non-mammalian transfer factor, compositions including the non-mammalian transfer factor, and methods for generating and preparing the non-mammalian transfer factor. The non-mammalian transfer...
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6451320 |
Combined hepatitis and herpesvirus antigen compositions
Novel combined vaccine compositions preferentially for administration to adolescents are provided, comprising a hepatitis B viral antigen and a herpes simplex viral antigen and optionally in...
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6419931 |
Compositions and methods for eliciting CTL immunity
Cytotoxic T lymphocyte responses are effectively induced to an antigen of interest, particularly viral, bacterial, parasitic and tumor antigens. Compositions, including pharmaceutical compositions,...
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6410009 |
Pharmaceutical composition for treating hepatitis B virus (HBV) infection
The invention provides a pharmaceutical composition for the treatment of hepatitis B virus (HBV) infection, comprising an amount of a soluble active agent which interacts with at least one of the...
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6403092 |
Immune response modulator alpha-2 macroglobulin complex
Activation of α 2 -macroglobulin (α 2 M) with a nucleophilic compound followed by incubation of the activated α 2 M at elevated temperature with a biomolecule results in covalent incorporation...
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6355248 |
Method of modulating an immune response in an infected mammal by transmucosal administration of modulating agent
Methods and compositions for modulating an immune response in a mammal infected with a bacterium, a virus, or a parasite are provided. The methods and compositions are useful in mammals...
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6322789 |
HLA-restricted hepatitis B virus CTL epitopes
Cytotoxic T lymphocyte-stimulating peptides induce HLA-restricted responses to hepatitis B virus antigens. The peptides, derived from CTL epitopic regions of both HBV surface and nucleocapsid...
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6319501 |
Method of immunizing against hepatitis B virus
A method for immunizing a human against hepatitis B virus comprising administering to the human a vaccine comprising a hepatitis B virus surface antigen, wherein included in the vaccine is one or...
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6306625 |
Method for obtaining expression of mixed polypeptide particles in yeast
The present invention provides a method for obtaining expression of a mixed hepatitis B surface antigen particle, e.g., a particle of mixed polypeptide composition, in yeast. Also disclosed is a...
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6297355 |
Polypeptides displaying HBV antigenicity or hbv antigen specificity
Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying HBV antigenicity and genes coding therefor and methods of making and using these molecules, hosts,...
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6270955 |
Pharmaceutical compositions and methods for producing antibodies to hepatitis b virus and kits and methods for detecting antibodies to hepatitis b virus
Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying HBV anti-genicity and genes coding therefor and methods of making and using these molecules, hosts,...
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6268122 |
Recombinant DNA molecules and their method of production
Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying HBV antigenicity and genes coding therefor and methods of making and using these molecules, hosts,...
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6261569 |
Retro-, inverso- and retro-inverso synthetic peptide analogues
Synthetic peptide antigen analogues of native peptide antigens with partial or complete retro, inverso or retro-inverso modifications are provided. When administered as an immunogen to an...
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6231864 |
Strategically modified hepatitis B core proteins and their derivatives
A strategically modified hepatitis B core protein is described, where an insert is provided, preferably in an immunodominant region of the nucleocapsid protein, containing a chemically reactive...
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6221664 |
Composite vaccine which contains antigen, antibody and recombinant DNA and its preparing method
This invention is a vaccine prepared from antigen-antibody-recombinant plasmid DNA complex. This invention is a complex vaccine composed of at least one microbial source antigen and its (their)...
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6149911 |
Method for enhancing the immunogenicity of an immunogenic compound or hapten, and use thereof for preparing vaccines
The present invention relates to a process for improving the immunogenicity of an immunogen, an antigen or a hapten, when it is administered to a host, independently of the mode of administration,...
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6099840 |
Hepatitis B vaccine
A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a...
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